CAZyme Information: MGYG000000020_01371

Basic Information

• Species: Latilactobacillus curvatus
• Lineage: Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Latilactobacillus; Latilactobacillus curvatus
• CAZyme ID: MGYG000000020_01371
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
761		82317.23	9.2795

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000020	1923680	Isolate	United Kingdom	Europe

• Gene Location: Start: 4607; End: 6892 Strand: +

Full Sequence      

MSDNRNNNNSRVARHKAEAKPANKKRRPLFLKILKWLLLLIVVAFVAGIGLFAYYVKDTP
NLTQADLQSPNATILYDDQGKPFKTIGGENRSYVKSDQIPQTLKDAVVSIEDRRFYKEKF
GIDPIRIASAAVANITGKSPLGLQGGSTLTQQLIKLSKFSTKNSDQTFRRKAQEAWLAVQ
VERQYSKDQILEYYMNKVYLNNGVNGMGTAAKYYYGKSLKELSLPQLALIAGMPQSPSNY
DPYLHPDLAKKRRDLVLDALLRNNKITATEAAEAKQVPINTGLVDQQTVANSSTDSKATD
AYVKEVLADLKKKGYDPYTAGLKVYTNINMDAQRKLYDIVNNDSSIPFPDDQLQTAVSIT
DPNNGRIVAMIGGRKTGDVQLGYNRAVQSGRSNGSSMKPLMDYGPAIEYLDYSTAQKLQD
VPYTYPGTNIQLHNFDGRYLGTITARNALANSRNVPAIELLEAVGMTKAREFVKGLGINV
PADTGLSYGIGGNVSTVDEAAAYGAFANGGTYYAPTYIHKVETADGITHNYDSDGTQAMK
SSTAYMITDMLKDVIKNGSGTLAQIPGLHQAGKTGTTDYSSEEIAKSGLNPTLAKDSWFA
GYTKNYSVTVWTGYDEPLKNGLTMSERNVAAYIYKAMMAYLAQNATNSDWSMPSNVVAKN
VAGVRELYIKGTTTIPSSSSSRSSSSSVLYSSSEAPVSSSSEISSSSSVVETPSESSSVP
ETSSSSTPTESSQSQPSTSTPPATTNPGTGSTTQTPAAPTN

Enzyme Prediction     

EC	2.4.1.129

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	80	260	1.9e-59	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	0.0	44	665	27	623	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	0.0	90	644	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	1.10e-121	42	672	17	762	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
COG4953	PbpC	5.07e-79	44	613	11	534	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	3.71e-77	79	261	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ASN61948.1	0.0	1	761	1	761
QAS49393.1	0.0	1	761	1	761
ASN60128.1	0.0	1	761	1	761
QEA49733.1	0.0	1	761	1	761
AWV72936.1	0.0	1	761	1	761

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3DWK_A	1.27e-99	67	666	2	616	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
2ZC5_B	1.72e-99	300	656	10	377	ChainB, Penicillin-binding protein 1A [unidentified],2ZC5_D Chain D, Penicillin-binding protein 1A [unidentified],2ZC6_B Chain B, Penicillin-binding protein 1A [unidentified],2ZC6_D Chain D, Penicillin-binding protein 1A [unidentified]
2C6W_B	1.99e-99	300	656	7	374	Penicillin-BindingProtein 1a (Pbp-1a) From Streptococcus Pneumoniae [Streptococcus pneumoniae]
2C5W_B	2.06e-99	300	656	8	375	PENICILLIN-BINDINGPROTEIN 1A (PBP-1A) ACYL-ENZYME COMPLEX (CEFOTAXIME) FROM STREPTOCOCCUS PNEUMONIAE [Streptococcus pneumoniae R6]
2OLU_A	8.72e-96	60	666	4	625	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q04707	2.29e-181	27	656	3	640	Penicillin-binding protein 1A OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=ponA PE=1 SV=2
Q8DR59	9.13e-181	27	656	3	640	Penicillin-binding protein 1A OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=pbpA PE=1 SV=1
Q00573	2.68e-175	31	652	7	637	Penicillin-binding protein 1A (Fragment) OS=Streptococcus oralis OX=1303 GN=ponA PE=3 SV=1
P39793	2.56e-139	9	680	6	695	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1
P38050	6.53e-84	25	656	5	610	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999972	0.000062	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
33	55