CAZyme Information: MGYG000001962_00740

Basic Information

• Species: CAG-877 sp900554315
• Lineage: Bacteria; Firmicutes; Bacilli; RF39; UBA660; CAG-877; CAG-877 sp900554315
• CAZyme ID: MGYG000001962_00740
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A/1B

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
755		82863.53	4.3749

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001962	1407635	MAG	Denmark	Europe

• Gene Location: Start: 377; End: 2644 Strand: +

Full Sequence      

MSLFYDSDEKKFAETGEERREKISYEDLPQVFVDALVATEDSRFFEHNGFDAPRFLKASV
GQLLGNSNAGGASTISMQVIKNSMTSTEDSGIQGIIRKFTDIYLAVFKLEKNYTKEQIIE
FYVNNHGLGGMVYGVEEAAQTYFGKSASDLNLSEAAIIAGMFQAPTYYKPDVNPENAEKR
RETVLYLMVRHGYITQEEADIANSIPVEDLVVNQSASSDPYQGYLDTVTKELEEKYNIDP
NKTPVEVYTALDRDRQNAVNSVMNGETYNWINDQVQAGVTVLNSENGEVQAIGAGRNRGA
GGWNYAVDNKRQPGSTAKPLFDYGPGIEYNDWSTYTLFDDSPYQYSNGKSIKNWDNGYFG
TITLRRALSTSRNIPALKAFQQVDNKKIIQFVESLGITPEIENGKIHEAHAIGAFSPGVS
SMEMAGAYAAFSNGGYFTEPHTIRKIVVRDTGEVIEFDGETKRVMSDATAFMISNVLEDV
TLNGGNPSNVARKTGTTNYDDDTMERYNLPSDAIRDSWVVGYSTKTVIALWYGYDKIDST
YVLHNVPATIQKDKIFNALINAGAMESNREEFKQPSSVVKLGIISGSNPPVVAGSGYTGN
VVYEYFKKGTEPEELDTSSVSLAKPGNFKVSYDESTNKVTLSWSAVNPGNNSNLGTFGYN
VYMGSTLLGFTESTSYTYTLGGSASPYTTYRVVATYKGYSGLQGDAATYTLKEPEEEPEE
PTTPTDPTTPGGGGTTEPEDPTTPTTPPDPEVTTP

Enzyme Prediction     

No EC number prediction in MGYG000001962_00740.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	10	188	1.7e-56	0.9774011299435028

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	6.97e-148	2	613	56	650	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	3.92e-98	1	638	48	786	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	4.29e-68	8	189	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
COG4953	PbpC	5.52e-68	12	634	50	618	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	1.74e-49	5	479	51	632	penicillin-binding protein 1a; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
APH04640.1	3.95e-172	2	644	75	714
QNF30636.1	5.72e-172	2	644	80	723
QNG61477.1	3.98e-168	2	644	78	716
QGQ46655.1	7.55e-167	2	644	80	722
ACJ33515.1	9.92e-160	2	644	71	716

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3DWK_A	4.69e-89	18	595	25	614	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
2OLU_A	7.56e-85	18	595	34	623	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]
3ZG8_B	2.14e-59	108	577	2	474	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	4.34e-55	108	577	2	474	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
3UDF_A	1.76e-51	5	536	24	690	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P39793	1.14e-147	2	644	77	728	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1
Q00573	5.34e-94	2	534	53	600	Penicillin-binding protein 1A (Fragment) OS=Streptococcus oralis OX=1303 GN=ponA PE=3 SV=1
Q04707	7.70e-92	2	582	53	644	Penicillin-binding protein 1A OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=ponA PE=1 SV=2
Q8DR59	2.92e-91	2	582	53	644	Penicillin-binding protein 1A OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=pbpA PE=1 SV=1
P38050	7.88e-77	2	581	49	619	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000054	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000001962_00740.