CAZyme Information: HCAG_04343-t26_1-p1

Basic Information

• Species: Histoplasma capsulatum
• Lineage: Ascomycota; Eurotiomycetes; ; Ajellomycetaceae; Histoplasma; Histoplasma capsulatum
• CAZyme ID: HCAG_04343-t26_1-p1
• CAZy Family: GH24
• CAZyme Description: negative regulator of the PHO system

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
788		88695.36	5.7480

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HcapsulatumNAm1	9402	339724	89	9313

• Gene Location: location=CH476658:1115023-1118510(-)

Full Sequence      

MGPLRFRVEGSTFRDSQNREVALRGINVDAAAKYPKTPNIPSYVSENFYDGDNVSFVGRP
FELKDAHTHFTRLKRWGYNFIRYIFTWEALEHSGPGKYDEEFIKFTIEILRLAKSYGFYV
YMDPHQDVWSRFSGGSGAPMWTVYAAGFNPRNFNVTQAALVQNTYLPEPASFPKMIWSTN
YSRLVCQTIFTLFWAGKDFAPKAIIDGKNIQDYLQSHYINACKHLATRIHEAGDLEDEVV
IGWENMNEVNRGLVGIQDLSIIPSDQHLQLGTSPTAFQGMLTGSGRACEVNTWGFGSFGP
YQIGRELVDPKGQSAWLTANFDDTLYGWKRDPQWKLGECLWAQHGVWDPNTDSLLKKDYF
AKDPKTGKTLNYEDFTNQYFMDHYRNFKNAIRSVHANAIMFCQPAVLELPPSIKGTEDDD
ANMVHAAHQYDGLTLMTKHWNRIYNVDVVGVIRGKYLSPVFAIKIGETAIRNCLRDQLRY
LRNESFDYMGLHPMVFTELGIPYDMDDKHAYKTGDFSSQTSAMDANHFAIEGSGSNGFSL
WCYTSENCHEWGDRWNGEDLSIFSADDLELPLQDLDVLGNIPQNRLSTSSDRTSPTFSTA
QSSSATHVSSQNLKNAIPQPSISQVSQLSPELTDKPGFRAAEAFIRPSPVATHGSIKEYG
FDLRNCIFTLSLSADTATTEAAPSTIYLPEWHYPKMNTEVAVSGGKWAIDVQEGLKRKAA
TVPDTSEDEGYLEQCQRNSCNGMVPGLVVDIHPSHCWYEPATTKTGTKKIGEPWMTKSVD
GTDPHLSA

Enzyme Prediction     

EC	3.2.1.21:3	3.2.1.45:1	3.2.1.104:1

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH5	15	549	3e-221	0.9981447124304267

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
408348	Glyco_hydro_5_C	1.92e-22	646	710	1	64	Glycoside hydrolase family 5 C-terminal domain. This is the C-terminal domain of endo-glycoceramidase II (EGC), a membrane-associated family 5 glycosidase pfam00150. The C-terminal domain assumes a beta-sandwich fold, which resembles that of many carbohydrate-binding modules.
225344	BglC	4.18e-04	70	125	79	137	Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism].
395098	Cellulase	8.35e-04	70	127	30	88	Cellulase (glycosyl hydrolase family 5).

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSS62066.1|GH5_12	0.0	1	743	1	766
QSS56400.1|GH5_12	0.0	1	743	1	766
QSS71241.1|GH5_12	0.0	1	743	1	766
ABA54914.1|GH5_12	0.0	1	740	1	761
BCS14927.1|GH5_12	0.0	1	743	1	762

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7LPO_A	5.45e-194	13	738	28	771	Chain A, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPO_B Chain B, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPO_C Chain C, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPO_D Chain D, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPP_A Chain A, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPP_B Chain B, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPP_C Chain C, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPP_D Chain D, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPQ_A Chain A, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPQ_B Chain B, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPQ_C Chain C, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99],7LPQ_D Chain D, Cytoplasmic protein [Cryptococcus neoformans var. grubii H99]
2OSW_A	2.31e-06	11	248	35	224	Endo-glycoceramidase II from Rhodococcus sp. [Rhodococcus sp.],2OSW_B Endo-glycoceramidase II from Rhodococcus sp. [Rhodococcus sp.],2OYK_A Endo-glycoceramidase II from Rhodococcus sp.: cellobiose-like isofagomine complex [Rhodococcus sp.],2OYK_B Endo-glycoceramidase II from Rhodococcus sp.: cellobiose-like isofagomine complex [Rhodococcus sp.],2OYL_A Endo-glycoceramidase II from Rhodococcus sp.: cellobiose-like imidazole complex [Rhodococcus sp.],2OYL_B Endo-glycoceramidase II from Rhodococcus sp.: cellobiose-like imidazole complex [Rhodococcus sp.],2OYM_A Endo-glycoceramidase II from Rhodococcus sp.: five-membered iminocyclitol complex [Rhodococcus sp.],2OYM_B Endo-glycoceramidase II from Rhodococcus sp.: five-membered iminocyclitol complex [Rhodococcus sp.]
2OSX_A	2.31e-06	11	248	35	224	Chain A, Endoglycoceramidase II [Rhodococcus sp.]
2OSY_A	9.20e-06	11	247	35	223	Chain A, Endoglycoceramidase II [Rhodococcus sp.],2OSY_B Chain B, Endoglycoceramidase II [Rhodococcus sp.]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|H1AE13|EGCR1_ASPFM	0.0	1	743	1	759	Glucosylceramidase OS=Neosartorya fumigata OX=746128 GN=egc1 PE=1 SV=1
sp|P40566|EGH1_YEAST	2.18e-174	13	746	13	750	Ergosteryl-beta-glucosidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=EGH1 PE=1 SV=1
sp|I1BTD7|EGCR1_RHIO9	1.59e-104	10	565	19	549	Glucosylceramidase OS=Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) OX=246409 GN=ERC1 PE=1 SV=1
sp|H1AE12|EGCR1_CRYNH	7.36e-91	8	710	18	657	Glucosylceramidase OS=Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) OX=235443 GN=EGC1 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000081	0.000000

TMHMM  Annotations     

There is no transmembrane helices in HCAG_04343-t26_1-p1.