CAZyme Information: MGYG000000519_00318

Basic Information

• Species: UBA1436 sp900541355
• Lineage: Bacteria; Elusimicrobiota; Elusimicrobia; Elusimicrobiales; Elusimicrobiaceae; UBA1436; UBA1436 sp900541355
• CAZyme ID: MGYG000000519_00318
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1C

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
702	MGYG000000519_1|CGC3	77047.99	7.2138

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000519	1498992	MAG	Fiji	Oceania

• Gene Location: Start: 326404; End: 328512 Strand: +

Full Sequence      

MKKRWTLLLSLLLLPCLAGGEEAFLLPSKQIYDRYGAPIRGFLSKNNTYYLPVSLNEVSP
WLIAAAVAAEDKRFFTHAGVDIRAVLRAAWQNTKEGEIVSGASTITQQLARAVEPYPKTL
WGKTREAFSALKIERKMTKEEILEEYFNLLELGNLTQGVEAASRFYFNTQAADLSLSQAA
FLAGLAKSPTYYNPLKHFARALKRRDWVLKKMLDNGFIDEEMYALAVSEKLELRSAARPF
DAPHFTQLLQPLLPQESKDIFSTLDRDLQLYAEQVVKNYIVRLTEQNVTNGAVVVLENAT
GAVLAYVGSADFYNTQNSGQVDGARALRQPGSALKPFVYGLALERGNLTPATLLADEDTF
FEGGFRPRNYDENYHGLVSVRRALACSYNIPAVKAAELSGTSNLLALLRRAGFESLNKAA
DFYGLGLSLGNGEVRLLDLTNAYASLARGGVYKPVLFAANPIIRAPGREARLFTPQTAYL
LTDMLADNNARAPAFGLNSPLFLPFPFAAKTGTSKDYKDNFAVGYTDRWTVGVWVGNFNA
TSMQKVSGITGAGPILHDLAVYLQEKYPAEPFSVPDGIVRAPTCLDSGLLAGENCPHTQE
NVFDAAHLPGVCPGKHKVVLQTLKITSPADKDIFKIDPSVPLASQAIKWQALCSADNCTW
KLDGHIQAGSACQNWWPLEVGKHTLSVSCHGETDSLTFEVLP

Enzyme Prediction     

No EC number prediction in MGYG000000519_00318.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	49	212	1.1e-57	0.9265536723163842

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG4953	PbpC	0.0	27	701	35	732	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
COG0744	MrcB	8.08e-145	27	601	54	636	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	2.62e-143	52	566	4	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	8.90e-121	30	603	50	758	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
PRK11240	PRK11240	1.57e-102	36	595	48	602	penicillin-binding protein 1C; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ACC98391.1	1.32e-247	27	701	42	718
AFY41184.1	6.32e-149	33	700	49	748
ARA92794.1	2.51e-148	60	609	100	657
BAY94674.1	4.17e-148	9	700	36	754
BAY97533.1	5.88e-148	30	700	60	754

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	2.31e-51	30	609	22	768	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	2.88e-45	51	545	40	696	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3DWK_A	6.65e-42	26	536	6	556	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
2OQO_A	4.73e-40	53	229	23	200	Crystalstructure of a peptidoglycan glycosyltransferase from a class A PBP: insight into bacterial cell wall synthesis [Aquifex aeolicus VF5],3D3H_A Crystal structure of a complex of the peptidoglycan glycosyltransferase domain from Aquifex aeolicus and neryl moenomycin A [Aquifex aeolicus],3NB7_A Crystal structure of Aquifex Aeolicus Peptidoglycan Glycosyltransferase in complex with Decarboxylated Neryl Moenomycin [Aquifex aeolicus]
3NB6_A	1.68e-39	53	229	23	200	Crystalstructure of Aquifex aeolicus peptidoglycan glycosyltransferase in complex with Methylphosphoryl Neryl Moenomycin [Aquifex aeolicus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P76577	2.05e-85	27	588	41	590	Penicillin-binding protein 1C OS=Escherichia coli (strain K12) OX=83333 GN=pbpC PE=1 SV=1
P38050	6.92e-64	21	536	41	569	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
O66874	1.09e-62	28	595	44	699	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P70997	3.01e-57	49	614	75	659	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
O87579	1.27e-54	65	579	83	721	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.001444	0.949702	0.047853	0.000380	0.000312	0.000273

TMHMM  Annotations     

There is no transmembrane helices in MGYG000000519_00318.