LOCUS       NZ_CP012938            21141 bp    DNA     linear   CON 08-JAN-2025
DEFINITION  Bacteroides ovatus strain ATCC 8483 chromosome, complete genome.
ACCESSION   NZ_CP012938 REGION: 14804..35944
VERSION     NZ_CP012938.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN03852683
            Assembly: GCF_001314995.1
KEYWORDS    RefSeq.
SOURCE      Bacteroides ovatus
  ORGANISM  Bacteroides ovatus
            Bacteria; Pseudomonadati; Bacteroidota; Bacteroidia; Bacteroidales;
            Bacteroidaceae; Bacteroides.
REFERENCE   1  (bases 1 to 21141)
  AUTHORS   Wu,M., McNulty,N.P., Rodionov,D.A., Khoroshkin,M.S., Griffin,N.W.,
            Cheng,J., Latreille,P., Kerstetter,R.A., Terrapon,N., Henrissat,B.,
            Osterman,A.L. and Gordon,J.I.
  TITLE     Genetic determinants of in vivo fitness and diet responsiveness in
            multiple human gut Bacteroides
  JOURNAL   Science 350 (6256), aac5992 (2015)
   PUBMED   26430127
REFERENCE   2  (bases 1 to 21141)
  AUTHORS   Wu,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-OCT-2015) Center for Genome Sciences and Systems
            Biology, Washington University School of Medicine, 4444 Forest Park
            Ave., Saint Louis, MO 63108, USA
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP012938.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            ##Genome-Assembly-Data-START##
            Assembly Method       :: HGAP 2.0 and Celera v. AUG-2014
            Genome Coverage       :: 350X
            Sequencing Technology :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001314995.1-RS_2025_01_08
            Annotation Date                   :: 01/08/2025 18:05:31
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,927
            CDSs (total)                      :: 4,834
            Genes (coding)                    :: 4,763
            CDSs (with protein)               :: 4,763
            Genes (RNA)                       :: 93
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 14 of 71
            Pseudo Genes (incomplete)         :: 53 of 71
            Pseudo Genes (internal stop)      :: 11 of 71
            Pseudo Genes (multiple problems)  :: 7 of 71
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..21141
                     /organism="Bacteroides ovatus"
                     /mol_type="genomic DNA"
                     /strain="ATCC 8483"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:8483"
                     /type_material="type strain of Bacteroides ovatus"
                     /db_xref="taxon:28116"
                     /geo_loc_name="USA:Woods Hole"
                     /collection_date="2009-10-11"
     gene            1..2745
                     /locus_tag="Bovatus_RS00070"
                     /old_locus_tag="Bovatus_00014"
                     /db_xref="GeneID:29455418"
     CDS             1..2745
                     /locus_tag="Bovatus_RS00070"
                     /old_locus_tag="Bovatus_00014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004296998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component regulator propeller
                     domain-containing protein"
                     /protein_id="WP_004296998.1"
                     /db_xref="GeneID:29455418"
                     /translation="MKKYILQLIIVLVFILLKVEGVYSSSPMNYYNITTFEGLPSNTV
                     NAIKKDVSGFIWIGTKVGLCRFDGCEVKTYPLLSEDDIWSIEELDSDTLLLGTVSGLK
                     YFSRKTNVTVKLDIPSAIVKSIWKIADSQFLVGTEAGLYFINNHTPRQIFLETGLSPC
                     NHITSIICEDKNIYWFSTADGLGRIDIRTMQPEIYRMPEEISNSNFFICLTRMGNHIY
                     LGSFNKGIFSFDMSGKKFAKVNGFEHNLIMTIDGQDNQLFVGTNGQGLKVLSLEDGSI
                     EVISHKEKARNSISSNTITAFLYDNGIRWIGTQFGGISYTPRIGAKFSYYSKNDFYST
                     DYRVRSFYMFPNGDKLIGTRTGLFFICEKTGEIRSYSLEKNFSNLRSDIVVFINRIQD
                     KILIGTYGGGVHVFDEKTWSLRDFSHEELFLYGCILNIVDDAKGNLWFASQSGLYQST
                     PEGHVLKKYDTMNSVLTTNAILCLCVDSMNRLWVGSKFGLFLLDIATGKMRADCFSVP
                     IKAEIKYIMEDLRKDMWVCTDNGLYKIGKDLVVHEHFTTDNLLPDNQVPCILEDSHGI
                     YWIATQKEIVRYNPIEEQHYTYQRQDGLSGLEFNNSVFVSNDSIIWWANEGGLVYTTT
                     GNINTERRIISTPIITSYAISNIEYDFPYMDMSKGIELPSSENTLRFKFSNMDYALPY
                     ANFYEYKLEGYDKEWLKQTGINEVSYKDLPGGHYVFKLRVPGGEKQMQTVDIYVRKSY
                     TFMAGILLMVLIISILVIYFCYRIWKLKKRMTDERMILSKVQERSKDKKAALPEMKVN
                     GILDNLLSYLEHEKPYLNPKLSIGDVAAKLDCTETELSQLLNNHMNVNFSNFINVYRV
                     NEIKKRLNQENLSKYTLKALSEQCGFSSKATFYRVFKNVTGMTPLEYCKKQNLVIKEN
                     "
     gene            2974..3384
                     /locus_tag="Bovatus_RS00075"
                     /old_locus_tag="Bovatus_00015"
                     /db_xref="GeneID:29455391"
     CDS             2974..3384
                     /locus_tag="Bovatus_RS00075"
                     /old_locus_tag="Bovatus_00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004319616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004296997.1"
                     /db_xref="GeneID:29455391"
                     /translation="MKSILEVIILLLLSFLIGSNKSVDTACSLPDTSQWSVANSDICL
                     KVNGDSIFWTMKSDKKDIPAITASARYNLLTSGRISLTYSLPLLSQDLSYIYGERNEI
                     LHRHIIHAFLCKQEDDKLVFYSSAGDSIVFCRKN"
     gene            3386..3916
                     /locus_tag="Bovatus_RS00080"
                     /old_locus_tag="Bovatus_00016"
                     /db_xref="GeneID:29455360"
     CDS             3386..3916
                     /locus_tag="Bovatus_RS00080"
                     /old_locus_tag="Bovatus_00016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004319614.1"
                     /GO_function="GO:0003700 - DNA-binding transcription
                     factor activity [Evidence IEA]; GO:0016987 - sigma factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]; GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_004296996.1"
                     /db_xref="GeneID:29455360"
                     /translation="METEDMQTMNSTTNQLLTETYTSLCPIIIHYINRKINDYESARD
                     MAQDVFLRLMEYKQILRKETVRSMAFFIAHNLVVDYLRRYYKKQEMSAYFYEYGVNIT
                     DDTESGVIANDLSAQENLKLLLLSPQRRTVYIMSRFQGKTAPEISEELCLSRRTIENH
                     LLASRKEIREYIKSCI"
     gene            4014..7172
                     /locus_tag="Bovatus_RS00085"
                     /old_locus_tag="Bovatus_00017"
                     /db_xref="GeneID:29455350"
     CDS             4014..7172
                     /locus_tag="Bovatus_RS00085"
                     /old_locus_tag="Bovatus_00017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004319611.1"
                     /GO_component="GO:0009279 - cell outer membrane [Evidence
                     IEA]; GO:0016020 - membrane [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SusC/RagA family TonB-linked outer membrane
                     protein"
                     /protein_id="WP_004296995.1"
                     /db_xref="GeneID:29455350"
                     /translation="MMASALLAGSPWTAFADTDNILEVLQNSTVRGKVVDASGEPVIG
                     ASVVVKGTTTGVITDLDGNFILNNVSEKSILVISYVGYKSQEIAVSGKSAINVTMQED
                     SEMLDEVVVVGYGAMKKSSLTGSVTVVDSKIFENKGSMSNPLQALQGQAPGVRITRSS
                     SAPGEEGWGVSLRGAVSKNTTEPLLIIDGVPSDAVSDLQYLNPSDIETMNFLKDASAA
                     IYGAKAAGGVIIVTTKRPQAGKLKIEYNGSYTRKMPGLQAELMSLDEWAGSFLQAMEN
                     DGLDDTYTWYRYVKLMQANKGGFINVHDGSNPNPIPGMGVNDYVFHDVNWTDVMWGPA
                     NSTQHDLSFSGGNEKVTYRLSAGYLFDDSNLRWGENNNQQYTFRSSNVIKATDRLTIE
                     SVISAVRKEQVTPTQIGRALNVTTPLPGRPVSTIDGKPYLWGTDYTANWLLELGGENK
                     LVVTTFNLNETLKYQFTKELTASATFGYSTNSAIRDEKMKSIQWYHYDGTVNTSTANP
                     YPTQAESKYTKRASRTDNYSVSGYLNYAKTIGKNHNINVMAGMQYDRRDYEITGTSAT
                     DIQSELGIINGNGVISIAEAKKNSYALLSYFGRLNYNYNQKYLIEFNARYDGSSKFQP
                     ENRWKGFYGVSAGWRITEEAFMVNIKKYIEELKIRASYGEVGNQSGIGLYDGVQLYNF
                     NTASGAYIGDGKVSYIAAAKELVTTNRTWERIKNYNVGFDFTVLNSRLTGSVDLYMKK
                     NDNMLIGLLYPGTLGGNAPASNNGKFESKGYEGMLRWSDKIGEVSYHIGGTYTYMENK
                     LLSGGNDVISAGFNSTINGYPLNSVFGYRYAGKIQNEEDLQAYKNLYYGNNTLSMPSN
                     LRVGDHMYEDVNKDGKLTQDDLVFLGTDDPKVTFAFDLGLEWRGFDVSAIFQGAAQRT
                     VCRDADSWKVPFKAVWMNTSNHTIGKVWSPENPNGRYPAYSTKSEINNWNYMPSSWFI
                     EDGTYLRLKNLTVGYTIPKAILTKITKGVLENFRVYVTGTDIWENSKINDGWDPEATR
                     KVSDRQRYPFTRTYTVGLNATF"
     gene            7186..8940
                     /locus_tag="Bovatus_RS00090"
                     /old_locus_tag="Bovatus_00018"
                     /db_xref="GeneID:29455348"
     CDS             7186..8940
                     /locus_tag="Bovatus_RS00090"
                     /old_locus_tag="Bovatus_00018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004319608.1"
                     /GO_component="GO:0009279 - cell outer membrane [Evidence
                     IEA]; GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_function="GO:2001070 - starch binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RagB/SusD family nutrient uptake outer membrane
                     protein"
                     /protein_id="WP_052587867.1"
                     /db_xref="GeneID:29455348"
                     /translation="MKLSNLYTTLLFSLCLLFQSCLDMNPEEQLSDGDMWQNRGQFEA
                     FAKNFYGWTRDFGGLGDAHGDVQADLFSTNPRNLFSNGTSTIPLTDKSYTDAYANLRQ
                     VNLLLQKAESYALPEEIKIPVGEAYFFRAYIYFDLLQRFGGVIKVEEPLDITSPELYR
                     TQNTREEINEFIISDLNEAIALLPKFKDITAANAGTISLEGAQAFLSRVGLYAGTWEK
                     FHNGNGSNTELSKKWLKIAYEAADAVIESKTFELFKPSDLVIEGDEGAAYRYLFILEN
                     EKSNPAGLNKSANKEYIFSRRHDTTLAPIGINITEGRFNNALYVTRKLANMYLQKSTG
                     LPIDISKWNYATKNSEYFDRDNRMTSIMMVDGGFYFSSNGGRYRRTWLGDAAEIKEAG
                     VTAHNAAGGTGYRCRKWCSEREVENRKEGYDYPIIRYAEVLLNYAEAKFEYDDNILDP
                     DLDKSLNLVRLRVNPTMPKLSNGLLRGTGTNMRTEIRRERTVELIDECFRLDDLKRWK
                     TAENEMPEDMLGIKYTGTAFETSGWAGVVTNTEGCLIWESGRKWDNKQYLYPFPLDQL
                     QLNTNLRPNWQSTNPYVK"
     gene            8959..10482
                     /locus_tag="Bovatus_RS00095"
                     /old_locus_tag="Bovatus_00019"
                     /db_xref="GeneID:29455338"
     CDS             8959..10482
                     /locus_tag="Bovatus_RS00095"
                     /old_locus_tag="Bovatus_00019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004319606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_052587861.1"
                     /db_xref="GeneID:29455338"
                     /translation="MKRIYTLSKTMAFLFSCMALIGTVISCADDYNTDPLTKNTILSS
                     ITIDEKYEVYTLVKGENYTLHFSTLPEDATNPGVSWVSGNEEVATVDANGKVTAVAVG
                     TSVITAKPAVGYADGVSAAITISVVEELALTQSVEITNLPEELTMMETQSVQLKTKTV
                     PEKPSFYLLSWKSSDEKVATVDENGRVLAVGEGKATITATTTDGTDLSHSVEVTVKPV
                     IHVETFEMSSIHNKLAKGEISVLKYTVTPADATVSALVWTTSDATVASIEKRVLGEEE
                     VFVILGGVNSGTATLTASITYADGSPGFEKSFEVSVVDGKINDDFLFTAGCFEGGDYG
                     VLENGRLVRKIEKEANAKCEAQFRGTMTFYPSKYPIYAVKTFFEDSLDPAKTPTLLLN
                     IWNNNPRISIGFYGGTAAGNAQNLYKVSMTRTSDGGYVTYADLSTPNIFKGANADFLT
                     NGVLNDGITLDRCEHRFYDTYYTEAVTEPFALDWVKTFESLEAYKAYLIENEGVVFE"
     gene            10503..11861
                     /locus_tag="Bovatus_RS00100"
                     /old_locus_tag="Bovatus_00020"
                     /db_xref="GeneID:29455336"
     CDS             10503..11861
                     /locus_tag="Bovatus_RS00100"
                     /old_locus_tag="Bovatus_00020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004296992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alginate lyase family protein"
                     /protein_id="WP_004296992.1"
                     /db_xref="GeneID:29455336"
                     /translation="MKKKMITLAMVLFTFLSCSNKDYFDEGHVDLTPGYTIEEEDTYK
                     VYTLNHPCLMHTNDDFQYVVGKIKTGAQPWGAAWEFLEQNQYTQLNENWTTDAPEILL
                     RNSSGGNFKVAREPGLAAYYLALRWRIAEGLGEEDAYKYADKAVKILDNWSTVCKAIQ
                     VENTNDHYALVTGFDGHRFAQAAEVMRDYQPWVDNGGFSKFQTWLKNVVAGPATYFIS
                     QKTDPYWSWGGWEVPNVAIMLAIGIVCDDQDMINEAINYYKHGPSSGCIQHLVVALHQ
                     DPAGLGEGYCLGQADESGRDQDHAGLSMATLAPMCQAAYNIGEDLYGIKANDSFTTED
                     GRVYNRYPKYAEYGDVNLTLAFFEYYAKFNCDPIEAVDMPFTYWETRHGQQNEISYQG
                     RGHFYAGYEMIYSHYKHVKGVSAPYSKKFAEKYRPATSIHPFEYDNDFPGIGTLMFYK
                     GE"
     gene            11946..13373
                     /locus_tag="Bovatus_RS00105"
                     /old_locus_tag="Bovatus_00021"
                     /db_xref="GeneID:29455330"
     CDS             11946..13373
                     /locus_tag="Bovatus_RS00105"
                     /old_locus_tag="Bovatus_00021"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004319603.1"
                     /GO_function="GO:0004348 - glucosylceramidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006665 - sphingolipid metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 30 protein"
                     /protein_id="WP_052587866.1"
                     /db_xref="GeneID:29455330"
                     /translation="MKLKTITAFFAITWAVSTTVSAQKVSIYSTTSTERWVEKKQTLD
                     KNPAGQADICVYPDSLLQNVVGFGGTFNELSWDALQCLSPAERDKVMAALFSEEGIHF
                     ALGRTPIGASDYAMGYYSYNDVKDDYTMRNFSIDRDRYILIPYIKEALKLRPDLKMWA
                     SPWTPPAWMKVNEHYSQKSSGIEGTEVGHNRLDPHRNLIGNVTGFKMQQGYLQAYAIY
                     FSKYVQAYKQNGINIQMIMPQNEIAWTPCWPSCTWRPEDLAIFVNQYLGPQFEKDSID
                     TEIWMGTVNYPNPDYVRTFFKQKDSDKYVKGVGVQWTGMRALPAVHKEYPDYCYMQTE
                     NMCGNSENDWSALENTWNAVVHCFNNGVDSYIYWNMVLNETCKSWWDWAQNTLIIIDR
                     KTGQVRYTDEYYLMKHLSHFVQPGSRLLKVSDGKNTLAFRSHDGKVVVVAYNPEEQER
                     SCSFKVGSKYIRVILKGKSINTIVI"
     gene            13547..14935
                     /locus_tag="Bovatus_RS00110"
                     /old_locus_tag="Bovatus_00022"
                     /db_xref="GeneID:29455328"
     CDS             13547..14935
                     /locus_tag="Bovatus_RS00110"
                     /old_locus_tag="Bovatus_00022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004296989.1"
                     /GO_function="GO:0004650 - polygalacturonase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl hydrolase family 28 protein"
                     /protein_id="WP_004296989.1"
                     /db_xref="GeneID:29455328"
                     /translation="MKRQICSILLFIFCVTLQAQLVTYPEGLKANMPHNDDYTVRVRI
                     PGGEWEDLFEYNVQVDMDAVQNASMVQFDMNGTVEVMVKKNNGTVREVDIRPLSCNIQ
                     YRQNKNVITFMLDKPQYLSVEFNGDRLHNLHLFANPLETEVYKKAEKGIMYFGPGVHA
                     PLDLPNNLIRVLGNTTVYLAPGAVLKAKLLVDGVENVRIIGRGILAHPVRGIEVTNAK
                     NVLIDGITVVNPNHYTVFGAGTKGLTVKNLKSFSCKSWSDGIDLMCCRDVLIDNVFMR
                     NSDDCIALYNHRWNWWGGSGNITVQNAVLWADIAHPINIGGHGDPESPVGEVMENLTF
                     RQIDILEHDEDDVPYQGCMAIDCGDKNLVRNVLFEDIRVESIQEGRLFHLNVRFNEKY
                     DKAPGRGIENVTFRNITYDGLGENPSLIKGFDNSRKVKNVIFDNVVINGQRMTDLNGF
                     VKNEFVEDIRVR"
     gene            14980..16911
                     /locus_tag="Bovatus_RS00115"
                     /old_locus_tag="Bovatus_00023"
                     /db_xref="GeneID:29455323"
     CDS             14980..16911
                     /locus_tag="Bovatus_RS00115"
                     /old_locus_tag="Bovatus_00023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004319599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 127 protein"
                     /protein_id="WP_004296988.1"
                     /db_xref="GeneID:29455323"
                     /translation="MIMSKQFLVAIALLAVSAISSAQSVYPGQHQGKMKKETVAPVRV
                     ESFDLKDIRLLPSRFRDNMLRDSAWMTSIDVNRLLHSFRTNAGVFAGREGGYMTVKKL
                     GGWESLDCELRGHTTGHLLSAYALIYAATGSEIFKLKGDSLVNGLTEVQNALKGGYLS
                     AFPEELINRNIRGKSVWAPWYTLHKLYSGLIDQYLYADNLQALKVVTKMGDWAYNKLK
                     PLTEETRKLMIRNEFGGINESFYNLYAITGDERYRWLAEYFYHNDVIDPLKELRDDLG
                     TKHTNTFIPKVIAEARNYELTRNETSRKLSEFFWHTMIDHHTFAPGCSSDKEHYFDPK
                     KLSQHLTGYTGETCCTYNMLKLSRHLFCWTGDSSIADYYERALYNHILGQQDPETGMV
                     AYFLPLLSGAHKLYSTKENSFWCCVGSGFENHAKYGEAIYYHNNQGIYVNLFIPSQVT
                     WKEKGLTIRQETEFPQEETTRFTLRTENPVRTTIYLRYPSWSKDVKVLVNGKKISVKQ
                     KPGSYIVITREWKDGDQISATYPMQIKLEATPDNPDKAALLYGPLVLAGERGTEGMQA
                     PAPFSNPALYNDYYTYNFHVPAHLRTSLKLDKKHPERALQRVGSDLKFTTEQGDVIRP
                     LYDLHRQRYVVYWDLQSEK"
     gene            16927..18852
                     /locus_tag="Bovatus_RS00120"
                     /old_locus_tag="Bovatus_00024"
                     /db_xref="GeneID:29455322"
     CDS             16927..18852
                     /locus_tag="Bovatus_RS00120"
                     /old_locus_tag="Bovatus_00024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004296987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_004296987.1"
                     /db_xref="GeneID:29455322"
                     /translation="MKNRLLIAAFVSICFLSGSCKISSGQGKQYDFSSLDSVIQGWVD
                     KGYYPGASICVVKNDTVIFQKNYRDYTPDTKVYVASAGKWVAAAVIGAVVDRTDLGWD
                     DPVEKWLPEFKDDAKGKILLRQLLSHTSGVRPYLPEPRVDNYNHLDSAVTEILPLDTV
                     FTPGTRFEYGGLAMQIAGRMAEVAMGKEFETLFQELLAQPLEMKNSHFTPINTDGGHA
                     PMLGGGLCTTMNDYLHFLSMIYHDGMYNGKQIISAETVKEMQADQVKGAIIPSNNSDN
                     YVAKGLGQSHNGIYGLGEWRELIDKKTGEAYQISSPGWAGAYPWINKHDKVYGFFISH
                     VTGSSAKEDGFSSFFGSPVISRTVSEILKGKPLVVKQGRINVGNGSLYYEEAGQGEPI
                     IFVHGHSLDHRMWDEQFSVFAKKYHVIRYDLRGYGTSSSQTEDYQFMHVEDLVTLMDS
                     LHIKKAHIVGLSLGGFITADMLAYFPDRMLSAFLASGNIRKSKGPSEPMTKEEAKVRD
                     EEIAALKQKGVEVMKKEWFEGLMKSGGSQRERMRVPLWQMIDEWDAWQPLHKEVRVVA
                     GLDAIEELKKSHPAVPALIVEGHSSDNKFSKNPPILEYLPNGKLKIIEDCGHMMNMER
                     PEEFNAALEEFLINIEQ"
     gene            18874..21141
                     /locus_tag="Bovatus_RS00125"
                     /old_locus_tag="Bovatus_00025"
                     /db_xref="GeneID:29455321"
     CDS             18874..21141
                     /locus_tag="Bovatus_RS00125"
                     /old_locus_tag="Bovatus_00025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004296986.1"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heparinase II/III domain-containing protein"
                     /protein_id="WP_004296986.1"
                     /db_xref="GeneID:29455321"
                     /translation="MKQIVLCLIGILFASFVSAQKINHPSLLYTPQRIQQVKQRMQNE
                     PKLREAWEDIQKTADEALQKKDFNRLDYLSLAYLMTDNKEYANIIKEILLKAVEAESW
                     GDMEMMARIPVWRSQLGMAHKSFLSAIGYDAAYNIMSSSERKKIAEGLKRLAVEPALG
                     DWLLEPARIHSLNSMGHNWWTSCVCQGGILALSLQNELPEVKDWVEQLHESLPEWFDF
                     AGDALQQKAKSFDEAGGMYESLNYANFGIQEALLFRIAWINTHPGQNPGDIPQLAKLP
                     NYFSQVCYPRTGMLYSLNFGDSHKNVSAESSMMLLYALGLKDPTILWYIAQVEQGQHR
                     DGFFLNRPMGFLYTPDLSKAPVTPDLKTSQLFSDFGWATMRTSWEKDATMLAVKSGHT
                     WNHSHADANSFIVFHKGVDIIKDGGNCWYPNPAYRNYFFQSQAHNVVLFNGEGQPREQ
                     QYSGSTLRGNLYHLLDAGNVKYVLANGTGPVSNNFSRNFRHFLWMDNVIYMIDDLKTH
                     KVGQFEWLWHTNGTYKKSGIDVNVINGNSSVVIRPLYPRMLAKSDFVHDYPEDLYWEE
                     IEAPTEDLKGTEKYYSFHLPAEVNRVKGLTAIILKDAPDEKDLPQMERREGQDWIGLR
                     IRHKGKITDLYINQLADGRLMHSNSWIMPDGWMTDAYMFAVSYPEGTEAKNAKDFFIA
                     YGSALRRGNETYFSSLAKLFVIQKAEDKKLDLWINGQPKINTTFRSTKKPVSVEVNDK
                     KIPVVYQKSQIKVKL"
ORIGIN      
        1 atgaaaaaat atattctgca attaatcata gtactggttt ttatactact taaagttgaa
       61 ggagtttatt cttcttctcc tatgaattat tataatataa cgacttttga gggactgcca
      121 agtaatacag taaacgcaat aaagaaagat gtatccgggt ttatctggat tggaacgaag
      181 gtggggttat gccgtttcga cggatgtgag gtgaaaactt atcccttact gtcagaagat
      241 gatatttggt cgatagaaga attggatagc gatacattgc tgcttggtac agtttccgga
      301 ctgaaatact ttagtcgtaa gactaatgta acggtaaaac tggacattcc atctgcaata
      361 gtcaaatcaa tctggaagat tgcagacagc caatttcttg tgggaacgga agctggtctt
      421 tattttataa ataatcatac tcctcgccag atatttttag aaaccgggct ttcaccgtgc
      481 aatcatatca cgtctattat ttgtgaggat aagaatatat attggttttc taccgccgac
      541 gggttgggta gaatagatat ccggacgatg caaccggaga tttaccggat gccggaagag
      601 atatcaaaca gcaatttctt catttgtctc acgcgtatgg gcaaccatat ctatttgggt
      661 agtttcaata aaggaatatt cagctttgat atgtccggaa agaaatttgc caaagtgaac
      721 ggttttgaac ataatctgat aatgacaata gacggacagg ataaccaatt gtttgtcggt
      781 acaaatggac agggattgaa agtgttgtct ttggaagatg gaagtatcga agttatttca
      841 cataaggaga aggcacggaa ttctatcagt tccaatacaa tcactgcatt tttatatgat
      901 aatggcattc gttggattgg aacccagttt gggggaatca gttatacacc tcgtattggt
      961 gccaagttct cttattacag taaaaatgat ttttactcaa ctgattatcg ggttcgtagt
     1021 ttttatatgt ttcctaatgg agacaagctg attggtacaa ggacagggct tttctttatt
     1081 tgtgaaaaaa caggggaaat aagaagttat agtttggaga aaaacttttc taatttgcgg
     1141 tcggacatag tagtgtttat aaatcggata caggacaaaa tattgatagg tacttacggt
     1201 ggaggggtgc atgtttttga tgaaaaaaca tggtctttaa gggacttctc ccatgaagag
     1261 ttgtttctgt atggttgcat tcttaatatt gtagacgatg cgaaggggaa tttatggttt
     1321 gcttctcaaa gtggacttta tcagagtacc cctgaaggac atgtgctgaa gaaatatgat
     1381 acgatgaact ccgtcctgac aacaaatgcc atattatgtt tgtgtgttga ttcgatgaat
     1441 cgtctatggg taggtagcaa attcggtctg tttttattgg atattgctac ggggaagatg
     1501 cgtgcggact gttttagtgt tccgataaag gctgaaatta agtatattat ggaggacttg
     1561 cggaaagata tgtgggtttg tacggataat ggtttgtata agatagggaa ggatttggtt
     1621 gttcatgaac attttactac tgataatctg cttccggata atcaagtgcc ttgtatcctg
     1681 gaagatagtc atggaattta ctggatcgct acacaaaaag agattgtacg ttacaatccg
     1741 atagaagaac agcattatac atatcagaga caggatgggt tgagcggtct ggaatttaat
     1801 aatagtgtct ttgtttccaa tgacagtatt atctggtggg ccaatgaagg cgggttagtc
     1861 tataccacaa ccgggaatat taatacagaa cgtcgtatta taagtacccc tataataaca
     1921 tcgtatgcta tttctaatat agaatatgac tttccgtata tggacatgtc gaaaggaatt
     1981 gaattgcctt cttctgaaaa tactcttcgt tttaaatttt ctaatatgga ttatgcgttg
     2041 ccttatgcca atttctatga gtataagttg gaagggtatg ataaggaatg gttgaaacag
     2101 acagggatta atgaagtttc ttataaggac ctaccaggag gacattatgt cttcaagttg
     2161 cgtgtcccgg gcggtgaaaa acagatgcag actgtggata tctatgtccg gaaatcatat
     2221 acttttatgg caggcatatt attgatggtt ctaataataa gtattctagt aatatatttc
     2281 tgttaccgga tatggaaact taaaaagcgg atgacggatg agcggatgat attaagtaag
     2341 gttcaggaga gaagtaaaga taaaaaggcg gcattgcccg aaatgaaagt gaatggtatc
     2401 ttggataatt tgctttccta tttggaacat gaaaagcctt atctgaatcc aaaattaagt
     2461 attggggacg ttgctgcaaa attggactgt accgagacag agctttctca attgctcaat
     2521 aaccacatga atgtgaactt ctctaatttc attaatgtat atcgtgtcaa tgagattaaa
     2581 aaacgtttaa atcaggaaaa cctctcaaaa tatactttga aagctttgtc agaacaatgt
     2641 ggctttagtt ctaaggctac tttctataga gtattcaaga atgtaactgg catgacacca
     2701 ctagaatatt gtaagaaaca gaaccttgtg ataaaagaaa attgagtaaa acctatattc
     2761 tcattttttt tgagacaagt tttatgacgc ttatctgctt gtataacaat actttatgct
     2821 gaaaatgtaa ttctcatttt agttgagata aaacagcgct tctattgttt ggaaataggg
     2881 tgagattgtg tgtagttttg catcagacag ggacagaaag cctttcgaat aaggcacgaa
     2941 tccttgctga tgtttaacta aataatcaat attatgaaga gcattttgga agttataatc
     3001 cttttacttc tttcctttct gataggaagt aataagtcgg ttgatactgc ttgttcattg
     3061 cccgacacct ctcaatggag tgtggctaat agtgatattt gtttaaaggt gaatggagat
     3121 tcgatttttt ggactatgaa atctgataaa aaggatattc ctgctatcac ggcatctgcc
     3181 agatacaatt tgcttacttc cggaagaatc agtctgacgt acagcttacc tttattatct
     3241 caagatttgt cctatatcta tggagaaagg aatgagatac tgcatcgtca tattatccat
     3301 gcattcttat gtaagcagga agatgataaa ttggtatttt attcatctgc gggtgattct
     3361 attgtttttt gtcgtaaaaa ctaaaatgga gacggaagat atgcagacaa tgaattctac
     3421 tacaaatcaa ttattgactg aaacttacac atccttatgt cccataatca ttcattatat
     3481 aaatcgtaaa atcaatgatt atgaatctgc cagagacatg gcgcaggatg tatttcttcg
     3541 tctcatggaa tataagcaaa tacttcgtaa agagacagtg agaagtatgg cgttcttcat
     3601 agctcacaat ctggtggttg attatttgcg acgttattac aagaagcagg aaatgtctgc
     3661 ctatttctat gaatatggcg tgaacattac tgatgataca gagagcgggg tgatagccaa
     3721 tgacctgtcg gcacaagaaa atctgaaact acttctactt tctccgcagc gtcggacagt
     3781 ttatataatg agtcgtttcc agggtaagac agcacctgaa atctctgaag aattgtgcct
     3841 ttcgcgacgt accatagaga atcatttact ggctagccgt aaagagattc gtgaatatat
     3901 caagtcatgt atttgagagt tatactatat caacaaaatt gttaatttta aattttaaaa
     3961 atgtgaataa gaagttattg aaattttcat cgaaaagaat attatattct gcgatgatgg
     4021 cttccgctct attggcagga agcccgtgga ctgcttttgc agacacggat aatatactgg
     4081 aagtgttgca aaacagtacc gtacgaggta aagttgtcga tgctagcggt gaacccgtta
     4141 tcggtgccag tgttgtggtg aaaggcacaa caacaggagt gattacagac ttggatggaa
     4201 actttatatt gaataatgtt tctgaaaaat caattctggt tatatcttat gtggggtata
     4261 agtcacagga gattgctgta agcggaaagt ccgccataaa cgtcacgatg caggaagata
     4321 gtgagatgtt ggacgaagtc gttgttgtgg ggtatggtgc tatgaagaaa tcttcattga
     4381 ccggttccgt aacagttgtt gatagcaaaa tattcgaaaa taaaggaagt atgtccaatc
     4441 ctcttcaggc attgcaagga caggctcccg gtgttcggat tacacgttca tcatcagctc
     4501 cgggtgaaga aggttgggga gtatcccttc gtggtgcagt ttccaaaaac acaacagaac
     4561 cgttgcttat tatagacggt gttccttcag acgcagtttc agacctgcaa tatctgaacc
     4621 cttcggatat cgagactatg aacttcttga aagatgcttc ggcagctatc tatggagcaa
     4681 aagctgcggg tggtgtgatt attgtaacaa ccaaaagacc gcaggccggt aaacttaaga
     4741 tagagtataa tggctcatat acccgtaaga tgccgggact tcaagctgaa ttgatgagcc
     4801 tggatgagtg ggctggttca tttctgcaag caatggagaa tgacggcctt gacgatactt
     4861 atacatggta tcgatatgtc aagttgatgc aggcaaacaa aggtggtttc attaatgtac
     4921 atgacgggag caatcccaac ccgattccag gtatgggtgt gaacgattac gtttttcatg
     4981 atgtcaactg gacggacgtg atgtgggggc ctgccaattc tacgcaacac gacttgagct
     5041 tttcaggagg taacgaaaag gtcacttacc gtttgtcggc cggttatttg tttgatgact
     5101 ccaacctgcg ttggggggaa aataacaatc aacagtatac tttccgttcg agtaatgtaa
     5161 ttaaggccac tgaccgtttg actatcgagt ctgtcatatc agcagtccgt aaagagcaag
     5221 ttactcctac gcaaatcgga agggcgttga atgttacgac tccgttgcca ggtcggcctg
     5281 tttcaactat tgatggcaag ccttatttgt ggggtaccga ctatacagcc aattggttac
     5341 tcgaattagg tggtgagaat aaattggtgg tgacaacttt caatttgaat gaaacattaa
     5401 agtatcagtt tacaaaagaa ctgactgctt ctgcaacatt cggatattca acgaacagtg
     5461 ctatacgtga cgagaaaatg aaatctatcc aatggtatca ttatgatgga acagtgaata
     5521 cctctacagc aaatccctat cctactcaag cggaatcaaa atatactaaa cgtgcttccc
     5581 gtacggataa ttactctgta tcaggttatt tgaactatgc gaaaacgata ggtaaaaatc
     5641 acaatatcaa tgtaatggcc ggtatgcaat acgatcgtag agattatgaa atcaccggaa
     5701 cgtctgccac tgatatccag tcggaactag gtatcattaa tggtaacgga gtcatttcta
     5761 ttgccgaagc caaaaagaac agctatgcgc tcctttccta tttcggacgt ttgaattata
     5821 actacaacca aaagtatctg atagaattta acgcgcgcta tgatggttct tcaaagtttc
     5881 aaccggaaaa cagatggaaa ggtttctatg gtgtttcagc aggttggaga attaccgaag
     5941 aagcgtttat ggtgaatatt aaaaagtata ttgaagaatt gaaaattagg gcttcttatg
     6001 gtgaggtcgg caaccaaagc ggtatagggc tttacgacgg ggtgcaactc tataacttca
     6061 atacagcttc gggcgcctat attggcgacg gaaaagtttc atatattgct gcggctaaag
     6121 aactggtgac aaccaataga acttgggaaa gaatcaaaaa ttataacgtc ggttttgatt
     6181 ttacagtact gaacagccgt ttgactggta gcgtagacct ctatatgaag aaaaacgaca
     6241 atatgttgat cgggttgctg tatcccggca ccttgggtgg caatgctccg gcaagtaaca
     6301 acggaaaatt cgaaagtaaa ggatatgaag gtatgcttcg ttggagtgac aaaataggag
     6361 aagtgagcta tcatattggc ggaacatata cttacatgga aaataagttg ttgtcaggag
     6421 gtaatgatgt tatctctgcc ggtttcaaca gcacgataaa cggttatccg ttaaactctg
     6481 ttttcggtta ccgatatgca ggaaaaatac agaatgagga agatttacag gcatataaga
     6541 acctgtatta tggaaacaat acgctttcaa tgccctcgaa tttacgcgtg ggtgaccaca
     6601 tgtatgaaga tgtgaataag gatggtaagc ttacacagga cgatttggtc tttctcggaa
     6661 cagatgaccc caaagtaact tttgcctttg accttggatt ggaatggaga ggttttgatg
     6721 tgtctgctat ttttcaaggt gcggcacaaa gaacggtttg tcgcgatgca gactcttgga
     6781 aagttccttt caaagcagtg tggatgaata cgtcaaacca tacgattgga aaagtctgga
     6841 gtccggaaaa ccctaatggc agataccctg cctattcaac taaatcagaa atcaataact
     6901 ggaattatat gccttcttca tggtttatag aagatggtac atatctccgg ttgaagaatc
     6961 tgacagtggg atatactata ccaaaagcca tattgacaaa gataaccaag ggtgtacttg
     7021 aaaatttcag ggtatatgtt accggtacgg atatttggga aaactcaaaa attaatgatg
     7081 gctgggatcc ggaagcaacc cgcaaggtaa gtgacagaca gcgttatcca ttcacaagaa
     7141 catatactgt tggtttaaat gcaacattct aatactatat ataatatgaa actatcgaat
     7201 ttatatacta ccttactttt tagtttgtgt ttgttgttcc agtcatgtct ggacatgaat
     7261 cccgaggagc aactctcgga tggcgacatg tggcagaatc gcgggcaatt cgaagctttt
     7321 gccaagaatt tctatggttg gacacgcgat ttcggtggct tgggggatgc tcacggtgat
     7381 gtacaagcag acctgtttag tacaaatccc aggaatcttt tcagtaatgg aacatctacc
     7441 attccactta ccgacaaaag ctatacagat gcttatgcca atcttcgtca agtaaatctg
     7501 ttgttacaaa aggcagaatc ttatgctctt cccgaagaaa ttaagatacc tgttggtgag
     7561 gcatattttt tcagggctta tatctatttt gacctgcttc aacgttttgg aggagtcatt
     7621 aaggtggaag aaccgttaga tatcacttct ccggagcttt atcgcactca aaatacaaga
     7681 gaagaaatta acgaattcat tatctccgat ttgaacgaag cgatagcgct tttgccgaag
     7741 tttaaggata tcactgctgc aaacgcaggc actatttcac ttgagggtgc acaagccttt
     7801 ttatcccgtg tgggacttta tgcggggaca tgggaaaaat tccataatgg taatggaagc
     7861 aatacggaat tgtcaaagaa atggttgaaa atagcatacg aagctgctga tgcagttatt
     7921 gagtcgaaaa cattcgaact cttcaaaccg tctgatttgg ttattgaagg ggatgaaggg
     7981 gctgcttacc gttatttgtt tatactggaa aatgagaaat cgaatccggc cggtttgaac
     8041 aaaagtgcaa ataaagaata tatattttcc agaagacatg atacgacatt ggcacctatt
     8101 ggtatcaata ttaccgaagg tcgttttaat aatgcgttat atgtaacacg taaattggcc
     8161 aatatgtatc ttcaaaagag caccggattg ccgattgata tatcgaagtg gaattacgct
     8221 actaaaaatt cggagtattt cgaccgtgac aaccgcatga caagcataat gatggtagac
     8281 ggaggttttt acttcagtag caacggtgga cgttatcgta gaacgtggtt gggagatgca
     8341 gctgaaatta aggaagccgg agtgactgct cacaatgcag caggtggtac cgggtaccgt
     8401 tgtcgcaaat ggtgttcgga aagagaagtg gaaaaccgga aggaaggata cgactatcct
     8461 attattcgtt atgcggaggt gcttttaaac tatgcagaag caaaatttga atacgatgac
     8521 aatatcttgg atcctgattt ggacaaatcg ttgaatctgg tacgtttgag agttaatcct
     8581 actatgccta aattgtctaa cggactgctt cggggtacag gtacaaacat gagaacggaa
     8641 attcgtcgtg aacgtacggt ggaattgatt gatgaatgtt tcagactgga tgacttgaaa
     8701 cgttggaaaa cagcagaaaa cgaaatgcct gaagatatgt tgggaatcaa atatacggga
     8761 accgcttttg aaacttccgg ttgggcaggg gttgtgacga atacggaagg atgcttgatt
     8821 tgggagagcg gcagaaaatg ggacaataag cagtatttgt atcctttccc gctggatcag
     8881 ttgcaactga atacgaactt gcggcccaac tggcaatcta caaatcctta tgtgaaataa
     8941 ttttaatgtt ataattatat gaaaagaata tatacattaa gcaagacgat ggctttcctg
     9001 ttttcatgca tggcactgat aggaactgta atctcttgtg cggacgatta caataccgat
     9061 ccgctgacta aaaataccat tctatcatcg ataacgattg atgagaaata tgaagtctat
     9121 acactggtaa agggcgaaaa ctatactttg catttctcta ctttgccgga agatgcgact
     9181 aatcccgggg tgtcttgggt atcaggtaac gaagaggtgg ctacggtaga tgctaacggt
     9241 aaggtgacgg ctgttgctgt cggaacatcg gttattacgg caaaaccagc tgtcggatat
     9301 gcagatggag tatcggctgc cataacaatt agtgtagttg aagaacttgc gcttacacaa
     9361 tcggttgaga taaccaattt gcctgaagag cttaccatga tggaaacgca atcggttcag
     9421 ctcaaaacga aaactgtacc ggagaaacct agtttctatc ttctatcgtg gaaaagtagc
     9481 gatgagaaag tggctacggt tgatgaaaac gggcgagtac tggctgtggg agaaggaaaa
     9541 gcgacaatta ctgcaacaac tacagatggc acggatctgt cccattcagt tgaggtaacg
     9601 gtaaaacctg ttattcacgt ggaaacattc gagatgagtt ctatacataa caaacttgcc
     9661 aaaggtgaaa tatctgtgtt gaaatacact gtaacacctg cggatgcaac tgtatctgct
     9721 ttggtatgga ctacttccga tgctacagtc gcttccattg aaaaacgagt tttgggagaa
     9781 gaagaggtat tcgtcatctt gggaggtgta aattctggta cagcaacatt aacggcaagt
     9841 attacctatg ctgacggttc tccgggcttt gagaaatcat ttgaagtttc tgtggtagat
     9901 ggtaagatta atgatgattt cctctttacg gcaggatgtt tcgaaggtgg ggattatgga
     9961 gtattggaga atggtagatt agtgaggaag atagaaaaag aagccaacgc gaaatgtgaa
    10021 gcacagttcc gtggaacgat gactttctac ccgtcgaaat atcctatata tgcagtgaag
    10081 actttcttcg aagatagtct cgacccggcc aagactccca cattgttact taatatctgg
    10141 aacaataatc cacgaatcag tatcggattc tatggtggta ctgctgcggg taatgcacaa
    10201 aatttatata aagtaagcat gacaagaacc agtgatggcg gatatgtaac ttatgccgac
    10261 ttaagcaccc ccaatatttt caagggagca aatgccgact ttttaacaaa cggagtgctg
    10321 aatgacggaa ttacattaga ccgctgtgaa cacaggttct atgatactta ctatactgaa
    10381 gctgtaacgg aaccttttgc gctcgattgg gttaagacct tcgaatcatt ggaagcatat
    10441 aaggcttatc tgatagagaa tgaaggagtt gtttttgaat aattatttaa atgagatgaa
    10501 atatgaaaaa gaaaatgata actctagcga tggtgttatt tacattcctg tcttgtagta
    10561 ataaggacta ttttgatgag gggcatgttg acctgacacc gggttataca atagaagaag
    10621 aggatactta taaagtatac actttgaatc atccctgtct gatgcatacc aatgacgatt
    10681 tccaatatgt agtggggaag ataaaaacag gtgctcaacc ttggggcgct gcatgggagt
    10741 tcctggaaca gaaccaatac acgcaactta acgaaaactg gacaactgac gctcccgaga
    10801 ttcttttgag aaattcttca ggtggtaact ttaaagttgc cagagaaccg ggattggccg
    10861 cctattattt ggccttgcgc tggagaatag cagaaggact aggcgaagaa gatgcatata
    10921 agtatgcgga taaggctgtg aagattctgg ataactggtc gactgtatgt aaagcaattc
    10981 aagtggagaa tacgaatgac cattatgcgt tagttaccgg atttgacgga catcggtttg
    11041 cacaagcggc ggaagtaatg cgggattatc agccttgggt agataatgga ggattttcta
    11101 agttccagac ttggttgaaa aatgtagttg caggtcctgc aacctacttc atcagtcaaa
    11161 aaacagatcc ttactggtct tggggcggat gggaagttcc aaacgtggca atcatgctgg
    11221 caataggtat tgtatgtgat gaccaggata tgattaatga agcgataaac tattataaac
    11281 atggtcccag ttcgggatgt atccagcact tggtggtagc actacatcaa gaccctgccg
    11341 gtctgggtga aggatattgc cttggacaag ctgatgaatc gggtcgcgac caggatcatg
    11401 ccggattgag tatggctaca ctggctccga tgtgtcaggc tgcgtataat atcggagaag
    11461 atttgtatgg catcaaagca aacgactctt ttacgacaga agacggacgt gtatataatc
    11521 gttaccctaa atatgctgaa tatggggatg taaatctgac tcttgcattc tttgaatatt
    11581 atgcaaagtt caattgtgat cctattgaag ctgtagatat gccgtttacc tattgggaaa
    11641 ccagacatgg tcagcaaaac gaaatttcat atcaaggtcg gggacacttc tatgcaggat
    11701 atgaaatgat ttatagtcat tataagcatg taaaaggagt gagtgctccc tattcgaaga
    11761 agtttgcgga gaaatatcgt ccggctacca gtattcaccc gtttgaatat gataatgatt
    11821 ttcccggaat aggtactctg atgttctaca aaggagaatg agttgaggta acaagttgat
    11881 aagataaaaa taagaaaccg tctgtaaacg ggcggtttct tatcctgatt agaataaaga
    11941 caatgatgaa attaaagact ataactgcat tttttgcaat aacatgggca gtttctacta
    12001 ctgtttctgc ccagaaggtt agtatatatt ccaccacttc taccgaacgt tgggtagaga
    12061 aaaaacagac attggataaa aatcctgccg gacaggcgga tatctgtgtt tatcctgaca
    12121 gtctgttaca gaatgttgtt gggtttggag gtacttttaa tgaacttagt tgggatgcct
    12181 tgcaatgctt gtctccggca gaacgtgata aagtgatggc agccttgttc tcggaagagg
    12241 gtattcattt cgcattagga cgtactccta ttggtgccag tgattatgct atgggatatt
    12301 attcttacaa tgacgtaaag gatgactata ccatgcgtaa ctttagtatt gaccgtgatc
    12361 gctatatcct cattccttat attaaggaag cgctgaagct gcgtcctgat ttgaagatgt
    12421 gggcctctcc ttggacaccg cctgcatgga tgaaagtcaa tgaacattat tcgcagaaga
    12481 gttccggtat tgaagggact gaagtggggc acaaccgtct cgaccctcat cgcaatctta
    12541 tagggaatgt taccggtttt aaaatgcaac aggggtatct tcaggcgtat gccatttatt
    12601 tttccaaata cgtacaggct tacaagcaga acggcataaa cattcagatg attatgccgc
    12661 aaaatgaaat cgcatggact ccctgctggc cttcctgtac ttggcgtccg gaagacttgg
    12721 ctatttttgt caatcagtat cttgggcccc agtttgaaaa agattccatt gatactgaaa
    12781 tctggatggg aacagtcaat tatccgaatc cggattatgt acgcactttt ttcaagcaga
    12841 aagattctga taaatatgta aaaggtgttg gcgtgcaatg gacaggcatg cgggctttgc
    12901 cggctgtaca taaagaatat ccggattatt gctacatgca gacagagaat atgtgtggta
    12961 attcggagaa tgactggtct gctttggaaa atacatggaa tgctgtagtt cactgcttca
    13021 ataatggtgt tgattcttat atttattgga atatggtatt gaacgaaacc tgtaagagtt
    13081 ggtgggactg ggcacaaaac actcttatta ttattgacag aaaaacaggg caggtacgct
    13141 atacggatga atattatttg atgaaacatc tttcccattt tgttcagccg ggcagtcgtc
    13201 tgctgaaagt gtcagatggt aagaatacgc ttgctttccg ttcgcatgat ggtaaagtgg
    13261 tagttgtagc ttacaatccg gaagaacaag aacgctcttg tagttttaag gtaggtagca
    13321 agtatatacg tgttatattg aaaggtaaat ctattaatac aattgtcatt tgattatttt
    13381 tagtactttc ggattgagta tttcggcata ttgctgcgta ttaaagaata agtactcata
    13441 aagaatttac ggttttattt aataacaatg ttgttgcact gtcatttcat agccggaaaa
    13501 cgtggctacg gaatggcagt gttttataaa aaatgtgtga ttatatatga aaagacaaat
    13561 ttgcagtatt ttattattca tattttgcgt gacattacag gcgcagttgg tgacttatcc
    13621 ggaaggtttg aaggcgaata tgccacataa tgatgattat acggtgcgtg tccgtattcc
    13681 gggaggtgaa tgggaagatt tgtttgaata taatgtacag gtagatatgg atgctgtgca
    13741 gaatgcttca atggttcagt ttgatatgaa tggaacggtt gaggtgatgg tgaaaaagaa
    13801 taatggaacc gtacgtgagg ttgatatacg tcctcttagt tgcaacatcc aataccggca
    13861 gaacaagaat gtgattactt ttatgttgga caagcctcaa tatctgtcag tggaatttaa
    13921 tggggacaga cttcataatc tgcatctttt tgcaaatccg ttggaaacag aggtttataa
    13981 aaaagcagaa aaaggtatca tgtatttcgg accgggtgtt catgctcctt tggatttgcc
    14041 aaataatctg atacgtgttc ttggcaatac taccgtatat ttggctccgg gtgcagtgct
    14101 taaggctaag ttattagttg acggtgtaga aaatgtacgt attatcggtc gtggtatatt
    14161 ggctcatccg gttcgtggta tcgaagtgac gaatgcaaag aatgtactca ttgatggaat
    14221 tacggtagtg aatccgaatc attatacggt gtttggtgca ggaacaaaag ggttgacggt
    14281 gaagaatctg aaatccttta gctgtaagag ttggagtgac ggaatcgacc tgatgtgctg
    14341 tcgtgatgtg ctgattgaca atgtttttat gcgtaacagt gatgattgca ttgcactcta
    14401 taatcaccgt tggaattggt ggggaggttc tggcaatatc acagtgcaga atgctgttct
    14461 ttgggcggat attgctcatc cgattaatat cggtggacat ggagacccgg aatcaccggt
    14521 aggcgaagta atggaaaacc ttactttccg gcagatagat attttggaac atgatgagga
    14581 cgatgttcca tatcaagggt gtatggctat tgattgcggt gataagaact tggtacgtaa
    14641 tgtcttgttt gaggacattc gtgtagagag tattcaagaa ggcagacttt ttcatctcaa
    14701 tgtgcgtttc aatgagaaat atgataaagc tcccggacgg ggaattgaaa atgtcacttt
    14761 ccgtaatatt acttatgacg ggcttggtga gaatccgtct ctaatcaaag ggttcgacaa
    14821 cagtcggaaa gtgaagaatg taatctttga taatgtcgtt attaatggtc agaggatgac
    14881 ggatctgaat ggatttgtaa agaacgaatt cgtagaggat atacgtgtgc ggtaaaatta
    14941 gtttaaatag tagctttata gatattaaat atataaacaa tgattatgag taagcagttt
    15001 ttggttgcaa tcgcattatt ggcagtatcg gctatatcgt cggctcaatc cgtgtacccc
    15061 ggacaacacc aggggaaaat gaaaaaagag acagtagctc ctgtacgggt ggaaagtttt
    15121 gatttgaaag acatccgttt attgccaagt cgttttcgtg acaatatgtt gcgggattcc
    15181 gcatggatga cttccattga tgtgaatcgc ctgttgcata gtttccggac aaatgccgga
    15241 gtctttgccg gtcgtgaagg cgggtatatg acagtgaaga aactcggtgg ctgggaatcc
    15301 ttggactgtg agcttcgcgg acatactacc ggacatttgc tttcggctta tgccttgata
    15361 tatgccgcta ccggaagtga gattttcaag ctgaaagggg atagccttgt caacgggctg
    15421 actgaagttc agaacgcttt gaaaggagga tatctaagtg cttttcccga agaattgata
    15481 aaccgtaata tccggggaaa gagtgtctgg gcaccttggt acaccttgca taagctttat
    15541 tccggtctga tagaccaata tctgtatgca gataatctgc aagccttgaa agtggtgact
    15601 aaaatgggcg actgggctta taacaaacta aaaccgctca cagaagaaac ccgcaaactt
    15661 atgatacgta atgagtttgg aggtatcaat gagtcatttt acaatttgta tgctatcaca
    15721 ggagacgaac gttatcgctg gctggcggaa tatttctacc acaatgacgt aatcgaccca
    15781 ttgaaagaac ttcgcgatga cttggggact aaacatacga atacctttat cccgaaagtc
    15841 atagccgaag cgcgtaacta cgagttaacc cgcaacgaga caagcaggaa actatcggaa
    15901 ttcttctggc acaccatgat tgaccatcat acttttgctc cgggatgtag cagtgacaaa
    15961 gaacactact ttgatccgaa gaagttatcc caacatctga ctggctatac cggagaaact
    16021 tgttgtacct ataacatgct caaacttagc cgccatcttt tttgctggac gggcgattca
    16081 tctattgcgg attattatga aagggcattg tataatcaca tcttgggaca acaagaccct
    16141 gaaacaggta tggtagctta ttttctgcct ttgctttccg gggctcataa actgtatagc
    16201 acaaaagaga actctttttg gtgttgtgtc ggcagcggat tcgaaaatca tgctaaatac
    16261 ggagaagcca tctactacca taacaatcag ggaatatatg taaatctatt tatcccttca
    16321 caggtaacct ggaaagaaaa aggactgaca atccgtcaag aaacggaatt cccacaggaa
    16381 gaaacaacgc gtttcactct ccggacagaa aatcctgttc gtaccaccat ttatctgcgc
    16441 tatccttcgt ggagcaagga tgtaaaagtg ttggtaaatg gtaagaaaat atctgtgaaa
    16501 cagaaacctg gttcttatat tgtcattacc cgtgaatgga aagatggcga ccaaatctcg
    16561 gctacttatc cgatgcaaat caaactggag gctaccccgg ataacccgga taaggcagcc
    16621 ctgttatatg gcccgttggt attggcggga gaacggggaa ctgaaggtat gcaagcccct
    16681 gctcctttct caaatcctgc tctttataat gattattata cctataattt tcatgtccca
    16741 gcacatttgc gtacctcttt gaaactagat aagaaacacc ctgaacgtgc tttgcaacgt
    16801 gtaggaagtg atttgaagtt tacgacagaa caaggagatg tgattcgtcc gctatacgat
    16861 ttgcatcgtc agcgctatgt cgtatattgg gatttacaat cagaaaaata gatagtaaac
    16921 aacgaaatga agaatcgttt attaattgcc gcttttgtaa gtatctgctt tttgtccggt
    16981 tcttgcaaaa tatcatccgg tcagggaaaa cagtatgact tctcttcttt ggattctgtt
    17041 atccaaggat gggtagacaa gggatattac cccggagcat ccatttgtgt agtgaagaat
    17101 gataccgtca tttttcagaa gaactatcgg gattatacac ccgatacaaa agtatatgtc
    17161 gcttctgccg gaaaatgggt agcggctgct gtcataggcg cggtggtaga ccgtactgat
    17221 ttgggatggg atgatccggt agaaaaatgg ttgccggaat ttaaagacga tgctaaaggt
    17281 aagattcttc tccggcaatt attatcccat acatcaggag tacgtccata tcttcccgag
    17341 cctcgtgtag ataactataa tcatttggat tcggcagtca ctgaaattct tcctttggat
    17401 acagtcttta ctcccggcac tcgttttgaa tatggtggac ttgccatgca aattgccgga
    17461 agaatggcag aagtggcgat gggaaaggag tttgaaacgc tttttcagga actgctggca
    17521 caacctttgg aaatgaagaa ctctcatttt accccaatca acacggacgg cggacatgca
    17581 cccatgttag ggggcggact gtgtactaca atgaatgatt atcttcactt cctgtccatg
    17641 atttatcacg atggaatgta taatggcaag caaattatat cagcagaaac tgtgaaagaa
    17701 atgcaggccg accaagtgaa aggcgccata atcccttcaa ataactcgga taattatgta
    17761 gcgaaaggac tgggacaatc ccacaatgga atctatggat taggagaatg gcgtgaatta
    17821 atagataaaa agacaggcga agcttatcag attagttcac cgggatgggc cggtgcttat
    17881 ccgtggataa ataaacacga taaagtttac gggttcttca tttctcatgt aacaggttct
    17941 tctgctaaag aagacggttt ctcttctttc tttggcagcc ctgtcatttc acggaccgtt
    18001 tcggaaatac tgaaagggaa gccattggtt gtcaaacaag gacgtatcaa tgtaggaaat
    18061 ggctctctat actatgagga agccggtcag ggtgaaccga tcatctttgt acacggtcat
    18121 tcgcttgacc atcgtatgtg ggatgagcaa ttttctgtgt ttgcgaaaaa gtatcatgtc
    18181 attcgctatg atttaagagg atacggcact tcttcttccc aaacagaaga ttatcaattt
    18241 atgcatgttg aagatctggt tactttaatg gactctttgc acatcaagaa agcgcatatt
    18301 gtcgggcttt ctttgggcgg gttcattact gctgatatgt tggcgtattt cccagaccgg
    18361 atgttatcgg cttttttagc cagtggaaac atccggaaat cgaagggtcc tagtgagccg
    18421 atgactaaag aagaagcaaa ggtgcgtgat gaagaaatag ctgccctgaa acagaaagga
    18481 gtggaagtga tgaagaaaga gtggtttgaa ggattaatga aatccggtgg tagccagcgt
    18541 gaacggatgc gtgtgccttt gtggcagatg attgacgaat gggatgcatg gcaaccgctg
    18601 cacaaagaag tacgggtagt agcagggctg gatgctattg aagaattgaa gaagagtcac
    18661 cctgccgtac ctgctttaat tgtagaaggt cattcttctg ataacaaatt ttcaaaaaat
    18721 cctcccatat tggaatatct acctaatgga aagctgaaaa tcatagagga ttgcgggcac
    18781 atgatgaata tggagcgacc ggaggaattc aatgcagctt tagaagaatt tttaatcaat
    18841 attgaacagt aaaatgaaaa agcaataaat atcatgaaac aaatagttct atgcctgatc
    18901 ggaatattat ttgcatcgtt tgtatctgca caaaagataa atcatccttc ccttttgtac
    18961 acccctcaac gtattcagca ggtaaaacaa cgtatgcaga atgaaccgaa attgcgggaa
    19021 gcctgggagg atattcagaa aaccgccgat gaagccttac aaaagaaaga tttcaatcgg
    19081 ttggattatt tgtcgttggc ctatctgatg acggataata aagagtatgc aaatataatc
    19141 aaagagattc ttttgaaagc tgtggaagcc gaatcctggg gagatatgga aatgatggca
    19201 cgtattccag tctggcgttc gcaactgggc atggcgcata agagcttcct ttctgccata
    19261 ggatatgatg cggcttataa cataatgtct tcttcggaaa gaaaaaagat tgctgaagga
    19321 ttgaaacgat tggctgtaga gccagccttg ggcgactggc tgttggaacc tgcccgaatc
    19381 cattctttga actctatggg acacaactgg tggacttcct gtgtatgcca gggtggaata
    19441 ttagcattaa gcctgcagaa tgaacttccc gaagtaaaag attgggtgga gcaacttcat
    19501 gaatcacttc ccgaatggtt tgactttgca ggcgatgcct tgcaacagaa agcaaagagt
    19561 tttgatgagg ccggaggaat gtatgaaagt ctgaattatg caaactttgg tattcaggaa
    19621 gctctattgt ttcgaatcgc ttggataaac actcatccgg gacaaaatcc cggcgatata
    19681 ccccaattag caaaacttcc gaactacttt tctcaagtat gctatcctcg tacaggtatg
    19741 ctgtatagtt tgaattttgg tgatagtcat aagaacgtat cagcagaatc cagtatgatg
    19801 ttattgtatg ctttgggact gaaagacccg actattctgt ggtatatagc ccaagtagag
    19861 caaggacagc atcgcgatgg attcttcctg aatcgtccga tgggctttct ctatacccct
    19921 gatttgagta aagctcccgt aactcccgat ttgaaaacct cacagctatt ctcggatttc
    19981 ggttgggcca ccatgcgtac ttcttgggag aaggatgcta cgatgcttgc tgtgaaaagc
    20041 ggtcatacgt ggaatcattc ccatgcggat gccaactcct ttattgtatt tcataaaggc
    20101 gttgatatta tcaaggatgg aggaaactgc tggtatccca atcctgccta tcgcaactat
    20161 ttttttcaaa gccaggcaca taatgtagtc ctgttcaacg gggaggggca acctcgtgaa
    20221 caacagtata gcggctctac tttgcgagga aatctttatc atctcttgga tgcgggtaat
    20281 gtgaaatatg ttttggccaa tggaacaggt cctgtctcta ataatttcag ccgtaacttc
    20341 cgtcatttcc tgtggatgga taatgtgatt tatatgatcg atgatttgaa gacacataag
    20401 gtaggacagt tcgaatggtt atggcatacc aatggaactt ataagaaatc gggcattgac
    20461 gtgaatgtga taaacggaaa ttcttcagta gtcatccgtc ctttatatcc ccgcatgctg
    20521 gctaagtccg attttgtgca cgactatccc gaagatttat attgggaaga aatagaagct
    20581 cctacggaag atttgaaagg aaccgaaaaa tattattcat tccatttacc agccgaggtg
    20641 aaccgtgtga aaggacttac agctattatt ctgaaagacg ctcccgatga aaaagacctg
    20701 cctcaaatgg aaagacgtga agggcaggac tggatagggc ttcgtatccg tcataaaggt
    20761 aaaattaccg atttatatat caaccaactg gcggacggaa gattaatgca cagtaattca
    20821 tggattatgc ccgacggctg gatgacagat gcttatatgt ttgcagtttc ttacccagaa
    20881 ggtactgaag caaagaacgc taaggacttc tttattgctt atggaagtgc attgagacgg
    20941 ggtaatgaaa cttacttttc atcattggct aagctgttcg ttattcagaa agcagaagat
    21001 aagaaacttg atctttggat aaacggacag ccgaagataa ataccacctt tagaagcaca
    21061 aagaagcctg tgtctgtaga agtgaatgat aagaaaatcc cggtagttta tcagaaatca
    21121 cagataaagg tgaaactgta a
//
