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CAZyme Information: MGYG000003684_05523
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Eisenbergiella massiliensis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Eisenbergiella; Eisenbergiella massiliensis | |||||||||||
| CAZyme ID | MGYG000003684_05523 | |||||||||||
| CAZy Family | GH73 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 43370; End: 44575 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH73 | 205 | 350 | 1.8e-22 | 0.9609375 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd02696 | MurNAc-LAA | 1.83e-37 | 2 | 176 | 1 | 172 | N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall. |
| COG1705 | FlgJ | 2.72e-37 | 181 | 360 | 30 | 194 | Flagellum-specific peptidoglycan hydrolase FlgJ [Cell wall/membrane/envelope biogenesis, Cell motility]. |
| pfam01520 | Amidase_3 | 8.77e-26 | 6 | 175 | 7 | 172 | N-acetylmuramoyl-L-alanine amidase. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls. |
| NF038016 | sporang_Gsm | 6.12e-22 | 184 | 354 | 150 | 312 | sporangiospore maturation cell wall hydrolase GsmA. The peptidoglycan-hydrolyzing enzyme GsmA occurs in some sporangia-forming members of the Actinobacteria, such as Actinoplanes missouriensis, and is required for proper separation of spores. GsmA proteins have one or two SH3 domains N-terminal to the hydrolase domain. |
| PRK06347 | PRK06347 | 5.40e-21 | 195 | 354 | 151 | 303 | 1,4-beta-N-acetylmuramoylhydrolase. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QBF75599.1 | 1.58e-60 | 192 | 390 | 1 | 198 |
| ADB89215.1 | 5.97e-56 | 182 | 354 | 198 | 372 |
| CBL18646.1 | 8.91e-54 | 192 | 354 | 201 | 365 |
| AMP42248.1 | 5.70e-52 | 190 | 361 | 207 | 381 |
| QQQ98955.1 | 1.28e-51 | 186 | 369 | 205 | 389 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3VWO_A | 3.82e-09 | 195 | 345 | 2 | 143 | Crystalstructure of peptidoglycan hydrolase mutant from Sphingomonas sp. A1 [Sphingomonas sp. A1] |
| 2ZYC_A | 4.50e-09 | 195 | 345 | 3 | 144 | ChainA, Peptidoglycan hydrolase FlgJ [Sphingomonas sp. A1] |
| 3QAY_A | 5.34e-09 | 1 | 158 | 2 | 154 | ChainA, Endolysin [Clostridium virus phiCD27],3QAY_B Chain B, Endolysin [Clostridium virus phiCD27],3QAY_C Chain C, Endolysin [Clostridium virus phiCD27],3QAY_D Chain D, Endolysin [Clostridium virus phiCD27] |
| 3K3T_A | 2.81e-08 | 195 | 345 | 3 | 144 | E185Amutant of peptidoglycan hydrolase from Sphingomonas sp. A1 [Sphingomonas sp. A1] |
| 5T1Q_A | 8.05e-08 | 196 | 361 | 62 | 218 | ChainA, N-acetylmuramoyl-L-alanine amidase domain-containing protein SAOUHSC_02979 [Staphylococcus aureus subsp. aureus NCTC 8325],5T1Q_B Chain B, N-acetylmuramoyl-L-alanine amidase domain-containing protein SAOUHSC_02979 [Staphylococcus aureus subsp. aureus NCTC 8325],5T1Q_C Chain C, N-acetylmuramoyl-L-alanine amidase domain-containing protein SAOUHSC_02979 [Staphylococcus aureus subsp. aureus NCTC 8325],5T1Q_D Chain D, N-acetylmuramoyl-L-alanine amidase domain-containing protein SAOUHSC_02979 [Staphylococcus aureus subsp. aureus NCTC 8325] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P58698 | 2.05e-18 | 1 | 163 | 1 | 158 | Uncharacterized protein CPE1502 OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=CPE1502 PE=4 SV=1 |
| O32083 | 9.83e-15 | 214 | 357 | 68 | 201 | Exo-glucosaminidase LytG OS=Bacillus subtilis (strain 168) OX=224308 GN=lytG PE=1 SV=1 |
| P18020 | 1.02e-14 | 1 | 163 | 1 | 158 | Uncharacterized 38.4 kDa protein OS=Clostridium perfringens OX=1502 PE=4 SV=1 |
| P0C2T5 | 5.53e-08 | 181 | 357 | 49 | 217 | Probable N-acetylmuramidase OS=Lactococcus lactis subsp. cremoris OX=1359 GN=acmA PE=3 SV=1 |
| Q9CIT4 | 5.55e-08 | 181 | 357 | 49 | 217 | Probable N-acetylmuramidase OS=Lactococcus lactis subsp. lactis (strain IL1403) OX=272623 GN=acmA PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000078 | 0.000001 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |