dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: AGR95_069680.mRNA-p1

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Basic Information help

Species

Histoplasma capsulatum

Lineage

Ascomycota; Eurotiomycetes; ; Ajellomycetaceae; Histoplasma; Histoplasma capsulatum

CAZyme ID

AGR95_069680.mRNA-p1

CAZy Family

GH65

CAZyme Description

unspecified product

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
988	HISTO_FE.Contig19\|CGC1	108801.42	6.5608

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_HcapsulatumG217B	11221	447094	0	11221

Gene Location

Full Sequence Download help

Enzyme Prediction help

EC	1.6.5.6:3

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
AA6	95	178	2.1e-27	0.4256410256410256

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
227431	NPL4	0.0	336	938	1	571	Nuclear pore protein [Nuclear structure].
398614	NPL4	0.0	621	935	1	308	NPL4 family. The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterized step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome. Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.
163692	MPN_NPL4	3.62e-109	587	892	1	274	Mov34/MPN/PAD-1 family: nuclear protein localization-4 (Npl4) domain. Npl4p (nuclear protein localization-4) is identical to Hmg-CoA reductase degradation 4 (HRD4) protein and contains a domain that is part of the pfam clan MPN/Mov34-like. Npl4 plays an intermediate role between endoplasmic reticulum-associated degradation (ERAD) substrate ubiquitylation and proteasomal degradation. Npl4p associates with Cdc48p (Cdc48 in yeast and p97 or valosin-containing protein (VCP) in higher eukaryotes), the highly conserved ATPase of the AAA family, via ubiquitin fusion degradation-1 protein (Ufd1p) to form a Cdc48p-Ufd1p-Npl4p complex which then functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation. This family of eukaryotic MPN-like domains lacks the key residues that coordinate a metal ion and therefore does not show catalytic isopeptidase activity.
398613	zf-NPL4	6.04e-102	474	618	1	145	NPL4 family, putative zinc binding region. The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterized step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome. This region of the protein contains possibly two zinc binding motifs (Bateman A pers. obs.). Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.
179647	PRK03767	8.91e-33	1	178	1	197	NAD(P)H:quinone oxidoreductase; Provisional

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start
1.08e-66	1	178	1	199
1.08e-66	1	178	1	199
9.69e-65	1	178	1	199
4.50e-55	1	178	1	199
1.94e-50	1	178	1	199

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
5.91e-267	336	987	1	641	Chain A, Npl4 [Thermochaetoides thermophila DSM 1495]
8.62e-245	467	943	1	474	Chain A, Npl4 zinc finger [Thermochaetoides thermophila DSM 1495],6CDD_B Chain B, Npl4 zinc finger [Thermochaetoides thermophila DSM 1495]
6.81e-171	336	938	1	580	Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP [Saccharomyces cerevisiae],6OAA_G Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 1 [Saccharomyces cerevisiae]
1.13e-160	470	938	2	473	Yeast Npl4 in complex with Lys48-linked diubiquitin [Saccharomyces cerevisiae S288C],6JWI_E Yeast Npl4 in complex with Lys48-linked diubiquitin [Saccharomyces cerevisiae S288C]
2.48e-159	470	938	2	473	Yeast Npl4 zinc finger, MPN and CTD domains [Saccharomyces cerevisiae S288C],6JWJ_A Npl4 in complex with Ufd1 [Saccharomyces cerevisiae S288C]

Swiss-Prot Hits download full data without filtering help

E-Value	Query Start	Query End	Hit Start	Hit End
330	987	1	651	Nuclear protein localization protein 4 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) OX=330879 GN=npl4 PE=3 SV=1
333	987	3	651	Nuclear protein localization protein 4 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=npl4 PE=3 SV=2
330	988	1	642	Nuclear protein localization protein 4 OS=Ajellomyces capsulatus (strain NAm1 / WU24) OX=2059318 GN=NPL4 PE=3 SV=1
330	987	1	651	Nuclear protein localization protein 4 OS=Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) OX=331117 GN=npl4 PE=3 SV=1
333	987	3	651	Nuclear protein localization protein 4 OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=npl4 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000032	0.000007

TMHMM Annotations help

There is no transmembrane helices in AGR95_069680.mRNA-p1.