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CAZyme Information: EEQ27215.1

You are here: Home > Sequence: EEQ27215.1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Microsporum canis
Lineage Ascomycota; Eurotiomycetes; ; Arthrodermataceae; Microsporum; Microsporum canis
CAZyme ID EEQ27215.1
CAZy Family AA1
CAZyme Description trehalose-6-phosphate synthase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
479 53835.16 4.9802
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_McanisCBS113480 8847 554155 82 8765
Gene Location Start: 252980; End:254867  Strand: +

Full Sequence      Download help

MFSTEVCDRA  ELELALSVSE  RLKTTMAKPQ  EGKKPQLLVV  SNRLPLSLKR  VGAGKYQSST60
SSGGLVTSLS  GISESIGFQW  FGWTGLEIPE  DEQEEVQRLL  AERNAVPVFL  NQELANNHYN120
GFSRIQNFNE  KWWHAYREVN  QKFAEIVAKA  TSEGDLVWVH  DYHLMLLPGM  LREEFAKQGK180
TSVKIGFSLH  TPFPVAEVYR  ALPTNHETLD  GVMNSDLIGF  HTDDYAGHFA  EACSQILGAS240
KDGLTLQYKD  RKVQVGKFIV  GIDPTCFAEA  VKSEAVQNRI  AELEDKYKGI  KRIVGVDRLD300
YIKGLPEKLR  GFEEFLRTHP  EWVGKIVLIQ  IAVPSREDVP  EYQELEAEVY  KLVGMVNGEF360
GKPDYAPVIF  VHQSIPFEEL  VALYAASDIC  LLTSTRDGMN  LVALEYIACQ  QERNGVLAVS420
EFAGVSSYLE  GGVKFNPFNS  SEVARVIDEA  VEMDTEQRQK  EHKRLLEFIE  THTRCVTDS479

Enzyme Prediction      help

EC 2.4.1.15:146

CAZyme Signature Domains help

Created with Snap2347719511914316719121523926328731133535938340743145511461GT20
Family Start End Evalue family coverage
GT20 33 473 1.7e-157 0.9473684210526315

CDD Domains      download full data without filtering help

Created with Snap2347719511914316719121523926328731133535938340743145535473Glyco_transf_2036473GT20_TPS37473trehalose_OtsA30473OtsA37473PRK14501
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
395781 Glyco_transf_20 0.0 35 473 1 456
Glycosyltransferase family 20. Members of this family belong to glycosyl transferase family 20. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex,.
340820 GT20_TPS 0.0 36 473 1 450
trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.
274112 trehalose_OtsA 0.0 37 473 2 442
alpha,alpha-trehalose-phosphate synthase [UDP-forming]. This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This model excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This model does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cutoffs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see Wolf, et al., ). [Cellular processes, Adaptations to atypical conditions]
223457 OtsA 2.34e-178 30 473 10 465
Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism].
184712 PRK14501 6.61e-166 37 473 3 448
putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional

CAZyme Hits      help

Created with Snap2347719511914316719121523926328731133535938340743145536473BCR94369.1|GT2036473BCS06972.1|GT2036473AAB05869.1|GT20|2.4.1.1536473CAK39664.1|GT20|2.4.1.1536473BCR91987.1|GT20
Hit ID E-Value Query Start Query End Hit Start Hit End
BCR94369.1|GT20 3.44e-176 36 473 13 463
BCS06972.1|GT20 3.44e-176 36 473 13 463
AAB05869.1|GT20|2.4.1.15 6.92e-176 36 473 13 463
CAK39664.1|GT20|2.4.1.15 6.92e-176 36 473 13 463
BCR91987.1|GT20 7.98e-174 36 473 12 462

PDB Hits      download full data without filtering help

Created with Snap23477195119143167191215239263287311335359383407431455364735HVO_A364735HVM_A364736JBI_A364735HUT_A364735HUV_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
5HVO_A 3.28e-172 36 473 12 462
Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293],5HVO_B Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293],5HVO_C Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293],5HVO_D Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293]
5HVM_A 7.32e-170 36 473 13 462
Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293],5HVM_B Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293]
6JBI_A 5.37e-165 36 473 1 450
Structure of Tps1 apo structure [Pyricularia oryzae 70-15],6JBI_B Structure of Tps1 apo structure [Pyricularia oryzae 70-15],6JBR_A Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_B Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_D Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_F Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_H Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_K Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_M Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_O Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBW_A Structure of Tps1/UDP complex [Pyricularia oryzae 70-15],6JBW_B Structure of Tps1/UDP complex [Pyricularia oryzae 70-15]
5HUT_A 1.34e-158 36 473 5 455
Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose [Candida albicans SC5314],5HUT_B Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose [Candida albicans SC5314],5HUU_A Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and glucose-6-phosphate [Candida albicans SC5314],5HUU_B Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and glucose-6-phosphate [Candida albicans SC5314],5HVL_A Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A [Candida albicans SC5314],5HVL_B Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A [Candida albicans SC5314]
5HUV_A 3.09e-157 36 473 5 455
Structure of Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose [Candida albicans SC5314],5HUV_B Structure of Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose [Candida albicans SC5314]

Swiss-Prot Hits      download full data without filtering help

Created with Snap2347719511914316719121523926328731133535938340743145536473sp|Q00217|TPS1B_ASPNG36473sp|Q4WHW0|TPS1B_ASPFU36473sp|Q4WLM9|TPS1A_ASPFU25473sp|Q00075|TPS1A_ASPNG36473sp|P40387|TPS1_SCHPO
Hit ID E-Value Query Start Query End Hit Start Hit End Description
sp|Q00217|TPS1B_ASPNG 1.23e-176 36 473 13 463
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 OS=Aspergillus niger OX=5061 GN=tpsB PE=2 SV=1
sp|Q4WHW0|TPS1B_ASPFU 1.69e-171 36 473 12 462
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=tpsB PE=1 SV=1
sp|Q4WLM9|TPS1A_ASPFU 3.76e-169 36 473 13 462
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=tpsA PE=1 SV=1
sp|Q00075|TPS1A_ASPNG 1.15e-168 25 473 3 463
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 OS=Aspergillus niger OX=5061 GN=tpsA PE=1 SV=1
sp|P40387|TPS1_SCHPO 1.51e-165 36 473 20 469
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=tps1 PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI CS Position
1.000042 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in EEQ27215.1.