You are browsing environment: HUMAN GUT
CAZyme Information: MGYG000002077_00527
You are here: Home > Sequence: MGYG000002077_00527
Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Cyanobacteria; Vampirovibrionia; Gastranaerophilales; Gastranaerophilaceae; Zag111; | |||||||||||
| CAZyme ID | MGYG000002077_00527 | |||||||||||
| CAZy Family | GT6 | |||||||||||
| CAZyme Description | O-antigen biosynthesis glycosyltransferase WbnI | |||||||||||
| CAZyme Property |
|
|||||||||||
| Genome Property |
|
|||||||||||
| Gene Location | Start: 125896; End: 126750 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT6 | 2 | 219 | 1.1e-66 | 0.7928571428571428 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd02515 | Glyco_transf_6 | 9.44e-38 | 3 | 198 | 36 | 235 | Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens. Glycosyltransferase family 6, GT_6, comprises enzymes with three known activities: alpha-1,3-galactosyltransferase, alpha-1,3 N-acetylgalactosaminyltransferase, and alpha-galactosyltransferase. UDP-galactose:beta-galactosyl alpha-1,3-galactosyltransferase (alpha3GT) catalyzes the transfer of galactose from UDP-alpha-d-galactose into an alpha-1,3 linkage with beta-galactosyl groups in glycoconjugates. The enzyme exists in most mammalian species but is absent from humans, apes, and old world monkeys as a result of the mutational inactivation of the gene. The alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase are responsible for the production of the human ABO blood group antigens. A N-acetylgalactosaminyltransferases use a UDP-GalNAc donor to convert the H-antigen acceptor to the A antigen, whereas a galactosyltransferase uses a UDP-galactose donor to convert the H-antigen acceptor to the B antigen. Alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase differ only in the identity of four critical amino acid residues. |
| pfam03414 | Glyco_transf_6 | 2.39e-33 | 3 | 198 | 53 | 252 | Glycosyltransferase family 6. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| VEG70534.1 | 1.40e-79 | 2 | 251 | 3 | 246 |
| QKJ30432.1 | 8.44e-75 | 3 | 246 | 2 | 235 |
| VEI54121.1 | 8.18e-72 | 1 | 278 | 1 | 271 |
| ARS38480.1 | 1.04e-71 | 2 | 257 | 3 | 245 |
| ATA80797.1 | 2.27e-71 | 1 | 247 | 1 | 240 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4AYJ_A | 1.87e-68 | 1 | 246 | 1 | 243 | Molecularstructure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen [Bacteroides ovatus],4AYJ_B Molecular structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen [Bacteroides ovatus],4AYJ_C Molecular structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen [Bacteroides ovatus],4AYJ_D Molecular structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen [Bacteroides ovatus],4AYL_A Molecular structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen [Bacteroides ovatus] |
| 4CJB_A | 5.31e-68 | 1 | 246 | 1 | 243 | orthorhombiccrystal form of Bogt6a E192Q in complex with GalNAc [Bacteroides ovatus],4CJB_B orthorhombic crystal form of Bogt6a E192Q in complex with GalNAc [Bacteroides ovatus],4CJB_C orthorhombic crystal form of Bogt6a E192Q in complex with GalNAc [Bacteroides ovatus],4CJB_D orthorhombic crystal form of Bogt6a E192Q in complex with GalNAc [Bacteroides ovatus],4CJC_A orthorhombic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP, GalNAc [Bacteroides ovatus],4CJC_B orthorhombic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP, GalNAc [Bacteroides ovatus],4CJC_C orthorhombic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP, GalNAc [Bacteroides ovatus],4CJC_D orthorhombic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP, GalNAc [Bacteroides ovatus] |
| 4CJ8_A | 5.66e-68 | 1 | 246 | 3 | 245 | monocliniccrystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_B monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_C monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_D monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_E monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_F monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_G monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_H monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_I monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_J monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_K monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_L monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_M monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_N monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_O monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus],4CJ8_P monoclinic crystal form of Bogt6a E192Q in complex with UDP-GalNAc, UDP and GalNAc [Bacteroides ovatus] |
| 2O1G_A | 4.91e-23 | 3 | 209 | 59 | 270 | ChainA, ABO glycosyltransferase [Homo sapiens],2O1H_A Chain A, ABO glycosyltransferase [Homo sapiens] |
| 3I0C_A | 1.54e-22 | 3 | 209 | 48 | 259 | ChainA, ABO glycosyltransferase [Homo sapiens],3I0D_A Chain A, ABO glycosyltransferase [Homo sapiens],3I0E_A Chain A, ABO glycosyltransferase [Homo sapiens],3I0F_A Chain A, ABO glycosyltransferase [Homo sapiens],3I0G_A Chain A, ABO glycosyltransferase [Homo sapiens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q5JBG6 | 5.54e-32 | 1 | 242 | 1 | 231 | O-antigen biosynthesis glycosyltransferase WbnI OS=Escherichia coli OX=562 GN=wbnI PE=1 SV=1 |
| P50127 | 5.29e-22 | 1 | 239 | 130 | 364 | N-acetyllactosaminide alpha-1,3-galactosyltransferase OS=Sus scrofa OX=9823 GN=GGTA1 PE=2 SV=1 |
| Q3L7M0 | 5.29e-22 | 1 | 198 | 130 | 332 | N-acetyllactosaminide alpha-1,3-galactosyltransferase OS=Rattus norvegicus OX=10116 GN=Ggta1 PE=1 SV=2 |
| Q8HYB2 | 3.72e-21 | 1 | 232 | 134 | 361 | N-acetyllactosaminide alpha-1,3-galactosyltransferase OS=Lemur catta OX=9447 GN=GGTA1 PE=2 SV=2 |
| Q8HY56 | 6.68e-21 | 1 | 239 | 129 | 363 | N-acetyllactosaminide alpha-1,3-galactosyltransferase OS=Felis catus OX=9685 GN=GGTA1 PE=2 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000085 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |