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CAZyme Information: EAQ89901.1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Chaetomium globosum | |||||||||||
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| Lineage | Ascomycota; Sordariomycetes; ; Chaetomiaceae; Chaetomium; Chaetomium globosum | |||||||||||
| CAZyme ID | EAQ89901.1 | |||||||||||
| CAZy Family | GH47 | |||||||||||
| CAZyme Description | Mannan endo-1,6-alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:Q2H495] | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | ||||||||||||
Enzyme Prediction help
| EC | 3.2.1.101:1 |
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CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH76 | 4 | 354 | 7.4e-102 | 0.9022346368715084 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 410686 | CYP52 | 0.0 | 434 | 854 | 2 | 419 | cytochrome P450 family 52. Cytochrome P450 52 (CYP52), also called P450ALK, monooxygenases catalyze the first hydroxylation step in the assimilation of alkanes and fatty acids by filamentous fungi. The number of CYP52 proteins depend on the fungal species: for example, Candida tropicalis has seven, Candida maltose has eight, and Yarrowia lipolytica has twelve. The CYP52 family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. |
| 397638 | Glyco_hydro_76 | 9.86e-180 | 1 | 340 | 14 | 348 | Glycosyl hydrolase family 76. Family of alpha-1,6-mannanases. |
| 410687 | CYP86A | 1.14e-68 | 440 | 825 | 7 | 409 | cytochrome P450 family 86, subfamily A. This subfamily includes several Arabidopsis thaliana cytochrome P450s (CYP86A1, CYP86A2, CYP86A4, among others), Petunia x hybrida CYP86A22, and Vicia sativa CYP94A1 and CYP94A2. They are P450-dependent fatty acid omega-hydroxylases that catalyze the omega-hydroxylation of various fatty acids. CYP86A2 acts on saturated and unsaturated fatty acids with chain lengths from C12 to C18; CYP86A22 prefers substrates with chain lengths of C16 and C18; and CYP94A1 acts on various fatty acids from 10 to 18 carbons. They play roles in the biosynthesis of extracellular lipids, cutin synthesis, and plant defense. The CYP86A subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. |
| 410651 | cytochrome_P450 | 1.17e-68 | 434 | 849 | 1 | 387 | cytochrome P450 (CYP) superfamily. Cytochrome P450 (P450, CYP) is a large superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs with > 40% sequence identity are members of the same family. There are approximately 2250 CYP families: mammals, insects, plants, fungi, bacteria, and archaea have around 18, 208, 277, 805, 591, and 14 families, respectively. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. Their monooxygenase activity relies on the reductive scission of molecular oxygen bound to the P450 heme iron, and the delivery of two electrons to the heme iron during the catalytic cycle. CYPs use a variety of redox partners, such as the eukaryotic diflavin enzyme NADPH-cytochrome P450 oxidoreductase and the bacterial/mitochondrial NAD(P)H-ferredoxin reductase and ferredoxin partners. Some CYPs are naturally linked to their redox partners and others have evolved to bypass requirements for redox partners, and instead react directly with hydrogen peroxide or NAD(P)H to facilitate oxidative or reductive catalysis. |
| 410692 | CYP_FUM15-like | 2.15e-61 | 441 | 849 | 10 | 433 | Fusarium verticillioides cytochrome P450 monooxygenase FUM15, and similar cytochrome P450s. Fusarium verticillioides cytochrome P450 monooxygenase FUM15, is also called fumonisin biosynthesis cluster protein 15. The FUM15 gene is part of the gene cluster that mediates the biosynthesis of fumonisins B1, B2, B3, and B4, which are carcinogenic mycotoxins. This FUM15-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 4.88e-238 | 1 | 392 | 44 | 436 | |
| 1.67e-230 | 1 | 392 | 6 | 402 | |
| 7.66e-229 | 1 | 392 | 6 | 402 | |
| 7.66e-229 | 1 | 392 | 6 | 402 | |
| 1.08e-228 | 1 | 392 | 6 | 402 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 1.98e-119 | 1 | 370 | 48 | 425 | Chain A, Mannan endo-1,6-alpha-mannosidase [Thermochaetoides thermophila DSM 1495],6RY1_A Chain A, Mannan endo-1,6-alpha-mannosidase [Thermochaetoides thermophila DSM 1495],6RY2_A Chain A, Mannan endo-1,6-alpha-mannosidase [Thermochaetoides thermophila DSM 1495],6RY5_A Chain A, Mannan endo-1,6-alpha-mannosidase [Thermochaetoides thermophila DSM 1495],6RY6_A Chain A, Mannan endo-1,6-alpha-mannosidase [Thermochaetoides thermophila DSM 1495],6RY7_A Chain A, Mannan endo-1,6-alpha-mannosidase [Thermochaetoides thermophila DSM 1495] |
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| 1.16e-27 | 483 | 855 | 87 | 450 | Chain A, Bifunctional P-450:NADPH-P450 reductase [Priestia megaterium],1ZOA_B Chain B, Bifunctional P-450:NADPH-P450 reductase [Priestia megaterium] |
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| 1.69e-27 | 483 | 855 | 84 | 447 | Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium],3CBD_B Chain B, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium] |
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| 3.04e-27 | 483 | 855 | 84 | 447 | Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium],4KEW_B Chain B, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium] |
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| 3.04e-27 | 483 | 855 | 84 | 447 | Chain A, PROTEIN (CYTOCHROME P450) [Priestia megaterium],1BU7_B Chain B, PROTEIN (CYTOCHROME P450) [Priestia megaterium],2BMH_A Chain A, CYTOCHROME P450 BM-3 [Priestia megaterium],2BMH_B Chain B, CYTOCHROME P450 BM-3 [Priestia megaterium],2J1M_A Chain A, CYTOCHROME P450 102 [Priestia megaterium],2J1M_B Chain B, CYTOCHROME P450 102 [Priestia megaterium],2J4S_A Chain A, BIFUNCTIONAL P-450:NADPH-P450 REDUCTASE [Priestia megaterium],2J4S_B Chain B, BIFUNCTIONAL P-450:NADPH-P450 REDUCTASE [Priestia megaterium],5ZIS_A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium NBRC 15308 = ATCC 14581],5ZIS_B Chain B, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium NBRC 15308 = ATCC 14581],5ZIS_C Chain C, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium NBRC 15308 = ATCC 14581],5ZIS_D Chain D, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium NBRC 15308 = ATCC 14581],5ZLH_A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium],5ZLH_B Chain B, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium],5ZLH_C Chain C, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium],5ZLH_D Chain D, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 1.69e-130 | 1 | 392 | 44 | 429 | Mannan endo-1,6-alpha-mannosidase DCW1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DCW1 PE=1 SV=1 |
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| 3.99e-127 | 1 | 392 | 41 | 426 | Mannan endo-1,6-alpha-mannosidase DCW1 OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) OX=284593 GN=DCW1 PE=3 SV=1 |
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| 7.84e-117 | 1 | 392 | 44 | 431 | Mannan endo-1,6-alpha-mannosidase DCW1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) OX=284811 GN=DCW1 PE=3 SV=2 |
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| 5.19e-114 | 1 | 370 | 41 | 411 | Mannan endo-1,6-alpha-mannosidase DCW1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=DCW1 PE=1 SV=1 |
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| 2.67e-107 | 1 | 370 | 49 | 415 | Mannan endo-1,6-alpha-mannosidase DFG5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=DFG5 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 0.977621 | 0.022400 |