dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000001903_00115

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Basic Information help

Species

Lineage

Bacteria; Firmicutes_A; Clostridia; Monoglobales; Firm-18; ;

CAZyme ID

MGYG000001903_00115

CAZy Family

GH4

CAZyme Description

Alpha-glucosidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
450		51041.4	5.4509

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001903	2217690	MAG	Denmark	Europe

Gene Location

Start: 24363; End: 25715 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000001903_00115.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH4	4	182	1.4e-43	0.9776536312849162

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd05297	GH4_alpha_glucosidase_galactosidase	1.69e-108	4	440	2	423	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases. linked to 3D####ucture
COG1486	CelF	1.68e-73	1	440	2	432	Alpha-galactosidase/6-phospho-beta-glucosidase, family 4 of glycosyl hydrolase [Carbohydrate transport and metabolism].
cd05197	GH4_glycoside_hydrolases	1.14e-71	4	439	2	425	Glycoside Hydrases Family 4. Glycoside hydrolases cleave glycosidic bonds to release smaller sugars from oligo- or polysaccharides. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by GH4 glycoside hydrolases. Other organisms (such as archaea and Thermotoga maritima) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. GH4 family members include 6-phospho-beta-glucosidases, 6-phospho-alpha-glucosidases, alpha-glucosidases/alpha-glucuronidases (only from Thermotoga), and alpha-galactosidases. They require two cofactors, NAD+ and a divalent metal (Mn2+, Ni2+, Mg2+), for activity. Some also require reducing conditions. GH4 glycoside hydrolases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
PRK15076	PRK15076	1.97e-51	4	439	3	415	alpha-galactosidase; Provisional
pfam02056	Glyco_hydro_4	4.33e-36	4	181	1	177	Family 4 glycosyl hydrolase.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QBD76473.1	3.80e-164	1	450	2	448
ACZ42865.1	1.01e-161	1	450	1	448
QTH41436.1	2.88e-161	4	449	3	447
BBI35842.1	8.20e-161	4	449	3	447
QHW35524.1	1.65e-160	1	450	2	448

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1OBB_A	8.25e-90	2	449	3	477	alpha-glucosidaseA, AglA, from Thermotoga maritima in complex with maltose and NAD+ [Thermotoga maritima MSB8],1OBB_B alpha-glucosidase A, AglA, from Thermotoga maritima in complex with maltose and NAD+ [Thermotoga maritima MSB8]
3U95_A	7.04e-61	4	450	2	468	Crystalstructure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_B Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_C Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_D Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_E Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359],3U95_F Crystal structure of a putative alpha-glucosidase from Thermotoga neapolitana [Thermotoga neapolitana DSM 4359]
7BR4_A	6.18e-59	4	450	14	479	ChainA, Alpha-glucosidase, putative [Thermotoga maritima MSB8]
6KCX_A	8.83e-59	4	450	14	480	Crystalstructure of citrate complex of alpha-glucuronidase (TM0752)from Thermotoga maritima [Thermotoga maritima MSB8],7CTD_A Chain A, Alpha-glucosidase, putative [Thermotoga maritima MSB8],7CTL_A Chain A, Alpha-glucosidase, putative [Thermotoga maritima MSB8]
7BRF_A	2.51e-57	4	450	14	480	ChainA, Alpha-glucosidase, putative [Thermotoga maritima MSB8],7CTM_A Chain A, Alpha-glucosidase, putative [Thermotoga maritima MSB8]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O33830	1.46e-90	2	449	3	477	Alpha-glucosidase OS=Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) OX=243274 GN=aglA PE=1 SV=2
O86960	8.57e-86	4	449	5	477	Alpha-glucosidase OS=Thermotoga neapolitana OX=2337 GN=aglA PE=1 SV=2
O34645	9.96e-24	4	438	3	422	Alpha-galactosidase OS=Bacillus subtilis (strain 168) OX=224308 GN=melA PE=1 SV=1
P30877	7.03e-20	4	438	6	439	Alpha-galactosidase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287 GN=melA PE=3 SV=2
P06720	7.47e-19	4	439	6	433	Alpha-galactosidase OS=Escherichia coli (strain K12) OX=83333 GN=melA PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000049	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM Annotations help

There is no transmembrane helices in MGYG000001903_00115.