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CAZyme Information: EPrPVT00000017896-p1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Phytopythium vexans | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Oomycota; NA; ; Pythiaceae; Phytopythium; Phytopythium vexans | |||||||||||
| CAZyme ID | EPrPVT00000017896-p1 | |||||||||||
| CAZy Family | GH18 | |||||||||||
| CAZyme Description | HECT E3 ubiquitin ligase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | ||||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| CBM51 | 790 | 907 | 8.6e-17 | 0.8059701492537313 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 238033 | HECTc | 3.40e-81 | 4705 | 5061 | 11 | 350 | HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains. |
| 395507 | HECT | 1.38e-77 | 4752 | 5060 | 1 | 299 | HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus. |
| 214523 | HECTc | 4.79e-73 | 4725 | 5061 | 1 | 327 | Domain Homologous to E6-AP Carboxyl Terminus with. E3 ubiquitin-protein ligases. Can bind to E2 enzymes. |
| 293939 | SPRY_HERC1 | 7.24e-59 | 565 | 726 | 1 | 162 | SPRY domain in HERC1. This SPRY domain is found in the HERC1, a large protein related to chromosome condensation regulator RCC1. It is widely expressed in many tissues, playing an important role in intracellular membrane trafficking in the cytoplasm as well as Golgi apparatus. HERC1 also interacts with tuberous sclerosis 2 (TSC2, tuberin), which suppresses cell growth, and results in the destabilization of TSC2. However, the biological function of HERC1 has yet to be defined. |
| 227354 | HUL4 | 4.50e-55 | 4718 | 5061 | 531 | 868 | Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 6.27e-14 | 728 | 908 | 422 | 579 | |
| 1.17e-13 | 740 | 906 | 440 | 578 | |
| 3.27e-10 | 794 | 908 | 230 | 340 | |
| 3.27e-10 | 794 | 908 | 230 | 340 | |
| 3.38e-10 | 805 | 909 | 281 | 380 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2.00e-43 | 4705 | 5061 | 88 | 430 | Structure of an Rsp5xUbxSna3 complex: Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 [Saccharomyces cerevisiae S288C],4LCD_B Structure of an Rsp5xUbxSna3 complex: Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 [Saccharomyces cerevisiae S288C] |
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| 3.10e-42 | 4705 | 5061 | 36 | 378 | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: Rsp5 and UbV R5.4 [Saccharomyces cerevisiae],5HPL_B System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: Rsp5 and UbV R5.4 [Saccharomyces cerevisiae] |
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| 9.49e-42 | 4705 | 5061 | 85 | 427 | Structure and Function of a Ubiquitin Binding Site within the Catalytic Domain of a HECT Ubiquitin Ligase [Saccharomyces cerevisiae] |
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| 1.77e-38 | 4705 | 5056 | 42 | 378 | Chain A, E3 ubiquitin-protein ligase SMURF2 [Homo sapiens] |
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| 1.05e-36 | 4705 | 5056 | 35 | 371 | Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain [Homo sapiens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3.29e-52 | 4468 | 5058 | 4264 | 4789 | E3 ubiquitin-protein ligase HERC2 OS=Mus musculus OX=10090 GN=Herc2 PE=1 SV=3 |
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| 1.25e-51 | 4468 | 5058 | 4262 | 4787 | E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens OX=9606 GN=HERC2 PE=1 SV=2 |
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| 1.56e-49 | 4729 | 5052 | 4510 | 4830 | Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2 |
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| 1.34e-47 | 4679 | 5052 | 473 | 842 | E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1 |
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| 1.78e-47 | 4679 | 5052 | 473 | 842 | E3 ubiquitin-protein ligase HECTD3 OS=Mus musculus OX=10090 GN=Hectd3 PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 0.999308 | 0.000740 |