CAZyme Information: EEP81948.1

Basic Information

• Species: Uncinocarpus reesii
• Lineage: Ascomycota; Eurotiomycetes; ; Onygenaceae; Uncinocarpus; Uncinocarpus reesii
• CAZyme ID: EEP81948.1
• CAZy Family: GT34
• CAZyme Description: conserved hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1445		162652.70	5.0331

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_Ureesii1704	7856	336963	96	7760

• Gene Location: location=CH476618:2009437-2014167(+)

Full Sequence      

MPFTYPSSSWPLGLFLGTLLLPSVRAGPSVNVALSASFSSPPYLLELLETAAAENSTSYF
PLLDRIANGVFVDSRTDKDLYDQFLRILQDDGHISDPSALSSFKLAMSLRSTAPRIQAHY
QYYNTSVEPSLMGAQDAVCQVWAHYAGEQYCSPSLEHAQQGVSGEQVRYRPSSSGHANQL
FVSGYGVELALKRTDYIVIDDRAAEQSPNSENAKATPPAAKDLKEESPADLKPLSASEVS
TLGLNAASFAVNSENPFETLLKLSEDFPRHSSVIASINATTEFLEEFGQNQEHMFPPGYN
VVWINGVQIDSRRVNAFSLLDHLRSERKLINSFRELGFSASEAVELLSHPIIANSQAAEV
GPRYDYRDDTEGGGVIIWLNDIEKDKRYQGWPSSLNALLQRMYPGQFPQVRRDIHNVVVL
LNLADGPDVQMLVSQIQTFITRKIPVRFGLVPTVVDQASMQQIRIASYLHQTYGLKTLLT
YLETVLEKSKSQTISPDKNSFNAAIHDREHREGENILTFEEILSSDEFEPIITKTKAYLR
RLASEEPAPLMFANGAVIPRDDNWIQPLTARLSQDLVNIQQSVFAGLYEDDFWMPNHYLE
GAVLSRNSLIIPEDPSMIQILDLNAAYRRYQSELETLPRIPASGDSDMGKWGNLMLIADF
DSDDGQKQLSTILEFREKNPEIEVLLLHNSSTNTHGRVSAELFDVVKSTRDVDESTLKSI
LQPDSERLVKQESEMEPVRNYFGSLSSLAKDLGPLRDRTNIVFNGRVVGPIPSTSLFEVQ
ELEQLLAYERERRLEPVVKAVSSLALKDKIRDPFAFARLTSLVARSTASDMPEDIYDSGR
VTRTSTYKKWNNMHSGFSLSNTDDPLIQVVATIDPASETAQRFIPILKVLSELNGVSLRV
FLSPTTSLKELPIKRFYRQVLESEPSFNGDGSLRRPGASFTGIPEDALLTLGMDVPPSWL
VAPKESIYDLDNIKLSSLKEGANVDAIYELEHILIEGHSRDTTHGSPPRGVQLLLGTERN
PHFADTIIMANLGYFQFKAQPGYWQITLKPGPSERIFHLDSVSGTAFGAGPSDGNNEVAL
LSFQGTTLFPRLSRKAGHEEDDVLEAGSKPNSAKNYFAKGLNFASDMISGMTGTRQDKQA
DINIFSVASGHLYERMLNIMMVSVMRHTKHSVKFWFIEQFLSPSFKSFLPHLAKEYGFSY
EMVTYKWPHWLRAQREKQREIWGYKILFLDVLFPLSLDKVIFVDADQIVRTDMYELIKTD
LEGAPYGFTPMCDSREEMEGFRFWKQGYWKKFLKGLPYHISALYVVDLNRFRQIASGDRL
RGQYQSLSADPNSLSNLDQDLPNNMQHSIPIKSLPQDWLWCETWCSDGALKTAKTIDLCN
NPLTKEPKLERARRQVPEWTEYDDEIAELGKRVAREQQRIRGKKGQEEDVDGEEDGATIM
EKDEL

Enzyme Prediction     

EC	2.4.1.-:29

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT24	1142	1389	1e-134	0.9959677419354839

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
133054	GT8_HUGT1_C_like	0.0	1142	1389	1	248	The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
408203	Glyco_transf_24	0.0	1142	1409	1	268	Glucosyltransferase 24. This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
408201	Thioredoxin_14	1.11e-92	364	610	1	248	Thioredoxin-like domain. This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
132996	Glyco_transf_8	4.84e-61	1142	1389	1	246	Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.
399437	UDP-g_GGTase	4.93e-58	996	1105	1	109	UDP-glucose:Glycoprotein Glucosyltransferase. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QSS69256.1|GT24	0.0	1	1421	1	1474
QSS63494.1|GT24	0.0	4	1421	15	1485
QSS51253.1|GT24	0.0	1	1436	1	1491
UDD64319.1|GT24	0.0	6	1445	7	1487
QRD91624.1|GT24	0.0	6	1445	7	1487

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5MU1_A	0.0	24	1416	5	1454	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5MZO_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],5N2J_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TRF_A Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5NV4_A	0.0	24	1416	5	1454	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
5Y7O_A	0.0	29	1110	5	1129	Crystal structure of folding sensor region of UGGT from Thermomyces dupontii [Thermomyces dupontii],5Y7O_B Crystal structure of folding sensor region of UGGT from Thermomyces dupontii [Thermomyces dupontii]
6TRT_A	0.0	24	1416	5	1454	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]
6TS2_A	0.0	24	1416	5	1220	Chain A, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_B Chain B, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_C Chain C, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495],6TS2_D Chain D, UDP-glucose-glycoprotein glucosyltransferase-like protein,UDP-glucose-glycoprotein glucosyltransferase-like protein [Thermochaetoides thermophila DSM 1495]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q09140|UGGG_SCHPO	2.01e-274	10	1409	3	1424	UDP-glucose:glycoprotein glucosyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gpt1 PE=1 SV=2
sp|Q9JLA3|UGGG1_RAT	4.67e-224	29	1409	46	1523	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Rattus norvegicus OX=10116 GN=Uggt1 PE=1 SV=2
sp|Q6P5E4|UGGG1_MOUSE	6.88e-223	29	1409	46	1523	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Mus musculus OX=10090 GN=Uggt1 PE=1 SV=4
sp|Q9NYU2|UGGG1_HUMAN	7.58e-223	20	1418	36	1532	UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3
sp|Q09332|UGGG_DROME	2.33e-216	30	1413	30	1511	UDP-glucose:glycoprotein glucosyltransferase OS=Drosophila melanogaster OX=7227 GN=Uggt PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000253	0.999707	CS pos: 26-27. Pr: 0.9768

TMHMM  Annotations     

There is no transmembrane helices in EEP81948.1.