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CAZyme Information: EPrPVT00000015633-p1

You are here: Home > Sequence: EPrPVT00000015633-p1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Phytopythium vexans
Lineage Oomycota; NA; ; Pythiaceae; Phytopythium; Phytopythium vexans
CAZyme ID EPrPVT00000015633-p1
CAZy Family CBM48
CAZyme Description Bifunctional purine biosynthesis protein PURH
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
1400 150369.05 5.2035
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_PvexansDAOMBR484 11991 1223560 34 11957
Gene Location

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.21:1

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH3 112 324 1.3e-56 0.9351851851851852

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
223216 PurH 0.0 833 1400 1 515
AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism].
180841 PRK07106 0.0 1012 1400 3 390
phosphoribosylaminoimidazolecarboxamide formyltransferase.
234854 purH 1.75e-163 831 1400 1 513
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional
396396 AICARFT_IMPCHas 8.05e-99 938 1270 2 308
AICARFT/IMPCHase bienzyme. This is a family of bifunctional enzymes catalyzing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalyzed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase EC:2.1.2.3 (AICARFT), this enzyme catalyzes the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate. This is catalyzed by a pair of C-terminal deaminase fold domains in the protein, where the active site is formed by the dimeric interface of two monomeric units. The last step is catalyzed by the N-terminal IMP (Inosine monophosphate) cyclohydrolase domain EC:3.5.4.10 (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP.
214822 AICARFT_IMPCHas 1.20e-96 937 1270 1 310
AICARFT/IMPCHase bienzyme. This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
9.05e-289 17 757 18 762
4.29e-262 45 758 1 725
1.96e-255 28 757 67 808
8.43e-254 1 763 1 769
2.86e-253 1 763 46 825

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1.17e-156 830 1400 9 601
Crystal structure of AICARFT bound to an antifolate [Homo sapiens],5UY8_B Crystal structure of AICARFT bound to an antifolate [Homo sapiens],5UY8_C Crystal structure of AICARFT bound to an antifolate [Homo sapiens],5UY8_D Crystal structure of AICARFT bound to an antifolate [Homo sapiens],5UZ0_A Crystal structure of AICARFT bound to an antifolate [Homo sapiens],5UZ0_B Crystal structure of AICARFT bound to an antifolate [Homo sapiens],5UZ0_C Crystal structure of AICARFT bound to an antifolate [Homo sapiens],5UZ0_D Crystal structure of AICARFT bound to an antifolate [Homo sapiens]
6.56e-156 831 1400 1 592
Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD [Homo sapiens],1P4R_B Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD [Homo sapiens],1PKX_A Crystal Structure of human ATIC in complex with XMP [Homo sapiens],1PKX_B Crystal Structure of human ATIC in complex with XMP [Homo sapiens],1PKX_C Crystal Structure of human ATIC in complex with XMP [Homo sapiens],1PKX_D Crystal Structure of human ATIC in complex with XMP [Homo sapiens],1PL0_A Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC [Homo sapiens],1PL0_B Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC [Homo sapiens],1PL0_C Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC [Homo sapiens],1PL0_D Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC [Homo sapiens]
1.94e-154 848 1400 47 593
Crystal Structure of Avian AICAR Transformylase in Complex with a Novel Inhibitor Identified by Virtual Ligand Screening [Gallus gallus],1THZ_B Crystal Structure of Avian AICAR Transformylase in Complex with a Novel Inhibitor Identified by Virtual Ligand Screening [Gallus gallus],2B1G_A Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus],2B1G_B Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus],2B1G_C Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus],2B1G_D Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus],2B1I_A crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus],2B1I_B crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus],2IU0_A crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus],2IU0_B crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus],2IU3_A Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus],2IU3_B Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase [Gallus gallus]
3.68e-154 848 1400 67 613
Crystal Structure Of The Homodimeric Bifunctional Transformylase And Cyclohydrolase Enzyme Avian Atic In Complex With Aicar And Xmp At 1.93 Angstroms. [Gallus gallus],1M9N_B Crystal Structure Of The Homodimeric Bifunctional Transformylase And Cyclohydrolase Enzyme Avian Atic In Complex With Aicar And Xmp At 1.93 Angstroms. [Gallus gallus],1OZ0_A Crystal Structure Of The Homodimeric Bifunctional Transformylase And Cyclohydrolase Enzyme Avian Atic In Complex With A Multisubstrate Adduct Inhibitor Beta-dadf. [Gallus gallus],1OZ0_B Crystal Structure Of The Homodimeric Bifunctional Transformylase And Cyclohydrolase Enzyme Avian Atic In Complex With A Multisubstrate Adduct Inhibitor Beta-dadf. [Gallus gallus]
8.46e-152 837 1400 8 605
Chain A, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase [Cryptococcus neoformans],7MGQ_B Chain B, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase [Cryptococcus neoformans],7MGQ_C Chain C, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase [Cryptococcus neoformans],7MGQ_D Chain D, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase [Cryptococcus neoformans]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1.23e-155 831 1400 1 592
Bifunctional purine biosynthesis protein ATIC OS=Pongo abelii OX=9601 GN=ATIC PE=2 SV=1
3.37e-155 831 1400 1 592
Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3
2.52e-154 831 1400 1 592
Bifunctional purine biosynthesis protein ATIC OS=Bos taurus OX=9913 GN=ATIC PE=2 SV=1
9.65e-154 831 1400 1 592
Bifunctional purine biosynthesis protein ATIC OS=Mus musculus OX=10090 GN=Atic PE=1 SV=2
9.96e-154 848 1400 47 593
Bifunctional purine biosynthesis protein ATIC OS=Gallus gallus OX=9031 GN=ATIC PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI CS Position
0.000279 0.999691 CS pos: 22-23. Pr: 0.9647

TMHMM  Annotations      help

There is no transmembrane helices in EPrPVT00000015633-p1.