dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000003769_03133

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Basic Information help

Species

Lineage

Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Lachnoclostridium;

CAZyme ID

MGYG000003769_03133

CAZy Family

GH5

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
657	MGYG000003769_37\|CGC1	74721.67	4.6748

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003769	4856301	MAG	Canada	North America

Gene Location

Start: 20345; End: 22318 Strand: +

Full Sequence Download help

Enzyme Prediction help

EC	3.2.1.4	3.2.1.-

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH5	65	344	8.5e-84	0.9927536231884058
CBM46	374	458	2.4e-21	0.9770114942528736

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam00150	Cellulase	3.77e-42	61	345	12	271	Cellulase (glycosyl hydrolase family 5).
pfam18448	CBM46	5.93e-29	463	562	2	102	Carbohydrate binding domain. Carbohydrate active enzymes (CAZYmes) that target recalcitrant polysaccharides are modular enzymes containing noncatalytic carbohydrate-binding modules (CBMs) that direct enzymes to their cognate substrate, thus potentiating catalysis. The structure of Bacillus halodurans endo-beta-1,4-glucanase B (Cel5B) reveals that CBM46 is tightly associated with the catalytic module and, dependent on the glucan presented to the enzyme, can contribute directly to substrate binding or play a targeting role in directing the enzyme to regions of the plant cell wall rich in the polysaccharide hydrolyzed by the enzyme. The CBM46 domain displays a classic beta-sandwich jelly roll fold. Against beta-1,3-1,4-glucans CBM46 domain participates in productive substrate binding and thus plays a direct role in the hydrolytic activity of the enzyme.
COG2730	BglC	5.42e-28	44	387	51	403	Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism].
PRK11198	PRK11198	1.02e-15	591	657	80	147	LysM domain/BON superfamily protein; Provisional
NF033163	lipo_LipL71	2.48e-12	515	655	301	459	lipoprotein LipL71. Members of this family are lipoprotein LipL71, also known as LruA, as described in Leptospira interrogans but found broadly in the genus Leptospira. Close homologs that are not lipoproteins by sequence are likely defective in their reported coding region.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AUS96699.1	2.04e-254	4	562	4	563
BCN31364.1	5.61e-243	33	562	42	569
ADL52313.1	1.00e-233	5	562	5	566
BAV13065.1	1.00e-233	5	562	5	566
ACZ98603.1	1.34e-223	1	574	1	572

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4V2X_A	4.34e-167	12	562	33	581	ChainA, Endo-beta-1,4-glucanase (cellulase B) [Halalkalibacterium halodurans]
5E0C_A	5.91e-157	39	548	12	519	StructuralInsight of a Trimodular Halophilic Cellulase with a Family 46 Carbohydrate-Binding Module [Bacillus sp. BG-CS10]
5XRC_A	7.03e-157	19	548	23	552	ATrimodular GH5_4 Subfamily Endoglucanase Structure with Large Unit Cell [Bacillus sp. BG-CS10],5XRC_B A Trimodular GH5_4 Subfamily Endoglucanase Structure with Large Unit Cell [Bacillus sp. BG-CS10],5XRC_C A Trimodular GH5_4 Subfamily Endoglucanase Structure with Large Unit Cell [Bacillus sp. BG-CS10]
5E09_A	2.17e-151	39	548	12	519	StructuralInsight of a Trimodular Halophilic Cellulase with a Family 46 Carbohydrate-Binding Module [Bacillus sp. BG-CS10]
4YZP_A	6.39e-64	42	521	29	497	Crystalstructure of a tri-modular GH5 (subfamily 4) endo-beta-1, 4-glucanase from Bacillus licheniformis [Bacillus licheniformis],4YZT_A Crystal structure of a tri-modular GH5 (subfamily 4) endo-beta-1, 4-glucanase from Bacillus licheniformis complexed with cellotetraose [Bacillus licheniformis]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P23550	2.89e-159	5	562	8	561	Endoglucanase B OS=Paenibacillus lautus OX=1401 GN=celB PE=3 SV=1
P28623	2.63e-48	44	343	50	339	Endoglucanase D OS=Clostridium cellulovorans (strain ATCC 35296 / DSM 3052 / OCM 3 / 743B) OX=573061 GN=engD PE=1 SV=2
P23660	3.25e-46	44	362	34	359	Endoglucanase A OS=Ruminococcus albus OX=1264 GN=celA PE=1 SV=1
P10477	6.64e-45	47	353	67	372	Cellulase/esterase CelE OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=celE PE=1 SV=2
P28621	1.11e-43	44	343	49	341	Endoglucanase B OS=Clostridium cellulovorans (strain ATCC 35296 / DSM 3052 / OCM 3 / 743B) OX=573061 GN=engB PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.002861	0.879206	0.117085	0.000335	0.000247	0.000227

TMHMM Annotations download full data without filtering help

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