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CAZyme Information: HCAG_01147-t26_1-p1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Histoplasma capsulatum | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Ascomycota; Eurotiomycetes; ; Ajellomycetaceae; Histoplasma; Histoplasma capsulatum | |||||||||||
| CAZyme ID | HCAG_01147-t26_1-p1 | |||||||||||
| CAZy Family | AA7 | |||||||||||
| CAZyme Description | cysteine desulfurase, mitochondrial precursor | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 4037711; End:4041696 Strand: + | |||||||||||
Full Sequence Download help
| MALPSQERTT IGSFLTDEEI IEPTSDRYAS ATDFWTAYKN PKPQLVLRPK SLPALQKTVQ | 60 |
| YLCASDLDFS VRSGGNNTSG AKHVQLSMSA FDSFEFDQDS ETVTIGAGQT WGEVDRKVEE | 120 |
| AAPGYTVLST RVPFVGVAGS LLLGGMSWFS GEHGLCSDPH NLLDAHVVLP DGRMLWASTE | 180 |
| PDLLWALRGG GGNFGVVSAF KVKVHRCPQK IHAGTIAFPK TAMKAVSQGL SDFMKRCTDP | 240 |
| KLGAHVIVMN FDPPTDTDDV PQPGIAIIIF DSHGEEHGRS ELGFKWAFDI EGAVDMTKVM | 300 |
| NIREVNEEGA SLRSLAGNTI MLSSPLVDTS SIDPDFVVRI AEFYQQAVEA NKALGSGTLV | 360 |
| VLEVLGKGAL TSSGGSNMTA WPHTKPQHVL QLVVGHPPGA DCSQELALGL LEKSPTQICP | 420 |
| SHKPGEYWPA FINESQNLNQ IFGPNYERLR HIKTKYDPRA SPQTGQLNNH AASLPSITMS | 480 |
| NLAPSAFRQA LRAYPRRCAS IRPAAPRTAA ARRCYTSESK PARAQSSVDL DVDVAIKTGQ | 540 |
| RPFAEQTGIR PHNVTVPGTA VDSDAMMGPS TGILKQATVL DQGSRPIYLD MQATTPTDPR | 600 |
| VLDAMLPFLT GLYGNPHSRT HAYGWETEKA TEQAREHVAK LIGADPKEII FTSGATESNN | 660 |
| MSIKGVAKFF GRSGKKKHII TSQTEHKCVL DSCRHLQDEG FEVTYLPVQS NGLIDLKDLE | 720 |
| AEIRPETALV SIMTVNNEIG VIQPVKEIGA LCRSKRVFFH TDAAQAVGKI PIDVNEWNVD | 780 |
| LLSISGHKIY GPKGIGACYV RRRPRVRIDP IITGGGQERG LRSGTLAPHL AVGIGEACRI | 840 |
| AKEEMEYDAK RIKALSKRLL DGLLSMEHTS LNGDPEKHYP GCVNVSFAYV EGESLLMALK | 900 |
| DIALSSGSAC TSASLEPSYV LRALGNSDES AHSSIRFGIG RFTTESEIDY VLKAVRERVS | 960 |
| FLRELSPLWE LVQEGVDLNT IEWSQH | 986 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| AA7 | 31 | 238 | 6e-44 | 0.4585152838427948 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 178257 | PLN02651 | 0.0 | 587 | 949 | 1 | 364 | cysteine desulfurase |
| 184450 | PRK14012 | 0.0 | 586 | 986 | 4 | 404 | IscS subfamily cysteine desulfurase. |
| 131061 | IscS | 0.0 | 586 | 986 | 4 | 402 | cysteine desulfurase IscS. This model represents IscS, one of several cysteine desulfurases from a larger protein family designated (misleadingly, in this case) class V aminotransferases. IscS is one of at least 6 enzymes characteristic of the IscSUA-hscAB-fsx system of iron-sulfur cluster assembly. Scoring almost as well as proteobacterial sequences included in the model are mitochondrial cysteine desulfurases, apparently from an analogous system in eukaryotes. The sulfur, taken from cysteine, may be used in other systems as well, such as tRNA base modification and biosynthesis of other cofactors. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Protein synthesis, tRNA and rRNA base modification] |
| 224029 | NifS | 0.0 | 585 | 970 | 1 | 386 | Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]. |
| 132443 | FeS_nifS | 4.66e-180 | 587 | 968 | 1 | 379 | cysteine desulfurase NifS. Members of this protein family are NifS, one of several related families of cysteine desulfurase involved in iron-sulfur (FeS) cluster biosynthesis. NifS is part of the NIF system, usually associated with other nif genes involved in nitrogenase expression and nitrogen fixation. The protein family is given a fairly broad interpretation here. It includes a clade nearly always found in extended nitrogen fixation genomic regions, plus a second clade more closely related to the first than to IscS and also part of NifS-like/NifU-like systems. This model does not extend to a more distantly clade found in the epsilon proteobacteria such as Helicobacter pylori, also named NifS in the literature, built instead in TIGR03403. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| UNI23960.1|AA7 | 1.28e-13 | 43 | 459 | 48 | 460 |
| UPK90596.1|AA7 | 1.98e-13 | 43 | 470 | 20 | 446 |
| QUC19098.1|AA7 | 9.10e-13 | 43 | 459 | 48 | 459 |
| QRW27390.1|AA7 | 1.32e-12 | 20 | 221 | 43 | 248 |
| VBB87167.1|AA7 | 3.09e-12 | 35 | 231 | 49 | 257 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 5WGB_A | 2.78e-207 | 570 | 986 | 11 | 426 | Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and E. coli ACP1 protein at 2.75A [Homo sapiens] |
| 6NZU_A | 1.36e-206 | 585 | 986 | 3 | 403 | Structure of the human frataxin-bound iron-sulfur cluster assembly complex [Homo sapiens],6NZU_E Structure of the human frataxin-bound iron-sulfur cluster assembly complex [Homo sapiens] |
| 5WKP_A | 1.52e-206 | 585 | 986 | 6 | 406 | Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A [Homo sapiens],5WKP_E Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A [Homo sapiens],5WLW_A Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A. [Homo sapiens],5WLW_E Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A. [Homo sapiens],6UXE_A Structure of the human mitochondrial desulfurase complex Nfs1-ISCU2(M140I)-ISD11 with E.coli ACP1 at 1.57 A resolution showing flexibility of N terminal end of ISCU2 [Homo sapiens],6W1D_A Structure of human mitochondrial complex Nfs1-ISCU2 (WT)-ISD11 with E.coli ACP1 at 1.8 A resolution (NIAU)2 [Homo sapiens],6WI2_A Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution (NIAU)2. N-terminal mutation of ISCU2 (L35) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. [Homo sapiens],6WIH_A N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2. [Homo sapiens],7RTK_A Chain A, Cysteine desulfurase, mitochondrial [Homo sapiens] |
| 5USR_A | 2.22e-206 | 570 | 986 | 11 | 426 | Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms [Homo sapiens],5USR_C Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms [Homo sapiens],5USR_E Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms [Homo sapiens],5USR_G Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms [Homo sapiens] |
| 5KZ5_1 | 5.18e-200 | 595 | 986 | 1 | 391 | Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_2 Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_3 Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_4 Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_M Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_N Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_O Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_P Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_Q Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_R Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_S Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens],5KZ5_T Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold [Homo sapiens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| sp|P0DN31|NFS1_ARTBC | 4.15e-288 | 479 | 986 | 1 | 503 | Cysteine desulfurase, mitochondrial OS=Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) OX=663331 GN=ARB_05732-2 PE=3 SV=1 |
| sp|P87185|NFS1_CANAL | 2.50e-214 | 583 | 986 | 85 | 488 | Cysteine desulfurase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=NFS1 PE=2 SV=1 |
| sp|P25374|NFS1_YEAST | 1.56e-212 | 531 | 986 | 54 | 497 | Cysteine desulfurase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=NFS1 PE=1 SV=2 |
| sp|P87187|NFS1_CANMA | 7.83e-212 | 559 | 986 | 53 | 484 | Cysteine desulfurase, mitochondrial OS=Candida maltosa OX=5479 GN=SPL1 PE=3 SV=1 |
| sp|O60028|NFS1_ASHGO | 1.40e-208 | 512 | 986 | 7 | 490 | Cysteine desulfurase, mitochondrial OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) OX=284811 GN=NFS1 PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 1.000053 | 0.000001 |