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Browserling all CAZymes in genome: FungiDB-61_CalbicansSC5314_B
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| Protein ID | Family | Start | End | Strand | Description |
|---|---|---|---|---|---|
| C1_00220W_B-T-p1 | AA1 | Glycosidase, role in vaginal not systemic infection (low pH not neutral), low pH, high iron, fluconazole, Hap43-induced, Rim101-repressed at pH8, rat catheter biofilm induced, Bcr1-repressed in RPMI a/a biofilms | |||
| C1_00630W_B-T-p1 | AA1 | Has domain(s) with predicted UDP-N-acetylmuramate dehydrogenase activity, catalytic activity, flavin adenine dinucleotide binding activity | |||
| C1_00810W_B-T-p1 | GT91 | Ortholog(s) have N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity and role in dolichol-linked oligosaccharide biosynthetic process | |||
| C1_01140C_B-T-p1 | AA1 | Putative type-1 protein phosphatase targeting subunit, transcript repressed by yeast-hyphal switch, transcript induced by Mnl1p under weak acid stress, flow model biofilm induced | |||
| C1_01360C_B-T-p1 | AA1 | Putative glycogen synthesis initiator, regulated by Efg1 and Efh1, Hog1-repressed, colony morphology-related gene regulation by Ssn6, induced by prostaglandins, flow model biofilm induced | |||
| C1_02360C_B-T-p1 | AA1 | Putative GPI-anchored beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family, fungal-specific (no human or murine homolog) | |||
| C1_02400C_B-T-p1 | AA2 | Ortholog(s) have alpha-1,6-mannosyltransferase activity, role in protein N-linked glycosylation, protein glycosylation and mannan polymerase complex localization | |||
| C1_02420C_B-T-p1 | AA2 | Essential beta-1,3-glucan synthase subunit, gsc1 allele determines resistance/sensitivity to echinocandins, 16 predicted membrane-spanning regions, mRNA abundance declines after yeast-to-hypha transition, Spider biofilm induced | |||
| C1_02520W_B-T-p1 | AA3 | Putative cell wall protein, substrate for Kex2p processing in vitro, expression regulated by white-opaque switch, alkaline repressed, possibly essential (UAU1 method), flow model biofilm induced, Spider biofilm induced | |||
| C1_02630C_B-T-p1 | AA4 | GPI-anchored cell wall protein, similar to S. cerevisiae exo-1,3-beta-glucosidase Exg2p, predicted Kex2p substrate, induced during cell wall regeneration, possibly an essential gene, disruptants not obtained by UAU1 method, Hap43p-repressed | |||
| C1_02990C_B-T-p1 | AA4 | Exo-1,3-beta-glucanase, 5 glycosyl hydrolase family member, affects sensitivity to chitin and glucan synthesis inhibitors, not required for yeast-to-hypha transition or for virulence in mice, Hap43-induced, Spider biofilm induced | |||
| C1_03380W_B-T-p1 | AA6 | Trehalose-6-phosphate (Tre6P) phosphatase, mutant heat sensitive, accumulates Tre6P, decreased mouse virulence, possible drug target, 2 conserved phospohydrolase motifs, no mammalian homolog, Hap43-repressed, flow model biofilm induced | |||
| C1_03680W_B-T-p1 | AA6 | Endo-1,3-beta-glucanase, ortholog of S. cerevisiae Dse4 needed for cell separation, caspofungin, fluconazole repressed, repressed by alpha pheromone in SpiderM medium, flow model biofilm induced, rat catheter biofilm repressed | |||
| C1_03730C_B-T-p1 | AA6 | Alpha-1,2-mannosidase, processes Man9GlcNAc2 to Man8GlcNAc2 isomer B, member of ER localized glycosyl hydrolase family 47, ER form is converted by Kex2 to cytosolic form, flow model biofilm repressed | |||
| C1_04000C_B-T-p1 | AA6 | Mannosyltransferase, induced during cell wall regeneration, fungal-specific (no human or murine homolog), Bcr1-repressed in RPMI a/a biofilms | |||
| C1_04280C_B-T-p1 | AA7 | Ortholog(s) have alpha-1,6-mannosyltransferase activity, mannosyltransferase activity and role in GPI anchor biosynthetic process | |||
| C1_04900W_B-T-p1 | CBM21 | Putative alpha-1,3-mannosyltransferase, predicted role in protein O-linked glycosylation, Spider biofilm induced | |||
| C1_05000W_B-T-p1 | CBM21 | Putative beta-mannosyltransferase required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan, 9-gene family memebr, regulated on yeast-hypha and white-opaque switches, Spider biofilm repressed | |||
| C1_05600W_B-T-p1 | CBM48 | Beta-1,3-glucan synthase subunit, 10 predicted transmembrane regions, caspofungin induced, repressed by yeast-to-hypha transition, young biofilm repressed, induced by biofilm drug exposure, Bcr1-repressed in RPMI a/a biofilms | |||
| C1_06940C_B-T-p1 | CBM48 | Cell wall acid trehalase, catalyzes hydrolysis of the disaccharide trehalose, similar to S. cerevisiae vacuolar acid trehalase (Ath1p), Hap43p-repressed gene | |||
| C1_07250C_B-T-p1 | CE4 | Putative mannosyltransferase, similar to S. cerevisiae Alg9p, has HKEXRF motif | |||
| C1_08010W_B-T-p1 | CE9 | Dolichol-phosphate mannose synthase catalytic subunit, filament induced, Tup1-regulated, flow model and rat catheter biofilm repressed | |||
| C1_10070C_B-T-p1 | GH125 | Alpha-1,2-mannosyltransferase, mutants hypersensitive to toxic ergosterol analog, amphotericin B, calcofluor white, growth at 42 degrees and have decreased cell wall mannan, flow model biofilm induced | |||
| C1_10290W_B-T-p1 | GH13 | Extracellular/plasma membrane-associated glucoamylase, expressed in rat oral infection, regulated by carbohydrates, pH, galactose, promotes biofilm matrix formation, flow model biofilm induced, Bcr1 repressed in RPMI a/a biofilms | |||
| C1_10300W_B-T-p1 | GH13 | Predicted alpha-1,3-mannosyltransferase activity with a role in protein glycosylation | |||
| C1_10550C_B-T-p1 | GH13 | Predicted extracellular glucoamylase, induced by ketoconazole, possibly essential, disruptants not obtained by UAU1 method, promotes biofilm matrix formation, Spider biofilm induced, Bcr1-induced in RPMI a/a biofilms | |||
| C1_10720C_B-T-p1 | GH13 | Alpha-1,2-mannosyltransferase, similar to S. cerevisiae Mnn2, role in cell wall integrity, temperature sensitivity, iron utilization in low iron, Tn mutation affects filamentous growth, filament induced, increased chitin exposes beta-glucan | |||
| C1_13110C_B-T-p1 | GH130 | Major chitin synthase of yeast and hyphae, synthesizes short-chitin fibrils, Chs4-activated, transcript induced at yeast-hyphal transition, Chs1 and Chs2, but not Chs3, are inhibited by the protoberberine HWY-289, Spider biofilm induced | |||
| C1_13940W_B-T-p1 | GH132 | Adhesin-like protein, involved in cell wall maintenance, redundant with Sun41, possibly secreted, macrophage-repressed, repressed by Rim101, Cyr1, Ras1, Spider biofilm induced | |||
| C1_14060W_B-T-p1 | GH132 | Glucan 1,3-beta-glucosidase, regulated by Nrg1, Tup1 and possibly Tac1, induced by NO and during cell wall regeneration, stationary phase enriched, possibly essential (UAU1 method), F-12/CO2 early biofilm induced, flow biofilm repressed | |||
| C1_14290C_B-T-p1 | GT91 | Ortholog(s) have role in pheromone-dependent signal transduction involved in conjugation with cellular fusion and membrane raft, plasma membrane localization | |||
| C2_00080C_B-T-p1 | GH132 | Putative alpha-1,6-mannanase, induced by mating factor in MTLa/MTLa opaque cells | |||
| C2_00520W_B-T-p1 | GH15 | N-linked mannoprotein of cell wall and membrane, possible signal transducer, role in hyphal growth and HWP1 induction in alkaline pH, GPI modification predicted, dfg5 dcw1 double mutant is inviable, caspofungin-induced, fungal-specific | |||
| C2_01300C_B-T-p1 | GH16 | Alpha-1,2-mannosyltransferase, required for normal cell wall mannan content | |||
| C2_01360C_B-T-p1 | GH16 | Protein with predicted GPI modification, dfg5 dcw1 double mutant is inviable, not required for wild-type hyphal growth, upregulated in cyr1 mutant (yeast or hyphal form), Hap43-induced | |||
| C2_01560W_B-T-p1 | GH16 | Putative beta-mannosyltransferase involved in beta-1,2-mannosylation of phospholipomannan, 9-member family includes Bmt1, Bmt2, Bmt3, and Bmtp with roles in mannosylation of cell wall phosphopeptidomannan, Spider biofilm induced | |||
| C2_01670C_B-T-p1 | GH16 | Putative oligosaccharyltransferase complex component, flow model and rat catheter biofilm repressed | |||
| C2_02010C_B-T-p1 | GH16 | Chitinase, similar to S. cerevisiae sporulation-specific Cts2p, functionally complements A. gossypii cts2 mutant sporulation defect, homozygous null mutation causes no obvious defects, transcription decreases upon yeast-to-hyphal switch | |||
| C2_02980C_B-T-p1 | GH16 | Putative D-lactate dehydrogenase, white cell-specific trancript, colony morphology-related gene regulation by Ssn6, Hap43-repressed, rat catheter biofilm induced, Spider biofilm repressed | |||
| C2_03070C_B-T-p1 | GH16 | Mannosyltransferase of glycosylphosphatidylinositol (GPI) biosynthesis, catalyzes mannosylation of Man3-GPI precursor, essential for viability, 8-9 transmembrane regions predicted, has HQEXRF motif, functional homolog of S. cerevisiae Smp3p | |||
| C2_03600W_B-T-p1 | GH17 | Putative beta-mannosyltransferase, member of a 9-gene family including characterized BMT genes with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan, transposon insertion in promoter region causes decreased colony wrinkling | |||
| C2_03910C_B-T-p1 | GH17 | Ortholog(s) have carbohydrate binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | |||
| C2_04560W_B-T-p1 | GH17 | Mannosyltransferase, transcription elevated in chk1, nik1, and sln1 homozygous null mutants, fungal-specific (no human or murine homolog), possibly an essential gene, disruptants not obtained by UAU1 method | |||
| C2_05050C_B-T-p1 | GT91 | Ortholog(s) have acetylglucosaminyltransferase activity, role in protein N-linked glycosylation and Golgi medial cisterna localization | |||
| C2_06100W_B-T-p1 | GH17 | Protein mannosyltransferase, required for WT cell wall composition and virulence in mice, roles in hyphal growth and drug sensitivity, one of 5 family members, Axl2 a substrate, Spider biofilm repressed, Bcr1-repressed in RPMI a/a biofilm | |||
| C2_06840W_B-T-p1 | GH17 | Putative GPI-anchored protein, similar but not orthologous to S. cerevisiae Spr1, a sporulation-specific exo-1,3-beta-glucanase, mutant is viable | |||
| C2_06870C_B-T-p1 | GH18 | Flavodoxin-like protein involved in oxidative stress protection and virulence, putative 1,4-benzoquinone reductase, hyphal-induced, regulated by Cyr1, Ras1, Efg1, Nrg1, Rfg1, Tup1, Hap43-induced, Spider biofilm induced | |||
| C2_08570W_B-T-p1 | GH18 | Putative mannosyltransferase of Golgi, member of Mnn9p family, similar to S. cerevisiae Anp1p, fungal-specific (no human or murine homolog) | |||
| C2_08640C_B-T-p1 | GH18 | Flavodoxin-like protein involved in oxidative stress protection and virulence, putative NADH:quinone oxidoreductase, similar to 1,4-benzoquinone reductase, induced by benomyl, oxidative stress via Cap1, fungal-specific | |||
| C2_09150W_B-T-p1 | GH18 | Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit, sphingolipid biosynthesis, fluconazole, caspofungin induced, macrophage-repressed, Spider biofilm induced | |||
| C2_09230C_B-T-p1 | GT91 | Snf1p complex scaffold protein, similar to S. cerevisiae Gal83p and Sip2p with regions of similarity to Sip1p (ASC and KIS domain), interacts with Snf4p, mutants are hypersensitive to caspofungin and hydrogen peroxide, Hap43p-repressed gene | |||
| C2_10020C_B-T-p1 | GH2 | Has domain(s) with predicted catalytic activity and role in carbohydrate metabolic process | |||
| C2_10030C_B-T-p1 | GH20 | Cell surface mannoprotein, cell-wall glucan metabolism, adhesion, adhesin motif, O-glycosylation, induced by heat, germ tube formation, wall regeneration, mycelial antigen, diagnostic marker, fluconazole-repressed, Spider biofilm induced | |||
| C2_10150W_B-T-p1 | GH3 | Secreted protein, fluconazole-induced | |||
| C2_10160W_B-T-p1 | GH3 | Secreted protein, fluconazole-induced | |||
| C2_10690W_B-T-p1 | GH3 | Predicted trehalose-phosphate synthase regulatory subunit, regulated by Efg1, regulated by Tsa1, Tsa1B under H2O2 stress conditions, flow model biofilm induced (reports differ) | |||
| C3_00710W_B-T-p1 | GH31 | Chitin synthase required for synthesis of long-chitin fibrils, nonessential, 8 or 9 membrane spanning regions, mRNA present in yeast and hyphae, induced during cell wall regeneration, flow model biofilm repressed | |||
| C3_01320C_B-T-p1 | GH31 | Putative glucoamylase, induced in oralpharyngeal candidasis, rat catheter and Spider biofilm induced | |||
| C3_01730C_B-T-p1 | GH31 | Putative GPI anchored cell wall glycosidase, role in adhesion, hyphal growth on Spider (not serum) medium, chitin-binding, glycosyl hydrolase domains, induced during cell wall regeneration, mRNA in yeast-form cells, Spider biofilm induced | |||
| C3_01810C_B-T-p1 | GH37 | Alpha-1,2-mannosyl transferase, predicted type II Golgi membrane protein, adds 2nd mannose during cell-wall mannoprotein biosynthesis, required for wild-type virulence and adherence to epithelial cells, Hap43-induced | |||
| C3_01820W_B-T-p1 | GH38 | Protein of unknown function, expression downregulated in an ssr1 null mutant | |||
| C3_01830C_B-T-p1 | GH47 | Alpha-1,2-mannosyl transferase, adds 3rd mannose in cell-wall mannoprotein biosynthesis, partially redundant with Mnt1, role in adherence and virulence, expressed in yeast and hyphae, fungal-specific, Hap43-induced, Spider biofilm induced | |||
| C3_01880W_B-T-p1 | GH47 | Putative glucosyltransferase involved in cell wall mannan biosynthesis, transcription is elevated in nik1 and sln1 homozygous null mutants, but not in the chk1 null mutant, possibly an essential gene, disruptants not obtained by UAU1 method | |||
| C3_02140C_B-T-p1 | GH5 | Has domain(s) with predicted catalytic activity and role in carbohydrate metabolic process | |||
| C3_02480C_B-T-p1 | GH5 | Cytochrome-c peroxidase N terminus, Rim101, alkaline pH repressed, induced in low iron or by macrophage interaction, oxygen-induced activity, regulated by Sef1, Sfu1, and Hap43, Spider biofilm induced, rat catheter biofilm repressed | |||
| C3_02960C_B-T-p1 | GH5 | UDP-glucose:glycoprotein glucosyltransferase, 1,6-beta-D-glucan biosynthesis, hyphal growth, virulence in mouse IV model, partially complements S. cerevisiae kre5 mutant defects, flow biofilm repressed, Bcr1-repressed in RPMI a/a biofilms | |||
| C3_03450C_B-T-p1 | GH5 | Beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan, downregulated in azole-resistant strain, Hap43p-induced | |||
| C3_03500W_B-T-p1 | GH5 | Protein with a potential role in beta-1,6 glucan biosynthesis, similarity to Kre6 and Skn1, possibly essential, disruptants not obtained by UAU1 method, Hap43-induced, flow model biofilm induced, rat catheter biofilm repressed | |||
| C3_04450C_B-T-p1 | GH63 | Protein of unknown function, induced by alpha pheromone in SpiderM medium | |||
| C3_05340W_B-T-p1 | GH65 | Ortholog(s) have dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity, role in protein N-linked glycosylation and endoplasmic reticulum membrane localization | |||
| C3_05610W_B-T-p1 | GH72 | Predicted alpha-1,3-mannosyltransferase activity with a role in protein glycosylation, Hap43-repressed, Spider biofilm induced | |||
| C3_05810C_B-T-p1 | GH72 | Protein with a role in beta-1,6-glucan synthesis, probable N-glycosylated type II membrane protein, transcript and mRNA length change induced by yeast-hypha transition, induced by Rim101, caspofungin, rat catheter and Spider biofilm induced | |||
| C3_05830W_B-T-p1 | GH72 | Essential beta-1,6-glucan synthase subunit, change in mRNA length, not abundance, at yeast-hypha transition, alkaline induced by Rim101, on cell wall regeneration, Spider biofilm induced, Bcr1-repressed in RPMI a/a biofilms | |||
| C3_06020W_B-T-p1 | GH72|CBM43 | Protein of N-linked outer-chain mannan biosynthesis, mutant has defective cell wall, required for wild-type hyphal growth, mutant is hygromycin B sensitive and vanadate resistant, has N-terminal membrane-spanning segment (positions 18-34) | |||
| C3_06090C_B-T-p1 | GH72|CBM43 | Alpha-1,6-mannosyltransferase, initiates N-glycan outer chain branch addition, similar to S. cerevisiae Och1p, required for wild-type virulence in mouse intravenous infection, fungal-specific (no human or murine homolog) | |||
| C3_06450W_B-T-p1 | GH76 | Putative self-glucosylating initiator of glycogen synthesis, expression regulated upon white-opaque switch, hypha-induced, Spider biofilm induced | |||
| C3_06890W_B-T-p1 | GH76 | Protein mannosyltransferase (PMT) with roles in hyphal growth and drug sensitivity, member of the PMT family which includes Pmt1p, Pmt2p, Pmt4p, Pmt5p, and Pmt6p, induced during cell wall regeneration, essential | |||
| C3_07180C_B-T-p1 | GH76 | Beta-mannosyltransferase, required for addition of the 1st beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan, 9-gene family member, mutants induce higher levels of inflammatory cytokines in mouse dendritic cells | |||
| C3_07360W_B-T-p1 | GH76 | Ortholog(s) have D-lactate dehydrogenase (cytochrome) activity, role in lactate catabolic process and mitochondrial inner membrane, mitochondrion localization | |||
| C3_07500W_B-T-p1 | GH76 | Member of Mnn9 family of mannosyltransferases, ortholog of S. cerevisiae Van1p, fungal-specific (no human or murine homolog) | |||
| C4_00090W_B-T-p1 | GH76 | Putative beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family, fungal-specific (no human or murine homolog), possibly an essential gene, disruptants not obtained by UAU1 method | |||
| C4_00310C_B-T-p1 | GH76 | Alpha-1,6-mannosyltransferase involved in biosynthesis and organization of cell wall polysaccharides | |||
| C4_01170C_B-T-p1 | GH81 | Beta-mannosyltransferase, 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan, regulated by Sef1, Sfu1, Hap43, rat catheter biofilm repressed | |||
| C4_01220C_B-T-p1 | GH81 | Protein with a glycoside hydrolase domain, mutants are viable | |||
| C4_02010C_B-T-p1 | GH92 | UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthase [GCS], EC 2.4.1.80), involved in glucosylceramide biosynthesis, which is important for virulence | |||
| C4_02100C_B-T-p1 | GT1 | Catalytic subunit of glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions | |||
| C4_02250C_B-T-p1 | GT1 | Cell wall 1,3-beta-glucosyltransferase, mutant has cell-wall and growth defects, but wild-type 1,3- or 1,6-beta-glucan content, antigenic, virulence role in mouse systemic infection, rat catheter biofilm induced | |||
| C4_02360W_B-T-p1 | GT15 | Putative alpha-mannosidase, transcript regulated by Nrg1, induced during cell wall regeneration, flow model biofilm induced, Spider biofilm induced | |||
| C4_02900C_B-T-p1 | GT15 | GPI-anchored cell wall transglycosylase, putative ortholog of S. cerevisiae Crh1p, predicted glycosyl hydrolase domain, similar to Csf4p and to antigenic A. fumigatus Aspf9, predicted Kex2p substrate, caspofungin-induced | |||
| C4_04530C_B-T-p1 | GT15 | Cell surface glycosidase, may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage, role in systemic, not vaginal virulence (neutral, not low pH), high pH or filamentation induced, Bcr1-repressed in RPMI a/a biofilm | |||
| C4_04770C_B-T-p1 | GT15 | Alpha-1,2-mannosyltransferase, required for normal cell wall mannan, regulated by Tsa1, Tsa1B at 37 deg, repressed in core stress response, NO, Hog1 induced, confers sensitivity to cell wall perturbing agents, Spider biofilm repressed | |||
| C4_04780W_B-T-p1 | GT15 | Protein mannosyltransferase, required for virulence in mice, adhesion to endothelium, role in hyphal growth signaling, hygromycin B sensitivity, no major role in cellular PMT activity, Hap4-repressed, Bcr1-repressed in RPMI a/a biofilms | |||
| C4_05140C_B-T-p1 | GT2 | Putative glycogen debranching enzyme, expression is regulated upon white-opaque switch, regulated by Nrg1, Tup1, rat catheter biofilm repressed | |||
| C4_06000W_B-T-p1 | GT2 | Protein similar to S. cerevisiae Alg1p, a mannosyltransferase involved in N-linked protein glycosylation, likely to be essential for growth, based on an insertional mutagenesis strategy | |||
| C4_06100W_B-T-p1 | GT2 | Processing alpha glucosidase I, involved in N-linked protein glycosylation and assembly of cell wall beta 1,6 glucan, rat catheter biofilm repressed | |||
| C5_00220W_B-T-p1 | GT2 | Alpha-glucosidase II, catalytic subunit, required for N-linked protein glycosylation and normal cell wall synthesis, alkaline downregulated | |||
| C5_00460C_B-T-p1 | GT20 | Putative multicopper ferro-O2-oxidoreductase, repressed in core caspofungin response, fails to complement S. cerevisiae fet3 iron-related phenotypes, rat catheter and Spider biofilm induced | |||
| C5_00470C_B-T-p1 | GT20 | Putative subunit of glucan synthase, macrophage-induced gene, Bcr1-regulated in a/a RPMI biofilms | |||
| C5_00810C_B-T-p1 | GT20 | Has domain(s) with predicted heme binding, peroxidase activity and role in response to oxidative stress | |||
| C5_02570W_B-T-p1 | GT21 | Predicted alpha-1,3-mannosyltransferase activity with a role in protein glycosylation, regulated by Sef1p-, Sfu1p-, and Hap43p | |||
| C5_02630C_B-T-p1 | GT22 | Putative alpha-1,3-mannosyltransferase, of the mannosyltransferase complex, negatively regulated by Rim101, transcript elevated in chk1 and nik1 mutants, but not in sln1 mutant, Spider and flow model biofilm induced | |||
| C5_03610W_B-T-p1 | GT22 | Beta-N-acetylhexosaminidase/chitobiase, highly glycosylated enzyme that is secreted to the periplasm and culture medium, required for full virulence, may have role in carbon or nitrogen scavenging, possibly an essential gene (UAU1 method) | |||
| C5_04110W_B-T-p1 | GT22 | Cell wall protein, repressed in ace2 mutant, repressed in core caspofungin response, induced in high iron, possibly an essential gene, disruptants not obtained by UAU1 method, rat catheter and Spider biofilm repressed | |||
| C5_04130C_B-T-p1 | GT22 | GPI-linked chitinase, required for normal filamentous growth, repressed in core caspofungin response, fluconazole, Cyr1, Efg1, pH-regulated, mRNA binds She3 and is localized to yeast-form buds and hyphal tips, Spider biofilm repressed | |||
| C5_04800W_B-T-p1 | GT24 | CRH family cell wall protein, transcript regulated by Nrg1 and Tup1, alkaline induced by Rim101, repressed during cell wall regeneration, flow model biofilm induced | |||
| C5_04940W_B-T-p1 | GT2|GT2 | Maltase, induced during growth on sucrose, induced by alpha pheromone in SpiderM medium, early-stage flow model biofilm indced | |||
| C5_05040W_B-T-p1 | GT2|GT2 | Putative mannosyltransferase, similar to S. cerevisiae Gpi10p, has HKEXRF motif | |||
| C5_05360C_B-T-p1 | GT3 | Ortholog(s) have steryl-beta-glucosidase activity, role in ergosteryl 3-beta-D-glucoside catabolic process and cytosol localization | |||
| C5_05390C_B-T-p1 | GT32 | GPI-anchored cell surface protein, beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family, transcript induced in RHE model of oral candidiasis, fluconazol-induced | |||
| C6_00440C_B-T-p1 | GT32 | Multicopper ferroxidase, induced by low iron, ciclopirox olamine, ketoconazole, hypoxia, alkaline induced by Rim101, repressed in fluconazole-resistant isolate, Sfu1, Hog1 repressed, complements S. cerevisiae fet3, Spider biofilm induced | |||
| C6_00460C_B-T-p1 | GT32 | Multicopper oxidase, required for growth in low iron and prostaglandin E2 synthesis | |||
| C6_00470C_B-T-p1 | GT33 | Multicopper oxidase family protein, similar to S. cerevisiae Fet3, does not complement S. cerevisiae fet3 mutant growth under low-iron, iron-repressed, regulated by Tup1, Rim101, flow model biofilm induced, Spider biofilm repressed | |||
| C6_00480C_B-T-p1 | GT34 | Putative multicopper oxidase, ketoconazole/caspofungin/amphotericin B repressed, Sef1/Sfu1/Hap43 regulated, reports differ if functional homolog of ScFet3, rat catheter and Spider biofilm induced | |||
| C6_00820W_B-T-p1 | GT34 | Cell wall glycosidase, role in biofilm formation and cell separation, possibly secreted, hypoxia, hyphal induced, caspofungin repressed, Efg1, Cph1 regulated, O-glycosylated, possible Kex2 substrate, 5'-UTR intron, Spider biofilm induced | |||
| C6_01390W_B-T-p1 | GT35 | Protein with similarity to mannosyltransferases, similar to S. cerevisiae Hoc1p and C. albicans Och1p | |||
| C6_01690W_B-T-p1 | GT39 | Putative endo-1,3-beta-glucanase, fungal-specific (no human or murine homolog) | |||
| C6_02270C_B-T-p1 | GT39 | Alpha-1,2-mannosyltransferase, catalyzes sequential addition of 2 terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER, Spider biofilm induced | |||
| C6_02940C_B-T-p1 | GT39 | Protein of unknown function, Spider biofilm repressed | |||
| C6_03160C_B-T-p1 | GT39 | Beta-mannosyltransferase, beta-1,2-mannosylation of phospholipomannan, member of a 9-member family including Bmt1, Bmt2, Bmt3, and Bmt4 with roles in mannosylation of cell wall phosphopeptidomannan, flow model biofilm induced | |||
| C6_03250W_B-T-p1 | GT39 | Beta-mannosyltransferase, for elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan, 9-gene family member, regulated by Tsa1, Tsa1B, flow model biofilm induced, rat catheter biofilm repressed | |||
| C6_03340C_B-T-p1 | GT4 | Putative 1,4-glucan branching enzyme, fluconazole-induced, colony morphology-related gene regulation by Ssn6, stationary phase enriched protein | |||
| C6_04030W_B-T-p1 | GT4 | Putative mannosyltransferase involved in cell wall mannan biosynthesis, transcription is elevated in chk1, nik1, and sln1 homozygous null mutants | |||
| C6_04340W_B-T-p1 | GT4 | Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, role in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins, rat catheter biofilm repressed | |||
| C6_04600W_B-T-p1 | GT48 | N-acetylglucosamine-6-phosphate (GlcNAcP) deacetylase, N-acetylglucosamine utilization, required for wild-type hyphal growth and virulence in mouse systemic infection, gene and protein are GlcNAc-induced, Spider biofilm induced | |||
| C7_00660W_B-T-p1 | GT48 | Putative regulatory subunit of ser/thr phosphoprotein phosphatase 1, fluconazole-induced, caspofungin repressed, transcript induced by Mnl1 under weak acid stress, regulated by Nrg1, Tup1, Spider and flow model biofilm induced | |||
| C7_00930W_B-T-p1 | GT48 | Putative glycogen phosphorylase, role in glycogen metabolism, regulated by Ssk1, Mig1, Tup1, Hap43, fluconazole-induced, localizes to cell surface of hyphae, not yeast, stationary phase enriched protein, Spider biofilm induced | |||
| C7_02450W_B-T-p1 | GT50 | Protein of unknown function, induced upon adherence to polystyrene, oxidative stress-induced via Cap1 | |||
| C7_02770W_B-T-p1 | GT57 | Chitin synthase, essential, for primary septum synthesis in yeast and hyphae, 1 of several chitin synthases, enzymatically activated by proteolytic processing, complements defects of S. cerevisiae chs1 or chs2, Spider biofilm repressed | |||
| C7_02890C_B-T-p1 | GT57 | Protein mannosyltransferase, required for virulence in mice and for adhesion to epithelial cells, role in hyphal growth and drug sensitivity, Als1, Sec20, Kre9, Pir1 are substrates, 1 of 5 PMT family members | |||
| C7_02970W_B-T-p1 | GT58 | Putative mannosyltransferase similar to S. cerevisiae Ecm39p, which has a role in Calcofluor white resistance, predicted Kex2p substrate, has HKEXRF motif | |||
| C7_03600W_B-T-p1 | GT59 | Putative alpha-1,2-mannosyltransferase, mutant sensitive to calcofluor, SDS and growth at 42 deg, present in detergent-resistant membrane fraction (possible lipid raft component), predicted N-terminal acetylation and transmembrane helix | |||
| CR_00180C_B-T-p1 | GT62 | Chitinase, putative N-terminal catalytic domain, has secretory signal sequence, lacks S/T region and N-glycosylation motifs of Chs2p and Chs3p, alkaline downregulated, expression not detected in yeast-form or hyphal cells | |||
| CR_00190W_B-T-p1 | GT62 | N-acetyltransferase related to Gcn5p, acts as N-acetylglucosamine (GlcNAc) sensor required for GlcNAc-induced histone acetylation at promoters of GlcNAc-inducible genes and activation of their transcription by Rep1p, Hap43-induced gene | |||
| CR_00300W_B-T-p1 | GT62 | Putative chitin deacetylase, transcription is positively regulated by Tbf1p | |||
| CR_00560W_B-T-p1 | GT62 | Neutral trehalase, hyphal induction in mutant delayed but not reduced overall, not required for virulence in mice, possible regulatory cAMP-dependent phosphorylation at S10,S213, Hap43-repressed gene, Spider biofilm induced | |||
| CR_00740C_B-T-p1 | GT66 | Beta-mannosyltransferase, adds 2nd beta-mannose to the acid-stable fraction of cell wall phosphopeptidomannan, elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction, Hap43-induced, Spider biofilm induced | |||
| CR_00780C_B-T-p1 | GT71 | Glycogen synthase (UDP glucose/starch glucosyltransferase), transcript repressed by yeast-hyphal switch, Efg1-regulated, strong oxidative stress induced, colony morphology-related regulation by Ssn6, stationary phase enriched | |||
| CR_00850C_B-T-p1 | GT71 | Protein similar to beta-1,3-glucan synthase, 16 predicted membrane-spanning regions, transcript regulated by Nrg1, very low gene expression in yeast-form and hyphal cells | |||
| CR_02160W_B-T-p1 | GT71 | UDP-glucose:sterol glucosyltransferase, enzyme of sterol glucoside (membrane-bound lipid) biosynthesis, has UDP-sugar binding domain, activity is UDP-glucose-specific in vitro, enzyme does not use UDP-mannose, Mig1-regulated | |||
| CR_02790C_B-T-p1 | GT71 | Putative glucosyltransferase involved in cell wall mannan biosynthesis, possibly an essential gene, disruptants not obtained by UAU1 method | |||
| CR_02800C_B-T-p1 | GT71 | Protein of unknown function, mutation confers hypersensitivity to amphotericin B, flow model biofilm induced | |||
| CR_04040C_B-T-p1 | GT71 | Putative DNA-binding transcription factor, predicted role in regulation of biogenesis of the cell wall, upregulated in biofilm, protein newly produced during adaptation to the serum | |||
| CR_04800W_B-T-p1 | GT71 | Predicted alpha-1,3-mannosyltransferase with a role in protein glycosylation, induced in low iron | |||
| CR_05290W_B-T-p1 | GT71 | Mannosyltransferase, transcription elevated in cyr1, chk1, nik1, and sln1 homozygous null mutants, fungal-specific (no human or murine homolog) | |||
| CR_05300C_B-T-p1 | GT71 | Ortholog(s) have alpha-1,2-mannosyltransferase activity, role in protein glycosylation and Golgi apparatus localization | |||
| CR_05380C_B-T-p1 | GT71 | Flavodoxin-like protein involved in oxidative stress protection and virulence, flow model, rat catheter and Spider biofilm repressed | |||
| CR_05390W_B-T-p1 | GT71 | Flavodoxin-like protein involved in oxidative stress protection and virulence, YNB biofilm induced, stationary phase enriched protein, rat catheter and Spider biofilm repressed | |||
| CR_05720W_B-T-p1 | GT71 | Trehalose-6-phosphate synthase, role in hyphal growth and virulence in mouse systemic infection, induced in presence of human neutrophils, macrophage/pseudohyphal-repressed after 16h, stationary phase enriched protein, Hap43-repressed | |||
| CR_05750W_B-T-p1 | GT76 | Predicted glycosyl hydrolase, hypoxia induced, flow model biofilm induced | |||
| CR_06030C_B-T-p1 | GT8 | Has domain(s) with predicted carbohydrate binding, catalytic activity and role in carbohydrate metabolic process | |||
| CR_06900C_B-T-p1 | GT8 | Putative glucosyltransferase involved in cell wall mannan biosynthesis, transcription is elevated in chk1, nik1, and sln1 homozygous null mutants, repressed by nitric oxide, possibly essential gene, disruptants not obtained by UAU1 method | |||
| CR_07250C_B-T-p1 | GT8 | Predicted long-chain-alcohol oxidase, Spider biofilm induced | |||
| CR_09020C_B-T-p1 | GT91 | Chitin synthase, nonessential, required for wild-type chitin deposition in hyphae, transcript regulated during dimorphic transition, Chs1 and Chs2, but not Chs3, are inhibited by the protoberberine HWY-289, flow model biofilm repressed | |||
| CR_09420C_B-T-p1 | GT91 | Putative glucanase, induced during cell wall regeneration | |||
| CR_09770C_B-T-p1 | GT91 | Protein mannosyltransferase (PMT), expressed at extremely low levels, not required for wild-type hyphal growth, drug resistance, or virulence in mouse systemic infection, one of five PMT family members | |||
| CR_10110W_B-T-p1 | GT91 | Major chitinase, secreted, functional homolog of S. cerevisiae Cts1p, 4 N-glycosylation motifs, possible O-mannosylation, putative signal peptide, hyphal-repressed, farnesol upregulated in biofilm, regulated by Efg1p, Cyr1p, Ras1p | |||
| CR_10790W_B-T-p1 | GT91 | Alpha-glucosidase, hydrolyzes sucrose for sucrose utilization, transcript regulated by Suc1, induced by maltose, repressed by glucose, Tn mutation affects filamentous growth, upregulated in RHE model, rat catheter and Spider biofilm induced |