CAZyme Information: CR_02800C_B-T-p1

Basic Information

• Species: Candida albicans
• Lineage: Ascomycota; Saccharomycetes; ; Debaryomycetaceae; Candida; Candida albicans
• CAZyme ID: CR_02800C_B-T-p1
• CAZy Family: GT71
• CAZyme Description: Protein of unknown function, mutation confers hypersensitivity to amphotericin B, flow model biofilm induced

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
816		95486.05	4.8165

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_CalbicansSC5314_B	6415	N/A	215	6200

• Gene Location: location=Ca22chrRB_C_albicans_SC5314:638843-641293(-)

Full Sequence      

MAVELINWQFCQISNHAESPLIPNQWYDTKNFTSHQIHTDLLEANIIPDPFIDDNEIHVQ
WISELNWQYRCIFDAPGNSNSNASLILEGIDTFANIKLNNKTILTTDNYFHKHVIPIIMN
DNNELVITFNSSLRIGQELEQEHGKLPVWNGDSSRVYVRKPQFQYGWDWGPNLNTCGFES
IKLITDEDYVKDFFIGYNLNQELDIAELSIEIEYLFDKSPENIEIEIKDDTGIVVDRIVP
TIPVTNYNITNVKLWYPINQGKQSLYQFSLIINGICKTTQKVGFRKIELVQVNDKYGKSF
YFKINNIPIQIWGTNWIPAHSFQSRLTKLDYQQWINLIIHGGYNLIRIWGGGQYEKDILY
SLCDEAGILIWQDFMFACGIYPETIIESVTQEVEDQLIRLRQHCSIIIYAGNNEDYQIAE
SINLDTNNSTQFPAKNIYEYIIPDKINKLCNFTPYHYGSPYSDTSHKSSDPTIGDLHQWN
VWHGTHEPYQNWPELSGRFVSEFGMLSIPSLQTLTKYINESQLSINSTLLNFHTKAAGGI
ENLDNYLWDNFLKPESLDISHYIYLTQLLQSEAMSLAYRYWRRNWENYKTGGIIMWQLND
CWPSISWSAIDFLKIPKLVYYGVKREIQQVGIACRRYQIKQQTYKQQNVFEVKNCLDIWG
FGEFLDIGVKIEFYTEYGDLYFSKSIKNLVFLNNQVNMVAEKLCFDNINDNTIIYLKLIE
NDKIIARSSDWPQPLKKLPWNKLSTNLTIEYLGQGDFQISTTKPVKRLELYFDYTHNYLF
DDNGIDLFPDDPQIIHINNFDELDVEKIRYRHLGSI

Enzyme Prediction     

EC	3.2.1.25:3

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH2	8	654	3.3e-73	0.6316489361702128

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
225789	LacZ	6.20e-51	7	621	18	624	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].
395572	Glyco_hydro_2	3.84e-05	189	285	2	106	Glycosyl hydrolases family 2. This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AOW31022.1|GH2	0.0	1	816	1	816
CAX39789.1|GH2	0.0	1	816	1	815
CCG20510.1|GH2	1.84e-299	5	814	4	832
CCE41561.1|GH2	1.29e-293	5	814	4	828
ABN65300.2|GH2	2.99e-250	1	813	1	837

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5N6U_A	3.16e-120	37	632	52	658	Crystal structure of Beta-D-Mannosidase from Dictyoglomus thermophilum. [Dictyoglomus thermophilum H-6-12],5N6U_B Crystal structure of Beta-D-Mannosidase from Dictyoglomus thermophilum. [Dictyoglomus thermophilum H-6-12],5N6U_C Crystal structure of Beta-D-Mannosidase from Dictyoglomus thermophilum. [Dictyoglomus thermophilum H-6-12],5N6U_D Crystal structure of Beta-D-Mannosidase from Dictyoglomus thermophilum. [Dictyoglomus thermophilum H-6-12]
2VJX_A	4.18e-88	37	632	34	656	Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VJX_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VL4_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VL4_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VMF_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VMF_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VO5_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VO5_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VOT_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VOT_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron VPI-5482],2VQT_A Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron],2VQT_B Structural and biochemical evidence for a boat-like transition state in beta-mannosidases [Bacteroides thetaiotaomicron],2VR4_A Transition-state mimicry in mannoside hydrolysis: characterisation of twenty six inhibitors and insight into binding from linear free energy relationships and 3-D structure [Bacteroides thetaiotaomicron VPI-5482],2VR4_B Transition-state mimicry in mannoside hydrolysis: characterisation of twenty six inhibitors and insight into binding from linear free energy relationships and 3-D structure [Bacteroides thetaiotaomicron VPI-5482]
2JE8_A	4.33e-88	37	632	36	658	Structure of a beta-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482],2JE8_B Structure of a beta-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482]
7OP6_A	4.41e-88	37	632	36	658	Chain A, Beta-mannosidase [Bacteroides thetaiotaomicron VPI-5482],7OP6_B Chain B, Beta-mannosidase [Bacteroides thetaiotaomicron VPI-5482],7OP7_A Chain A, Beta-mannosidase [Bacteroides thetaiotaomicron VPI-5482],7OP7_B Chain B, Beta-mannosidase [Bacteroides thetaiotaomicron VPI-5482]
2WBK_A	1.13e-87	37	632	34	656	Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis [Bacteroides thetaiotaomicron VPI-5482],2WBK_B Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis [Bacteroides thetaiotaomicron VPI-5482]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|I2C092|MANBB_THETO	4.86e-164	7	816	12	855	Beta-mannosidase B OS=Thermothelomyces thermophilus OX=78579 GN=man9 PE=1 SV=1
sp|Q5B7W2|MANBB_EMENI	1.10e-158	23	815	23	843	Beta-mannosidase B OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=mndB PE=1 SV=2
sp|A2QYN2|MANBB_ASPNC	1.79e-153	37	815	36	844	Beta-mannosidase B OS=Aspergillus niger (strain CBS 513.88 / FGSC A1513) OX=425011 GN=mndB PE=3 SV=1
sp|Q0CCA0|MANBB_ASPTN	1.61e-150	37	815	36	843	Beta-mannosidase B OS=Aspergillus terreus (strain NIH 2624 / FGSC A1156) OX=341663 GN=mndB PE=3 SV=2
sp|B8NW36|MANBB_ASPFN	2.32e-150	38	815	37	844	Beta-mannosidase B OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) OX=332952 GN=mndB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000030	0.000003

TMHMM  Annotations     

There is no transmembrane helices in CR_02800C_B-T-p1.