CAZyme Information: Afu4g12900-T-p1

Basic Information

• Species: Aspergillus fumigatus
• Lineage: Ascomycota; Eurotiomycetes; ; Aspergillaceae; Aspergillus; Aspergillus fumigatus
• CAZyme ID: Afu4g12900-T-p1
• CAZy Family: GH3
• CAZyme Description: Ortholog(s) have alpha-1,6-mannosyltransferase activity, role in dolichol-linked oligosaccharide biosynthetic process, protein glycosylation and endoplasmic reticulum localization

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
575		63965.81	10.0891

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_AfumigatusAf293	10130	330879	290	9840

• Gene Location: location=Chr4_A_fumigatus_Af293:3374668-3376522(-)

Full Sequence      

MGSNVVFLLLIVLLPVLVCLHLLVAPYTKVEESFHIQAIHDILKYGIPTGDVSGILARYD
HSTFPGAVPRTFVGAVVLSGLSQPFIWLNESIDKQALARGILGLFNSVSLISFALGVRRA
FGKTTAIWYLLFQASQFHIIYYASRTLSNMFAFGITTLAMRALLPEPVAPAVYRKRCRVG
LFLLTIAGIIFRSELALLLAAHTLCLFSTGRIRIVQEIIPAGALGLVVGLAITVSVDSFF
WQQFPLWPELAAFKFNVLAGQASAWGTHPWHFYFSSAIPRLLLNPLTYLLALPFALTHPS
TRSSTAYIIIPSLVFVVIYSAQPHKEWRFIAYIIPPLTAAAAQGAAYIWTHRAKSIIYRL
LSLALIASTAASFFLSNFVLLPVSSANYPGARALTTLHTHANNTKPVINVYLGNLACQTG
VTRFLEMPPPQMPAKTAQNSELATVESAGSAPGSGSVWRYDKTEDETTKAFPPFWKRFDY
VLIEPSEEKKVRRASGRPHSWEEVEVIHGFAGLRVLRPDDEATGQLEERVFSIVLGPEGA
RYWTMVRDYARKHVTRGWWAELKMEPKIKILRRIR

Enzyme Prediction     

No EC number prediction in Afu4g12900-T-p1.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT22	10	404	4.2e-84	0.9305912596401028

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
281842	Glyco_transf_22	1.58e-32	59	425	44	413	Alg9-like mannosyltransferase family. Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.
215437	PLN02816	1.95e-07	78	335	108	348	mannosyltransferase

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QRD89046.1|GT22	2.78e-266	3	574	4	559
QMW25030.1|GT22	2.78e-266	3	574	4	559
QMW37088.1|GT22	2.78e-266	3	574	4	559
UCK57379.1|GT22	2.78e-266	3	574	4	559
BCS08490.1|GT22	6.02e-265	1	573	1	555

PDB Hits     

Afu4g12900-T-p1 has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|P53730|ALG12_YEAST	2.08e-69	21	512	17	490	Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ALG12 PE=1 SV=1
sp|Q23361|ALG12_CAEEL	3.10e-66	20	483	14	431	Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Caenorhabditis elegans OX=6239 GN=algn-12 PE=1 SV=2
sp|Q8VDB2|ALG12_MOUSE	1.99e-65	13	484	17	433	Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Mus musculus OX=10090 GN=Alg12 PE=2 SV=2
sp|Q9BV10|ALG12_HUMAN	1.15e-63	13	465	16	419	Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Homo sapiens OX=9606 GN=ALG12 PE=1 SV=1
sp|Q9VH78|ALG12_DROME	2.73e-63	12	515	3	456	Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Drosophila melanogaster OX=7227 GN=Alg12 PE=2 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
0.944638	0.055389

TMHMM  Annotations     

Start	End
5	27
95	117
137	159
179	201
214	236
277	296
303	322
327	349
356	378