CAZyme Information: ASPACDRAFT_79393-t33_1-p1

Basic Information

• Species: Aspergillus aculeatus
• Lineage: Ascomycota; Eurotiomycetes; ; Aspergillaceae; Aspergillus; Aspergillus aculeatus
• CAZyme ID: ASPACDRAFT_79393-t33_1-p1
• CAZy Family: GT39
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
776		88207.11	7.7764

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_AaculeatusATCC16872	11165	690307	322	10843

• Gene Location: location=KV878978:1413639-1416087(-)

Full Sequence      

MSSPSPSLRKRGGKKESTPVPADNFSTPFSSTKAPRPQSEWSYWLAIAVLTVLAFITRFY
KISYPNEVVFDEVHFGKFASYYLQRTYFFDVHPPFGKLLFAFVGWLIGYDGHFLFDNIGD
SYIDHNVPYVALRAMPATLGALTVPVVFLIMWESGYSLPACVLSAGLVLFDNAHIGEDRL
ILLDASLVLAMALSVLCYVRFYKLRHQPFGRKWWKWLLLTGVSLSCVISTKYVGVFTFVT
IGSAVLVDLWNLLDIRRPGGSLSMFRWSQHFAARAFALVVVPFFFYLFWFQVHFTILNRS
GPGDDFMTPEFQETLSDNALTADSIGIQYYDSLTIRHKDTKVFLHSHLETYPLRYDDGRI
SSQGQQVTGYPYNDTNNHWQIIPTVPFDVTDTTGHPVRNGDVVQLRHLGTDTVLLTHDVA
SPYYPTNQEFTTVSQELANGERHNDTLFEIKIENAKPQQEFRTLSSHFKLVHVPTRVAMW
THTTPLPEWAFKQAEINGNKNILQTSNLWFIDSIESLEEGSPRLVKEERQVKHLSFFRKY
LELQRAMFHHNNALTSSHPYASEPFQWPFLLRGVSFWTKNDTREQIYFLGNPIGWWIASS
LLAVFAGVIGADQLSLRRGVDAVEEIWGVGARSRLYNSTGFLFLCWAAHYFPFWLMGRQR
FLHHYLPAHLASALVAGALIEFIFNLEPISAVKSVPLEDDSTGKSKATARITHFVTASER
LGQKSLIAGWVATLVILAATIYGFVFYAPLTYGTPGLDVPGILARKWLAYDLHFAK

Enzyme Prediction     

EC	2.4.1.109:8

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT39	50	294	2.1e-72	0.9910313901345291

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
224839	PMT1	0.0	43	768	23	690	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones].
396786	PMT	8.07e-87	48	298	1	245	Dolichyl-phosphate-mannose-protein mannosyltransferase. This is a family of Dolichyl-phosphate-mannose-protein mannosyltransferase proteins EC:2.4.1.109. These proteins are responsible for O-linked glycosylation of proteins, they catalyze the reaction:- Dolichyl phosphate D-mannose + protein <=> dolichyl phosphate + O-D-mannosyl-protein. Also in this family is Drosophila rotated abdomen protein which is a putative mannosyltransferase. This family appears to be distantly related to pfam02516 (A Bateman pers. obs.). This family also contains sequences from ArnTs (4-amino-4-deoxy-L-arabinose lipid A transferase). They catalyze the addition of 4-amino-4-deoxy-l-arabinose (l-Ara4N) to the lipid A moiety of the lipopolysaccharide. This is a critical modification enabling bacteria (e.g. Escherichia coli and Salmonella typhimurium) to resist killing by antimicrobial peptides such as polymyxins. Members such as undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase are predicted to have 12 trans-membrane regions. The N-terminal portion of these proteins is hypothesized to have a conserved glycosylation activity which is shared between distantly related oligosaccharyltransferases ArnT and PglB families.
406576	PMT_4TMC	8.38e-76	538	768	1	197	C-terminal four TMM region of protein-O-mannosyltransferase. PMT_4TMC is the C-terminal four membrane-pass region of protein-O-mannosyltransferases and similar enzymes.
397103	MIR	5.50e-18	339	492	7	164	MIR domain. The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function.
197746	MIR	3.66e-07	327	383	4	56	Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BCS03793.1|GT39	0.0	2	776	3	775
BCS15407.1|GT39	0.0	2	776	3	775
CAK42948.1|GT39	0.0	2	776	3	771
QMW29154.1|GT39	0.0	3	776	4	775
QMW41228.1|GT39	0.0	3	776	4	775

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6P25_A	3.95e-105	45	755	51	712	Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor and a peptide acceptor [Saccharomyces cerevisiae W303],6P2R_A Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor [Saccharomyces cerevisiae W303]
6P25_B	9.94e-98	49	668	70	681	Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor and a peptide acceptor [Saccharomyces cerevisiae W303],6P2R_B Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor [Saccharomyces cerevisiae W303]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
sp|Q59X23|PMT4_CANAL	9.33e-257	5	776	2	755	Dolichyl-phosphate-mannose--protein mannosyltransferase 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=PMT4 PE=2 SV=2
sp|O42933|PMT4_SCHPO	1.02e-256	45	768	60	767	Dolichyl-phosphate-mannose--protein mannosyltransferase 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ogm4 PE=3 SV=1
sp|P46971|PMT4_YEAST	2.14e-249	35	776	46	762	Dolichyl-phosphate-mannose--protein mannosyltransferase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PMT4 PE=1 SV=1
sp|Q8BGQ4|POMT2_MOUSE	2.31e-117	43	756	127	799	Protein O-mannosyl-transferase 2 OS=Mus musculus OX=10090 GN=Pomt2 PE=1 SV=1
sp|Q8R2R1|POMT1_MOUSE	1.06e-116	45	668	39	669	Protein O-mannosyl-transferase 1 OS=Mus musculus OX=10090 GN=Pomt1 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000027	0.000020

TMHMM  Annotations     

Start	End
41	60
87	109
130	152
180	202
222	244
271	290
587	609
635	657
726	748