CAZyme Information: EPrPIT00000022015-p1

Basic Information

• Species: Globisporangium irregulare
• Lineage: Oomycota; NA; ; Pythiaceae; Globisporangium; Globisporangium irregulare
• CAZyme ID: EPrPIT00000022015-p1
• CAZy Family: GT8
• CAZyme Description: Cellulose synthase 4

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1043		118805.96	7.8129

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_GirregulareDAOMBR486	13869	1223557	65	13804

• Gene Location: location=PirrDAOMBR486_SC0841:2065-5272(-)

Full Sequence      

MAQRGQQPRAIPEDDAFRTPQTGMYQQQFSTGASDSYASGFDLQGQQPTNYRENPHAPLM
KMESSMNEDTKKAISELTKADESEALGKITVHGWMHKQGTRKFKGPVAKSWRKRYFALEG
NKIYYFHDFVDCRKYFNSRNGELVVGAIDLRDAFKLEQSERLDLPARGIAIHTRHRVWLV
CPETDSDFTMWFDALEFTIMSTGNGNVVKRELPNVRVYEMKGRFSYRFWYIVFVLTALVE
LAGIVLWFPLGIEPCDMKYKKMSCDIIQQTRSETIQCGSKPFNGVWDPPQWYKWSSGIEE
VICFREPVIAHWVSYFMFYLAEFISISLGFLYYLGMWKPVRRGAQYLRDFKPHFPPSKWP
TVDILLCHYSEPAEDTIATLEKIMNLDYPPHLFHVWICDDGYCKSKWEPGATVPKVGVNR
GLIEDAGDVRHEVAQFMYERVYEADEVEVDEWRKQHTTVKMPTNSNPRVMRRLDCAVGSV
RDDYNYPGYPKVTFCGRIKPPVHHSKAGNINNVLYNEGACGRYCIILDNDMKPHEMFIQA
VLPFFFDAPQNSKIARCVAPGCGDIGKICCALCQNAGVPEQQISFCSKDCYNASNHVASS
LHRRQTQNTVTERMVCSTCGSKINQKKGVCKKCNTPVQRQSSMAGNQQFVEVSADDYSDN
VNVNQVGYVQTPQYFEDCLQLRLGDPCGHRNSTFFDSAQTGMDGYECASFAGTNAIFRRE
ALDSVCGIQYGSLTEDAFTGKMMIDKGWKGFYFRKDLEGEESDRIRLAEGAVPESVAAAL
AQRKRWAKGNFQIYLRKKKSLVDPEWAPPIVELPPPRKINKFMRWVFFMNLTVYPIGSFP
AIFFFYITGYFLYTGNAPIYTSGLRLLMALVPKIVAQSILSALSNRTVENNDVLRSQQTW
FSYAFVHVLAVFEAFYWKITDKEASWANTGALSGNSPMEAPNLLVFLAMVFGCLWSIVRY
FVGYNNAETTHGTPLLFASLFLGGFTASQLGPMVRMSLQTYFGWSHKSLTDQGNIVGSFS
LAFVLIVICFWVYVETPNHQIFG

Enzyme Prediction     

EC	2.4.1.12:3

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
133043	CESA_CelA_like	2.26e-33	360	793	1	233	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose. Family of proteins related to Agrobacterium tumefaciens CelA and Gluconacetobacter xylinus BscA. These proteins are involved in the elongation of the glucan chain of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues. They are putative catalytic subunit of cellulose synthase, which is a glycosyltransferase using UDP-glucose as the substrate. The catalytic subunit is an integral membrane protein with 6 transmembrane segments and it is postulated that the protein is anchored in the membrane at the N-terminal end.
236918	bcsA	1.20e-13	665	794	369	492	cellulose synthase catalytic subunit; Provisional
224136	BcsA	3.08e-13	664	927	166	404	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility].
133057	CESA_NdvC_like	2.23e-11	665	796	113	234	NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase. NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase. Bradyrhizobium japonicum synthesizes periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans during growth under hypoosmotic conditions. Two genes (ndvB, ndvC) are involved in the beta-(1, 3), beta-(1,6)-glucan synthesis. The ndvC mutant strain resulted in synthesis of altered cyclic beta-glucans composed almost entirely of beta-(1, 3)-glycosyl linkages. The periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans function for osmoregulation. The ndvC mutation also affects the ability of the bacteria to establish a successful symbiotic interaction with host plant. Thus, the beta-glucans may function as suppressors of a host defense response.
214574	PH	4.65e-10	89	199	1	101	Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ABP96909.1|GT2	0.0	20	1043	13	1022
AXF53810.1|GT2	0.0	10	1043	11	1019
ABP96905.1|GT2|2.4.1.12	0.0	10	1043	11	1019
AEZ51040.1|GT2	0.0	11	1043	13	1032
ABP96913.1|GT2	0.0	10	1043	11	1019

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7LBY_A	1.08e-10	665	879	382	575	Chain A, Cellulose synthase catalytic subunit [UDP-forming] [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q9U720|DCSA_DICDI	3.85e-22	490	908	584	880	Cellulose synthase catalytic subunit A [UDP-forming] OS=Dictyostelium discoideum OX=44689 GN=dcsA PE=1 SV=1
sp|P19449|BCSA1_KOMXY	5.74e-11	665	794	258	381	Cellulose synthase catalytic subunit [UDP-forming] OS=Komagataeibacter xylinus OX=28448 GN=bcsA PE=1 SV=1
sp|O82859|BCSA2_KOMSB	5.75e-11	665	794	260	383	Cellulose synthase catalytic subunit [UDP-forming] OS=Komagataeibacter sucrofermentans (strain ATCC 700178 / DSM 15973 / CECT 7291 / JCM 9730 / LMG 18788 / BPR 2001) OX=1307942 GN=bcsA PE=3 SV=1
sp|Q9WX61|BCSA3_KOMXY	9.84e-11	661	794	254	381	Cellulose synthase 1 catalytic subunit [UDP-forming] OS=Komagataeibacter xylinus OX=28448 GN=bcsAI PE=3 SV=1
sp|Q8X5L7|BCSA_ECO57	5.51e-10	665	879	382	575	Cellulose synthase catalytic subunit [UDP-forming] OS=Escherichia coli O157:H7 OX=83334 GN=bcsA PE=3 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000050	0.000000

TMHMM  Annotations     

Start	End
898	920
940	962
975	997
1012	1034
228	250
312	334
826	848
863	885