CAZyme Information: EAW21128.1

Basic Information

• Species: Aspergillus fischeri
• Lineage: Ascomycota; Eurotiomycetes; ; Aspergillaceae; Aspergillus; Aspergillus fischeri
• CAZyme ID: EAW21128.1
• CAZy Family: GH47
• CAZyme Description: Fibronectin type III domain protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
990	DS027690|CGC19	108580.63	4.7832

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_AfischeriNRRL181	10668	331117	278	10390

• Gene Location: location=DS027690:355875-359476(+)

Full Sequence      

MYGQLWHGLAAIATLGSCALANPLVYWDGRGNASMNYEHFMARDTADFDQSDLSFITRMA
AIGDSYSTGIGAGNRIQTDADWACSRYDHSYPYLIHNDPQLGDPEARTFQFVSCSGAVTA
DALDKQIPQISGNQQVILLSVGGNDAELSSILNQCIFGWAALAPETVKSAKEAALKHPEF
AWAANFDWDSLGHGCEKQLARTRDIIAGDTFSRSLDSVIEAAKKKLSPEYAKFFAEDLSP
ACDSVSWSTFIYKIASLFQGAQKLTRANRKIMNDLVDAANAQIVKFVDYDSWVGHFKGRF
CENGVDESTVESNTRTGLMFYELNMMDPFGTNPWKRSDKQPFEGTFEGTVNQFAEITRLM
DPDAKFSEQAFISDAGTASIASSNVKLVNSASVLGLTIPNLLPDGYGRVFHPQILLHELI
ASLVIYEMVNKNEQDHGFPAIPETLTLDSCPNYGDGNGNGAGDGQQIALALYVNPLADPV
AWDRMIAYPSSKVSVLVANVLNGPDTTMNEDWAKVIDRAHTSGKRILGYVWTGYLGQSQQ
AFETQLGSADLANWVSQIQTDVDLWYQLYPSKISGIFFDEGWNDCGPDNLYADLYHFITN
AIKRKHPRAFTMLNPGATMPQCFEHSADTLMIFEQSYDTYMNNYVPNPGWTPKDPRKLWH
IIYSVPEADAGKVAALALKRGAGLIHITNNLLPSPYDTLPDEAYMKAITDIIKGGGPDVA
DPTLYPAGGHAAFPPGPLSVTASDYSSVSLKWDISNREPPHAYAVYRDGNEVARLPGIMS
RVIISNISPGSSMSFTVRAIGTDGKETRDSNSMAATTQSLPNNQAVMNVRVSKSATSTTI
QADFLVPYAFMRVYLTDPNTHCQIPVWLINFNAGNFIYTHYMVENEVLYKYSGANLTEGQ
TNYPWAWSSKGAAPVKRDGYTFTWTLPVGTNTTDSSYFSVQAQGYGSLTNVFHPCLSEWD
DSTPGAGAFCTGSSPYDCKGETLCSTTNVK

Enzyme Prediction     

No EC number prediction in EAW21128.1.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH135	468	700	3.1e-22	0.9535864978902954

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
403383	Spherulin4	4.04e-44	472	708	1	238	Spherulation-specific family 4. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 250 and 398 amino acids in length. There is a conserved NPG sequence motif and there are two completely conserved G residues that may be functionally important. Starvation will often induce spherulation - the production of spores - and this process may involve DNA-methylation. Changes in the methylation of spherulin4 are associated with the formation of spherules, but these changes are probably transient. Methylation of the gene accompanies its transcriptional activation, and spherulin4 mRNA is only detectable in late spherulating cultures and mature spherules. It is a spherulation-specific protein.
238861	SEST_like	1.01e-27	58	304	2	224	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.
404371	Lipase_GDSL_2	7.91e-05	61	146	1	74	GDSL-like Lipase/Acylhydrolase family. This family of presumed lipases and related enzymes are similar to pfam00657.
214495	FN3	0.002	734	804	3	81	Fibronectin type 3 domain. One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
238020	FN3	0.008	734	817	3	93	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BCS11365.1|GH0	0.0	1	990	1	1013
BCR99052.1|GH0	0.0	1	990	1	1013
UNO38501.1|CE3|GH0	8.07e-125	440	970	466	1000
CCT67685.1|CE0	2.64e-118	4	457	3	463
QGI80975.1|CE0	2.68e-118	4	457	3	463

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4HYQ_A	4.20e-14	61	171	7	110	Crystal structure of phospholipase A1 from Streptomyces albidoflavus NA297 [Streptomyces albidoflavus]
5MAL_A	5.55e-11	57	155	2	93	Crystal structure of extracelular lipase from Streptomyces rimosus at 1.7A resolution [Streptomyces rimosus],5MAL_B Crystal structure of extracelular lipase from Streptomyces rimosus at 1.7A resolution [Streptomyces rimosus]
5C5G_A	2.88e-07	466	671	9	211	Crystal Structure of Aspergillus clavatus Sph3 [Aspergillus clavatus NRRL 1]
5D6T_A	3.40e-07	466	671	27	229	Crystal Structure of Aspergillus clavatus Sph3 in complex with GalNAc [Aspergillus clavatus NRRL 1]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q9S2A5|LIP1_STRCO	7.20e-12	61	156	40	128	Lipase 1 OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) OX=100226 GN=SCO1725 PE=1 SV=1
sp|Q93MW7|LIP_STRRM	4.58e-10	57	155	36	127	Lipase OS=Streptomyces rimosus OX=1927 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000275	0.999679	CS pos: 21-22. Pr: 0.9719

TMHMM  Annotations     

Start	End
5	27