CAZyme Information: HCAG_05129-t26_1-p1

Basic Information

• Species: Histoplasma capsulatum
• Lineage: Ascomycota; Eurotiomycetes; ; Ajellomycetaceae; Histoplasma; Histoplasma capsulatum
• CAZyme ID: HCAG_05129-t26_1-p1
• CAZy Family: GH5
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
914	CH476659|CGC10	104548.24	5.6303

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HcapsulatumNAm1	9402	339724	89	9313

• Gene Location: location=CH476659:924631-928312(-)

Full Sequence      

MVLALQSLLVLLLSISLAAGEDSSAGSHEVPILAKELRRASNESLLWGPYRPNLYFGVRP
RIPKSLIMGLMWANVDEFQNIQEKFRHTCEQNEGMAGYGWDEYDIRKGGRQTIHDTGNAI
DLTIDFIKVPGGGNGGNWGARVKGTPRADASPDQATTVVFYAAIEGLGTLELANEVDALG
YKDAVKFTGSTEIDATLKKYGTDNPLPPAQLITIANKPDAGNMYFVQRAFEGSFEVCPRF
YYNHLLISLADYGKFDILFSSASSPAPMTSTVLTEEIEPASASFSKKFKDVFPPLPPFNL
PKYTEFSKAMFSNLVGGVGYFYGDSVVDRSNSPEYEEENELFWEETEQARAQVKPSVDGP
LELFTSIPSRPFFPRGFLWDEGFHLIPVIEWDLDLALEITRSWFNLMDDDGWIAREQILG
PEARSKVPTEFQVQYPHYANPPTLFMILEAFVEKIQLSRKQAGVRDGPSDIRSAHLENPD
LAILYLRSVYPLLKRQFFWFKKTQWGDLKSYDREAFSSKEAYRWRGRSIKHILTSGLDDY
PRPQPPHPGELHVDLISWMGMMSRAIRRIAETLEEAEDAKEFAAYETRIIRNIDDLHWDK
DAQTFCDATVDDFEEHVHVCHKGYISLFPFMTGLVPADSPRLGPILDLIQDPKELWSDYG
IRSLSKKDEFYGTDENYWRGPIWININYMILKNLLDVATVPGPHQEQARKMYIQLRQNIV
DNVFNQWEETGFAWEQYNPETGAGQRTQHFTGWTSLVVKMMVMPDLSADHRTRHEELRPY
HLISNDVFASQSISSGPGIEPHNLYPQMESGAFVLFGVHQFFRVFYSSYLFLLRDLHRYS
YLPFDDRHSHHTRPEFPVHLVSHAAPARFLAPFHNLSLPSYLPDLQPLYLPFPETTQTQH
PWNRHHPALPRRPH

Enzyme Prediction     

EC	3.2.1.106:25	3.2.1.-:4

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH63	550	761	1.8e-36	0.43157894736842106

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
397353	Glyco_hydro_63	0.0	268	763	1	494	Glycosyl hydrolase family 63 C-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain.
407154	Glyco_hydro_63N	8.74e-80	45	192	1	146	Glycosyl hydrolase family 63 N-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the N-terminal beta sandwich domain.
225942	GDB1	2.00e-08	484	711	359	561	Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism].
236653	PRK10137	4.38e-06	553	761	578	779	alpha-glucosidase; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSS63216.1|GH63	0.0	1	777	1	818
QSS68976.1|GH63	0.0	1	777	1	818
QSS50985.1|GH63	0.0	1	777	1	818
QVM12625.1|GH63	0.0	12	768	15	808
BCR88942.1|GH63	0.0	24	777	19	816

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4J5T_A	6.12e-165	35	761	5	800	Crystal structure of Processing alpha-Glucosidase I [Saccharomyces cerevisiae S288C]
5MHF_A	1.33e-131	45	770	37	784	Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_B Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_C Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus],5MHF_D Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin [Mus musculus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|O14255|GCS1_SCHPO	8.51e-227	35	761	32	804	Probable mannosyl-oligosaccharide glucosidase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC6G10.09 PE=3 SV=1
sp|P53008|CWH41_YEAST	5.97e-164	35	761	35	830	Mannosyl-oligosaccharide glucosidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CWH41 PE=1 SV=1
sp|Q80UM7|MOGS_MOUSE	6.16e-133	45	761	92	830	Mannosyl-oligosaccharide glucosidase OS=Mus musculus OX=10090 GN=Mogs PE=1 SV=1
sp|O88941|MOGS_RAT	2.02e-129	47	761	94	830	Mannosyl-oligosaccharide glucosidase OS=Rattus norvegicus OX=10116 GN=Mogs PE=1 SV=1
sp|Q13724|MOGS_HUMAN	3.59e-126	45	761	94	833	Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000238	0.999711	CS pos: 20-21. Pr: 0.9544

TMHMM  Annotations     

There is no transmembrane helices in HCAG_05129-t26_1-p1.