CAZyme Information: MGYG000004044_01290

Basic Information

• Species: UMGS1633 sp900553645
• Lineage: Bacteria; Firmicutes_A; Clostridia_A; Christensenellales; CAG-74; UMGS1633; UMGS1633 sp900553645
• CAZyme ID: MGYG000004044_01290
• CAZy Family: GH33
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
355	MGYG000004044_60|CGC1	39915.1	5.2545

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004044	2665198	MAG	United Kingdom	Europe

• Gene Location: Start: 7305; End: 8372 Strand: +

Full Sequence      

MMDKGRIVLELAPDEVCTRQSEGDFCRLPDGSILFAYSRFTQSGDDDAPSDIMGRLSRDE
GDTWTEPVTLISAARHGVKNVMSLTLMNMANGDIGMFYLIKQSPLENRVMLARSKDGLTF
GEAVECQNTARKGLYILNNQRAERLSCGRIILPVALHYASMGKQGRLFNGYGECYCLCSD
DDGYTWREMPGQIHASFTRSHSGLQEPGIVEMRNGALWMYARTDMMYQYECFSNDGGESW
TLPQPSRFTSPQSPMKIARSPYNGVLYSIWNPIPNYNGREYTHYNGGRTPLVIARSDNDG
RTWSEPYVLEDNPDCGYCYPAMFFLPDGRALVAYCAGDIPDGGCLNRTRVRKIEL

Enzyme Prediction     

No EC number prediction in MGYG000004044_01290.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH33	28	334	2.6e-31	0.8654970760233918

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd15482	Sialidase_non-viral	2.82e-49	27	343	21	331	Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam13088	BNR_2	4.67e-29	42	329	8	277	BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QNM08403.1	7.17e-110	5	354	12	365
AOH43019.1	4.92e-88	19	355	21	358
AEL26177.1	6.36e-82	6	355	28	366
AKP51796.1	1.11e-78	6	355	35	373
QDU47982.1	4.27e-69	4	355	36	381

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4X6K_A	2.60e-08	133	334	271	455	Crystalstructure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with Siastatin B [[Ruminococcus] gnavus CC55_001C]
4X47_A	2.61e-08	133	334	274	458	Crystalstructure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with Neu5Ac2en [[Ruminococcus] gnavus ATCC 29149],4X49_A Crystal structure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with oseltamivir carboxylate [[Ruminococcus] gnavus ATCC 29149],4X4A_A Crystal structure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with 2,7-Anhydro-Neu5Ac [[Ruminococcus] gnavus ATCC 29149]
1SLI_A	6.92e-07	146	334	472	648	LeechIntramolecular Trans-Sialidase Complexed With Dana [Macrobdella decora],1SLL_A Sialidase L From Leech Macrobdella Decora [Macrobdella decora],2SLI_A Leech Intramolecular Trans-Sialidase Complexed With 2,7- Anhydro-Neu5ac, The Reaction Product [Macrobdella decora],3SLI_A Leech Intramolecular Trans-Sialidase Complexed With 2,7- Anhydro-Neu5ac Prepared By Soaking With 3'-Sialyllactose [Macrobdella decora],4SLI_A Leech Intramolecular Trans-Sialidase Complexed With 2- Propenyl-Neu5ac, An Inactive Substrate Analogue [Macrobdella decora]
7LBU_A	2.36e-06	6	303	74	384	ChainA, Exo-alpha-sialidase [Cutibacterium acnes],7LBV_A Chain A, Exo-alpha-sialidase [Cutibacterium acnes]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q27701	3.94e-06	146	334	552	728	Anhydrosialidase OS=Macrobdella decora OX=6405 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000047	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000004044_01290.