CAZyme Information: HCBG_02819-t26_1-p1

Basic Information

• Species: Histoplasma capsulatum
• Lineage: Ascomycota; Eurotiomycetes; ; Ajellomycetaceae; Histoplasma; Histoplasma capsulatum
• CAZyme ID: HCBG_02819-t26_1-p1
• CAZy Family: GH16
• CAZyme Description: glucosidase I

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
896		101747.16	4.9295

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HcapsulatumG186AR	9364	447093	110	9254

• Gene Location: location=GG663365:1994947-1997999(+)

Full Sequence      

MGQILRSERHFIRCPAQSTDYRCCEKFPTVCGFKLGANGLDPCVNSEKMVLALQSLLFLL
LSISLAAKEDSSAASHEVPILAKELGRASNESLLWGPYRPNLYFGVRPRLPKSLIMGLMW
ANVDEFQNIQESRYTFIVKRNLGSPRSYYVVVLPISITCDLLTFPEEFRHTCEQNEGMAG
YGWDEYDIRKGGRQTIHDTGNAIDLTIDFIKVPGGGNGGNWGARVKGTPRADASPDQATT
VVFYAAIEGLGTLELANEVDALGYKDDVKFTGSTVGLGDFTLDLTRGPESNAHPPRRHAA
YDDKPLDRTMVAGLQVPADVLWNAKSLLFMHMKEEIDATLKKYGTDNPLPPAQLITIANK
PDAGNMYFVQRAFEGSFEFDILFSSASSPAPMTSTVLTEEIEPASASFSKKFKEVFPPLP
PFNLPKYTEFSKAMFSNLVGGVGYFYGDSVVDRSNSPEYEEENELFWEETEQARAQVKPS
VDGPSELFTSIPSRPFFPRGFLWDEGFHLIPVIEWDLDLASWFNLMDDDGWIAREQILGP
EARSKVPTEFQVQYPHYANPPTLFMILEAFVEKIQLSREQAGVRDAPSDIRSAHLENPDL
AILYLRSVYPLLKRQFFWFKKTQWGDLKSYDREAFSSKEAYRWRGRSIKHILTSGLDDYP
RPQPPHPGELHVDLISWMGMMSRAIRRIAETLEETEDAKEFAAYETRIIRNIDDLHWDKD
AQTFCDATVDDFEEHVHVCHKGYISLFPFMTGLMPADSPRLGPTLDLIQDPKELWSDYGI
RSLSKKDEFYGTDENYWRGPIWININYMILKNLLDVATVPGPHQEQARKMYTQLRQNIVD
NVFNQWKETGFAWEQYNPETGAGQRTQHFTGWTSLVVKMMVMPDLSADHGTRHEEL

Enzyme Prediction     

EC	3.2.1.106:25	3.2.1.-:4

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH63	669	880	4.3e-36	0.43157894736842106

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
397353	Glyco_hydro_63	0.0	392	882	1	494	Glycosyl hydrolase family 63 C-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain.
407154	Glyco_hydro_63N	1.06e-113	93	350	1	221	Glycosyl hydrolase family 63 N-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the N-terminal beta sandwich domain.
225942	GDB1	9.34e-08	603	830	359	561	Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism].
236653	PRK10137	2.03e-05	672	880	578	779	alpha-glucosidase; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSS68976.1|GH63	0.0	49	896	1	818
QSS50985.1|GH63	0.0	49	896	1	818
QSS63216.1|GH63	0.0	49	896	1	818
QVM12625.1|GH63	0.0	60	887	15	808
BCR88942.1|GH63	0.0	72	896	19	816

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4J5T_A	4.50e-170	83	880	5	800	Crystal structure of Processing alpha-Glucosidase I [Saccharomyces cerevisiae S288C]
5MHF_A	3.06e-132	93	889	37	784	Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_B Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_C Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_D Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|O14255|GCS1_SCHPO	1.60e-233	83	880	32	804	Probable mannosyl-oligosaccharide glucosidase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC6G10.09 PE=3 SV=1
sp|P53008|CWH41_YEAST	4.42e-169	83	880	35	830	Mannosyl-oligosaccharide glucosidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CWH41 PE=1 SV=1
sp|Q80UM7|MOGS_MOUSE	1.41e-133	93	880	92	830	Mannosyl-oligosaccharide glucosidase OS=Mus musculus OX=10090 GN=Mogs PE=1 SV=1
sp|O88941|MOGS_RAT	1.69e-130	95	880	94	830	Mannosyl-oligosaccharide glucosidase OS=Rattus norvegicus OX=10116 GN=Mogs PE=1 SV=1
sp|Q13724|MOGS_HUMAN	1.37e-123	93	880	94	833	Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
0.957837	0.042164

TMHMM  Annotations     

There is no transmembrane helices in HCBG_02819-t26_1-p1.