dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: AGR57_4871T0-p1

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Basic Information help

Species

Phanerochaete chrysosporium

Lineage

Basidiomycota; Agaricomycetes; ; Phanerochaetaceae; Phanerochaete; Phanerochaete chrysosporium

CAZyme ID

AGR57_4871T0-p1

CAZy Family

GH31

CAZyme Description

Glycoside Hydrolase Family 18 protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
441		46393.73	3.9920

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_PchrysosporiumRP-78	13602	273507	0	13602

Gene Location

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in AGR57_4871T0-p1.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH18	34	414	1.5e-62	0.9290540540540541

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
214753	Glyco_18	2.63e-70	35	411	6	334	Glyco_18 domain.
225862	ChiA	2.34e-61	24	427	33	439	Chitinase, GH18 family [Carbohydrate transport and metabolism].
395573	Glyco_hydro_18	4.31e-61	35	411	6	307	Glycosyl hydrolases family 18.
119365	GH18_chitinase	6.80e-61	35	411	5	322	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
119351	GH18_chitolectin_chitotriosidase	8.90e-51	56	406	31	336	This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start
1.30e-143	10	433	2	427
1.24e-141	18	428	33	428
1.24e-141	18	428	33	428
1.24e-141	18	428	33	428
1.89e-137	18	438	33	439

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
5.37e-50	46	422	15	367	Chain A, Fungal chitinase from Rhizomucor miehei (SeMet-substituted proteins) [Rhizomucor miehei]
1.49e-32	51	424	88	419	Chain A, Glycosyl Hydrolase [Niallia circulans]
1.78e-31	51	411	117	448	Chitinase ChiA74 from Bacillus thuringiensis [Bacillus thuringiensis],6BT9_B Chitinase ChiA74 from Bacillus thuringiensis [Bacillus thuringiensis]
7.84e-30	34	424	12	370	Crystal structure of the catalytic domain of chitinase ChiL from Chitiniphilus shinanonensis (CsChiL) [Chitiniphilus shinanonensis],6KST_B Crystal structure of the catalytic domain of chitinase ChiL from Chitiniphilus shinanonensis (CsChiL) [Chitiniphilus shinanonensis],6KXL_A Crystal structure of the catalytic domain of Chitiniphilus shinanonensis chitinase ChiL (CsChiL) complexed with N,N'-diacetylchitobiose [Chitiniphilus shinanonensis],6KXL_B Crystal structure of the catalytic domain of Chitiniphilus shinanonensis chitinase ChiL (CsChiL) complexed with N,N'-diacetylchitobiose [Chitiniphilus shinanonensis]
2.79e-29	47	424	27	370	Crystal structure of W50A mutant of Chitiniphilus shinanonensis chitinase ChiL (CsChiL) complexed with N,N'-diacetylchitobiose [Chitiniphilus shinanonensis],6KXN_B Crystal structure of W50A mutant of Chitiniphilus shinanonensis chitinase ChiL (CsChiL) complexed with N,N'-diacetylchitobiose [Chitiniphilus shinanonensis]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
4.03e-31	51	427	120	454	Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1
2.92e-28	34	411	9	347	Endochitinase B OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=chiB PE=1 SV=1
2.92e-28	34	411	9	347	Endochitinase B OS=Emericella nidulans OX=162425 GN=chiB PE=1 SV=3
4.99e-27	80	432	109	405	Chitinase 1 OS=Aphanocladium album OX=12942 GN=CHI1 PE=1 SV=2
1.04e-24	81	436	111	416	Endochitinase 46 OS=Trichoderma harzianum OX=5544 GN=chit46 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	CS Position
0.000240	0.999728	CS pos: 19-20. Pr: 0.9736

TMHMM Annotations help

There is no transmembrane helices in AGR57_4871T0-p1.