You are browsing environment: HUMAN GUT
CAZyme Information: MGYG000002470_03226
You are here: Home > Sequence: MGYG000002470_03226
Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Bacteroides intestinalis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides intestinalis | |||||||||||
| CAZyme ID | MGYG000002470_03226 | |||||||||||
| CAZy Family | GH43 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
|
|||||||||||
| Genome Property |
|
|||||||||||
| Gene Location | Start: 261193; End: 263952 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH10 | 585 | 917 | 1.9e-108 | 0.9867986798679867 |
| GH43 | 68 | 362 | 3.1e-107 | 0.9928825622775801 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd18617 | GH43_XynB-like | 1.95e-155 | 68 | 364 | 1 | 285 | Glycosyl hydrolase family 43, such as Bacteroides ovatus alpha-L-arabinofuranosidase (BoGH43, XynB). This glycosyl hydrolase family 43 (GH43) subgroup includes enzymes that have been characterized to have alpha-L-arabinofuranosidase (EC 3.2.1.55) and beta-1,4-xylosidase (beta-D-xylosidase;xylan 1,4-beta-xylosidase; EC 3.2.1.37) activities. Beta-1,4-xylosidases are part of an array of hemicellulases that are involved in the final breakdown of plant cell-wall whereby they degrade xylan. They hydrolyze beta-1,4 glycosidic bonds between two xylose units in short xylooligosaccharides. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Also included in this subfamily are Bacteroides ovatus alpha-L-arabinofuranosidases, BoGH43A and BoGH43B, both having a two-domain architecture, consisting of an N-terminal 5-bladed beta-propeller domain harboring the catalytic active site, and a C-terminal beta-sandwich domain. However, despite significant functional overlap between these two enzymes, BoGH43A and BoGH43B share just 41% sequence identity. The latter appears to be significantly less active on the same substrates, suggesting that these paralogs may play subtly different roles during the degradation of xyloglucans from different sources, or may function most optimally at different stages in the catabolism of xyloglucan oligosaccharides (XyGOs), for example before or after hydrolysis of certain side-chain moieties. It also includes Phanerochaete chrysosporium BKM-F-1767 Xyl, a bifunctional xylosidase/arabinofuranosidase. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller. |
| pfam00331 | Glyco_hydro_10 | 8.23e-115 | 585 | 917 | 1 | 309 | Glycosyl hydrolase family 10. |
| smart00633 | Glyco_10 | 1.51e-106 | 626 | 916 | 1 | 263 | Glycosyl hydrolase family 10. |
| COG3507 | XynB2 | 8.03e-96 | 61 | 574 | 16 | 529 | Beta-xylosidase [Carbohydrate transport and metabolism]. |
| COG3693 | XynA | 3.42e-95 | 617 | 916 | 58 | 337 | Endo-1,4-beta-xylanase, GH35 family [Carbohydrate transport and metabolism]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QDO67768.1 | 0.0 | 1 | 919 | 1 | 919 |
| ALJ59290.1 | 0.0 | 1 | 919 | 1 | 919 |
| QUT89652.1 | 0.0 | 1 | 919 | 1 | 919 |
| ADQ79799.1 | 0.0 | 13 | 579 | 15 | 582 |
| AKQ46600.1 | 0.0 | 13 | 581 | 15 | 583 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7ERL_A | 0.0 | 38 | 582 | 1 | 545 | ChainA, Beta-xylanase [Bacteroides intestinalis],7ERL_B Chain B, Beta-xylanase [Bacteroides intestinalis] |
| 5AY7_A | 1.05e-124 | 585 | 919 | 19 | 346 | Apsychrophilic glycoside hydrolase family 10 endo-beta-1,4-xylanase [Aegilops speltoides subsp. speltoides],5AY7_B A psychrophilic glycoside hydrolase family 10 endo-beta-1,4-xylanase [Aegilops speltoides subsp. speltoides],5D4Y_A A psychrophilic glycoside hydrolase family 10 endo-beta-1,4-xylanase [environmental samples],5D4Y_B A psychrophilic glycoside hydrolase family 10 endo-beta-1,4-xylanase [environmental samples] |
| 6WQW_A | 1.35e-94 | 585 | 917 | 6 | 327 | ChainA, Beta-xylanase [Thermobacillus composti] |
| 2Q8X_A | 3.61e-92 | 584 | 918 | 7 | 330 | Thehigh-resolution crystal structure of ixt6, a thermophilic, intracellular xylanase from G. stearothermophilus [unidentified],2Q8X_B The high-resolution crystal structure of ixt6, a thermophilic, intracellular xylanase from G. stearothermophilus [unidentified],3MSD_A Enzyme-Substrate interactions of IXT6, the intracellular xylanase of G. stearothermophilus. [Geobacillus stearothermophilus],3MSD_B Enzyme-Substrate interactions of IXT6, the intracellular xylanase of G. stearothermophilus. [Geobacillus stearothermophilus],3MSG_A Enzyme-Substrate interactions of IXT6, the intracellular xylanase of G. stearothermophilus. [Geobacillus stearothermophilus],3MSG_B Enzyme-Substrate interactions of IXT6, the intracellular xylanase of G. stearothermophilus. [Geobacillus stearothermophilus] |
| 3EMC_A | 5.04e-92 | 581 | 917 | 3 | 328 | Crystalstructure of XynB, an intracellular xylanase from Paenibacillus barcinonensis [Paenibacillus barcinonensis],3EMQ_A Crystal structure of xilanase XynB from Paenibacillus barcelonensis complexed with an inhibitor [Paenibacillus barcinonensis],3EMZ_A Crystal structure of xylanase XynB from Paenibacillus barcinonensis complexed with a conduramine derivative [Paenibacillus barcinonensis] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| D5EY13 | 8.95e-113 | 585 | 912 | 33 | 362 | Endo-1,4-beta-xylanase/feruloyl esterase OS=Prevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23) OX=264731 GN=xyn10D-fae1A PE=1 SV=1 |
| O69231 | 2.85e-91 | 581 | 917 | 4 | 329 | Endo-1,4-beta-xylanase B OS=Paenibacillus barcinonensis OX=198119 GN=xynB PE=1 SV=1 |
| P45703 | 3.04e-87 | 582 | 917 | 5 | 328 | Endo-1,4-beta-xylanase OS=Geobacillus stearothermophilus OX=1422 GN=xynA PE=1 SV=1 |
| P45982 | 5.55e-86 | 68 | 595 | 6 | 514 | Xylosidase/arabinosidase OS=Butyrivibrio fibrisolvens OX=831 GN=xylB PE=3 SV=1 |
| A7LXT8 | 1.38e-81 | 66 | 592 | 23 | 513 | Non-reducing end alpha-L-arabinofuranosidase BoGH43A OS=Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153) OX=411476 GN=BACOVA_02654 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.010086 | 0.953437 | 0.035466 | 0.000422 | 0.000304 | 0.000243 |
