CAZyme Information: MGYG000000542_00439

Basic Information

• Species: UBA2883 sp900768915
• Lineage: Bacteria; Cyanobacteria; Vampirovibrionia; Gastranaerophilales; Gastranaerophilaceae; UBA2883; UBA2883 sp900768915
• CAZyme ID: MGYG000000542_00439
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
373	MGYG000000542_3|CGC1	42745.58	9.9874

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000542	1922508	MAG	Fiji	Oceania

• Gene Location: Start: 21796; End: 22917 Strand: +

Full Sequence      

MKKLFIITGEYSGSMHAVKVVECLKSQYPDIEIEGIGDSNLEKAGVKLFTNHSKMSAMGL
SPKIIINHLLLGKRLIDYLTKEYKPDLVLMIDYGAFNLSVSKFLKKNGLKIFYYIPPQVW
ASRKWRINTIKKNIDKVLCIFPFEVDIYKKMGIDTHYCGHPLVKQLPPKANRNEFFEKHN
LDKSKKLVSIFPGSRVFELKFLMKLFLKSAKLLQSKHPDLQFVISHAPNLSDKVYNKYLK
GDTTFKIIQGENQALLSVSDALILASGTVALEATLYQVPMIISYKGPWLFYFIYLLVRCI
KMVSLPNIILNKIVVPEIIQGQANTKNITSEIEKLLYNEEYRNKNIEELGKVKKLLSDKY
SAQEVANIIKENI

Enzyme Prediction     

No EC number prediction in MGYG000000542_00439.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	5	356	5.1e-106	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	3.90e-116	1	372	1	378	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	1.03e-103	1	371	1	377	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	2.91e-79	4	365	1	374	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	1.02e-71	6	345	10	354	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	3.26e-50	1	371	1	346	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AOR39331.1	3.96e-193	1	371	1	370
VEH12442.1	2.10e-70	2	371	5	377
QMU61387.1	5.73e-70	4	368	13	379
SNV50078.1	1.48e-69	2	373	5	379
CEK10842.1	4.14e-69	2	373	5	379

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8N_A	4.15e-41	6	338	11	347	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]
5W8S_A	8.07e-41	6	338	11	347	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
B6J161	1.17e-67	2	369	4	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuG_Q212) OX=434923 GN=lpxB PE=3 SV=1
A9NCA7	1.66e-67	2	369	4	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain RSA 331 / Henzerling II) OX=360115 GN=lpxB PE=3 SV=1
Q83DS5	1.66e-67	2	369	4	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain RSA 493 / Nine Mile phase I) OX=227377 GN=lpxB PE=3 SV=1
A9KC41	1.66e-67	2	369	4	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain Dugway 5J108-111) OX=434922 GN=lpxB PE=3 SV=1
B6J9H1	2.33e-67	2	369	4	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuK_Q154) OX=434924 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000059	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000542_00439.