You are browsing environment: HUMAN GUT
CAZyme Information: MGYG000003984_01021
You are here: Home > Sequence: MGYG000003984_01021
Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Mediterraneibacter sp900752395 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Mediterraneibacter; Mediterraneibacter sp900752395 | |||||||||||
| CAZyme ID | MGYG000003984_01021 | |||||||||||
| CAZy Family | GH89 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
|
|||||||||||
| Genome Property |
|
|||||||||||
| Gene Location | Start: 51062; End: 56653 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH89 | 542 | 1211 | 1.1e-215 | 0.9864253393665159 |
| CBM32 | 1241 | 1371 | 2.5e-19 | 0.9596774193548387 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam05089 | NAGLU | 8.36e-149 | 600 | 935 | 1 | 333 | Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. |
| pfam12972 | NAGLU_C | 2.00e-84 | 949 | 1205 | 1 | 250 | Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. |
| pfam12971 | NAGLU_N | 1.27e-27 | 502 | 585 | 1 | 81 | Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. |
| pfam00754 | F5_F8_type_C | 1.30e-17 | 1244 | 1371 | 3 | 127 | F5/8 type C domain. This domain is also known as the discoidin (DS) domain family. |
| PTZ00121 | PTZ00121 | 4.17e-08 | 1375 | 1833 | 1181 | 1572 | MAEBL; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QNM12248.1 | 0.0 | 558 | 1589 | 2 | 1030 |
| ABG85709.1 | 3.69e-237 | 357 | 1319 | 44 | 1001 |
| AMN35090.1 | 2.10e-235 | 357 | 1319 | 53 | 1010 |
| ABG84150.1 | 2.65e-235 | 357 | 1319 | 44 | 1001 |
| AMN32327.1 | 1.17e-234 | 357 | 1319 | 53 | 1010 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2VC9_A | 4.84e-244 | 357 | 1224 | 19 | 881 | Family89 Glycoside Hydrolase from Clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin [Clostridium perfringens],2VCA_A Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine [Clostridium perfringens],2VCB_A Family 89 Glycoside Hydrolase from Clostridium perfringens in complex with PUGNAc [Clostridium perfringens],2VCC_A Family 89 Glycoside Hydrolase from Clostridium perfringens [Clostridium perfringens] |
| 7MFK_A | 6.30e-244 | 357 | 1224 | 27 | 889 | ChainA, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124],7MFL_A Chain A, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124] |
| 4A4A_A | 7.84e-243 | 357 | 1224 | 42 | 904 | CpGH89(E483Q, E601Q), from Clostridium perfringens, in complex with its substrate GlcNAc-alpha-1,4-galactose [Clostridium perfringens] |
| 4XWH_A | 1.41e-90 | 530 | 1220 | 36 | 711 | Crystalstructure of the human N-acetyl-alpha-glucosaminidase [Homo sapiens] |
| 2V72_A | 2.15e-15 | 1230 | 1373 | 8 | 141 | Thestructure of the family 32 CBM from C. perfringens NanJ in complex with galactose [Clostridium perfringens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q9FNA3 | 4.98e-95 | 542 | 1220 | 92 | 804 | Alpha-N-acetylglucosaminidase OS=Arabidopsis thaliana OX=3702 GN=NAGLU PE=2 SV=1 |
| P54802 | 7.16e-90 | 530 | 1220 | 59 | 734 | Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2 |
| P0DTR4 | 8.73e-15 | 1217 | 1383 | 497 | 653 | A type blood N-acetyl-alpha-D-galactosamine deacetylase OS=Flavonifractor plautii OX=292800 PE=1 SV=1 |
| E8MGH9 | 1.50e-13 | 1458 | 1659 | 1667 | 1871 | Beta-L-arabinobiosidase OS=Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b) OX=565042 GN=hypBA2 PE=1 SV=1 |
| P29767 | 5.37e-12 | 1233 | 1373 | 51 | 183 | Sialidase OS=Clostridium septicum OX=1504 PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000285 | 0.998992 | 0.000215 | 0.000190 | 0.000162 | 0.000144 |
