LOCUS       NC_003063              10048 bp    DNA     linear   CON 23-AUG-2024
DEFINITION  Agrobacterium fabrum str. C58 chromosome linear, complete sequence.
ACCESSION   NC_003063 REGION: 302505..312552
VERSION     NC_003063.2
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02603108
            Assembly: GCF_000092025.1
KEYWORDS    RefSeq.
SOURCE      Agrobacterium fabrum str. C58
  ORGANISM  Agrobacterium fabrum str. C58
            Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
            Hyphomicrobiales; Rhizobiaceae; Rhizobium/Agrobacterium group;
            Agrobacterium; Agrobacterium tumefaciens complex.
REFERENCE   1  (bases 1 to 10048)
  AUTHORS   Goodner,B., Hinkle,G., Gattung,S., Miller,N., Blanchard,M.,
            Qurollo,B., Goldman,B.S., Cao,Y., Askenazi,M., Halling,C.,
            Mullin,L., Houmiel,K., Gordon,J., Vaudin,M., Iartchouk,O., Epp,A.,
            Liu,F., Wollam,C., Allinger,M., Doughty,D., Scott,C., Lappas,C.,
            Markelz,B., Flanagan,C., Crowell,C., Gurson,J., Lomo,C., Sear,C.,
            Strub,G., Cielo,C. and Slater,S.
  TITLE     Genome sequence of the plant pathogen and biotechnology agent
            Agrobacterium tumefaciens C58
  JOURNAL   Science 294 (5550), 2323-2328 (2001)
   PUBMED   11743194
REFERENCE   2  (bases 1 to 10048)
  AUTHORS   Wood,D.W., Setubal,J.C., Kaul,R., Monks,D.E., Kitajima,J.P.,
            Okura,V.K., Zhou,Y., Chen,L., Wood,G.E., Almeida,N.F. Jr., Woo,L.,
            Chen,Y., Paulsen,I.T., Eisen,J.A., Karp,P.D., Bovee,D. Sr.,
            Chapman,P., Clendenning,J., Deatherage,G., Gillet,W., Grant,C.,
            Kutyavin,T., Levy,R., Li,M.J., McClelland,E., Palmieri,A.,
            Raymond,C., Rouse,G., Saenphimmachak,C., Wu,Z., Romero,P.,
            Gordon,D., Zhang,S., Yoo,H., Tao,Y., Biddle,P., Jung,M.,
            Krespan,W., Perry,M., Gordon-Kamm,B., Liao,L., Kim,S., Hendrick,C.,
            Zhao,Z.Y., Dolan,M., Chumley,F., Tingey,S.V., Tomb,J.F.,
            Gordon,M.P., Olson,M.V. and Nester,E.W.
  TITLE     The genome of the natural genetic engineer Agrobacterium
            tumefaciens C58
  JOURNAL   Science 294 (5550), 2317-2323 (2001)
   PUBMED   11743193
REFERENCE   3  (bases 1 to 10048)
  AUTHORS   Hinkle,G., Slater,S.C. and Goodner,B.
  TITLE     Complete Genome Sequence of Agrobacterium tumefaciens C58
            (Rhizobium radiobacter C58), the Causative Agent of Crown Gall
            Disease in Plants
  JOURNAL   Unpublished
REFERENCE   4  (bases 1 to 10048)
  AUTHORS   Slater,S.C., Setubal,J.C., Zhao,Y., Goodner,B., Houmiel,K., Sun,J.,
            Kaul,R., Goldman,B., Chen,Q., Huang,W.Mun., Casjens,S., Farrand,S.,
            Burr,T., Nester,E., Kadoi,R., Ostheimer,T., Pride,N., Sabo,A.,
            Henry,E., Telepak,E. and Wood,D.
  CONSRTM   agrobacterium.org
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2007) Virginia Bioinformatics institute, Virginia
            Polytechnic Institute and State University, Washington Street Box
            0477, Blacksburg, VA 24060, USA
  REMARK    Sequence update by submitter
REFERENCE   5  (bases 1 to 10048)
  AUTHORS   Hinkle,G., Slater,S.C. and Goodner,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-AUG-2001) Cereon Genomics, 45 Sidney Street,
            Cambridge, MA 02139, USA
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            AE007870.2.
            
            On or before Nov 7, 2007 this sequence version replaced
            NC_003305.1, NC_003063.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000092025.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 01:35:40
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,332
            CDSs (total)                      :: 5,261
            Genes (coding)                    :: 5,173
            CDSs (with protein)               :: 5,173
            Genes (RNA)                       :: 71
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 6
            Pseudo Genes (total)              :: 88
            CDSs (without protein)            :: 88
            Pseudo Genes (ambiguous residues) :: 0 of 88
            Pseudo Genes (frameshifted)       :: 32 of 88
            Pseudo Genes (incomplete)         :: 63 of 88
            Pseudo Genes (internal stop)      :: 16 of 88
            Pseudo Genes (multiple problems)  :: 21 of 88
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10048
                     /organism="Agrobacterium fabrum str. C58"
                     /mol_type="genomic DNA"
                     /strain="C58"
                     /culture_collection="ATCC:33970"
                     /type_material="type strain of Agrobacterium fabrum"
                     /db_xref="taxon:176299"
                     /chromosome="linear"
     gene            complement(1..525)
                     /locus_tag="ATU_RS15135"
                     /old_locus_tag="AGR_L_3083"
                     /old_locus_tag="Atu3277"
                     /db_xref="GeneID:1135151"
     CDS             complement(1..525)
                     /locus_tag="ATU_RS15135"
                     /old_locus_tag="AGR_L_3083"
                     /old_locus_tag="Atu3277"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020810531.1"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA];
                     GO:0016491 - oxidoreductase activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase family protein"
                     /protein_id="WP_010972905.1"
                     /db_xref="GeneID:1135151"
                     /translation="MTVVEAIKMPNEHVFVPGGENSRSFRNALGAFTTGVTVVTATTP
                     EGPIGMTVNSFASVSLDPPLVLWSPAKSSSRHPAFSEATHFAIHVLSADQDVLSARFT
                     RNGRAFDDLDWEINDEGVPVIPGTLARFECRRAAAHDAGDHTIIVGEVLRAAHRDGDP
                     LCFSGGAFGRFSRQ"
     gene            complement(525..1418)
                     /locus_tag="ATU_RS15140"
                     /old_locus_tag="AGR_L_3080"
                     /old_locus_tag="Atu3278"
                     /db_xref="GeneID:1135152"
     CDS             complement(525..1418)
                     /locus_tag="ATU_RS15140"
                     /old_locus_tag="AGR_L_3080"
                     /old_locus_tag="Atu3278"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010972906.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="WP_010972906.1"
                     /db_xref="GeneID:1135152"
                     /translation="MQRIALSDKLELSRIVYGMWRIGDDADTSPAHVQAKIEACLAQG
                     ITTMDQADIYGGYTAEAILGGGLKAAPGLRDKIEIVTKCGIVAPAGRHSSARVKHYDT
                     TAGHINVSVEASLRDMGTDHVDLLLIHRPDPLIDAEETGKALDALVASGKVKAVGVSN
                     FRPWDFSLLQSAMSNRLVTNQIEMSLLATDTFTNGDLAYLQEKRVSPMAWSPLGGGSL
                     FSGAYGGTMAALQRIGKEQGVDATAVAIAWLLRHPAKIVPVLGTNNLERIRTAADALR
                     VTMDRQTWFELYTLAIGKEVA"
     gene            complement(1418..2575)
                     /locus_tag="ATU_RS15145"
                     /old_locus_tag="AGR_L_3078"
                     /old_locus_tag="Atu3279"
                     /db_xref="GeneID:1135153"
     CDS             complement(1418..2575)
                     /locus_tag="ATU_RS15145"
                     /old_locus_tag="AGR_L_3078"
                     /old_locus_tag="Atu3279"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003500750.1"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA];
                     GO:0016491 - oxidoreductase activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_006314866.1"
                     /db_xref="GeneID:1135153"
                     /translation="MTVVPVTSADLDAAEVSWFSALCSDDYAYLGVPDGSLRSSFEHC
                     SDIVKKAEELGFRNILCPSSYQVGQDTLSFVAGCAPISDRINFLAAIRCGEMQPIMLA
                     RTVATLDHMLKGRLTLNVISSDFPGEVADSAFRYKRSHEVVEILRQAWTRDTIDHDGE
                     IYQFKGVSTEPARPYQLNGGPLLYFGGYSPDALELCGAQCDVYLMWPETKDQLADRMR
                     AAHERAAAHGRTLDYGLRVHMVVRDTEQEAREYADHLVSKLDDEYGQLIRNRAHDSGS
                     LGVSHQARARELADKFGYVEPNLWTGIGRARSGCGAALVGSTDQVLSALEEYQKMGIR
                     AFILSGYPHLDEAEHFGTKVLPQMKTCSLPHAYGRVPSETPATPLGNGERH"
     gene            2677..3381
                     /locus_tag="ATU_RS15150"
                     /old_locus_tag="AGR_L_3074"
                     /old_locus_tag="Atu3280"
                     /db_xref="GeneID:1135154"
     CDS             2677..3381
                     /locus_tag="ATU_RS15150"
                     /old_locus_tag="AGR_L_3074"
                     /old_locus_tag="Atu3280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003506435.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_010972907.1"
                     /db_xref="GeneID:1135154"
                     /translation="MKHTGGSLPMYMQIAEMLVREVAAGRLIDGEKLAPERDMAADLG
                     IAVGTLRKSLAELQERGLLERVQGSGNYIRAVSDPQSVYAFFRLELIEGGGLPTAEVL
                     DVARLAKPADLPAFGTSTEGHRIRRLRRIAGKPAAIEEIWLDGSYVDTITIENMSESL
                     YLYYRTRLNLWISKAEDRIDLGDVPEWAPEVFGQKAGSSVPRVLRLSQAQDGAVAEVS
                     WTWFDHTVARYVSRIR"
     gene            3716..4792
                     /gene="ugpC"
                     /locus_tag="ATU_RS15155"
                     /old_locus_tag="AGR_L_3073"
                     /old_locus_tag="Atu3281"
                     /db_xref="GeneID:1135155"
     CDS             3716..4792
                     /gene="ugpC"
                     /locus_tag="ATU_RS15155"
                     /old_locus_tag="AGR_L_3073"
                     /old_locus_tag="Atu3281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006698542.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_010972908.1"
                     /db_xref="GeneID:1135155"
                     /translation="MASVSLRKLDKSYGALRIVKGIDLEINDGEFVVFVGPSGCGKST
                     TLRMVAGLESITGGEVKIGDRVVNQLPPRERDIAMVFQDYALYPHKTVRENMGFSLKV
                     RGVSASQANASIDEAAKMLGIEHLLDRRPGQLSGGQRQRVAMGRAIVRRPQVFLFDEP
                     LSNLDAKLRGQVRTEIKRLHQQLGTTIIYVTHDQVEAMTLADRIVILRGGDIEQVGTP
                     DEVYNRPESVFVGGFVGAPAMNFARARVNGDRLAFSDGNSLPMAAIRPSRETGLEGRD
                     VIVGIRPEHFGPAEGFDSQLAVSVQVVEPLGSDTLVHFSLGDAALTARMPPQLRPTPN
                     EELRIGVDPSKVHLFDATTERSIH"
     gene            4844..6094
                     /locus_tag="ATU_RS15160"
                     /old_locus_tag="AGR_L_3070"
                     /old_locus_tag="Atu3282"
                     /db_xref="GeneID:1135156"
     CDS             4844..6094
                     /locus_tag="ATU_RS15160"
                     /old_locus_tag="AGR_L_3070"
                     /old_locus_tag="Atu3282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010972909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_010972909.1"
                     /db_xref="GeneID:1135156"
                     /translation="MTLKTIRGKALMGAALCATMLTFSGQAFADAELKIFVSSQHQPD
                     IWRKALDQYEAKTPGVKVVIETGGNTSEMQAQYLNTVMSAKDSSLDVLMLDVIRPAQF
                     ATAGWTSDFSGKDLSAYLPTYAEANTVNGKIVALPAFADSMFLYYRKDLLDKYGIKPP
                     TTWDELKEASKKVMEGEKNPELQGLSFQGKAIEGAVCTFLLPYWSEGKSLVENGKLNF
                     DNKAAVDSLKLWKSFVDDGISKKNISEVATDDTRKEFQAGKVLFAVNWSYAWTHFQGK
                     ESQVNDKVGVARLPAVKGGEQTTCLGGWEFGVSAYSKQQDEAKKLVEYLSSQDVSKFM
                     AINAALLPTYAALYKDADVTKTIPWFADALPVVETAKARPVTPRYNEVSETIRTTVNG
                     VLAGVMTPEDGAKQMESRLRRVLR"
     gene            6269..7180
                     /locus_tag="ATU_RS15165"
                     /old_locus_tag="AGR_L_3068"
                     /old_locus_tag="Atu3283"
                     /db_xref="GeneID:1135157"
     CDS             6269..7180
                     /locus_tag="ATU_RS15165"
                     /old_locus_tag="AGR_L_3068"
                     /old_locus_tag="Atu3283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020810525.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_035257404.1"
                     /db_xref="GeneID:1135157"
                     /translation="MVRVDEKQLPRWTRWLDLGDRLLAVLLLAPAAILLSLIIVYPVA
                     RLVYTSFFSLSLTSGLPAEFIGFENYTAMFDDPIFWETTWNTVLITLITVPGALFMGL
                     GLALLANLPFSMQWPMRLSLLIPWALPLSFAGLIFAWFFHYEYGVVNDVLNRLGFEGI
                     IWFNSPNWAFAAICLTIIWKTSSFMALMILAGLQTIPRSLYEAADVDGAGKIRRFFEI
                     TLPLLKPSIVVALIFRTITALQTFDIPYMMTGGGPGTSTTTLAMYIHQNTVSFLDLGY
                     GSALAVVMFALSMCVTAVYLRIIRTKD"
     gene            7185..8042
                     /locus_tag="ATU_RS15170"
                     /old_locus_tag="AGR_L_3066"
                     /old_locus_tag="Atu3284"
                     /db_xref="GeneID:1135158"
     CDS             7185..8042
                     /locus_tag="ATU_RS15170"
                     /old_locus_tag="AGR_L_3066"
                     /old_locus_tag="Atu3284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006314872.1"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]; GO:0055085 - transmembrane transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_006314872.1"
                     /db_xref="GeneID:1135158"
                     /translation="MSTVATSPGLSSFFSGKPLRFIAASILLVNGLFPAIWILFTSLK
                     TEAELTVKPITWFPHAPTLANYMQAFSDQPLHLFLFNSFMVALLSTALTILISVLAAY
                     ALARLNLKYRALILSLIIAVSTFPLVTLLVPLFEIMRALNLLNSWTALILPYTVLSLP
                     VCTLMLVSFFESIPRDLENAAMIDGCTRIGALFKVVVPLCAPGVFTAGILAFVNAWDE
                     FLLALSFNSNPALRTLPVGIQLYQGEFAFPWPVISAALVVGIVPVAILIVIFQERVVS
                     GLTAGGLKG"
     gene            8054..10048
                     /locus_tag="ATU_RS15175"
                     /old_locus_tag="AGR_L_3064"
                     /old_locus_tag="Atu3285"
                     /db_xref="GeneID:1135159"
     CDS             8054..10048
                     /locus_tag="ATU_RS15175"
                     /old_locus_tag="AGR_L_3064"
                     /old_locus_tag="Atu3285"
                     /EC_number="3.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003506421.1"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="WP_010972911.1"
                     /db_xref="GeneID:1135159"
                     /translation="MHFETTKDGFTIAIGNRIILSHSPDKPAFFAGFGEERMDMYRGN
                     FDIEDYVIERTALRHAEVSGDSVTLSSAPGQAPRLRLTLDGNAIRLTALDETINRLWL
                     RVVAETDEHVWGGGEQMSYFDMRGRRFPLWTSEPGVGRDKTTEITFKSDVSGKAGGDY
                     YNTNYPQPTWLSSRKYALHVETSAYSVFDFRNGDFHEIEIWAVPEKIEFFAGDSFADI
                     VSALSLHFGRQPELPDWVYNGAIIGLKDGVNSFARLEKIRAAGTKVSGLWCEDWVGLR
                     QTSFGARLFWDWQANDTRYPHLRQKIAELADQGIRFLGYVNPYLCVDGPLFPVAESAG
                     YFATDVDGKTALVDFGEFDCGVVDFTNPAAADWFAEEIIGKNMLDFGLSGWMADFGEY
                     LPIDIKLSNGVDAKLMHNAWPTLWAEVNAKGVESRGKTGEALFFMRAGFTGVQAHCPL
                     IWGGDQSVDFSRHDGLVTVICGALSSGLMGNAYHHSDIGGYTSLFGNVRTAELIMRWT
                     EMAAFTPVMRTHEGNRPRDNLQIDQDETVLAHFARMTAIYVALAPYLKSLSAEAAKTG
                     LPVQRPLFLHYENEPQTYAVQDCYLYGADMLVAPVWKAGETQRSLYLPGHGEWVHLWS
                     GKRHAGGRDITVETPLGEPAVFYRADSSHHRLFEQLRTIG"
ORIGIN      
        1 ctattgcctt gaaaaacgac cgaaggcccc gcccgaaaag cacagcggat caccgtcgcg
       61 atgggcggcg cgcagcactt cgccgacgat gatggtgtgg tcacccgcat catgggcggc
      121 ggcgcgacgg cattcgaaac gggcgagcgt gcccggaata acgggaacac cctcgtcgtt
      181 gatttcccag tcaagatcgt cgaaagcgcg accgttgcgg gtaaagcggg cgctcagcac
      241 atcctgatcg gcgctcagca catggatggc gaaatgggtc gcctcactga aagccggatg
      301 gcgtgacgag cttttcgccg gggaccacaa taccagcggc ggatcgagag aaaccgacgc
      361 aaagctgttg accgtcatgc cgatagggcc ttccggcgtc gttgccgtca ccactgtgac
      421 acctgtcgtg aaagcgccga gcgcgttgcg aaagctgcgg ctgttctcgc cgccgggaac
      481 gaatacatgc tcattgggca tcttgattgc ctctacaact gtcatcacgc cacctctttt
      541 ccaatcgcaa gggtgtagag ttcaaaccag gtctgacggt ccatcgtcac gcgaagcgca
      601 tcggccgcgg ttctgatacg ttcgagatta ttggtaccca gtaccggcac gatctttgcc
      661 ggatggcgca gcagccaggc gatggcgacc gccgtcgcgt cgacgccctg ttccttgccg
      721 atgcgctgca gggcagccat ggtgccgcca tacgcgcctg aaaacagcga gccaccgccg
      781 agcggcgacc aggccatggg cgagacacgc ttttcctgca ggtaggcgag atcgccattg
      841 gtaaaggtat cggtggcaag aaggctcatt tcgatctggt tggtcacgag ccggttgctc
      901 atggccgatt gcagcagcga aaaatcccac ggacggaagt tggagacgcc caccgccttg
      961 accttgccgg aagcgaccag cgcatccagc gccttgccgg tttcttccgc atcgatcagc
     1021 gggtccggac ggtgaatgag cagcaggtcg acatgatcgg ttcccatgtc gcgcagcgag
     1081 gcttcgaccg agacgttgat gtggccggcc gtcgtatcgt aatgcttgac gcgagcggag
     1141 gagtgtcggc cggccggcgc gacgatgccg catttggtga cgatttcgat tttgtcgcgc
     1201 agtccgggcg ccgccttcag gccgccgccg agaatggctt ccgccgtgta cccaccgtaa
     1261 atatcggcct gatccatggt ggtgatgccc tgcgcgaggc aagcctcgat cttcgcctgc
     1321 acatgcgccg gcgaggtgtc ggcatcgtca ccgatgcgcc acatgccata aacgatgcgg
     1381 ctgagttcga gtttgtcaga aagagcgata cgttgcatca gtggcgttcc ccgttgccga
     1441 gcggcgtagc aggcgtttca gaaggcaccc ggccgtaggc atgcggcagg gagcaggttt
     1501 tcatctgcgg cagaaccttg gtgccgaaat gttccgcctc gtcgagatgc ggataaccgg
     1561 agaggatgaa ggcgcggata cccatcttct ggtattcctc cagcgccgaa agaacctgat
     1621 ccgtcgaacc gacaagtgct gcaccgcagc ccgagcgcgc ccggccgatg ccggtccaca
     1681 gattgggctc gacgtaaccg aacttgtcgg cgagttcgcg ggcgcgcgcc tgatgcgaca
     1741 cgccgagcga gccgctgtca tgggcacggt tgcggataag ttggccatat tcgtcatcga
     1801 gcttggagac tagatggtcg gcatattcgc gggcttcctg ttcggtatcg cgtaccacca
     1861 tgtgaacgcg caggccataa tccagcgtgc ggccatgggc ggcggcgcgc tcatgggcgg
     1921 cgcgcatgcg gtcggccagc tggtccttcg tctccggcca catcagatag acgtcacact
     1981 gtgcgccgca gagttccagc gcgtcgggag aataaccgcc gaaatagaga agcgggccgc
     2041 cattcagctg gtagggtctt gccggttcgg tcgacacacc cttgaactgg taaatctcgc
     2101 cgtcatggtc gatggtgtcg cgcgtccagg cctgacgcag gatctcgacg acctcgtggc
     2161 tgcgcttgta acggaaagcg ctgtcggcca cttcgccggg gaaatcggag ctgatgacgt
     2221 tgagcgtcag gcggcccttc agcatgtggt cgagtgttgc cacggtccgc gccagcatga
     2281 tcggctgcat ctcgccgcaa cggatcgccg cgaggaaatt gatgcggtcg ctaatcggcg
     2341 cgcagccagc aacgaagctc aacgtatcct gcccgacctg ataggacgaa gggcagagaa
     2401 tgttgcggaa gccgagttcc tcggcttttt tgacgatatc ggagcaatgt tcgaagctgg
     2461 aacgcaggct tccatccggc acgccgagat aggcgtaatc atcggaacac aaagcggaaa
     2521 accaggagac ctcggcagca tcgagatcag cagatgtaac gggtacgacg gtcatgcaat
     2581 tcctcctcag ggccgctctc gtttttcttg cataacatca agaaatatgt aaatcaatga
     2641 tgtatcaatt tttgtttcgg cggaggaaac tgcatcatga aacacactgg cggcagcctg
     2701 cccatgtata tgcagatcgc tgaaatgctg gtgcgcgagg tggcggcggg ccggctgatc
     2761 gatggcgaaa agctggcgcc ggagcgcgac atggcggcag atctgggcat cgccgtcggc
     2821 acgctgcgca agtcacttgc cgaattgcag gagcgcggtc ttctcgagcg cgtgcagggc
     2881 tccggcaatt acatccgcgc cgtcagcgat ccgcaaagcg tctacgcctt tttccggctt
     2941 gaactgatcg aaggcggcgg cctgccgacg gcagaggttc tggatgtggc ccgccttgcc
     3001 aagccagccg atctgccggc cttcggcacc tcgacagaag ggcacaggat acgccgcctg
     3061 cggcgcatcg ccggcaaacc ggcagctatc gaggaaatct ggcttgatgg ttcttacgtc
     3121 gacacaatta ccatcgaaaa catgtcggaa tccctctacc tctattaccg cacccgcctc
     3181 aatctctgga tatcgaaggc ggaagatcgc atcgatctcg gtgacgtgcc cgaatgggcg
     3241 cccgaggtct tcggccagaa agccggctcc tctgtgccgc gggttctgcg cctcagccag
     3301 gcgcaggatg gcgcagtcgc cgaagtttca tggacctggt tcgaccatac cgttgcccgc
     3361 tacgtttctc gcatacgttg agattacgca aatttcgcgt gatccacgtg gacggaggaa
     3421 tttgacggga ggcaagcacg ccacggcccg cgctgcgggt tattttgcag ttatatttgt
     3481 tagaatcaaa gacttattag tttttgattt ctgtcagaaa taaaattgat acactattga
     3541 tttccttttt atgaaaggta atatcacgtc ctcagggaga caggcgtttc gccatccccg
     3601 ctatcgccag acaatcggga tcgattttcg aagatgcgat acggggaact tgaaggttga
     3661 taccggctat tgcgtccatt caaattctgg gcgcgccggt cgtgaggagg aaaatatggc
     3721 ttcggtcagc ctgcgcaagc tggacaagag ttacggtgcg cttcgcatcg tcaagggcat
     3781 cgaccttgaa atcaacgatg gcgaattcgt cgtgttcgtc ggcccttccg gctgcggcaa
     3841 atcgacgacg ctacgcatgg tcgcggggct ggagagcatt accggcggcg aggtgaagat
     3901 cggcgaccgc gtcgtcaacc agctgccgcc gcgtgaacgc gacatcgcca tggtgtttca
     3961 ggactatgcg ctttatccgc acaagacggt gcgcgaaaac atgggtttca gcctgaaggt
     4021 gcgcggcgtc agcgcttccc aggccaatgc cagcatcgat gaagcggcga agatgctggg
     4081 catcgagcac cttctcgacc ggcggcccgg ccagctttcc ggcggccagc gtcagcgtgt
     4141 ggccatggga cgcgccatag tacgccgccc gcaggtcttc ctgttcgatg agccgctttc
     4201 caacctagac gccaagctgc gcggacaggt gcgcaccgaa atcaaacgcc tgcatcagca
     4261 gctcggcacg acgatcattt acgttaccca tgatcaggtg gaggcgatga cgctcgccga
     4321 ccgcatcgtc atcctgcgcg gcggcgatat cgaacaggtt ggtacgccgg atgaggttta
     4381 taaccgcccg gaaagcgtct ttgtgggtgg tttcgtcggt gcgcccgcca tgaatttcgc
     4441 ccgcgccagg gtcaatggcg accggctggc attttccgac ggcaactccc tgccgatggc
     4501 ggccatccgg ccatcgcgcg aaacagggct cgaaggccga gacgtcatcg tcggcattcg
     4561 tccggaacat ttcggtcccg ccgaaggctt cgacagccag cttgccgtca gcgtgcaggt
     4621 ggtggaaccg ttgggttcgg acacgctcgt ccatttcagc cttggcgacg cggcgctgac
     4681 cgcacggatg ccgccgcagc ttcggccaac gccgaacgag gaactgcgga tcggcgtcga
     4741 tccatccaag gtccatcttt tcgacgcgac gacggaacgc tcgattcact gattgccggg
     4801 caaaaaggct gcgcggccaa gagtttaata acgggaggaa cacatgacac ttaaaaccat
     4861 caggggcaaa gcccttatgg gcgcagcgct ctgcgcaaca atgcttactt tttcgggaca
     4921 ggcctttgcc gacgccgaac tgaaaatctt cgtttccagc cagcatcagc cggatatctg
     4981 gcgcaaggcg ctggaccaat atgaggcaaa gacgccgggt gtgaaggtag tcatcgagac
     5041 tggcggcaat acttcggaaa tgcaggcgca atatctcaac accgtcatgt cggccaagga
     5101 ttcgagcctt gacgtgctga tgctcgacgt catccgcccc gcccaattcg ccaccgccgg
     5161 ctggaccagc gatttctccg gcaaggactt gtccgcctat ctgccgacct atgccgaagc
     5221 caatacggtg aacggcaaga tcgtggcgct gcctgccttt gccgactcga tgtttctcta
     5281 ttaccgcaaa gacctgctcg acaaatacgg catcaagccg ccgaccacct gggatgagct
     5341 gaaggaagcc tccaagaagg tcatggaagg cgaaaagaac cccgagcttc aaggcctgtc
     5401 cttccagggc aaggcgatcg aaggcgcggt ctgcaccttc ctcctgccct actggagtga
     5461 aggcaagtct ctggttgaaa acggcaagct gaatttcgac aacaaggctg cggtggattc
     5521 gctgaagctg tggaagagct ttgttgacga cggcatttcc aagaagaaca tttcggaagt
     5581 ggcgaccgac gacacccgca aggaattcca agccggcaag gtgctcttcg ccgtcaactg
     5641 gtcctacgcc tggacccatt tccaaggcaa ggaatcgcag gtgaacgaca aggtcggcgt
     5701 cgcccgcctg ccggccgtca agggcggtga gcagacgacc tgcctcggcg gctgggaatt
     5761 cggcgtctcc gcctattcca agcagcagga tgaagccaag aagctggtgg aatatctctc
     5821 cagtcaggat gtgtcgaagt tcatggcgat caacgcagca cttctgccca cctatgccgc
     5881 actctacaag gatgcggacg tgaccaagac aatcccgtgg ttcgcggacg ccctgcccgt
     5941 cgttgaaacg gcaaaggccc gtccggttac cccgcgttac aacgaggtca gcgaaacgat
     6001 ccgcaccacc gtcaatggcg ttcttgccgg cgtgatgaca ccggaagatg gcgcaaagca
     6061 gatggaaagc cgtctgcggc gcgttctgcg ctaaacttca ggccggaagg cggcatgcgc
     6121 gccatgccct ttccggtcgt ttcgactgac aggaataaag ccgcctgaac ggcgcgataa
     6181 acgggccgga cataaaccgg tccgatcggg agacgatgac gtgaatccag ttgcgggagc
     6241 ggcaaaggtg acaatgccgg aaagaaccat ggtccgggtg gacgaaaagc agctgccgcg
     6301 ctggacgcgc tggctcgatc tcggcgaccg gttgctggcc gtgctactgc tggcgcccgc
     6361 agcgatcctg ctgtcgctca tcatcgttta tccggtggcg cggctcgtct ataccagctt
     6421 cttcagcctg tcgctgacct caggtctgcc ggcggaattc atcggctttg aaaattatac
     6481 ggcgatgttc gatgatccga tcttctggga aacgacctgg aatacggtgc tgatcacgct
     6541 gatcacggtg cccggcgcgc tcttcatggg ccttggccta gcactgctcg ccaacctgcc
     6601 tttctccatg caatggccga tgcggctttc gcttctgatc ccctgggcgc tgccgctgtc
     6661 ctttgcgggc ctcatcttcg cgtggttctt ccattacgaa tatggcgtgg tcaatgatgt
     6721 gctgaaccgg ctcggctttg aaggcatcat ctggttcaac tcgccgaact gggcctttgc
     6781 cgccatctgc ctgacgatca tctggaaaac ctcctccttc atggcgctga tgatccttgc
     6841 gggcttgcag accattccgc gctcgcttta cgaggcagcg gatgtggatg gcgccggcaa
     6901 gatcaggcgg ttcttcgaga tcaccctgcc gctgctcaag ccctcgatcg tcgtcgcact
     6961 catcttccgc acgatcacgg cgctgcaaac ctttgatatt ccttacatga tgaccggcgg
     7021 cggacccggc acatccacca ccacgcttgc catgtatatc caccagaaca ccgtctcctt
     7081 cctcgatctc ggttacggtt cggccttagc ggtcgtgatg tttgcgcttt ccatgtgcgt
     7141 taccgccgtt tacctccgca ttatcaggac gaaggactaa acccatgagc accgttgcca
     7201 cctcccccgg tctgtcctcc ttcttctccg gcaagccgct gcgcttcatc gccgcctcca
     7261 ttcttctggt gaatggcctt ttccccgcga tctggattct cttcacctcg ctgaagaccg
     7321 aggcagaact gaccgtgaaa ccgatcacat ggtttccgca cgcgccgacg cttgccaatt
     7381 acatgcaggc cttttccgat cagccgttgc acctcttcct gtttaacagc ttcatggtgg
     7441 cgctgctctc caccgcactc accatcctga tttctgtact ggcggcttac gcgctggcgc
     7501 ggctgaacct caaataccgc gcgctgatcc tgtcgctcat catcgccgtt tccaccttcc
     7561 cgcttgtcac gctgctggtg ccgctgttcg aaatcatgcg ggcgctcaat ctgctgaata
     7621 gctggacggc actgatcctg ccctacacgg tgctgtcgct accggtctgc acgctgatgc
     7681 tggtatcctt cttcgaaagc attccgcgcg acctcgaaaa cgccgccatg atcgatggct
     7741 gcacccgcat cggcgccctg ttcaaggtcg tcgtgccgct ctgcgcgccg ggcgtcttta
     7801 ccgccggcat tctcgccttc gtcaatgcct gggatgagtt cctgctggcg ctctctttca
     7861 actccaaccc ggcccttcgc accctgcccg tcggcattca gctttatcag ggtgagttcg
     7921 ccttcccctg gccggtcatc tcggcggcgc tggtggtcgg catcgtgccg gttgcgatcc
     7981 tgatcgtcat cttccaggaa cgggtcgtct cgggcctcac cgccggtggt ctcaagggct
     8041 aaaaggttaa gtcatgcatt tcgaaacgac caaagacggc ttcacgatcg cgatcggcaa
     8101 ccgcatcatc ctttcccatt cgcccgataa accggccttc ttcgccggtt tcggcgagga
     8161 acgaatggac atgtatcgtg gcaatttcga tatcgaggac tatgtcatcg agagaacggc
     8221 cctgcgccat gccgaggtga gtggcgacag cgtcacgctc tcatccgcgc caggacaggc
     8281 gccgcgcctt cgcctgacgc tcgacggcaa cgccatcagg ctgacggcgc tggacgagac
     8341 gatcaaccgc ctctggctgc gcgtcgtcgc ggagacggac gagcatgtct ggggtggcgg
     8401 cgagcagatg tcctatttcg acatgcgcgg ccggcgcttc ccgctctgga cctctgagcc
     8461 cggggtcggc cgagacaaga ccaccgaaat caccttcaag tctgatgtca gcggcaaggc
     8521 gggtggtgat tattacaaca ccaactatcc gcagccgacc tggctctcct cgcgcaaata
     8581 cgccctgcat gtggaaacga gcgcctattc ggtcttcgac ttccgcaatg gcgatttcca
     8641 cgagatcgaa atctgggccg tccccgaaaa gatcgaattc ttcgccggcg acagtttcgc
     8701 cgatatcgtc tccgccctgt ctcttcactt cggacgccag cccgaattgc ctgattgggt
     8761 ctataacggc gcgatcatcg gattgaagga tggcgtcaac tcctttgccc ggctggagaa
     8821 aatccgtgcg gccggaacga aggtgtccgg cctctggtgc gaggactggg tggggcttcg
     8881 tcagacgtcc ttcggcgcac gcctcttctg ggactggcag gcgaatgaca cgcgctaccc
     8941 gcatctgcgc cagaagatcg ccgagttagc cgatcagggt atccgctttc tgggttacgt
     9001 gaacccctat ctctgcgtag atggcccact ctttccggtc gctgaatcgg cgggttattt
     9061 cgccaccgat gtggatggaa agacggcgtt ggtggacttc ggcgaattcg attgcggcgt
     9121 ggtggatttc accaaccctg ccgccgccga ctggttcgcc gaagagatca tcggcaaaaa
     9181 catgctggat ttcgggcttt ccggctggat ggccgatttc ggtgaatatc tgccgatcga
     9241 tatcaagctg tccaatggcg tcgacgccaa gctgatgcat aatgcctggc cgacgctctg
     9301 ggccgaagtc aatgcgaagg gcgtcgaaag ccgtggcaag accggcgaag cactgttctt
     9361 catgcgtgca ggcttcaccg gcgtgcaggc ccattgcccg ctgatctggg gtggcgacca
     9421 gtctgtcgac ttctcccgtc atgacggcct tgtcaccgtc atctgcggcg cgctctcctc
     9481 cggcctcatg ggcaatgcct atcatcactc agacatcggc ggctacacca gcctgttcgg
     9541 caatgtccgg acagcggaac tcatcatgcg ctggacggag atggccgcct tcaccccggt
     9601 catgcgcacc catgagggca accggccgcg ggacaatctc cagatcgatc aggatgaaac
     9661 tgttcttgcc catttcgccc gcatgacggc gatatacgtc gcgctcgccc cctatctgaa
     9721 atcgctctcc gccgaggccg caaaaaccgg cctgccggtg cagcgacccc tattccttca
     9781 ttacgagaat gagccgcaga cctatgccgt tcaggactgc tatctctacg gggcggacat
     9841 gcttgtcgca ccggtctgga aagcaggcga aacgcaacgc tcgctctacc ttccgggtca
     9901 tggcgaatgg gtgcatctct ggagcggcaa gcgtcatgcc ggcgggcgag acatcaccgt
     9961 cgaaacaccg ctcggagagc cggcggtgtt ctatcgtgcc gatagcagcc atcaccggct
    10021 gttcgaacag cttcgcacca tcggctga
//
