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CAZyme Information: MGYG000002490_03181
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Paenibacillus_B thiaminolyticus | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; Paenibacillales; Paenibacillaceae; Paenibacillus_B; Paenibacillus_B thiaminolyticus | |||||||||||
| CAZyme ID | MGYG000002490_03181 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 142341; End: 148817 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd00833 | PKS | 0.0 | 13 | 434 | 2 | 421 | polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits. |
| COG3321 | PksD | 0.0 | 14 | 924 | 6 | 908 | Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]. |
| smart00825 | PKS_KS | 1.11e-154 | 14 | 436 | 1 | 298 | Beta-ketoacyl synthase. The structure of beta-ketoacyl synthase is similar to that of the thiolase family and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. |
| cd19531 | LCL_NRPS-like | 1.09e-133 | 1013 | 1428 | 1 | 427 | LCL-type Condensation (C) domain of non-ribosomal peptide synthetases(NRPSs) and similar domains including the C-domain of SgcC5, a free-standing NRPS with both ester- and amide- bond forming activity. LCL-type Condensation (C) domains catalyze peptide bond formation between two L-amino acids, ((L)C(L)). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). In addition to the LCL-type, there are various subtypes of C-domains such as the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. Streptomyces globisporus SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity. An HHxx[SAG]DGxSx(6)[ED] motif is characteristic of LCL-type C-domains. |
| smart00827 | PKS_AT | 6.87e-119 | 536 | 832 | 1 | 296 | Acyl transferase domain in polyketide synthase (PKS) enzymes. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| BAZ00088.1 | 0.0 | 13 | 2155 | 1213 | 3295 |
| BAY30132.1 | 0.0 | 13 | 2155 | 1215 | 3297 |
| BAY90071.1 | 0.0 | 13 | 2155 | 1212 | 3286 |
| BAZ75991.1 | 0.0 | 13 | 2155 | 1213 | 3295 |
| AFY93865.1 | 7.60e-262 | 7 | 994 | 954 | 1977 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4MZ0_A | 4.19e-184 | 14 | 887 | 41 | 937 | ChainA, CurL [Moorena producens 3L],4MZ0_B Chain B, CurL [Moorena producens 3L] |
| 4WKY_A | 8.50e-169 | 10 | 526 | 5 | 526 | Streptomcyesalbus JA3453 oxazolomycin ketosynthase domain OzmN KS2 [Streptomyces albus],4WKY_B Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmN KS2 [Streptomyces albus] |
| 7VEE_A | 3.65e-155 | 14 | 887 | 23 | 913 | ChainA, Polyketide synthase [Streptomyces graminofaciens],7VEF_A Chain A, Polyketide synthase [Streptomyces graminofaciens] |
| 4OQJ_A | 6.87e-154 | 8 | 621 | 17 | 612 | Streptomcyesalbus JA3453 oxazolomycin ketosynthase domain OzmQ KS1 [Streptomyces albus] |
| 7M7J_A | 1.03e-151 | 7 | 891 | 28 | 915 | ChainA, EryAI [Saccharopolyspora erythraea],7M7J_B Chain B, EryAI [Saccharopolyspora erythraea] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q7TXL6 | 1.19e-238 | 14 | 1318 | 8 | 1344 | Phenolphthiocerol/phthiocerol polyketide synthase subunit E OS=Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) OX=233413 GN=ppsE PE=1 SV=1 |
| P9WQE1 | 1.66e-238 | 14 | 1318 | 8 | 1344 | Phenolphthiocerol/phthiocerol polyketide synthase subunit E OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=ppsE PE=1 SV=1 |
| P9WQE0 | 1.66e-238 | 14 | 1318 | 8 | 1344 | Phenolphthiocerol/phthiocerol polyketide synthase subunit E OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=ppsE PE=3 SV=1 |
| B2HIL7 | 5.52e-156 | 14 | 885 | 44 | 914 | Phenolphthiocerol synthesis polyketide synthase type I Pks15/1 OS=Mycobacterium marinum (strain ATCC BAA-535 / M) OX=216594 GN=pks15/1 PE=1 SV=1 |
| I6XD69 | 7.82e-154 | 14 | 897 | 2059 | 2932 | Mycoketide-CoA synthase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=pks12 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.996392 | 0.003584 | 0.000040 | 0.000011 | 0.000005 | 0.000013 |