CAZyme Information: C6_04340W_B-T-p1

Basic Information

• Species: Candida albicans
• Lineage: Ascomycota; Saccharomycetes; ; Debaryomycetaceae; Candida; Candida albicans
• CAZyme ID: C6_04340W_B-T-p1
• CAZy Family: GT4
• CAZyme Description: Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, role in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins, rat catheter biofilm repressed

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
518		59660.63	6.8480

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_CalbicansSC5314_B	6415	N/A	215	6200

• Gene Location: location=Ca22chr6B_C_albicans_SC5314:957308-958864(+)

Full Sequence      

MPIVQESPKEVDTVLKNQSTNASTNTNTNKQQFRESPEFTLSNVLDDIKQGIIAFLINPK
VTIIVYPIIICLSSILTKIVINKISYTEIDFITYMQQIKLINQGIIKYSEIEGDSGPIVY
PGGFVQIYQFIQWLISSSSSSSSSTGEEILSYDVREAQYIFSYLFTTSIIFNCLIYINLI
NIPPWTIYLFLLSKRLVSIYVLRLFNDCWTTLAILGVILILQQASTNITEDWLVYLLVIL
ASDLYSIAISIKMNALLYFPGFIIIVYFLLDESLIKSTSVLIVMIFIQIIMGWQFLLPLE
LFNNDVDVRRMASIIRWDYINQAFNFKRKFLYEWTVNWKFLSIETFTSDGFAKLLLLLHV
FTLLVFIITRFLNSRITGKSITSLIYQIVLPFSSSSSSKSSSSSNGNNSNLIKNPQSGPQ
LIFIIMSITNLIGILFARSLHYQFLSWYAWSLPGLLYLNFPIYFTLPIWFVHEWCWNVFP
SNSISSITLVSILSLIIGATWWNFDHWXPTISQFIIYF

Enzyme Prediction     

EC	2.4.1.258:10

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT58	67	486	3.1e-128	0.9945054945054945

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
398745	ALG3	5.67e-134	67	486	1	358	ALG3 protein. The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9GlcNAc2-PP-Dol on the lumenal side use Dol-P-Man. ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AOW30352.1|GT58	0.0	1	518	1	519
CAX41333.1|GT58	3.17e-275	1	509	1	506
CCE39689.1|GT58	1.72e-157	35	509	13	499
CCG24434.1|GT58	9.82e-153	35	512	14	518
QEO20316.1|GT58	1.15e-149	19	512	7	474

PDB Hits     

C6_04340W_B-T-p1 has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q6BYY8|ALG3_DEBHA	1.61e-146	35	513	13	465	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase OS=Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) OX=284592 GN=ALG3 PE=3 SV=1
sp|A3LTB7|ALG3_PICST	7.96e-138	38	507	23	463	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase OS=Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) OX=322104 GN=ALG3 PE=3 SV=2
sp|A5DJQ5|ALG3_PICGU	3.51e-133	28	507	21	472	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase OS=Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) OX=294746 GN=ALG3 PE=3 SV=2
sp|Q6DNA2|ALG3_KOMPG	1.25e-104	35	497	8	443	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase OS=Komagataella phaffii (strain GS115 / ATCC 20864) OX=644223 GN=ALG3 PE=3 SV=2
sp|P38179|ALG3_YEAST	6.26e-78	47	497	28	428	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ALG3 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
0.999453	0.000541

TMHMM  Annotations     

Start	End
51	73
160	182
197	219
232	249
253	270
277	299
350	372
421	440
450	472
479	501