CAZyme Information: EGD97715.1

Basic Information

• Species: Trichophyton tonsurans
• Lineage: Ascomycota; Eurotiomycetes; ; Arthrodermataceae; Trichophyton; Trichophyton tonsurans
• CAZyme ID: EGD97715.1
• CAZy Family: GH72|CBM43
• CAZyme Description: beta-1,4-mannosyltransferase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
456	GG698504|CGC1	49838.29	8.6514

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_TtonsuransCBS112818	8625	647933	104	8521

• Gene Location: location=GG698504:71300-72878(+)

Full Sequence      

MTLVLLLSILAIGFSSVAFIQLLPTRREKKSSEAHDAVSVQIVVLGDIGHSPRMQCHALS
IARHGGRVTVIGYHNSTPNQELLDHPLISIVALPSPPALLQTKKKFLFPVAAILKVLQQA
WHLWAALGYRTGPAHWILVQNPPAAPTLALALLACHLRHSRLIIDWHNFGYSILALKLGS
AHPMVKLMAWYEKAFSCYATAHFCVSNAMARILQEQFMIKKPLMVLHDRPSSAFSPIFDA
KQRLAILSSIPETSQSATDIIEGRCRLLVSSTSWTPDEDFSLLLDALCRYSTSAKSSVLP
SVPLLVIITGKGPLKDMYLSQIDKLKAEGKLFNVFIKTAWLSFENYAQLLACATLGVCLH
TSSSGVDLPMKVVDMFGAGLPVVGWDQYEAWPELVTEGVTGLGFDSADKLSGLLKSVLGG
DGSALKVLREGAVKESRNRWDQTWDPIAGTFLGLVT

Enzyme Prediction     

EC	2.4.1.142:10	2.4.1.-:1

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT33	39	449	3.6e-147	0.9882352941176471

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
340843	GT33_ALG1-like	0.0	35	452	1	411	chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins. This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.
215155	PLN02275	1.41e-118	40	414	7	371	transferase, transferring glycosyl groups
223515	RfaB	3.75e-14	56	452	6	371	Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis].
340831	GT4_PimA-like	1.64e-09	88	454	34	364	phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
340839	GT4_GT28_WabH-like	5.12e-07	162	439	86	347	family 4 and family 28 glycosyltransferases similar to Klebsiella WabH. This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSS73446.1|GT33	5.04e-187	39	454	51	466
QSS48656.1|GT33	5.82e-186	39	454	51	466
QGA12416.1|GT33	3.31e-176	21	455	26	461
QKX64524.1|GT33	4.23e-176	20	455	20	459
CAP97332.1|GT33	2.44e-173	40	455	48	462

PDB Hits     

EGD97715.1 has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|D4AZD1|ALG1_ARTBC	9.42e-297	1	456	1	447	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) OX=663331 GN=ARB_01551 PE=3 SV=1
sp|Q6C3K2|ALG1_YARLI	2.00e-94	10	454	10	440	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) OX=284591 GN=ALG1 PE=3 SV=1
sp|O13933|ALG1_SCHPO	4.91e-91	36	447	23	415	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=alg1 PE=3 SV=2
sp|Q59Q79|ALG1_CANAL	6.74e-87	39	444	53	444	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=ALG1 PE=3 SV=1
sp|Q921Q3|ALG1_MOUSE	7.99e-82	29	444	24	453	Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Mus musculus OX=10090 GN=Alg1 PE=1 SV=3

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
0.994332	0.005714

TMHMM  Annotations     

Start	End
2	24