dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000000390_01880

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Basic Information help

Species

Lineage

Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Acutalibacteraceae; ;

CAZyme ID

MGYG000000390_01880

CAZy Family

CBM57

CAZyme Description

Beta-galactosidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
803		89732.63	5.6002

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000390	2232010	MAG	Sweden	Europe

Gene Location

Start: 14; End: 2425 Strand: -

Full Sequence Download help

Enzyme Prediction help

EC	3.2.1.31	3.2.1.185

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
CBM57	634	798	5.8e-42	0.9863945578231292

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam11721	Malectin	2.25e-30	632	801	1	156	Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognizes and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan.
COG3250	LacZ	1.87e-16	228	342	291	407	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].
pfam02836	Glyco_hydro_2_C	6.52e-14	227	379	5	167	Glycosyl hydrolases family 2, TIM barrel domain. This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.
PRK10150	PRK10150	2.00e-11	198	373	257	449	beta-D-glucuronidase; Provisional
pfam16355	DUF4982	2.25e-09	544	600	8	62	Domain of unknown function (DUF4982). This family is found in the C-terminal of uncharacterized proteins and beta-galactosidases around 680 residues in length from various Bacteroides species. The function of this protein is unknown.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ALJ01732.1	1.26e-239	226	801	329	900
QHJ06763.1	2.99e-232	226	801	327	899
ACU05015.1	1.41e-231	229	801	326	893
QEC55690.1	1.24e-226	229	801	407	974
QTE40581.1	2.49e-225	228	801	367	933

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6D1P_A	4.14e-36	227	646	313	745	Apostructure of Bacteroides uniformis beta-glucuronidase 3 [Bacteroides uniformis str. 3978 T3 ii],6D1P_B Apo structure of Bacteroides uniformis beta-glucuronidase 3 [Bacteroides uniformis str. 3978 T3 ii]
6D7J_A	1.39e-30	227	590	315	700	TheCrystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) with Glycerol in Active-Site [Parabacteroides merdae CL03T12C32],6D7J_B The Crystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) with Glycerol in Active-Site [Parabacteroides merdae CL03T12C32],6D7J_C The Crystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) with Glycerol in Active-Site [Parabacteroides merdae CL03T12C32],6D7J_D The Crystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) with Glycerol in Active-Site [Parabacteroides merdae CL03T12C32],6DXU_A Crystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) [Parabacteroides merdae ATCC 43184],6DXU_B Crystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) [Parabacteroides merdae ATCC 43184],6DXU_C Crystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) [Parabacteroides merdae ATCC 43184],6DXU_D Crystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) [Parabacteroides merdae ATCC 43184]
5UJ6_A	7.04e-28	226	770	302	845	CrystalStructure of Bacteroides Uniformis beta-glucuronidase [Bacteroides uniformis str. 3978 T3 ii],5UJ6_B Crystal Structure of Bacteroides Uniformis beta-glucuronidase [Bacteroides uniformis str. 3978 T3 ii],6NZG_A Bacteroides uniformis beta-glucuronidase 2 covalently bound to cyclophellitol-6-carboxylate aziridine [Bacteroides uniformis],6NZG_B Bacteroides uniformis beta-glucuronidase 2 covalently bound to cyclophellitol-6-carboxylate aziridine [Bacteroides uniformis]
6D50_A	7.12e-28	226	770	310	853	Bacteroidesuniforms beta-glucuronidase 2 bound to D-glucaro-1,5-lactone [Bacteroides uniformis str. 3978 T3 ii],6D50_B Bacteroides uniforms beta-glucuronidase 2 bound to D-glucaro-1,5-lactone [Bacteroides uniformis str. 3978 T3 ii]
6D8G_A	1.24e-27	226	770	310	853	D341AD367A calcium binding mutant of Bacteroides uniformis beta-glucuronidase 2 [Bacteroides uniformis str. 3978 T3 ii],6D8G_B D341A D367A calcium binding mutant of Bacteroides uniformis beta-glucuronidase 2 [Bacteroides uniformis str. 3978 T3 ii]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
T2KPJ7	3.00e-34	230	603	318	718	Putative beta-glucuronidase OS=Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) OX=1347342 GN=BN863_21970 PE=2 SV=1
O77695	6.16e-14	227	513	330	623	Beta-glucuronidase (Fragment) OS=Chlorocebus aethiops OX=9534 GN=GUSB PE=2 SV=1
Q4FAT7	1.70e-12	227	513	333	626	Beta-glucuronidase OS=Sus scrofa OX=9823 GN=GUSB PE=3 SV=1
P08236	2.24e-12	227	513	333	626	Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2
O18835	6.76e-12	227	513	332	625	Beta-glucuronidase OS=Canis lupus familiaris OX=9615 GN=GUSB PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000030	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM Annotations help

There is no transmembrane helices in MGYG000000390_01880.