LOCUS       NZ_CP102288            11765 bp    DNA     linear   CON 29-JUL-2024
DEFINITION  Segatella copri DSM 18205 chromosome, complete genome.
ACCESSION   NZ_CP102288 REGION: 864253..876017
VERSION     NZ_CP102288.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN20222705
            Assembly: GCF_025151535.1
KEYWORDS    RefSeq.
SOURCE      Segatella copri DSM 18205
  ORGANISM  Segatella copri DSM 18205
            Bacteria; Pseudomonadati; Bacteroidota; Bacteroidia; Bacteroidales;
            Prevotellaceae; Segatella.
REFERENCE   1  (bases 1 to 11765)
  AUTHORS   Cheng,A.G., Ho,P.Y., Aranda-Diaz,A., Jain,S., Yu,F.B., Meng,X.,
            Wang,M., Iakiviak,M., Nagashima,K., Zhao,A., Murugkar,P., Patil,A.,
            Atabakhsh,K., Weakley,A., Yan,J., Brumbaugh,A.R., Higginbottom,S.,
            Dimas,A., Shiver,A.L., Deutschbauer,A., Neff,N., Sonnenburg,J.L.,
            Huang,K.C. and Fischbach,M.A.
  TITLE     Design, construction, and in vivo augmentation of a complex gut
            microbiome
  JOURNAL   Cell 185 (19), 3617-3636 (2022)
   PUBMED   36070752
REFERENCE   2  (bases 1 to 11765)
  AUTHORS   Cheng,A.G., Jain,S., Meng,X. and Fischbach,M.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2022) Chem-H, Stanford University, 290 Jane
            Stanford Way, Stanford, CA 94305, USA
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP102288.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            ##Genome-Assembly-Data-START##
            Assembly Date          :: 2021
            Assembly Method        :: Unicycler v. 0.4.8
            Assembly Name          :: Prevotella-copri-DSM-18205-MAF-2
            Genome Representation  :: Full
            Expected Final Version :: Yes
            Genome Coverage        :: 100x
            Sequencing Technology  :: Illumina HiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_025151535.1-RS_2024_07_29
            Annotation Date                   :: 07/29/2024 03:59:40
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,796
            CDSs (total)                      :: 2,718
            Genes (coding)                    :: 2,663
            CDSs (with protein)               :: 2,663
            Genes (RNA)                       :: 78
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 13 of 55
            Pseudo Genes (incomplete)         :: 44 of 55
            Pseudo Genes (internal stop)      :: 9 of 55
            Pseudo Genes (multiple problems)  :: 11 of 55
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..11765
                     /organism="Segatella copri DSM 18205"
                     /mol_type="genomic DNA"
                     /strain="DSM 18205"
                     /host="Homo sapiens"
                     /culture_collection="DSM:18205"
                     /type_material="type strain of Prevotella copri"
                     /db_xref="taxon:537011"
     gene            complement(1..2022)
                     /locus_tag="NQ544_RS03475"
                     /old_locus_tag="NQ544_03475"
     CDS             complement(1..2022)
                     /locus_tag="NQ544_RS03475"
                     /old_locus_tag="NQ544_03475"
                     /EC_number="2.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007133480.1"
                     /GO_function="GO:0016744 - transketolase or transaldolase
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="WP_006846782.1"
                     /translation="MNDIKVMNHAADNIRILAASMVEKANSGHPGGAMGGSDFINVLF
                     SEYLVYDPSDPTWTGRDRFFLDPGHMSPMLYAGLALRGFFSMEDLKQFRQWGSVTPGH
                     PELDLERGIENSSGPLGQGHALAAGAAVAEKFLEARLGSTMMQHKIYAYISDGAVEEE
                     ISQGVGRIAGNLGLNNLIMFYDSNDIQLSTECGVVMNEDTEMKYKAWGWNVIKINGND
                     VAQIREALDAAQKEQDRPTLIIGKTVMGKGALRADGTSYEACINTHGAPLGGDAYVNT
                     IKHLGGDPENPFVIFDDVKEIYAKRAEELKKIVAERKAAEAEWRKANPEKAAQMDEWF
                     SGKAPKVDWSKVEQKAGSATRAASAACLGVLAEQVPNMICASADLSNSDKTDGFLKKT
                     KSIVRGDFSGAFFQAGVAELTMADMCIGMMLHGGVVAAMGTFFVFSDYMKPAVRIAAL
                     MQVPVKFIWTHDAFRVGEDGPTHEPVEQEAQIRLMEKLKNHAGKDSVRVFRPADADET
                     TVCWKLAMENVETPTALIFSRQGIAKLPEGTDYEQAAKGAYIVAGSDENPDVILVASG
                     SEVSTLEAGCEALRADGIKVRVVSAPSEGLFRGQSKEYQESVLPKNAKIFGMTAGLPV
                     TLQGLVGANGKVWGMESFGFSAPYKVLDEKLGYTGENVYKQVKAFLAEA"
     gene            complement(2129..3703)
                     /locus_tag="NQ544_RS03480"
                     /old_locus_tag="NQ544_03480"
     CDS             complement(2129..3703)
                     /locus_tag="NQ544_RS03480"
                     /old_locus_tag="NQ544_03480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009036827.1"
                     /GO_function="GO:0046556 - alpha-L-arabinofuranosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0046373 - L-arabinose metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-N-arabinofuranosidase"
                     /protein_id="WP_006846781.1"
                     /translation="MMKKLFATTLLSTAVAFSAQAQDVTGTIHANQGTQKINKEIYGQ
                     FAEHLGSCIYGGLWVGPDSKIPNTQGYRNDVLQALKDLKVPVLRWPGGCFADEYHWMD
                     GIGPREKRPKMQNNNWGGTIEDNSFGTHEFLNLCEMLGCEPYISGNVGSGTVEELAKW
                     VEYMTSDGDTPMAKLRRQNGRDKAWKVKYLGVGNESWGCGGNMRPEYYSDLFRRYSVY
                     CRNYDGNQLYKIASGASDYDYNWTKVLMDRIGNRANAISLHYYTVTGWTGSKGSATKF
                     NNEDYYWTMGKALGIEDVIKKHEAIMDKADPKKQVALLVDEWGTWWDEEPGTIKGHLY
                     QQNCMRDAFVAALSLNVFHRHTERVKMTNIAQIVNVLQSMILTDTKGTGHMVLTPTYH
                     VFNMYKDFQEATYLPMDVKCDSMDVRGDDHARDGRKIPLVSTSAAKKADGTIVVALAN
                     VSLDKAQQVEFNLDGAAAPKTVTGQILSCNKVSDYNDFAHPDVVKPAVFKDAKVKKNT
                     LKVKIPAKSIVVLKIK"
     gene            complement(3783..5375)
                     /locus_tag="NQ544_RS03485"
                     /old_locus_tag="NQ544_03485"
     CDS             complement(3783..5375)
                     /locus_tag="NQ544_RS03485"
                     /old_locus_tag="NQ544_03485"
                     /EC_number="2.7.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007411715.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0004856 - D-xylulokinase activity [Evidence IEA]"
                     /GO_process="GO:0005998 - xylulose catabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xylulokinase"
                     /protein_id="WP_006846780.1"
                     /translation="MSAKTIIESGKAILGIEFGSTRIKAVLIDTDNNPIAQGSFEWEN
                     QLVDGLWTYSIDTIWKGLQDCYADLRKNVKAEYDCEIKQLAAIGISAMMHGYMAFGKD
                     ENILVPFRTWRNTNTAKAAAELSELFHFNIPLRWSISHVYQAILNGEDHINKIDFLTT
                     LAGYIHWQLTGKKVLGVGDASGMLPIDSNTNNYDAEMVAKFDKLIEPKNLGWKILDIL
                     PEVLNAGEDAGVLTEEGAKKLDPSGALQAGTPLCPPEGDAGTGMVATNAVRQRTGNVS
                     AGTSSFSMIVLEKALSQPYEVIDMVTTPDGSPVAMVHCNNCTSDLNAWVGLFKQYQEL
                     LGVPVDMNEVFGKLYNHALEGDADCGGLIAYNYISGEPVTGLAEGRPMFVRSANDHFN
                     LANFMRANLYASVAVLKIGNDVLFKDEKVQVDRITGHGGLFKTKGVGQRILAAAINSP
                     ISVMETAGEGGAWGIALLAGYLVNNEEKLSLADYLDKKVFAGNTGVEIAPTAEDVAGF
                     DKYIETYKAGLAIEKAAIENKK"
     gene            complement(5457..6998)
                     /gene="araA"
                     /locus_tag="NQ544_RS03490"
                     /old_locus_tag="NQ544_03490"
     CDS             complement(5457..6998)
                     /gene="araA"
                     /locus_tag="NQ544_RS03490"
                     /old_locus_tag="NQ544_03490"
                     /EC_number="5.3.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008774879.1"
                     /GO_function="GO:0008733 - L-arabinose isomerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005996 - monosaccharide metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-arabinose isomerase"
                     /protein_id="WP_006846779.1"
                     /translation="MIKAFENLEVWFVTGAQLLYGGETVKIVDGHSKDMVDGLNNSGI
                     IPIKVVYKGTANSSAEVEAVMKAANNDKKCVGIITWMHTFSPAKMWIKGLQALEKPLL
                     HFHTQYNAELPWDTIDMDFMNLNQSAHGDIEFGHICSRMRIPRKVVVGHWKSAEAQKK
                     IAIWARVAAAVADAHNVRCLMFGMNMNNVAVTDGDRVEFEQRLGYHVDYYPVSNLMEY
                     WKQVSDEEALALIEQYKKEYIIKIDESGEEVYWEKVLHAAKAEIALRRVLKEEGATAF
                     TTNFDDLGEADITDPNFIGFDQIPGLASQRLMAEGIGFGAEGDWKTACLYRSLWIMNQ
                     GLTKGCSFLEDYTLNFAADRTSSLQSHMLEVCPLIAVNKPTLEVHFLGIGIRKEQTAR
                     LVFTSKTGKGVKATVVDLGNRFRLIASEVECIEPKAMPKLPVASALWVPQPTFEIGAG
                     AWILAGGTHHSAFSYDITAEYWEDFCEILGIEFVNIDKNTTISSFKQQLRNNEIYYML
                     NKALR"
     gene            complement(7065..7763)
                     /locus_tag="NQ544_RS03495"
                     /old_locus_tag="NQ544_03495"
     CDS             complement(7065..7763)
                     /locus_tag="NQ544_RS03495"
                     /old_locus_tag="NQ544_03495"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013065512.1"
                     /GO_function="GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA]; GO:0008742 - L-ribulose-phosphate
                     4-epimerase activity [Evidence IEA]; GO:0008270 - zinc ion
                     binding [Evidence IEA]"
                     /GO_process="GO:0019569 - L-arabinose catabolic process to
                     xylulose 5-phosphate [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="WP_006846778.1"
                     /translation="MLEELKEKVFKANLDLVKHNLVLFTWGNVSGIDREKGLVVIKPS
                     GVDYDTMKASDMVVVDLETGKVVEGDLNPSSDTPTHLVLYRAFPELGGVVHTHSTYAT
                     AWAQAGLDIPNIGTTHADYFHDCIPCTDAMTEDMMAEYEHNTGVVIVDRFKKDNINPV
                     HTPGVLVKNHGPFTWGKDADQAVYHAVVAEQVAKMAFISFSVNPNTTMNPLLVEKHFN
                     RKHGPNAYYGQKKH"
     gene            complement(7791..8471)
                     /locus_tag="NQ544_RS03500"
                     /old_locus_tag="NQ544_03500"
     CDS             complement(7791..8471)
                     /locus_tag="NQ544_RS03500"
                     /old_locus_tag="NQ544_03500"
                     /EC_number="3.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004346854.1"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="WP_040552774.1"
                     /translation="MTQFYNEYSKVLVSVDCIIFGFDGSNLQVLIGKRKMDPGRGEWS
                     LYGGFVGATENLEDAANRVILELTGMKNLYIRQVGAFGRIDRDPGERVISIAYCTLIN
                     VKDYDDSLRVEHGLEWVSLNELPELYSDHKLMIRNAIAQIRRRINHEPLSFKLLPDLF
                     TLTQLQHVFEAVIGEEIDKRNFRKRVKDIDFIEKTELIDKVNSKRGAALYRFNKKAYE
                     EDPSFNLK"
     gene            complement(8670..10394)
                     /locus_tag="NQ544_RS03505"
                     /old_locus_tag="NQ544_03505"
     CDS             complement(8670..10394)
                     /locus_tag="NQ544_RS03505"
                     /old_locus_tag="NQ544_03505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008671067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="WP_006846776.1"
                     /translation="MNWNSTEFVWLDWAILAIGVIGVIWAVWHAIMKDRKAQKGEDSS
                     AYLFGKGEPWYVIGMAIFAANIGSEHLVGLAGTGAKSGVGMAHWEMQGWMILILGWLF
                     VPFYQLLINKMGKIITMPDFLKFRYTQRTGSWLSIITLVAYILTKVSVTALTGGIFFE
                     YLWGLNFWVGAIGLIILTTIFTVFGGMKGVMTLSTIQTPILVIGSFLVLFLGLSTLGG
                     GSISAGWADMMDYCGKLNNGYGTTHMFHWEAGDSMYQDYPGFVVFIGATIIGFWYWCT
                     DQHIVQRVLGQVPGESNVEVMKRARRGTIAAGFFKVLPCFMFLIPGMIAAALAQKGAI
                     QMNETDAAFAIMVKTVLPAGIKGIVTIGFICALVASLAAFFNSCATLFTEDFYKPLKK
                     GMSEAHYVLVGRIATVVVVVLGFAWLPIMMKMDTLYNYLQGIQSLLAPAMVAVFAMGI
                     FFKKITPKAGEYTMITGFLIGMLRLVTNVITDTGKATMDGAFWDYTAWFWQTNWLVFE
                     CWLLVFLIIFMVVVSCFTPAPSKEQVEAITFTSDFKKSIRESWSAFDIIGTLVVIGLC
                     AAFYAYFW"
     gene            complement(10578..11765)
                     /locus_tag="NQ544_RS03510"
                     /old_locus_tag="NQ544_03510"
     CDS             complement(10578..11765)
                     /locus_tag="NQ544_RS03510"
                     /old_locus_tag="NQ544_03510"
                     /EC_number="5.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018464645.1"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]; GO:0016857 - racemase and epimerase activity, acting
                     on carbohydrates and derivatives [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldose epimerase family protein"
                     /protein_id="WP_006846775.1"
                     /translation="MSTFKTLFMGVGFAAIATLSACSSSSNASLTQSGLNPADFDSTV
                     LGKKTELVTLKNANGMEVCLTNYGGRVVSISVPDKDGKPTDVVLGYDNIHQYADTLNS
                     PSDYGSSVGRYANRIKDAKLSLAGSTYQLKANDNGNCLHGGGATGWLNQVYDITEKND
                     SSVTFTINAKDGENGFPGNVTATAKYTVKSDNTLDIEFGATTDKETVVNMTNHSYFNL
                     NGDPSKEGFDQVMYINADKFTPADSLYIPTGEIKSVEGTPMDFRKPAEIGKKVDYNFD
                     QIKNATGYDHNWCLNTYKNGKGDDKTVCASLYSPKSGILLEVFTNEPGIQVYTGNFQG
                     TGIACKHGIKYPKHVSVCFESQKYPDSPTKIAQGVKDWTDATLKPGEKYYSHLAYKFS
                     VKK"
ORIGIN      
        1 ttaagcctct gccaagaaag cctttacctg cttgtaaacg ttctcgcctg tgtaaccgag
       61 cttctcatca agtaccttgt aaggagctga gaaaccgaag ctctccatac cccaaacctt
      121 accattagcg cctacgagac cctggagtgt tacaggaaga ccggcagtca taccgaagat
      181 cttagcgttc tttggcaata cgctctcctg atactccttg ctctgaccgc ggaacaagcc
      241 ctctgatgga gcacttacca cgcgaacctt gatgccgtcg gcacgcaaag cctcgcaacc
      301 agcctccaat gtagaaacct cagaaccgct agctacgagg ataacgtctg gattctcgtc
      361 gctgcctgct acgatgtaag cacccttggc tgcctgctca tagtctgttc cctctggcaa
      421 tttagcgatg ccctggcgag agaagatcaa agctgtagga gtctcaacat tctccatagc
      481 gagcttccag caaactgtag tctcgtcagc atcagctgga cggaatacgc gaacgctgtc
      541 cttacctgcg tggttcttca acttctccat caagcggatc tgtgcctcct gctcaactgg
      601 ctcgtgagta ggtccatcct caccaacgcg gaatgcatcg tgagtccaga tgaacttcac
      661 tggaacctgc atcagggcag cgatacgaac agctggcttc atataatcag agaatacgaa
      721 gaatgtaccc attgctgcaa ccacaccacc gtggagcatc ataccgatac acatatcagc
      781 cattgtcaac tcagcaacac ctgcctgaaa gaaagcacct gagaaatcac cacgaacgat
      841 gctcttggtc ttcttcaaga aaccatctgt cttatcagag ttagaaaggt cagcagaagc
      901 acagatcatg ttaggaacct gctctgccaa aacaccgaga caggcagctg atgctgcacg
      961 tgtagctgaa ccagccttct gctcaacctt gctccagtct accttaggag ccttgccgct
     1021 gaaccactca tccatctggg cagccttctc tgggttagcc ttgcgccact cagcctctgc
     1081 agccttgcgc tcagctacga tcttcttcaa ctcctcagca cgcttagcgt agatttcctt
     1141 tacatcgtcg aagataacga atggattctc aggatcacca ccgaggtgct tgatggtatt
     1201 aacgtaagcg tcgccaccga gaggagcacc gtgagtattg atgcaagcct cgtagcttgt
     1261 gccgtctgcg cggagagcac ccttacccat tacggtctta ccgatgatga gggtaggacg
     1321 gtcctgctcc ttctgggcag catcgagcgc ctcacgaatc tgagctacgt cgttaccgtt
     1381 gatcttgatg acattccagc cccaagcctt gtacttcatc tctgtatcct cgttcattac
     1441 aacgccacac tctgtagaga gctggatgtc gttagaatcg tagaacatga tgaggttgtt
     1501 cagaccgagg ttaccggcga tacgaccaac accctgagaa atctcttcct ctacagcacc
     1561 atcagagatg tatgcgtaga tcttgtgctg catcatggtt gaacccagac gagcctcgag
     1621 gaacttctct gcaacagctg caccagctgc gagggcatga ccctgaccga gaggaccaga
     1681 tgagttctcg ataccacgct caaggtcgag ctctgggtga ccaggagtta cagaacccca
     1741 ctggcggaac tgcttgaggt cttccattga gaagaaacca cgcaaagcca aacctgcata
     1801 gagcattgga ctcatgtgac ctgggtcgag gaagaaacgg tcacgacctg tccatgttgg
     1861 atctgatgga tcataaacca ggtactcaga gaagagcacg ttgatgaagt cagaaccacc
     1921 catagcacca cctgggtgac cggaatttgc cttttctacc attgaagcag ccaagatacg
     1981 gatgttatca gctgcatgat tcattacttt aatgtcgttc ataattttat atttattatt
     2041 gttgttattt ctgctgaaat attcttgttt ttctagctct gaaggctact caaaagaagg
     2101 atacttcctt ttttcgcctt caaaaatact attttatttt caaaactacg atagattttg
     2161 caggaatttt tactttaagg gtgtttttct ttacttttgc atccttaaaa actgcaggct
     2221 tcactacatc cgggtgtgcg aagtcgttgt aatcgctcac cttgttgcag gaaagaatct
     2281 gtcctgttac agttttcgga gcagctgcac catccagatt aaactctacc tgctgagcct
     2341 tgtcaaggct gacattggca agagcaacca caatggttcc atctgccttc ttggctgctg
     2401 aagtagatac caatggaatc tttcttccat ctcttgcgtg atcatcgccg cgaacatcca
     2461 tagagtcgca ctttacatcc attgggagat aggttgcctc ctggaagtcc ttgtacatgt
     2521 tgaatacatg ataggttgga gtcagaacca tgtgacctgt tccctttgta tctgtcagga
     2581 tcattgactg gagtacgttg acaatctgtg cgatattggt catcttcaca cgctctgtat
     2641 ggcggtggaa tacattcagc gagagcgcag caacgaaggc atcgcgcata cagttctgct
     2701 gatagaggtg gcccttgata gtgccaggct cctcatccca ccaggttccc cattcgtcaa
     2761 cgaggagggc tacctgcttc tttggatcag ccttgtccat gatagcctcg tgcttcttga
     2821 tgacatcttc tatgccgagc gccttgccca tggtccagta gtaatcctca ttgttgaact
     2881 tggtggcaga acccttgctg cctgtccagc ctgttactgt ataataatgt agagagatgg
     2941 cgttggcacg gttgccgatg cggtccatca ataccttagt ccagttataa tcgtaatcgc
     3001 tcgctccaga tgcaatctta tagagctggt ttccgtcata gttgcggcaa taaacagagt
     3061 agcggcggaa gagatctgaa taatactcag gacgcatgtt gccaccgcag ccccaacttt
     3121 cgttaccaac accgaggtat tttaccttcc aggccttgtc gcggccgttc tgtcggcgga
     3181 gttttgccat aggagtatct ccatcgctgg tcatatattc cacccacttt gccaattcct
     3241 caacagtgcc ggaacccacg ttaccgctga tgtaaggctc gcaacccaac atctcgcaga
     3301 gattcagaaa ctcgtgtgta ccaaaagagt tgtcctcaat ggttccaccc cagttgttgt
     3361 tctgcatctt tggtcgcttc tcacgtggac cgataccatc catccagtga tactcgtcag
     3421 cgaagcatcc tccaggccat cttaatacag gtactttcag gtccttgagg gcttggagca
     3481 cgtcgttgcg gtaaccctga gtgttaggaa tcttagaatc aggacctacc caaagaccac
     3541 catagataca acttccgaga tgctcggcaa actggccata aatctcttta ttgattttct
     3601 gtgttccctg gttggcatgg attgttcctg ttacatcctg agcttgagct gagaatgcaa
     3661 ctgctgttga aagcaatgtg gtagcgaata gtttcttcat cattgttctt attaattgtt
     3721 gtcgattttt agtataatac gtttgtggag gtagaatccc cacaaacgta tttatctttt
     3781 atttactttt tgttctcaat tgctgccttt tcgatagcaa gaccagcctt gtaggtttca
     3841 atatatttat caaaaccggc tacatcttcg gcagtaggtg caatctctac accagtattg
     3901 cctgcaaata ccttcttgtc gagataatct gccaggctca acttctcttc gttgttaacg
     3961 agataacctg cgagcagggc gataccccat gcaccacctt cgcctgctgt ctccatgaca
     4021 gagatagggg agttaatggc tgcagcgagg atgcgctgac ctacaccctt ggtcttgaac
     4081 aaaccgccat gacctgtgat gcgatctacc tgtaccttct cgtccttgaa caatacatcg
     4141 ttaccaatct tcaatacagc tactgaagca tagaggttgg cacgcatgaa gttggcaagg
     4201 ttgaagtggt cgttggcaga acgtacgaac atagggcgac cttctgcaag acctgttaca
     4261 ggctcaccag agatatagtt gtaagcaatc aatcctccgc aatcagcatc gccttcaaga
     4321 gcgtggttgt agagcttgcc gaatacctcg ttcatatcta ctggaacacc gagcaactcc
     4381 tgatattgct tgaacaaacc tacccatgca ttgaggtcgg aagtacagtt gttacagtga
     4441 accattgcta cagggctgcc gtctggagta gtcaccatat caatgacttc gtaaggttgg
     4501 ctcaaggctt tctccaatac aatcatagag aaagaagatg tacctgcact gacgttacct
     4561 gtacgctgac gtacagcgtt ggtagctacc ataccagtac ctgcatcacc ttctggagga
     4621 cagagtgggg tgcctgcctg gagtgcgcct gatgggtcga gcttctttgc accttcctcg
     4681 gtcaatacgc cagcatcttc gcctgcgttc agtacctctg ggagaatgtc gagaatcttc
     4741 cagcccaggt tcttaggctc gatgagctta tcgaacttag ctaccatctc tgcatcgtag
     4801 ttgttggtgt tagagtcgat agggagcata cctgatgcat cgcctacgcc caaaaccttc
     4861 ttgcctgtga gctgccagtg gatataaccg gcgagagtgg taaggaagtc aatcttgttg
     4921 atgtggtcct caccattcag gatagcctga tatacgtgag agatactcca acgcaatggg
     4981 atgttgaagt ggaagagctc tgaaagttca gctgcggcct tggctgtatt ggtgttacgc
     5041 catgtgcgga aaggaacgag aatgttctca tccttaccga aagccatgta gccgtgcatc
     5101 atcgcagaaa taccgatggc agccaactgc ttgatttcgc agtcgtactc agccttcacg
     5161 ttcttgcgga ggtcggcata acaatcctgc aaacctttcc agattgtgtc gatgctgtaa
     5221 gtccagagac catcaaccaa ctggttttcc cactcaaagc taccctgtgc gatagggttg
     5281 ttgtcggtgt cgatcaagac agccttgatt ctggtagagc caaactcgat accgagaatg
     5341 gccttacctg attctataat agtttttgcg ctcattattg attctttctt taatgtaagg
     5401 aacaaagaga aaagcaatgg aattcttcac tcttcgttct tcactcttca cttaaattat
     5461 ctcaacgcct tgttgagcat gtagtaaatc tcgttgttgc ggagctgctg cttgaagctg
     5521 ctgatagttg tgttcttgtc gatgttgacg aactcaatac cgagaatctc gcagaagtct
     5581 tcccagtact cagcagtgat atcgtaagag aatgcactgt ggtgagtacc accagcgagg
     5641 atccaagcac ctgcaccaat ctcgaaggtt ggctgtggaa cccagagagc tgaagctaca
     5701 gggagcttag gcattgcctt tggctcgatg cactctacct cacttgcgat gagacggaaa
     5761 cggttgccga ggtcaactac agttgcctta acacccttac ctgtcttaga tgtgaatacc
     5821 aaacgggctg tctgctcctt gcggataccg atgccgagga agtgtacttc gagtgttggc
     5881 ttgttgactg cgatgagagg gcagacctca agcatgtggc tctggaggct agatgtgcgg
     5941 tcggcagcga agttgagggt atagtcctca aggaatgagc agccctttgt caagccctgg
     6001 ttcattatcc agagtgagcg atagagacac gctgtcttcc agtcaccttc ggcaccgaag
     6061 ccgatacctt cagccatcag gcgttgtgaa gcaagaccag gaatctggtc gaagccgatg
     6121 aagttaggat cggtgatgtc tgcctcacca aggtcgtcga agttggtagt gaaggctgtt
     6181 gcaccttcct ccttgagcac gcgacgaaga gcgatctctg cctttgcggc atggagcact
     6241 ttctcccaat aaacctcttc gcctgactcg tcgatcttga ttatatattc cttcttgtat
     6301 tgctcaatga gagccagtgc ctcttcgtca gaaacctgct tccaatattc catgaggtta
     6361 gaaactggat agtagtcaac atgatagccg agacgctgtt cgaactcaac gcggtcacca
     6421 tctgttacag caacattgtt catgttcata ccgaacatga ggcaacgtac attgtgtgca
     6481 tcagcaacgg ctgcagcaac acgtgcccag atagcaatct tcttctgagc ctcagcgctc
     6541 ttccagtgtc caactactac cttgcgagga atgcgcatgc gagagcagat gtgaccgaac
     6601 tcaatatcac cgtgagctga ctggttgagg ttcatgaagt ccatgtcgat agtgtcccat
     6661 ggcaactctg cgttgtactg ggtgtggaag tggaggagag gcttctcgag agcctgcaag
     6721 cccttgatcc acatcttagc tggagagaag gtgtgcatcc atgtgatgat acctacgcac
     6781 ttcttatcgt tgttggcagc cttcatgacg gcctctactt ctgcagaaga gttagctgtg
     6841 cccttgtaaa ctaccttgat tgggatgatg ccactgttgt tcagaccatc taccatgtcc
     6901 tttgagtgac catcaactat cttaactgtt tcgcctccgt aaagaagctg tgcaccagtt
     6961 acaaaccata cctctaaatt ttcaaatgct ttaatcatga ttgtttgttg tattaattgt
     7021 tattgttaat gttatctaat atctttattt gaaacaccct ttaattagtg ctttttttgt
     7081 ccatagtaag cgttaggacc gtgcttgcgg ttgaagtgct tctctacgag caatgggttc
     7141 atggtggtgt ttggattcac agagaatgag atgaaagcca tcttggccac ctgttcagct
     7201 actactgcgt gataaacagc ctggtcagca tccttacccc atgtaaaagg accatggttc
     7261 ttaaccaata cgccaggagt atgaactggg ttgatgttat ctttcttgaa acggtcaacg
     7321 atgacaacac ctgtgttgtg ctcatattct gccatcatat cctctgtcat cgcatcagtg
     7381 caagggatgc aatcgtggaa gtaatcagca tgagttgtac caatattagg gatgtccaag
     7441 ccagcctgtg cccaagcggt agcataagta gagtgagtat gaactacgcc acccaactct
     7501 gggaatgcgc ggtagagaac caagtgggtt ggtgtatcag atgatggatt cagatcgcct
     7561 tctactacct tacctgtttc caagtctact actaccatat cgctagcctt catggtgtca
     7621 taatcgacgc ctgatggttt gatgacaacc agacctttct cgcggtcgat gccactcacg
     7681 ttaccccatg taaagagcac gaggttgtgc ttaacgagat caaggtttgc cttgaacact
     7741 ttttctttta attcttctaa catagttttt tttgttttaa gttgtttatt ctatttcaaa
     7801 ttgaacgatg ggtcttcctc gtatgctttc ttgttgaagc ggtagagggc ggcgcctcgt
     7861 ttcgagttga ctttatcgat gagttctgtt ttctcgatga agtcgatatc cttcacgcgt
     7921 ttgcggaagt tgcgcttatc aatctcttcg cctattactg cctcgaatac atgctgaagc
     7981 tgtgtcagcg taaagaggtc tgggaggagt ttgaagctta atggctcatg attgatgcgg
     8041 cggcgtatct gtgcgatagc gttgcggatc atgagtttgt ggtctgagta aagttctgga
     8101 agttcgttca gactaaccca ttccaatccg tgttctacac ggaggctgtc atcatagtct
     8161 ttcacattga tgagagtgca ataggcgata gagataactc gctcacctgg gtcacggtcg
     8221 atgcggccga aagctcctac ttgtcttata tagaggtttt tcattccagt aagttccagg
     8281 atgactctgt tggcagcatc ttcgagattt tctgttgcgc caacgaaacc accatagagt
     8341 gaccattcgc ctcttcccgg gtccatcttg cgtttgccta tcagtacctg gaggttacta
     8401 ccgtcgaaac cgaaaatgat acaatcgacg gatactaata ctttggagta ttcattataa
     8461 aactgggtca tggtcttact gctgttttga tgtaatgatt caatgtatgt tgtgttcttt
     8521 tgcttgctct tcatagagca gcttcgagag gaaaatcaag gagtaagaag gagaagaaag
     8581 aatcacggat ttttcaacag aaacagtttt gtctgatctt tgagaaaatt ccagactcct
     8641 cacttcttac tcctgacgtg aataatattt taccagaagt atgcgtagaa tgctgcgcag
     8701 aggccgatta ctacgagggt accgataata tcgaaggcac tccaactctc acggatagac
     8761 ttcttgaagt ctgatgtgaa ggtgattgcc tctacctgct ccttgcttgg agctggtgtg
     8821 aagcagctta ctactaccat gaagatgatg aggaatacga gcaaccagca ctcgaatacg
     8881 agccagttgg tctgccagaa ccatgcggtg taatcccaga atgcaccatc cattgtagcc
     8941 ttacctgtat cagtgatgac gttggtaacg aggcggagca taccgatgag gaaaccggtg
     9001 atcatagtgt actcacctgc ctttggagta atcttcttga agaagatacc cattgcaaat
     9061 acggctacca tggctggtgc cagaagtgac tggataccct ggagatagtt gtacaaagta
     9121 tccatcttca tcatgattgg caaccatgcg aaaccgagaa ctacaactac aacggtagcg
     9181 atacggccaa cgagtacgta gtgagcctca gacatgccct tcttcaatgg cttgtagaag
     9241 tcctcggtga agagggtagc acagctattg aagaatgctg ccaatgaagc aacgagtgcg
     9301 cagatgaaac cgatggttac aatacccttg atacctgcag gaagaacggt ctttaccatg
     9361 atggcgaagg ctgcatcagt ctcgttcatc tggatagcac ccttctgagc caaggctgct
     9421 gcaatcatac ctgggatgag gaacatgaag caagggagta ccttgaagaa accggctgcg
     9481 atagtaccgc ggcgggcacg cttcataacc tctacgttgc tctcgccagg aacctgaccg
     9541 agtacacgct gaacgatgtg ctggtcagta caccagtacc agaaaccgat gatggttgca
     9601 ccgatgaata ctacgaaacc aggataatcc tgatacatag agtcacctgc ctcccagtgg
     9661 aacatgtggg ttgtaccata accattgttc agcttgccgc agtaatccat catgtcggcc
     9721 caaccggcag agatgctgcc accgccgagg gtagagagac cgaggaagag tacgaggaaa
     9781 gaaccgatga cgaggatagg agtctggatg gttgacaatg tcatcacacc cttcatacca
     9841 ccgaatacgg tgaagatggt agtgaggata atcaagccga tggcaccaac ccagaagttc
     9901 aagccccaaa gatattcaaa gaagatacca cctgtaaggg ctgtaacact caccttagta
     9961 aggatgtaag ctacgagggt gatgatagag agccatgaac ctgtgcgctg ggtatagcgg
    10021 aacttcagga agtctggcat ggtgatgatt ttacccatct tgttgatgag caactggtag
    10081 aaaggtacga acagccaacc caagatgagg atcatccagc cctgcatctc ccagtgtgcc
    10141 ataccgacac cactcttggc acctgtacca gccaaaccaa cgaggtgctc tgaaccaatg
    10201 ttggctgcaa aaatagccat accgattaca taccatggct cacccttacc gaagaggtag
    10261 gcagaagagt cttcaccttt ctgagccttt ctgtctttca tgattgcgtg ccagacagcc
    10321 caaattacgc cgataacacc aatggcgagt atagcccaat caagccatac gaattctgtt
    10381 gaattccaat tcataattac tataagattg tttgtttatt attatttgtt tattcttttc
    10441 ttttattgga tgcttattat gttagtttct tatccagcac atttcgtttt tttgttattg
    10501 cgaaaacttc ttgttggatg ttagctgttc cagcggactt tatccgccgg ttcgctaact
    10561 tttaaactaa cttacgctta ctttttaacg ctgaatttgt aagcgaggtg agaatagtat
    10621 ttctctcctg gcttcaatgt ggcatctgtc caatccttta caccctgagc aatcttggtt
    10681 ggagaatcag gatatttctg gctctcgaag caaacgctta cgtgtttagg atacttgatg
    10741 ccatgcttgc aggcaatacc tgtgccttgg aagttaccgg tgtaaacctg aatgcctggc
    10801 tcgttggtaa atacttcaag aaggataccg ctctttggtg agtagaggct tgcgcaaact
    10861 gttttgtcat cgcccttacc gttcttatat gtgttcaaac accagttgtg gtcgtaacct
    10921 gtggcattct taatctggtc aaagttatag tctaccttct tgccgatttc tgcaggttta
    10981 cggaaatcca taggggttcc ctcgacactc ttgatttcac ctgttgggat gtaaagtgaa
    11041 tctgcaggag tgaacttatc tgcattgatg tacattacct gatcgaaacc ttccttagat
    11101 ggatcgccat tcaagttgaa gtaactgtgg ttggtcatat tgacaacggt ctctttgtct
    11161 gttgtagcgc caaactcgat gtcgagtgtg ttgtcactct tgaccgtata tttagctgtt
    11221 gctgttacgt tgccagggaa accattctcg ccatccttcg cattgatagt gaaggtaacg
    11281 gatgagtcgt tcttctctgt aatgtcgtaa acctggttca accatcctgt tgcaccacca
    11341 ccatgcaggc agttgccatt atcatttgcc ttcaactggt atgttgaacc agcaagtgaa
    11401 agtttagcat ccttgatacg gttggcataa cgtcctactg aagaaccata atctgaagga
    11461 gagttaaggg tgtcagcata ctgatggata ttatcgtaac caagaaccac atctgttggc
    11521 tttccgtcct tgtctggaac ggaaatggaa acgacacgtc caccataatt ggtgaggcaa
    11581 acttccatgc cgtttgcatt cttgagagtt actaactcag tcttcttgcc caatactgtt
    11641 gaatcgaaat ctgctggatt caaaccagat tgtgtgagac ttgcattgct gcttgatgaa
    11701 caagctgaga gggtagcgat agccgcaaaa ccaactccca taaatagggt cttaaatgta
    11761 ctcat
//
