CAZyme Information: HCDG_00143-t38_1-p1

Basic Information

• Species: Histoplasma capsulatum
• Lineage: Ascomycota; Eurotiomycetes; ; Ajellomycetaceae; Histoplasma; Histoplasma capsulatum
• CAZyme ID: HCDG_00143-t38_1-p1
• CAZy Family: AA1
• CAZyme Description: glycosyl hydrolase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
649		73540.44	5.7849

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HcapsulatumH143	9796	544712	249	9547

• Gene Location: location=GG692419:579685-582192(+)

Full Sequence      

MAPLRFRVEGSTFRDSQNREVTLRGINVDAAAKYPKKPNIPSYVSENFYDGDNVSFVGRP
FELKDAHTHFTRLKRWGYNFIRYIFTWEALEHSGPGKYDEEFIQFTIEILRLAKSYGFYV
YMDPHQDVWSRFSGGSGAPMWTVYAAGFNPRNFNVTQAALVQNTYLPEPASFPKMIWSTN
YSRLVCQTIFTLFWAGKDFAPKAIIDGKNIQDYLQSHYINACKHLATRIHEAGDLEDEVV
IGWENMNETGKTLNYEGFTNQYFMDHYRNFKNAIRSVHANAIMFCQPAVLELPPSIKGTE
DDDVNMVHAAHQYDGLTLMTKHWNRIYNVDVVGVIRGKYLSPVFAIKIGETAIRNCLRDQ
LRYLRNESFDYMGLHPMVFTELGIPYDMDDKHAYKTGDFSSQTSAMDANHFAIEGSGSNG
FSLWCYTSENCHEWGDRWNGEDLSIFSADDLELPLQDLDVLGNIPQNRLSTSSDRTSPTF
STAQSSSATHVSSQNLKNAIPQPSISQVSQPSPELTDKPGFRAAEAFIRPSPFATHGSIK
EYGFDLRNCLFTLSLSADTATTEAAPSIIYLPEWHYPKMNTEVAVSGGKWAIDVQEVGSG
TMQMLKWWHAEGDQNIKIQGLKRKAATVPDTSEDEGYLEQCQRNSCSVM

Enzyme Prediction     

EC	3.2.1.21:3	3.2.1.45:1	3.2.1.104:1

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH5	15	250	3.9e-116	0.4397031539888683

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
408348	Glyco_hydro_5_C	1.07e-26	529	618	1	86	Glycoside hydrolase family 5 C-terminal domain. This is the C-terminal domain of endo-glycoceramidase II (EGC), a membrane-associated family 5 glycosidase pfam00150. The C-terminal domain assumes a beta-sandwich fold, which resembles that of many carbohydrate-binding modules.
225344	BglC	3.50e-04	70	125	79	137	Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism].
395098	Cellulase	3.78e-04	70	127	30	88	Cellulase (glycosyl hydrolase family 5).

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSS56400.1|GH5_12	0.0	1	649	1	766
QSS71241.1|GH5_12	0.0	1	649	1	766
QSS62066.1|GH5_12	0.0	1	649	1	766
ABA54914.1|GH5_12	0.0	1	649	1	764
QQK48136.1|GH5_12	5.80e-309	1	649	1	755

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7LPO_A	3.17e-134	13	640	28	784	Chain A, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPO_B Chain B, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPO_C Chain C, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPO_D Chain D, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPP_A Chain A, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPP_B Chain B, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPP_C Chain C, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPP_D Chain D, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPQ_A Chain A, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPQ_B Chain B, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPQ_C Chain C, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPQ_D Chain D, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99]
2OSW_A	1.45e-07	11	311	35	292	Endo-glycoceramidase II from Rhodococcus sp. [Rhodococcus sp.],2OSW_B Endo-glycoceramidase II from Rhodococcus sp. [Rhodococcus sp.],2OYK_A Endo-glycoceramidase II from Rhodococcus sp.: cellobiose-like isofagomine complex [Rhodococcus sp.],2OYK_B Endo-glycoceramidase II from Rhodococcus sp.: cellobiose-like isofagomine complex [Rhodococcus sp.],2OYL_A Endo-glycoceramidase II from Rhodococcus sp.: cellobiose-like imidazole complex [Rhodococcus sp.],2OYL_B Endo-glycoceramidase II from Rhodococcus sp.: cellobiose-like imidazole complex [Rhodococcus sp.],2OYM_A Endo-glycoceramidase II from Rhodococcus sp.: five-membered iminocyclitol complex [Rhodococcus sp.],2OYM_B Endo-glycoceramidase II from Rhodococcus sp.: five-membered iminocyclitol complex [Rhodococcus sp.]
2OSX_A	1.45e-07	11	311	35	292	Chain A, Endoglycoceramidase II [Rhodococcus sp.]
2OSY_A	7.69e-07	11	311	35	292	Chain A, Endoglycoceramidase II [Rhodococcus sp.],2OSY_B Chain B, Endoglycoceramidase II [Rhodococcus sp.]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|H1AE13|EGCR1_ASPFM	2.83e-303	1	649	1	759	Glucosylceramidase OS=Neosartorya fumigata OX=746128 GN=egc1 PE=1 SV=1
sp|P40566|EGH1_YEAST	6.72e-134	13	634	13	756	Ergosteryl-beta-glucosidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=EGH1 PE=1 SV=1
sp|I1BTD7|EGCR1_RHIO9	4.33e-77	10	448	19	549	Glucosylceramidase OS=Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) OX=246409 GN=ERC1 PE=1 SV=1
sp|H1AE12|EGCR1_CRYNH	3.73e-63	8	593	18	657	Glucosylceramidase OS=Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) OX=235443 GN=EGC1 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000061	0.000000

TMHMM  Annotations     

There is no transmembrane helices in HCDG_00143-t38_1-p1.