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CAZyme Information: MGYG000002359_03771

You are here: Home > Sequence: MGYG000002359_03771

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Mycobacterium tuberculosis
Lineage Bacteria; Actinobacteriota; Actinomycetia; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis
CAZyme ID MGYG000002359_03771
CAZy Family GT53
CAZyme Description putative arabinosyltransferase B
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
1098 118021.43 9.8629
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002359 4387829 Isolate Sweden Europe
Gene Location Start: 296794;  End: 300090  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

EC 2.4.2.-

CAZyme Signature Domains help

Family Start End Evalue family coverage
GT53 24 1096 0 0.998093422306959

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam04602 Arabinose_trans 0.0 214 688 2 458
Mycobacterial cell wall arabinan synthesis protein. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol.
pfam14896 Arabino_trans_C 3.48e-180 720 1095 1 384
EmbC C-terminal domain. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate.
pfam17689 Arabino_trans_N 1.42e-66 51 209 2 155
Arabinosyltransferase concanavalin like domain. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
APR59030.1 0.0 1 1098 1 1098
AHZ31637.1 0.0 1 1098 1 1098
AIB50554.1 0.0 1 1098 1 1098
AJK63844.2 0.0 1 1098 1 1098
AFN51821.1 0.0 1 1098 1 1098

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6X0O_A 0.0 24 1098 24 1082
Single-ParticleCryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis [Mycolicibacterium smegmatis MC2 155]
7BVC_B 0.0 24 1098 24 1082
Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVG_B Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with di-arabinose. [Mycolicibacterium smegmatis MC2 155]
7BVF_B 0.0 1 1098 1 1098
Cryo-EMstructure of Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol [Mycobacterium tuberculosis H37Rv]
7BWR_A 0.0 24 1098 24 1082
Mycobacteriumsmegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BWR_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BX8_A Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155],7BX8_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155]
7BVE_A 8.71e-294 24 1096 13 1073
Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVE_B Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P9WNL7 0.0 1 1098 1 1098
Probable arabinosyltransferase B OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=embB PE=1 SV=1
Q50395 0.0 24 1098 24 1082
Probable arabinosyltransferase B OS=Mycolicibacterium smegmatis OX=1772 GN=embB PE=3 SV=3
Q7TVN3 0.0 1 1098 1 1098
Probable arabinosyltransferase B OS=Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) OX=233413 GN=embB PE=3 SV=1
P9WNL6 0.0 1 1098 1 1098
Probable arabinosyltransferase B OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=embB PE=3 SV=1
Q9CDA9 0.0 24 1098 22 1083
Probable arabinosyltransferase B OS=Mycobacterium leprae (strain TN) OX=272631 GN=embB PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.999991 0.000036 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      download full data without filtering help

start end
28 50
217 239
271 293
402 419
434 456
472 494
541 558
570 587
597 619
626 648
663 685
698 720