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CAZyme Information: ELR03900.1

You are here: Home > Sequence: ELR03900.1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Pseudogymnoascus destructans
Lineage Ascomycota; Leotiomycetes; ; Pseudeurotiaceae; Pseudogymnoascus; Pseudogymnoascus destructans
CAZyme ID ELR03900.1
CAZy Family GH13
CAZyme Description Mannosyltransferase [Source:UniProtKB/TrEMBL;Acc:L8FSE5]
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
805 90221.48 8.3965
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_Pdestructans20631-21 9225 658429 150 9075
Gene Location

Full Sequence      Download help

Enzyme Prediction      help

EC 2.4.1.259:12 2.4.1.261:12

CAZyme Signature Domains help

Family Start End Evalue family coverage
GT22 7 432 6e-89 0.9948586118251928

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
381301 AKR_AKR7A1-5 4.51e-117 537 803 8 281
AKR7A family of aldo-keto reductase (AKR). Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
281842 Glyco_transf_22 1.81e-87 23 432 19 414
Alg9-like mannosyltransferase family. Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.
395190 Aldo_ket_red 1.14e-38 537 805 6 270
Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
223739 Tas 1.54e-37 530 804 7 287
Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only].
381313 AKR_AKR12A1_B1_C1 4.47e-36 530 799 7 283
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR). Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
3.35e-250 2 538 39 575
6.43e-250 2 538 35 570
4.55e-249 2 538 35 570
6.45e-249 2 538 35 570
5.09e-221 2 532 29 566

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1.06e-51 549 802 9 291
Aflatoxin aldehyde reductase (AKR7A1) from Rat Liver [Rattus norvegicus],1GVE_B Aflatoxin aldehyde reductase (AKR7A1) from Rat Liver [Rattus norvegicus]
6.83e-48 546 802 35 311
Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_B Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_C Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_D Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_E Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_F Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_G Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_H Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_I Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_J Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens],2CLP_K Crystal structure of human aflatoxin B1 aldehyde reductase member 3 [Homo sapiens]
1.60e-46 546 802 48 324
Structure of the aflatoxin aldehyde reductase in complex with NADPH [Homo sapiens],2BP1_B Structure of the aflatoxin aldehyde reductase in complex with NADPH [Homo sapiens],2BP1_C Structure of the aflatoxin aldehyde reductase in complex with NADPH [Homo sapiens],2BP1_D Structure of the aflatoxin aldehyde reductase in complex with NADPH [Homo sapiens]
7.50e-45 546 802 26 302
mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus],2C91_B mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus],2C91_C mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus],2C91_D mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus],2C91_E mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus],2C91_F mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus],2C91_G mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus],2C91_H mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus],2C91_I mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus],2C91_J mouse succinic semialdehyde reductase, AKR7A5 [Mus musculus]
5.27e-22 553 777 34 266
Structure of NADPH-dependent family 11 aldo-keto reductase AKR11A(apo) [Bacillus subtilis],1PZ0_A Structure of NADPH-dependent family 11 aldo-keto reductase AKR11A(holo) [Bacillus subtilis]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2.72e-110 4 539 12 542
Alpha-1,2-mannosyltransferase alg9 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=alg9 PE=3 SV=1
3.16e-101 14 532 69 572
Alpha-1,2-mannosyltransferase ALG9 OS=Homo sapiens OX=9606 GN=ALG9 PE=1 SV=2
4.90e-99 14 532 69 572
Alpha-1,2-mannosyltransferase ALG9 OS=Mus musculus OX=10090 GN=Alg9 PE=2 SV=1
2.20e-76 558 804 1 262
Aldo-keto reductase MYCFIDRAFT_156381 OS=Pseudocercospora fijiensis (strain CIRAD86) OX=383855 GN=MYCFIDRAFT_156381 PE=2 SV=1
1.32e-74 14 532 64 570
Alpha-1,2-mannosyltransferase algn-9 OS=Caenorhabditis elegans OX=6239 GN=algn-9 PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI CS Position
0.153599 0.846378 CS pos: 20-21. Pr: 0.8105

TMHMM  Annotations      download full data without filtering help

Start End
7 24
85 107
114 136
140 159
166 188
271 293
298 320
330 352
359 381