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CAZyme Information: CCG84997.1
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Taphrina deformans | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Ascomycota; Taphrinomycetes; ; Taphrinaceae; Taphrina; Taphrina deformans | |||||||||||
| CAZyme ID | CCG84997.1 | |||||||||||
| CAZy Family | GT59 | |||||||||||
| CAZyme Description | Bifunctional lycopene cyclase/phytoene synthase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | ||||||||||||
Enzyme Prediction help
| EC | 2.4.1.-:14 |
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CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT50 | 550 | 813 | 3.6e-90 | 0.9923664122137404 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| 178434 | PLN02841 | 2.17e-100 | 435 | 815 | 11 | 416 | GPI mannosyltransferase |
| 252941 | Mannosyl_trans | 8.18e-74 | 550 | 814 | 1 | 259 | Mannosyltransferase (PIG-M). PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilize nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates. |
| 173831 | Trans_IPPS_HH | 1.23e-37 | 167 | 418 | 25 | 265 | Trans-Isoprenyl Diphosphate Synthases, head-to-head. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze a head-to-head (HH) (1'-1) condensation reaction. This CD includes squalene and phytoene synthases which catalyze the 1'-1 condensation of two 15-carbon (farnesyl) and 20-carbon (geranylgeranyl) isoprenyl diphosphates, respectively. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DXXXD) located on opposite walls. These residues mediate binding of prenyl phosphates. A two-step reaction has been proposed for squalene synthase (farnesyl-diphosphate farnesyltransferase) in which, two molecules of FPP react to form a stable cyclopropylcarbinyl diphosphate intermediate, and then the intermediate undergoes heterolysis, isomerization, and reduction with NADPH to form squalene, a precursor of cholestrol. The carotenoid biosynthesis enzyme, phytoene synthase (CrtB), catalyzes the condensation reaction of two molecules of geranylgeranyl diphosphate to produce phytoene, a precursor of beta-carotene. These enzymes produce the triterpene and tetraterpene precursors for many diverse sterol and carotenoid end products and are widely distributed among eukareya, bacteria, and archaea. |
| 395397 | SQS_PSY | 3.87e-31 | 168 | 400 | 20 | 244 | Squalene/phytoene synthase. |
| 163278 | HpnD | 1.21e-19 | 168 | 426 | 20 | 264 | squalene synthase HpnD. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. In the organisms Zymomonas mobilis and Bradyrhizobium japonicum these genes have been characterized as squalene synthases (farnesyl-pyrophosphate ligases). Often, these genes appear in tandem with the HpnC gene which appears to have resulted from an ancient gene duplication event. Presumably these proteins form a heteromeric complex, but this has not yet been experimentally demonstrated. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| 6.08e-119 | 438 | 815 | 31 | 425 | |
| 4.97e-118 | 431 | 815 | 7 | 413 | |
| 4.02e-116 | 435 | 815 | 13 | 407 | |
| 4.88e-116 | 441 | 815 | 19 | 406 | |
| 1.27e-115 | 441 | 815 | 19 | 401 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6.90e-10 | 133 | 316 | 7 | 185 | Crystal structure of a dehydrosqualene synthase in complex with ligand [Enterococcus hirae ATCC 9790] |
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| 3.17e-06 | 141 | 319 | 14 | 188 | Crystal structure of squalene synthase HpnC from Alicyclobacillus acidocaldarius [Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2.46e-111 | 441 | 815 | 19 | 406 | GPI mannosyltransferase 1 OS=Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) OX=229533 GN=GPI14 PE=3 SV=1 |
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| 3.79e-107 | 438 | 815 | 14 | 408 | GPI mannosyltransferase 1 OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=gpi14 PE=3 SV=2 |
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| 1.06e-104 | 442 | 814 | 18 | 425 | GPI mannosyltransferase 1 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=gpi14 PE=3 SV=1 |
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| 1.16e-104 | 442 | 792 | 1 | 346 | GPI mannosyltransferase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gpi14 PE=3 SV=2 |
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| 4.63e-104 | 431 | 815 | 6 | 419 | GPI mannosyltransferase 1 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=gpi14 PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | CS Position |
|---|---|---|
| 1.000052 | 0.000000 |
TMHMM Annotations download full data without filtering help
| Start | End |
|---|---|
| 15 | 37 |
| 44 | 66 |
| 89 | 111 |
| 434 | 453 |
| 506 | 528 |
| 549 | 571 |
| 586 | 608 |
| 628 | 650 |
| 693 | 715 |
| 722 | 744 |
| 759 | 781 |
| 794 | 811 |