CAZyme3D

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Entry ID

Information for CAZyme ID: ACM22227.1

Basic Information

GenBank IDACM22227.1
FamilyGT4
Sequence Length370
UniProt IDB9KB31(100,100)Download
Average pLDDT?92.44
CAZy50 ID119398
CAZy50 RepYes, ACM22227.1
Structure ClusterSC_GT4_clus864
EC Number(s)-
Substrates(s)-

Taxonomy

Tax ID309803
KingdomBacteria
PhylumThermotogota
ClassThermotogae
OrderThermotogales
FamilyThermotogaceae
GenusThermotoga
SpeciesThermotoga neapolitana

Protein Sequence:
90 < plddt <=100;
70 < plddt <= 90;
50 < plddt <= 70;
0 <= plddt <= 50;     Download help

MTAVKILVIG  YMHSRDDKRV  FRTVRALSKR  WKVIYQYRTK  ESESGFEERG  IEYIPLKCEN60
TGSVLRKLSE  RRIFDEKICH  LVEREDYDVL  YLHHFPATKP  LKPFLITKKQ  GKKIIYDIHE120
YHPQNFLNVL  PRPLSDLKEF  FMWRIFKKQL  ELSDLCIFVS  EETRDEIVAK  TGLAPSKTFV180
VPNYASLKIE  PDSGRKRKEI  IMVGKTQRNL  TYEKKLIKAL  IEKGFSFRVI  GMESKVFSDV240
PHTYTSFLPY  EKMMEEISKG  MFSLVSYSTI  GREDYKNDLY  ALPHKFYDSI  AAGTPVVVKK300
SFVSMARLVK  ELEIGVVIDP  SNTEDSLRKI  EDACQRYERI  LENIKKHQNL  FVWDERKEEE360
FLKKIAEVIE  370

Predicted 3D structure by AlphaFold2 with pLDDT = 92.44 ; Download help

pLDDT is for per-residue accuracy of the structure, which representes the quality of the residue. A higher value indicates better prediction accuracy. More detail please see AlphaFold .

Residues were colored according to plddt ( blue-> high quality; red-> low quality ).

Full Sequence:
CAPSIF:V and CAPSIF:G =99.9;
CAPSIF:V =59.9;
CAPSIF:G =40;
Non-Binding=0;     Download help

MTAVKILVIG  YMHSRDDKRV  FRTVRALSKR  WKVIYQYRTK  ESESGFEERG  IEYIPLKCEN60
TGSVLRKLSE  RRIFDEKICH  LVEREDYDVL  YLHHFPATKP  LKPFLITKKQ  GKKIIYDIHE120
YHPQNFLNVL  PRPLSDLKEF  FMWRIFKKQL  ELSDLCIFVS  EETRDEIVAK  TGLAPSKTFV180
VPNYASLKIE  PDSGRKRKEI  IMVGKTQRNL  TYEKKLIKAL  IEKGFSFRVI  GMESKVFSDV240
PHTYTSFLPY  EKMMEEISKG  MFSLVSYSTI  GREDYKNDLY  ALPHKFYDSI  AAGTPVVVKK300
SFVSMARLVK  ELEIGVVIDP  SNTEDSLRKI  EDACQRYERI  LENIKKHQNL  FVWDERKEEE360
FLKKIAEVIE  370

Carbohydrate binding residues Predicted by CAPSIF from 3D structure; Download help

Residues were colored according to prediction score:

Nonbinder, CAPSIF:G Predicted Binder, CAPSIF:V Predicted Binder, CAPSIF:V and CAPSIF:G Predicted Binder

CArbohydrate–Protein interaction Site IdentiFier (CAPSIF) that predicts non-covalent carbohydrate-binding sites on proteins: (1) a 3D-UNet voxel-based neural network model (CAPSIF:V) and (2) an equivariant graph neural network model (CAPSIF:G).

Details:
⋆B-Factor = 0.0 : Nonbinder.
⋆B-Factor = 40.0 : CAPSIF:G Predicted Binder.
⋆B-Factor = 59.9 : CAPSIF:V Predicted Binder.
⋆B-Factor = 99.9 : CAPSIF:V and CAPSIF:G Predicted Binder.

For more detail please see CAPSIF.

Full Sequence:
AA;
CE;
PL;
GH;
GT;
CBM;     Download structure help

dbCAN3 predicted domain(s) : GT113(64-349)

MTAVKILVIG  YMHSRDDKRV  FRTVRALSKR  WKVIYQYRTK  ESESGFEERG  IEYIPLKCEN60
TGSVLRKLSE  RRIFDEKICH  LVEREDYDVL  YLHHFPATKP  LKPFLITKKQ  GKKIIYDIHE120
YHPQNFLNVL  PRPLSDLKEF  FMWRIFKKQL  ELSDLCIFVS  EETRDEIVAK  TGLAPSKTFV180
VPNYASLKIE  PDSGRKRKEI  IMVGKTQRNL  TYEKKLIKAL  IEKGFSFRVI  GMESKVFSDV240
PHTYTSFLPY  EKMMEEISKG  MFSLVSYSTI  GREDYKNDLY  ALPHKFYDSI  AAGTPVVVKK300
SFVSMARLVK  ELEIGVVIDP  SNTEDSLRKI  EDACQRYERI  LENIKKHQNL  FVWDERKEEE360
FLKKIAEVIE  370

Predicted CAZyme domains from dbCAN; Download help

Domains were colored according to CAZyme classification: (AA), (CE), (PL), (GH), (GT), (CBM), & (Null)

dbCAN3 server is a web server for automated Carbohydrate-active enzyme ANnotation.

Details:
dbCAN3 server integrates three state-of-the-art tools/databases for automated CAZyme annotation:
⋆HMMER search for CAZyme family annotation vs. dbCAN CAZyme domain HMM database
⋆DIAMOND search for BLAST hits in the CAZy database
⋆HMMER search for CAZyme subfamily annotation vs. dbCAN-sub HMM database of CAZyme subfamilies (derived from eCAMI classification of CAZyDB families)

For more details, please see dbCAN3.

Similarites between the same cluster seqeunces from DIAMOND; Download help