CAZyme Information: MGYG000002256_00077

Basic Information

• Lineage: Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; UBA3282
• CAZyme ID: MGYG000002256_00077
• CAZy Family: GT11
• CAZyme Description: O-antigen biosynthesis glycosyltransferase WbnK

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
296	MGYG000002256_1|CGC2	34668.24	5.7748

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002256	2755304	MAG	Peru	South America

• Gene Location: Start: 97627; End: 98517 Strand: -

Full Sequence      

MVVIQLAGGLGNQMFQYALYWQLRSLGKDVKIDDVTGFEADLQREPELDIYGVTYERPTQ
KELRKMLDSEPDLFHKVRRKLAGRNKRAYFEEDKRFKPEIFGWDDIYLEGYWQSEKYFEK
VSGELRRIYDTDRLLEKLGEQNNPFLEQITGTESVSVHIRRGDYLTPENEKLFGGICTES
YYGKAMAEMEKRHPGCRYFVFTNDKEGTNRFLKNVYAEIPADRITMVDIPAGEHADCLEF
ALMSKCRHNILANSSFSWWASYLNKNGDKTVLVPGRWLNGWDCSDFYRTDMQKIGQ

Enzyme Prediction     

No EC number prediction in MGYG000002256_00077.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT11	1	280	3.2e-62	0.9311594202898551

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd11301	Fut1_Fut2_like	2.18e-59	1	291	1	261	Alpha-1,2-fucosyltransferase. Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer of alpha-L-fucose to the terminal beta-D-galactose residue of glycoconjugates via an alpha-1,2-linkage, generating carbohydrate structures that exhibit H-antigenicity for blood-group carbohydrates. These structures also act as ligands for morphogenesis, the adhesion of microbes, and metastasizing cancer cells. Fut1 is responsible for producing the H antigen on red blood cells. Fut2 is expressed in epithelia of secretory tissues, and individuals termed "secretors" have at least one functional copy of the gene; they secrete H antigen which is further processed into A and/or B antigens depending on the ABO genotype. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
pfam01531	Glyco_transf_11	3.09e-23	107	274	125	276	Glycosyl transferase family 11. This family contains several fucosyl transferase enzymes.
cd11548	NodZ_like	0.005	1	263	1	280	Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ. Bradyrhizobium NodZ is an alpha 1,6-fucosyltransferase involved in the biosynthesis of the nodulation factor, a lipo-chitooligosaccharide formed by three-to-six beta-1,4-linked N-acetyl-d-glucosamine (GlcNAc) residues and a fatty acid acyl group attached to the nitrogen atom at the non-reducing end. NodZ transfers L-fucose from the GDP-beta-L-fucose donor to the reducing residue of the chitin oligosaccharide backbone, before the attachment of a fatty acid group. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AOZ97425.1	1.53e-82	1	294	1	288
ADL35260.1	8.01e-80	1	294	1	288
SNX52916.1	1.74e-55	1	285	1	276
ADL35250.1	7.54e-50	1	283	1	287
AOZ97415.1	1.06e-49	1	272	1	276

PDB Hits     

has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q58YV9	1.01e-22	6	280	5	288	O-antigen biosynthesis glycosyltransferase WbnK OS=Escherichia coli OX=562 GN=wbnK PE=1 SV=1
Q10979	9.31e-09	104	273	158	326	Galactoside alpha-(1,2)-fucosyltransferase 1 OS=Oryctolagus cuniculus OX=9986 GN=FUT1 PE=2 SV=1
Q866F1	2.95e-08	103	273	142	327	Galactoside alpha-(1,2)-fucosyltransferase 1 OS=Saimiri sciureus OX=9521 GN=FUT1 PE=3 SV=1
Q866E8	2.95e-08	103	273	142	327	Galactoside alpha-(1,2)-fucosyltransferase 1 OS=Sapajus apella OX=9515 GN=FUT1 PE=3 SV=1
Q866F0	2.95e-08	103	273	142	327	Galactoside alpha-(1,2)-fucosyltransferase 1 OS=Saimiri boliviensis boliviensis OX=39432 GN=FUT1 PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000038	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002256_00077.