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CAZyme Information: MGYG000002372_00750
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Clostridium_P perfringens | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Clostridiales; Clostridiaceae; Clostridium_P; Clostridium_P perfringens | |||||||||||
| CAZyme ID | MGYG000002372_00750 | |||||||||||
| CAZy Family | CBM40 | |||||||||||
| CAZyme Description | Sialidase A | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 875995; End: 878079 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH33 | 253 | 681 | 2.1e-109 | 0.956140350877193 |
| CBM40 | 55 | 236 | 1.2e-51 | 0.9888268156424581 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd15482 | Sialidase_non-viral | 3.20e-93 | 252 | 680 | 1 | 335 | Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases. |
| pfam02973 | Sialidase | 2.58e-70 | 50 | 235 | 3 | 188 | Sialidase, N-terminal domain. |
| COG4409 | NanH | 5.69e-40 | 66 | 671 | 87 | 700 | Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis]. |
| pfam13088 | BNR_2 | 1.27e-14 | 428 | 622 | 79 | 243 | BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases. |
| pfam13859 | BNR_3 | 1.25e-09 | 425 | 508 | 84 | 165 | BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AOY53136.1 | 0.0 | 1 | 694 | 1 | 694 |
| AMN32150.1 | 0.0 | 1 | 694 | 1 | 694 |
| QQA11681.1 | 0.0 | 1 | 694 | 1 | 694 |
| QUD73799.1 | 0.0 | 1 | 694 | 1 | 694 |
| CAA60796.1 | 0.0 | 1 | 694 | 1 | 694 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2BF6_A | 0.0 | 243 | 691 | 1 | 449 | AtomicResolution Structure of the bacterial sialidase NanI from Clostridium perfringens in complex with alpha-Sialic Acid (Neu5Ac). [Clostridium perfringens] |
| 2VK5_A | 0.0 | 243 | 694 | 1 | 452 | TheStructure Of Clostridium Perfringens Nani Sialidase And Its Catalytic Intermediates [Clostridium perfringens],2VK6_A The Structure Of Clostridium Perfringens Nani Sialidase And Its Catalytic Intermediates [Clostridium perfringens],2VK7_A The Structure Of Clostridium Perfringens Nani Sialidase And Its Catalytic Intermediates [Clostridium perfringens],2VK7_B The Structure Of Clostridium Perfringens Nani Sialidase And Its Catalytic Intermediates [Clostridium perfringens] |
| 5TSP_A | 0.0 | 242 | 694 | 1 | 453 | Crystalstructure of the catalytic domain of Clostridium perfringens neuraminidase (NanI) in complex with a CHES [Clostridium perfringens ATCC 13124],5TSP_B Crystal structure of the catalytic domain of Clostridium perfringens neuraminidase (NanI) in complex with a CHES [Clostridium perfringens ATCC 13124] |
| 5FRE_A | 4.70e-119 | 44 | 236 | 2 | 194 | Characterizationof a novel CBM from Clostridium perfringens [Clostridium perfringens],5FRE_B Characterization of a novel CBM from Clostridium perfringens [Clostridium perfringens],5FRE_C Characterization of a novel CBM from Clostridium perfringens [Clostridium perfringens] |
| 5FRA_A | 5.23e-119 | 44 | 236 | 5 | 197 | Cbm40_cpf0721-6'sl[Clostridium perfringens],5FRA_B Cbm40_cpf0721-6'sl [Clostridium perfringens],5FRA_C Cbm40_cpf0721-6'sl [Clostridium perfringens],5FRA_D Cbm40_cpf0721-6'sl [Clostridium perfringens],5FRA_E Cbm40_cpf0721-6'sl [Clostridium perfringens],5FRA_F Cbm40_cpf0721-6'sl [Clostridium perfringens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P29767 | 5.86e-236 | 51 | 690 | 193 | 828 | Sialidase OS=Clostridium septicum OX=1504 PE=3 SV=1 |
| P62575 | 4.79e-105 | 46 | 680 | 116 | 777 | Sialidase A OS=Streptococcus pneumoniae OX=1313 GN=nanA PE=1 SV=1 |
| P62576 | 4.79e-105 | 46 | 680 | 116 | 777 | Sialidase A OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=nanA PE=1 SV=1 |
| Q27701 | 9.01e-92 | 75 | 686 | 112 | 742 | Anhydrosialidase OS=Macrobdella decora OX=6405 PE=1 SV=1 |
| Q54727 | 1.07e-48 | 81 | 671 | 71 | 669 | Sialidase B OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=nanB PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.453589 | 0.496679 | 0.048722 | 0.000360 | 0.000253 | 0.000388 |