CAZyme Information: CPC735_044150-t26_1-p1

Basic Information

• Species: Coccidioides posadasii
• Lineage: Ascomycota; Eurotiomycetes; ; Onygenaceae; Coccidioides; Coccidioides posadasii
• CAZyme ID: CPC735_044150-t26_1-p1
• CAZy Family: GH72|CBM43
• CAZyme Description: trehalose-phosphatase, putative

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
903		102573.01	6.7697

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_CposadasiiC735deltSOWgp	7255	222929	26	7229

• Gene Location: location=ACFW01000035:1017622-1020746(+)

Full Sequence      

MTIFIVSLFLPHTVNFILPEGTSQRRPSSPRRRHHRRESSDFNRRAHNTLFPKRPTSSSS
SSSPTSTTAPKHLLKDHARLFAPTPDKFTPLDLLRRTEDGRQQPLTPSDPHAPLWGATGV
FNQPRPRPSQSPSSSILQHNSIAGPAPKLVKRASTPVKVEERPESSPPEKAFSDAAWTIE
PSEQGNGGLFNAIRSANLEAPQDKLWVGTLGMPTDALEDHVKDTIAEKLDVDYACLTVFA
NDSDFDGHYLHFCKTILWPVFHYQIPDNPKSKAYEDHSWVYYKAVNQAFADRIVRNWKRG
DIIWVHDYHLLLVPSMIRKQLPDAKIGFFLHTAFPSSEVFRCLSVRKELLYGILGANLVG
FQTQEYCHHFLQTCSRILTVEATNEGVQLEDRFVNVGTFPIGIDPPSLDLRRKGSDVENW
MRTIRDRYQGKRLVVARDKLDNIRGVRQKLLAYELFLNKYPKWRDSPLVFLNQDLLFPQY
LALISVADVFMVTSLREGMNLTSHEYIHCQDGKYTNNKHGPLILSEFTGSASVFEGHPLL
VNPWNYQQCADALNTALEMPPEEREQQWTRLNDQVNAHTTDKWVKNYIEALDRAFSEQAC
RDNVSIPRLSVNNLMKLYRASSRRLFIVDYEGTLASWGSPTSIVLTTPKRAIDTLNDLLE
DPKNTVYVMSSRMPEEMERLFRQVPGLGLIAENGCFVREAHREEWIKLIDDEETREWKDS
LADMINYFHVRTEGSWVEERHSSLVFHYDNAEDPQTAGRHASDCANHINDTCQQHRIRAV
AVDGAVITEPISPNKATAADLVLRHILARAEKDKDSAAKPDFLFVAGDGREDEVVFRWAN
KLEEKKLIENIETVTLGSANTEAKATLAQGVTGVLSCLGKLAAISHDVEPNEYLAEREIP
YKI

Enzyme Prediction     

EC	2.4.1.15:11

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT20	171	465	6.2e-102	0.5894736842105263

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
340820	GT20_TPS	0.0	178	591	19	462	trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.
395781	Glyco_transf_20	6.06e-174	156	593	11	470	Glycosyltransferase family 20. Members of this family belong to glycosyl transferase family 20. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex,.
184712	PRK14501	2.13e-158	156	884	11	726	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional
223457	OtsA	1.79e-148	147	594	15	480	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism].
215555	PLN03063	1.52e-128	176	882	31	784	alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QVM13697.1|GT20	0.0	212	903	1	729
QSS50113.1|GT20	0.0	1	885	6	918
QSS68616.1|GT20	0.0	1	885	6	918
QSS59828.1|GT20	0.0	1	885	1	899
QMW41842.1|GT20	0.0	1	885	1	925

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6JBI_A	3.30e-92	178	593	12	464	Structure of Tps1 apo structure [Pyricularia oryzae 70-15],6JBI_B Structure of Tps1 apo structure [Pyricularia oryzae 70-15],6JBR_A Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_B Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_D Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_F Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_H Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_K Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_M Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBR_O Tps1/UDP/T6P complex [Pyricularia oryzae 70-15],6JBW_A Structure of Tps1/UDP complex [Pyricularia oryzae 70-15],6JBW_B Structure of Tps1/UDP complex [Pyricularia oryzae 70-15]
5HVM_A	7.81e-87	178	599	24	482	Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293],5HVM_B Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293]
5HUV_A	2.11e-83	186	602	31	478	Structure of Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose [Candida albicans SC5314],5HUV_B Structure of Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose [Candida albicans SC5314]
5HUT_A	7.89e-83	186	602	31	478	Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose [Candida albicans SC5314],5HUT_B Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose [Candida albicans SC5314],5HUU_A Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and glucose-6-phosphate [Candida albicans SC5314],5HUU_B Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and glucose-6-phosphate [Candida albicans SC5314],5HVL_A Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A [Candida albicans SC5314],5HVL_B Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A [Candida albicans SC5314]
5HVO_A	3.03e-79	178	591	23	474	Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293],5HVO_B Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293],5HVO_C Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293],5HVO_D Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A [Aspergillus fumigatus Af293]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q9UUI7|TPSY_SCHPO	2.47e-177	100	883	97	891	Putative alpha,alpha-trehalose-phosphate synthase [UDP-forming] 100 kDa subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC22F8.05 PE=1 SV=1
sp|O14081|TPSX_SCHPO	3.76e-174	170	881	193	941	Putative alpha,alpha-trehalose-phosphate synthase [UDP-forming] 106 kDa subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC2E11.16c PE=1 SV=1
sp|P38427|TSL1_YEAST	3.39e-145	169	791	338	976	Trehalose synthase complex regulatory subunit TSL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TSL1 PE=1 SV=1
sp|P38426|TPS3_YEAST	1.30e-144	172	779	309	929	Trehalose synthase complex regulatory subunit TPS3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TPS3 PE=1 SV=3
sp|Q54K57|TPSA_DICDI	2.84e-119	170	752	30	628	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] A OS=Dictyostelium discoideum OX=44689 GN=tpsA PE=2 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
0.964854	0.035148

TMHMM  Annotations     

There is no transmembrane helices in CPC735_044150-t26_1-p1.