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CAZyme Information: AMAG_17354-t26_1-p1

You are here: Home > Sequence: AMAG_17354-t26_1-p1

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Allomyces macrogynus
Lineage Blastocladiomycota; Blastocladiomycetes; ; Blastocladiaceae; Allomyces; Allomyces macrogynus
CAZyme ID AMAG_17354-t26_1-p1
CAZy Family GT48
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
1866 201919.11 8.0717
Genome Property
Genome Version/Assembly ID Genes Strain NCBI Taxon ID Non Protein Coding Genes Protein Coding Genes
FungiDB-61_AmacrogynusATCC38327 19333 578462 535 18798
Gene Location

Full Sequence      Download help

Enzyme Prediction      help

EC 2.4.1.16:11

CAZyme Signature Domains help

Family Start End Evalue family coverage
GT2 1177 1684 1.1e-222 0.9924098671726755

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
367353 Chitin_synth_2 0.0 1175 1684 1 526
Chitin synthase. Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyze chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).
276845 MYSc_Myo17 1.94e-83 116 583 71 528
class XVII myosin, motor domain. This fungal myosin which is also known as chitin synthase uses its motor domain to tether its vesicular cargo to peripheral actin. It works in opposition to dynein, contributing to the retention of Mcs1 vesicles at the site of cell growth and increasing vesicle fusion necessary for polarized growth. Class 17 myosins consist of a N-terminal myosin motor domain with Cyt-b5, chitin synthase 2, and a DEK_C domains at it C-terminus. The chitin synthase region contains several transmembrane domains by which myosin 17 is thought to bind secretory vesicles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
133033 Chitin_synth_C 1.53e-75 1318 1537 50 244
C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin. Chitin synthase, also called UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyltransferase, catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of GlcNAc residues formed by covalent beta-1,4 linkages. Chitin is an important component of the cell wall of fungi and bacteria and it is synthesized on the cytoplasmic surface of the cell membrane by membrane bound chitin synthases. Studies with fungi have revealed that most of them contain more than one chitin synthase gene. At least five subclasses of chitin synthases have been identified.
276950 MYSc 5.77e-54 115 442 60 395
Myosin motor domain superfamily. Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
214580 MYSc 2.17e-44 115 595 78 534
Myosin. Large ATPases. ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
2.42e-266 115 1861 89 1891
8.82e-264 115 1683 87 1686
2.29e-263 115 1684 90 1710
5.72e-262 115 1861 92 1906
5.72e-262 115 1861 92 1906

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1.87e-30 115 483 136 501
Myosin Vc pre-powerstroke state [Homo sapiens],5HMP_B Myosin Vc pre-powerstroke state [Homo sapiens]
1.98e-30 115 483 140 505
Myosin Vc Pre-powerstroke [Homo sapiens],4ZG4_E Myosin Vc Pre-powerstroke [Homo sapiens]
7.37e-29 115 483 142 507
Crystal Structure Of Myosin V Motor Domain - Nucleotide-Free [Gallus gallus],1W8J_B Crystal Structure Of Myosin V Motor Domain - Nucleotide-Free [Gallus gallus],1W8J_C Crystal Structure Of Myosin V Motor Domain - Nucleotide-Free [Gallus gallus],1W8J_D Crystal Structure Of Myosin V Motor Domain - Nucleotide-Free [Gallus gallus]
8.02e-29 115 483 142 507
Chain A, Unconventional myosin-Va [Gallus gallus],7PLU_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLU_D Chain D, Unconventional myosin-Va [Gallus gallus],7PLV_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLW_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLX_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLY_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLZ_A Chain A, Unconventional myosin-Va [Gallus gallus],7PLZ_D Chain D, Unconventional myosin-Va [Gallus gallus],7PM0_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM1_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM2_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM5_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM6_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM6_D Chain D, Unconventional myosin-Va [Gallus gallus],7PM7_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM8_A Chain A, Unconventional myosin-Va [Gallus gallus],7PM9_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMA_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMB_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMC_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMD_A Chain A, Unconventional myosin-Va [Gallus gallus],7PME_A Chain A, Unconventional myosin-Va [Gallus gallus],7PME_D Chain D, Unconventional myosin-Va [Gallus gallus],7PMF_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMG_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMH_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMI_A Chain A, Unconventional myosin-Va [Gallus gallus],7PMJ_A Chain A, Unconventional myosin-Va [Gallus gallus],7PML_A Chain A, Unconventional myosin-Va [Gallus gallus]
8.10e-29 115 483 142 507
Crystal structure of Myosin V motor with essential light chain-nucleotide-free [Gallus gallus],1W7I_A Crystal Structure Of Myosin V Motor Without nucleotide soaked in 10 mM MgADP [Gallus gallus],1W7J_A Crystal Structure Of Myosin V Motor With Essential Light Chain + ADP-BeFx - Near Rigor [Gallus gallus]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2.00e-255 115 1863 101 1931
Chitin synthase 5 OS=Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) OX=235443 GN=CHS5 PE=2 SV=1
2.99e-251 116 1863 88 2004
Chitin synthase 8 OS=Ustilago maydis (strain 521 / FGSC 9021) OX=237631 GN=CHS8 PE=3 SV=1
1.09e-220 874 1684 63 892
Chitin synthase 6 OS=Ustilago maydis (strain 521 / FGSC 9021) OX=237631 GN=CHS6 PE=3 SV=2
2.91e-217 878 1683 160 989
Chitin synthase 4 OS=Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) OX=235443 GN=CHS4 PE=2 SV=2
4.62e-142 1202 1691 690 1195
Chitin synthase 4 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=chs-4 PE=3 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI CS Position
0.998742 0.001288

TMHMM  Annotations      download full data without filtering help

Start End
1130 1152
1165 1187
1558 1580
1593 1610
1620 1642