| Basic Information | |
|---|---|
| Species | Prunus persica |
| Cazyme ID | ppa001357m |
| Family | GT47 |
| Protein Properties | Length: 846 Molecular Weight: 93798.2 Isoelectric Point: 6.3378 |
| Chromosome | Chromosome/Scaffold: 2 Start: 22479863 End: 22487403 |
| Description | DHFS-FPGS homolog B |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 47 | 293 | 3.3e-37 |
| SFKIFIYNPNTPFTFNSPSQSLFYTTLTLQDSVFVTQDAEQAQLFFVPFPSDLSTRSIARLIRGLRNDLPYWNRTLGADHFYLSCAGIGYESDRNLVELK KNSIQISCFPTPAGKFIPHKDISLPPLASSHAPTNKTTRFLGYARFNWLKESTLVNELSSDPEFLIESEPSDLNSYAERIASSKFCLFEYGGGDVSGIGE ALRFGCVPAVVTDRPIQDLPFSDVLRWQEIAVFVERRGVGELKRVLA | |||
| Full Sequence |
|---|
| Protein Sequence Length: 846 Download |
| MSLTTIFLLL LYFSLFTFLT THSKPHLPSP YLSPTTIFPN YQNMLKSFKI FIYNPNTPFT 60 FNSPSQSLFY TTLTLQDSVF VTQDAEQAQL FFVPFPSDLS TRSIARLIRG LRNDLPYWNR 120 TLGADHFYLS CAGIGYESDR NLVELKKNSI QISCFPTPAG KFIPHKDISL PPLASSHAPT 180 NKTTRFLGYA RFNWLKESTL VNELSSDPEF LIESEPSDLN SYAERIASSK FCLFEYGGGD 240 VSGIGEALRF GCVPAVVTDR PIQDLPFSDV LRWQEIAVFV ERRGVGELKR VLARTCGDRH 300 EKMKGLGVTA SGDGSSKPTP YEEALDALSS LITKRSRADT SNNGDCFELL SDYLKILELD 360 EPISQLKIIH VAGTKGKGST CTFTESILRH CGFRTGLFTS PHLIDVRERF RLDGVDISEE 420 KFLAYFWWCF ERLKEKASDG IPMPSYFRFL ALLAFKIFAA EEVDVAILEV GLGGKYDATN 480 VVKAPVVCGV SSLGYDHMEI LGNTLGAIAG EKAGIFKPGV PALTVPQPDE AMCVLEEKAS 540 ELNVPLQLVR PLDANLLNGF KLGLEGEHQY VNAGLAIALS STWLQRTGHL EVPYPEHTTS 600 LPEQFIKGLT ATVSLQGRAQ IVPDNNESPE DLVFYLDGAH SPESMEICAR WFSLSIKGDS 660 QEKILSCQPL DASRSSHDLV QRKPDGKSRK NSTQILLFNC MSVRDPQLLL PNLMKTCASH 720 GVYFKKALFV PNTSVYNKVG SHSLPATDSQ VDLSWQFALQ RVWENLMLGD KAGGDEKSTG 780 AVFEELTDDT EMAVRSCENS AVFPSLPSAI KWLRDSVRKS QSVRFQVLVT GSLHLIGDVL 840 KLIKK* 900 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PRK10846 | PRK10846 | 3.0e-32 | 367 | 642 | 293 | + bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional | ||
| COG0285 | FolC | 9.0e-82 | 318 | 652 | 351 | + Folylpolyglutamate synthase [Coenzyme metabolism] | ||
| TIGR01499 | folC | 2.0e-96 | 350 | 842 | 510 | + folylpolyglutamate synthase/dihydrofolate synthase. This model represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]. | ||
| PLN02881 | PLN02881 | 0 | 303 | 845 | 546 | + tetrahydrofolylpolyglutamate synthase | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004326 | tetrahydrofolylpolyglutamate synthase activity |
| GO:0005524 | ATP binding |
| GO:0009058 | biosynthetic process |
| GO:0009396 | folic acid-containing compound biosynthetic process |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI31610.1 | 0 | 302 | 845 | 76 | 618 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002277686.1 | 0 | 308 | 845 | 1 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002311192.1 | 0 | 310 | 845 | 2 | 539 | folylpolyglutamate synthase [Populus trichocarpa] |
| RefSeq | XP_002316257.1 | 0 | 313 | 844 | 7 | 580 | folylpolyglutamate synthase [Populus trichocarpa] |
| RefSeq | XP_002524236.1 | 0 | 319 | 845 | 14 | 531 | folylpolyglutamate synthase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 1o5z_A | 1e-37 | 358 | 659 | 44 | 343 | A Chain A, Crystal Structure Of Folylpolyglutamate Synthase (Tm0166) From Thermotoga Maritima At 2.10 A Resolution |
| PDB | 3qcz_A | 1e-30 | 367 | 644 | 53 | 324 | A Chain A, Crystal Structure Of Folylpolyglutamate Synthase (Tm0166) From Thermotoga Maritima At 2.10 A Resolution |
| PDB | 3pyz_A | 1e-30 | 367 | 644 | 53 | 324 | A Chain A, Crystal Structure Of Folylpolyglutamate Synthase (Tm0166) From Thermotoga Maritima At 2.10 A Resolution |
| PDB | 3nrs_A | 1e-30 | 367 | 644 | 53 | 324 | A Chain A, Crystal Structure Of Folylpolyglutamate Synthase (Tm0166) From Thermotoga Maritima At 2.10 A Resolution |
| PDB | 3n2a_A | 1e-30 | 367 | 644 | 53 | 324 | A Chain A, Crystal Structure Of Bifunctional Folylpolyglutamate SynthaseDIHYDROFOLATE SYNTHASE FROM YERSINIA PESTIS CO92 |
