dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: AFUB_014510-T-p1

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Basic Information help

Species

Aspergillus fumigatus

Lineage

Ascomycota; Eurotiomycetes; ; Aspergillaceae; Aspergillus; Aspergillus fumigatus

CAZyme ID

AFUB_014510-T-p1

CAZy Family

AA9

CAZyme Description

Has domain(s) with predicted flavin adenine dinucleotide binding, UDP-N-acetylmuramate dehydrogenase, D-arabinono-1,4-lactone oxidase activity, role in oxidation-reduction process, biosynthetic process and membrane localization

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
595	scf_000001_A_fumigatus_A1163\|CGC6	67455.64	6.8955

Genome Property

Genome Version/Assembly ID	Genes	Strain NCBI Taxon ID	Non Protein Coding Genes	Protein Coding Genes
FungiDB-61_AfumigatusA1163	10106	451804	199	9907

Gene Location

Full Sequence Download help

Enzyme Prediction help

EC	1.1.3.-:2

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
AA7	44	238	1.7e-28	0.4344978165938865

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
273751	FAD_lactone_ox	5.08e-143	45	487	7	436	sugar 1,4-lactone oxidases. This model represents a family of at least two different sugar 1,4 lactone oxidases, both involved in synthesizing ascorbic acid or a derivative. These include L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae. Members are proposed to have the cofactor FAD covalently bound at a site specified by Prosite motif PS00862; OX2_COVAL_FAD; 1.
397924	ALO	2.73e-106	212	494	1	259	D-arabinono-1,4-lactone oxidase. This domain is specific to D-arabinono-1,4-lactone oxidase EC:1.1.3.-, which is involved in the final step of the D-erythroascorbic acid biosynthesis pathway.
223354	GlcD	4.13e-46	52	486	31	450	FAD/FMN-containing dehydrogenase [Energy production and conversion].
215258	PLN02465	5.99e-42	12	490	61	565	L-galactono-1,4-lactone dehydrogenase
396238	FAD_binding_4	3.41e-39	53	188	1	139	FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start
2.42e-12	98	486	121	491
5.50e-12	64	236	73	256
1.20e-11	59	402	170	522
3.58e-10	59	214	50	208
3.77e-10	53	218	61	232

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
7.33e-27	40	271	110	348	Assembly intermediate of the plant mitochondrial complex I [Brassica oleracea]
4.69e-18	38	222	6	186	Alditol Oxidase from Streptomyces coelicolor A3(2): Native Enzyme [Streptomyces coelicolor A3(2)],2VFS_A Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Xylitol [Streptomyces coelicolor A3(2)],2VFT_A Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Sorbitol [Streptomyces coelicolor A3(2)],2VFU_A Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Mannitol [Streptomyces coelicolor A3(2)],2VFV_A Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Sulphite [Streptomyces coelicolor A3(2)]
5.88e-15	65	493	44	464	Chain A, Decaprenyl-phosphoryl-beta-d-ribofuranose-2- Oxidoreductase [Mycolicibacterium smegmatis],4F4Q_A Crystal structure of M. smegmatis DprE1 in complex with FAD and covalently bound BTZ043 [Mycolicibacterium smegmatis MC2 155]
7.42e-14	98	493	13	399	Chain A, oxidoreductase DprE1 [Mycolicibacterium smegmatis],4G3U_A Chain A, oxidoreductase DprE1 [Mycolicibacterium smegmatis],4G3U_B Chain B, oxidoreductase DprE1 [Mycolicibacterium smegmatis]
1.30e-11	53	218	61	232	Xylooligosaccharide oxidase from Myceliophthora thermophila C1 [Thermothelomyces thermophilus ATCC 42464],5L6F_A Xylooligosaccharide oxidase from Myceliophthora thermophila C1 in complex with Xylobiose [Thermothelomyces thermophilus ATCC 42464],5L6G_A Xylooligosaccharide oxidase from Myceliophthora thermophila C1 in complex with Xylose [Thermothelomyces thermophilus ATCC 42464]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
6.53e-203	35	537	33	548	Putative D-arabinono-1,4-lactone oxidase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=alo-1 PE=3 SV=1
6.83e-124	40	487	13	514	D-arabinono-1,4-lactone oxidase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) OX=284591 GN=ALO1 PE=3 SV=1
7.37e-109	41	487	18	542	D-arabinono-1,4-lactone oxidase OS=Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) OX=284592 GN=ALO1 PE=3 SV=2
7.37e-109	37	487	13	543	D-arabinono-1,4-lactone oxidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=ALO1 PE=1 SV=1
8.93e-103	39	504	15	532	D-arabinono-1,4-lactone oxidase OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) OX=284811 GN=ALO1 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	CS Position
1.000043	0.000000

TMHMM Annotations help

There is no transmembrane helices in AFUB_014510-T-p1.