LOCUS       NC_004663              12405 bp    DNA     linear   CON 05-SEP-2024
DEFINITION  Bacteroides thetaiotaomicron VPI-5482, complete sequence.
ACCESSION   NC_004663 REGION: 3989587..4001991
VERSION     NC_004663.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02604314
            Assembly: GCF_000011065.1
KEYWORDS    RefSeq.
SOURCE      Bacteroides thetaiotaomicron VPI-5482
  ORGANISM  Bacteroides thetaiotaomicron VPI-5482
            Bacteria; Pseudomonadati; Bacteroidota; Bacteroidia; Bacteroidales;
            Bacteroidaceae; Bacteroides.
REFERENCE   1  (bases 1 to 12405)
  AUTHORS   Mahowald,M.A., Rey,F.E., Seedorf,H., Turnbaugh,P.J., Fulton,R.S.,
            Wollam,A., Shah,N., Wang,C., Magrini,V., Wilson,R.K.,
            Cantarel,B.L., Coutinho,P.M., Henrissat,B., Crock,L.W., Russell,A.,
            Verberkmoes,N.C., Hettich,R.L. and Gordon,J.I.
  TITLE     Characterizing a model human gut microbiota composed of members of
            its two dominant bacterial phyla
  JOURNAL   Proc Natl Acad Sci U S A 106 (14), 5859-5864 (2009)
   PUBMED   19321416
REFERENCE   2  (bases 1 to 12405)
  AUTHORS   Xu,J., Bjursell,M.K., Himrod,J., Deng,S., Carmichael,L.K.,
            Chiang,H.C., Hooper,L.V. and Gordon,J.I.
  TITLE     A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
  JOURNAL   Science 299 (5615), 2074-2076 (2003)
   PUBMED   12663928
REFERENCE   3  (bases 1 to 12405)
  AUTHORS   Mahowald,M.A. and Gordon,J.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2009) Center for Genome Science, Washington
            University in St. Louis, 4444 Forest Park Ave., St. Louis, MO
            63108, USA
  REMARK    Protein update by submitter
REFERENCE   4  (bases 1 to 12405)
  AUTHORS   Xu,J., Bjursell,M.K., Himrod,J., Deng,S., Carmichael,L.K.,
            Chiang,H.C., Hooper,L.V. and Gordon,J.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-OCT-2002) Department of Molecular Biology and
            Pharmacology, Washington University in St. Louis, 660 S. Euclid,
            St. Louis, MO 63110, USA
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            AE015928.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000011065.1-RS_2024_09_05
            Annotation Date                   :: 09/05/2024 02:14:13
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,888
            CDSs (total)                      :: 4,801
            Genes (coding)                    :: 4,687
            CDSs (with protein)               :: 4,687
            Genes (RNA)                       :: 87
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 55 of 114
            Pseudo Genes (incomplete)         :: 60 of 114
            Pseudo Genes (internal stop)      :: 20 of 114
            Pseudo Genes (multiple problems)  :: 17 of 114
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..12405
                     /organism="Bacteroides thetaiotaomicron VPI-5482"
                     /mol_type="genomic DNA"
                     /strain="VPI-5482"
                     /type_material="type strain of Bacteroides
                     thetaiotaomicron"
                     /db_xref="taxon:226186"
     gene            complement(1..2208)
                     /locus_tag="BT_RS15855"
                     /old_locus_tag="BT3130"
                     /old_locus_tag="BT_3130"
     CDS             complement(1..2208)
                     /locus_tag="BT_RS15855"
                     /old_locus_tag="BT3130"
                     /old_locus_tag="BT_3130"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008767393.1"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH92 family glycosyl hydrolase"
                     /protein_id="WP_011108651.1"
                     /translation="MKKLLLSVCAFSLTLATLQAGEITKYVNPFIGTGAIDGGLSGNN
                     YPGATSPFGMIQLSPDTSEAPNWGDASGYDYNRNTIFGFSHTRLSGTGASDLIDITLM
                     PTSSGRTSSAFTHDEEKARPGYYQVMLKDENINAELTTTQRNGIHRYQYPAGKDAEII
                     LDMDHSADKGSWGRRIINSQIRILNDHAVEGYRIITGWAKLRKIYFYMEFSSPILTST
                     LRDGGRVHENTAVINGTNLHGCFRFGQLNGKPLTCKVALSSVSMENARQNMEQEAPHW
                     DFDRYVAAADADWEKQLGKIEVKGTEVQKEIFYTALYHTMIQPNTMSDVNGEYMAADY
                     TTRKVANNETHYTTFSLWDTFRASHPLYTLLEPERVTDFVKSMIRQYEYYGYLPIWQL
                     WGQDNYCMIGNHSIPVITDAILKGIPGIDMEKAYEAVYNSSVTSHPNSPFEVWEKYGF
                     MPENIQTQSVSITLEQAFDDWCVAQLAAKLNKDADYQRFHKRSEYYRNLFHPKTKFFQ
                     SKNDKGEWIEPFDPYQYGGNGGHPFTEGNAWQYFWYVPHNIQALMELTGGTKAFEQKL
                     DTFFTSTYKSEQMNHNASGFVGQYAHGNEPSHHVAYLYNFAGQPWKTQKYVSHILNTL
                     YNNTSSGYAGNDDCGQMSAWYVFSAMGFYPVNPADGRYIIGSPLLDECTLKLAGNKEF
                     RIRTIRKSPEDIYIQSVTLNGKKHKDFFITHQDIMNGGTMVFKMGKKPSGWGK"
     gene            complement(2255..4411)
                     /locus_tag="BT_RS15860"
                     /old_locus_tag="BT3131"
                     /old_locus_tag="BT_3131"
     CDS             complement(2255..4411)
                     /locus_tag="BT_RS15860"
                     /old_locus_tag="BT3131"
                     /old_locus_tag="BT_3131"
                     /EC_number="3.2.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008767394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosidase"
                     /protein_id="WP_011108652.1"
                     /translation="MKLKAFLLFFLLSSFSLLQAADKPLIKIETERTSLIYQVADNGR
                     LYQKYLGKKLNHDSDIQYLPQGTEAYLTHGMEDYFEPAIHIRHNDNNSSLLLKYVDHS
                     SNAIGNGVNETVITLKDDKYPVTVKLHYVAYGKENIIRTFTEISHEEKKPVILCKYAS
                     SMLHLNSSKYFLTEFSGDWAHEANVTERELAFGKKVIDTKLGARANMFVSPFFQLALD
                     NPSQENAGEVLVGTIGWTGNFRFTFEVDNKNELRIISGINPYDSEYSLPAREVFRTPD
                     FYFTYSTQGKGEASRNFHDWARNHQVKNGNDTRMTLLNNWESTYFDFDENKLIGLMDE
                     ATKLGVDMFLLDDGWFANKYPRSSDHQGLGDWEETADKLPNGVGRLVEEAQKKGIKFG
                     IWIEPEMVNPKSELYEKHKDWVIHLPNRDEYYFRNQMVLDLSNPKVQDHVFGVVDNLM
                     TKYPGIAFFKWDCNSPITNIYSVYLKDKQSHLYVDYVRGLYKVLDRIKAKYPNLPMML
                     CAGGGGRSDYEALKYFTEFWPSDNTDPIERLFIQWGYSQIFPSKTLCAHVTTWNRGTS
                     IKFRTDVAMMCKLGFDIKLEDMNQNEHLYCDQAVKNYNRLKPVILEGDLYRLVSPYGS
                     NHTSSMFVGKDKKTAAVFAFDIHPRYAEKTLPVRLQGLNADKKYRVKEINMMPGSGSS
                     LKGNNQVFSGEYLMNVGLDLFTTQQLNSRLIEITEE"
     gene            complement(4436..6382)
                     /locus_tag="BT_RS15865"
                     /old_locus_tag="BT3132"
                     /old_locus_tag="BT_3132"
     CDS             complement(4436..6382)
                     /locus_tag="BT_RS15865"
                     /old_locus_tag="BT3132"
                     /old_locus_tag="BT_3132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016269150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sialate O-acetylesterase"
                     /protein_id="WP_011108653.1"
                     /translation="MKKYQLTLLSLCVAAFAQAKVTLPSFFTDNMVIQQNSQLTLPGK
                     AKAGKQVTVKVSWNHEKYTAKASADGHFSIEVPTPPAGGPYQIIVSDGEKLVLNNVLS
                     GEVWICSGQSNMEMPVAGWGKVMNYEQEVADADYPSIRLLQVKKTVAFSPQDNVEMNM
                     NGWQECSSATVPEFSSVAYFYARKLWKELNVPVGVIDCTWGGTPAESWTSHQTLKQVV
                     GFQKKMAEMESAGFQREKLVELYHREMDEWLQQFDAKDAGFKDGVPQWISALQTGNEW
                     KPMELPAYWETRGLNFDGTVWFQKEVEIPADWNGKEISFHLAMIDDDDVTYFNGKEIG
                     RTSGCNTMRTYKIPAALAKAGKGVITIRAIDYGGEGGIHGEPQQMYMEANDKKISLAG
                     NWNYHTGVSMTGAPSRPLSPEGTGWPTSCYPTVLYNAMIHPFTVFPIKGAIWYQGENN
                     VGFDEQYRVLFQSMITDWRRAWKQDFPFYFVQLANYLKPEEVQPDSKWAALRDAQAHA
                     LHLPNTGMACAIDLGEAYDIHPKNKQEVGKRLAQAALAKTYNKGTYEVPAFLGYRISG
                     RTLILSFDQEVVAKEGTPKGFILAGPDGKYVPAQAIIRGKEVILQSDRIEIPTAACYA
                     WADNPVCNLYGKNGLPVPPFRTRE"
     gene            complement(6391..8412)
                     /locus_tag="BT_RS15870"
                     /old_locus_tag="BT3133"
                     /old_locus_tag="BT_3133"
     CDS             complement(6391..8412)
                     /locus_tag="BT_RS15870"
                     /old_locus_tag="BT3133"
                     /old_locus_tag="BT_3133"
                     /EC_number="3.2.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008767396.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosidase"
                     /protein_id="WP_048698132.1"
                     /translation="MKNQKLLLKKMSGVSLMLLLFLFISNCASGDKIFSTDVWNITYD
                     DQQGGIALTYKSKNICNGMYASYQWEGKEIKTSDYARHKISTGKVSDSFGKGHIYKVE
                     YTDKELPKLTQYFYLYPGKEYILTDFTVEAKEEIRSGRMAPVNVDSISGFLQAGDNRA
                     LFVPFDNDKWIRYQSHPLGFDTLVSYEVTAIFNNESRNGLVIGSVEHDNWKTGISIGK
                     GDRDNIGSLVCYGGIADEQTRDVKAHGALAGKKIKSPKVFLGFFEDWCDGLEAYAKAN
                     AVIAPPKAWEKAVPFGWNSWGALQFNLTYEKAMEVSDYFKENLQNNHFVNPDQTVYIG
                     LDSGWDCMNEEQLKSFIEKCKSNGQIGGIYWTPFTDWARDPERTVDAAPEYKYKDIYL
                     YANGKPQELDGAYAVDPTHPAVEAMMKKTSGLFHRAGFEYVKMDFMTHGAMEADKWYN
                     PEITTGIQGYNYGMKLLNQYFGDMYINLSISPVFPAQYAQSRRIACDAWNQIKDTEYT
                     LNALSYGWWQKYIYQYNDADHIVLRDATDGENRARITSGVITGIYITGDDFSAGGGKD
                     AKEKSQKYLTNAAVNAVATGEVFRPVEGNGEKSEHIFVRKTPDGRFHCAVFNYSDQEQ
                     TTVLSLERIGLDKARGYQVKELWSGNETFATGQLEVTVPSKDVQLLEFK"
     gene            complement(8590..12405)
                     /locus_tag="BT_RS15875"
                     /old_locus_tag="BT3134"
                     /old_locus_tag="BT_3134"
     CDS             complement(8590..12405)
                     /locus_tag="BT_RS15875"
                     /old_locus_tag="BT3134"
                     /old_locus_tag="BT_3134"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010535910.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hybrid sensor histidine kinase/response
                     regulator transcription factor"
                     /protein_id="WP_011108655.1"
                     /translation="MPIWQLCANLLIPNCLRSNLSYSPLTALELYVNIYNPAVDVFKR
                     FKIASSEGITLDNWVAEILSDSLDNIWVLIPDQGLFRYKDGKVHHYSLIDKDNLKNNN
                     PECICINEQGEVWVGTSGIGLFKYNYRDDNFEQYLTDRMGRSLIDKTIISICFQKENA
                     ILGIHEGDLLKYNTRTDELSEVSFLGEKKTFLRDVMCFGDEIWVGSLHGIFIINEKEN
                     NVIHLKEDLMRSFSLSDNSIYSIYKDYEGGIWIGTMFGGVNYLPNRILTFAKYVPGSD
                     SYSLNTKRIRGLAEDNNGCIWIGTEDNGVNVLDPRTGKVHQIYDNVPGRLITLSVKHY
                     ENHIYVGLFKQGMNDISIPGEHLKYVSDKDLGIEEGSVYSFLKDSKGRTWIGPGWGLY
                     VSQPKERKFHRVEEVGYNWVFDIMEARDGTIWLATMGNGVWKCDPKNNSYKNYSYKEG
                     VDNSLSSNSVSSIMQDSKGNIWFSTDRGGICRYNEAQDNFTTFSIEDGLPDDVAYNIL
                     EDDAGNLWFGTNKGLVKFNPESGDVRVFTNKDGLLGNQFNYQSALKAQDGRFYFGGVD
                     GLIAFDPTVQEEEKPLPPVYISKFSIYNKEVTVHTPESPLKQCIVHTDEIVLPYDQAN
                     ISFDVALLSYSTAESNQYYYRMEPLDRDWVRAASNQNISYAKLPPGKYTFRVQATHGS
                     KSESSTRSLSIIILPPWWQSIIAYIVYTVCIILIVVGTILWYKRRKEKQLEERQKLFE
                     IEKEKELYESKVDFFTEIAHEVRTPLTLINGPLEAIEEMEIQEPKMKKYISVMVQNTK
                     RLLELTGQLLDFQKIGANKLTMKFESVDITELLAGIVARFEVTFSLNRKELQLKSTDE
                     QVWAAVDKEAITKILSNLLNNALKYASQNVLVELEKGEDSFTIRVTSDGNKIPAEVSQ
                     YIFEPFYQVDRKEKPRNGVGIGLSLARSLASLHKGTIYLDTRQENNMFVLTIPLNMEG
                     IKQENNKAIQKDIVELDEHTPVTADMYGYTLLLVEDNESMLTFILERLQENFTVETAM
                     NGVEALEILRSSHIDLIISDIMMPVMDGYQLCKEVKSDMELSHIPIIFLTAKNDIDSK
                     INGLKYGAEAYVEKPFSFNYLKEQVLSLLDNRRREREAFAKRPFFSVNNMQMNKADEE
                     FMNKVIKVIEDNITDDNFGVERMADILCMSRSSLLRKIKTLFNLSPLDFIRLIKLKKA
                     AEFIQEGKYRIGDICYMVGINSPSYFSKLFLKQFGMTPKDFEKQYQSGKQIIITQEIK
                     NVEAGEGTK"
ORIGIN      
        1 ttactttccc catccggatg gtttcttacc catcttgaat accatcgtac caccgttcat
       61 gatgtcctga tgagtgatga agaaatcttt gtgtttcttc ccgttcaaag tcaccgactg
      121 aatgtagata tcttcgggag acttgcggat ggtccggata cggaactcct tattacctgc
      181 cagtttcaaa gtacactcat ccaaaagcgg ggaaccgatg atataccggc cgtcggcagg
      241 attgaccgga tagaatccca tcgcactgaa tacataccag gcagacatct gaccgcagtc
      301 atcatttccg gcatatcccg aagaagtgtt gttatacagc gtgttcagaa tatgactgac
      361 atacttttgc gtcttccacg gctgacctgc aaaattatag agataagcta cgtgatggct
      421 gggttcatta ccatgtgcat actgtcccac aaatcccgaa gcgttatgat tcatctgctc
      481 actcttatag gtagaggtaa aaaaggtatc cagcttttgt tcaaaggctt tcgttcctcc
      541 tgtcagttcc atcaaggcct ggatgttatg cggaacatac caaaagtatt gccatgcatt
      601 tccttcggta aacggatgcc cgccgtttcc accgtattga tacgggtcga aaggttcgat
      661 ccattctccc ttgtcattct tggactggaa gaacttcgtt ttcggatgga aaaggttccg
      721 gtaatattcg gagcgtttgt ggaatcgctg ataatcggca tccttgttca attttgcagc
      781 cagttgggca acacaccagt catcaaaagc ctgctccaga gtgatggaga cagattgagt
      841 ctgaatgttt tcgggcataa agccgtattt ctcccatacc tcaaaaggag agttggggtg
      901 tgaggttacc gaactgttat agactgcttc ataggccttc tccatatcaa ttccgggaat
      961 acctttcagg atggcatcag tgatcacagg gatggagtgg ttaccgatca tacagtaatt
     1021 gtcctgtccc cataattgcc agataggcag gtagccgtaa tattcatact ggcgtatcat
     1081 gctcttcacg aagtcagtca cccgttcggg ttccagcaat gtgtagagag gatgagaagc
     1141 gcggaaagta tcccacaggg agaatgtggt gtaatgagtt tcattgttcg ctactttgcg
     1201 ggtcgtatag tcggcagcca tgtattcgcc gttcacgtcg gacatggtgt taggctgtat
     1261 catggtgtgg taaagagccg tatagaatat ctctttctgc acttccgtac ctttcacttc
     1321 gatctttccc agttgttttt cccaatcagc gtccgcagca gccacatagc ggtcgaaatc
     1381 ccagtgcggt gcttcctgtt ccatgttctg acgggcattc tccatagaga cggatgaaag
     1441 ggctacctta cacgtcagtg gtttgccatt cagttggccg aaacggaaac agccatgaag
     1501 attcgtaccg ttgatcacgg ctgtgttttc atgaacacgc ccgccgtctc tcagcgtaga
     1561 agtaaggata ggactggaaa actccatgta gaaataaatc ttgcgcagtt tcgcccatcc
     1621 ggtgatgata cggtaacctt ccactgcatg atcattcaga atgcggatct gagagttaat
     1681 gatccggcgt ccccaactgc ccttatctgc cgagtggtcc atatccaata taatctccgc
     1741 atctttgccg gcgggatatt gatagcggtg gataccgttt ctctgagtag tggtaagctc
     1801 tgcattaata ttctcatctt tcagcattac ctgataatag ccgggacggg ccttctcttc
     1861 gtcatgcgtg aatgcggaag aagtgcgtcc gctactggtc ggcatcaatg taatgtcgat
     1921 caggtccgag gctcctgtcc cactcaggcg ggtatggctg aaaccgaaga tcgtattccg
     1981 gttatagtcg tagccggaag cgtcccccca attgggagct tcgctggtgt ccggagaaag
     2041 ctgtatcata ccgaacggcg aggtcgcccc cgggtaatta ttacccgaaa gtcccccatc
     2101 gatggccccc gttccaataa acggatttac atatttagtg atttcccctg cctgcaacgt
     2161 agcgagagtc aatgaaaatg cacatacact taaaagtaat ttcttcatgg ttcatggtgt
     2221 ttttataaga tatgtttctt atgtctatgg ctttttattc ttctgttatt tcaatgagac
     2281 ggctgttgag ctgctgtgtt gtgaaaagat ccagtccgac gttcattaga tattctccgg
     2341 agaaaacctg gttgttaccc ttcaatgagg aaccgctacc gggcatcata ttgatttcct
     2401 tcacacggta cttcttgtcg gcattcaacc cttgcaggcg gacaggcaat gtcttttccg
     2461 catagcgcgg atggatatcg aaggcaaata ccgcagccgt tttcttgtcc ttgcctacaa
     2521 acatggaaga agtatggttg cttccgtaag gagaaacgag gcgatacaaa tcaccttcaa
     2581 ggatgacagg tttcagacgg ttgtagttct tgactgcctg atcacagtaa aggtgctcat
     2641 tctgattcat gtcttccagt ttgatgtcga atcctaattt gcacatcatg gctacatcgg
     2701 tacggaactt gatactggtt ccacgattcc aagtagtgac gtgggcacac agtgtcttac
     2761 ttgggaagat ctgcgaatag ccccattgga taaacaggcg ttcgatagga tcggtattgt
     2821 cgcttggcca gaactctgtg aagtacttca atgcttcata gtcggagcgt ccgccgccac
     2881 cggcacacag catcatcgga agattaggat atttagcctt gattctgtcc agcaccttgt
     2941 aaagtccgcg cacataatca acgtacagat gagactgttt atctttcaga tacaccgaat
     3001 agatattcgt aatcgggctg ttgcagtccc atttgaagaa agcgatgccg ggatatttgg
     3061 tcatcaggtt gtccaccacg ccgaatacat gatcctgtac tttcggattg ctaaggtcga
     3121 gcaccatctg gttgcggaag tagtattcat cacggttagg cagatgaatc acccagtcct
     3181 tatgcttttc gtaaagctcg cttttgggat ttaccatttc cggctctatc catataccga
     3241 acttgatacc tttcttttgt gcttcttcaa caagacgccc tactccgttc ggaagtttgt
     3301 cggcagtctc ttcccagtcg cccaacccct gatggtcact gctacgggga tatttgttgg
     3361 caaaccaacc atcgtccagc aggaacatat ctacgcccag cttggtagcc tcatccatca
     3421 agccgatcag tttattttca tcaaagtcaa aataggtaga ttcccagttg ttgagcaaag
     3481 tcatgcgggt atcattaccg tttttcacct gatgattgcg cgcccagtca tggaagttac
     3541 ggctggcctc acctttcccc tgcgtgctgt aagtgaaata gaagtccgga gtacggaaca
     3601 cttctctggc gggcaggctg tattcggagt cgtacgggtt gataccgctg ataatacgca
     3661 gttcgttttt gttgtccact tcgaaagtaa agcgaaagtt acccgtccat ccgatggttc
     3721 ctaccagcac ttcgcctgca ttctcctgcg aaggattgtc aagagccagc tggaagaaag
     3781 gagatacaaa catattggca cgtgcaccca acttcgtatc gatcaccttt ttaccgaaag
     3841 ccagttctct ttcggtcacg ttggcttcgt gtgcccagtc accggaaaat tcagtcagga
     3901 aatacttgct gctgttcagg tgaagcattg atgaagcata cttgcaaagt atcacaggtt
     3961 tcttctcttc atggctgatt tcagtaaacg tacggataat gttctctttg ccgtaagcca
     4021 cataatgcag cttcacggtc acagggtatt tatcatcctt aagggtaatt acggtttcgt
     4081 tgaccccgtt accgatggca ttgctcgaat gatctacgta tttcagcagc aatgaagagt
     4141 tattatcgtt atgacgtatg tgaatagccg gttcaaagta gtcctccata ccgtgagtca
     4201 gataagcttc agtcccttgt ggcagatact ggatatcgga atcatggtta agctttttgc
     4261 ccaagtattt ctgatacaga cgtccgttgt cagctacttg atagataagg ctggtccgtt
     4321 cggtttctat tttgatcagc ggcttgtcgg cagcctgcaa aagagaaaaa gaactcaata
     4381 gaaaaaaaag taagaatgct tttaatttca tggtttacat tgttatggtt gatatttatt
     4441 ctctggtgcg gaacgggggt acgggaagcc cgttcttgcc atatagatta caaacaggat
     4501 tgtctgccca cgcatagcag gccgccgtcg gtatttctat ccggtcggat tgcagaatga
     4561 cttcttttcc ccggataata gcctgtgccg gaacgtattt cccgtccggt cctgccagta
     4621 taaagccttt cggagtacct tctttggcta ctacttcctg atcgaaacta agaatcagcg
     4681 tacgtcccga aatgcggtat ccaaggaatg cgggcacttc gtatgtacct ttgttatagg
     4741 tcttcgccaa tgccgcttgc gccagtcgct ttcctacttc ctgtttgttt ttcgggtgga
     4801 tatcataagc ttcgccgagg tcgatggcac atgccatacc tgtattaggt aggtgcagcg
     4861 catgtgcctg tgcatcacgg agagccgccc atttggagtc cggctgtact tcttccggct
     4921 tcagataatt ggccaactgc acaaagtaga aaggaaaatc ctgtttccat gcccttctcc
     4981 aatctgtaat cattgattgg aaaagtactc tgtactgctc gtcgaatcct acattatttt
     5041 ctccctgata ccagatagcg cccttgatag ggaagacggt aaaaggatgt atcattgcat
     5101 tgtaaagtac ggtcggatag caggatgtcg gccagccggt tccttcggga gacaatggtc
     5161 tagaaggtgc accggtcatc gatactccgg tgtgatagtt ccagttgccc gccaaggaaa
     5221 tcttcttgtc gttcgcttcc atatacatct gctgaggttc tccgtggata ccgccttcgc
     5281 cgccataatc tatggcacgg atggtgataa cccctttgcc tgcctttgcc aaggctgcgg
     5341 gaatcttata agtacgcatc gtattgcatc ccgaagttct tcctatctcc ttcccgttaa
     5401 agtaagtaac atcgtcgtcg tcgatcatag ccagatggaa ggagatttcc ttgccgttcc
     5461 agtcagcagg tatttccact tctttctgga accagacagt gccgtcaaaa ttcagtccgc
     5521 gagtttccca ataagcgggc agttccatcg gtttccattc attccctgtc tgaagagctg
     5581 atatccattg gggaactccg tctttgaatc cggcatcctt ggcatcaaac tgctgaagcc
     5641 actcgtccat ttcccgatgg taaagttcga caagtttctc tctttggaag cctgcgcttt
     5701 ccatttcggc catctttttc tgaaatccca cgacttgctt caatgtctga tggcttgtcc
     5761 atgattcggc aggtgtgccg ccccaagtgc agtcaatcac cccaacgggc acattcagtt
     5821 ctttccacaa cttacgggca tagaaataag caacggaaga aaactccggt acagtagcgg
     5881 aactacattc ctgccagccg ttcatattca tttctacgtt atcctgcgga gagaaagcga
     5941 cggtcttctt tacctgcaac agacggatgg aaggataatc ggcatcggca acctcctgtt
     6001 cgtaattcat cacttttccc catccggcaa cgggcatttc catattcgac tgaccggaac
     6061 atatccagac ttcgcccgat aagacgttgt tcaacactag tttctcacca tccgaaacaa
     6121 tgatctgata aggtcctccg gcaggcggag tcgggacttc tatgctaaaa tgaccatcag
     6181 ctgacgcttt agccgtatat ttctcatgat tccagctcac cttcacagtc acttgtttac
     6241 cggcttttgc ttttcccggc aacgtcagct gactgttttg ctgaataacc atattatcgg
     6301 taaagaatga cggcaatgtg accttcgctt gcgcaaaggc tgccacacat aacgataaga
     6361 gtgttaattg atattttttc atttcttcgg ttatttaaat tcaagtaatt gcacgtcttt
     6421 ggagggtacg gtcacttcaa gctgtcctgt ggcaaaagtc tcattgccgc tccacaactc
     6481 tttcacctga tagccgcgtg ccttgtccaa tcctattctt tctaacgaaa gcacagttgt
     6541 ctgttcctgg tccgagtagt tgaataccgc acaatggaaa cgaccatcgg gtgtcttcct
     6601 tacaaagata tgttccgact tctctccgtt tccttccacg ggacggaaca cttctcctgt
     6661 cgctactgca ttcactgccg cattggtcag atatttctgt gacttttctt tggcgtcttt
     6721 tcctcctccc gcactgaaat cgtctcctgt aatgtaaata cccgtaatga cacccgaagt
     6781 aatacgggca cggttttctc cgtcggtagc atctctcagt acaatatgat cggcatcgtt
     6841 atattgatag atatacttct gccaccagcc gtatgaaaga gcgttcaatg tatattcggt
     6901 atccttgatc tgattccacg catcacaggc tattctgcgt gactgcgcat actgggcagg
     6961 gaagacagga gaaatggaga gattgatata catatctcca aaatattgat tgagcagttt
     7021 catgccataa ttatatccct gtatacctgt ggtaatctca ggattatacc atttgtccgc
     7081 ttccatcgca ccgtgtgtca tgaagtccat cttcacatac tcgaatcctg cacggtggaa
     7141 caaaccggaa gtcttcttca tcatagcttc cactgccgga tgcgttggat cgactgcata
     7201 agcgccgtcc agttcctgcg gctttccgtt ggcatagaga tagatatctt tgtatttata
     7261 ttccggtgcg gcatctaccg tccgttccgg atcgcgtgcc cagtcggtga acggagtcca
     7321 gtagatacca ccgatctgtc cgttcgactt acatttttcg ataaatgact tcagttgctc
     7381 ctcattcata cagtcccaac cggaatccag accgatatag acagtctgat cagggtttac
     7441 aaaatgatta ttctgcagat tctccttgaa ataatcggag acttccatcg ctttctcata
     7501 agtcagattg aattgtaatg ccccccagct gttccaacca aatggaacag ctttctccca
     7561 tgctttggga ggggcaatta cagcgttggc ttttgcatac gcttcaagtc catcgcacca
     7621 atcttcaaag aaacccaaaa agactttagg ggatttaatc tttttacctg ctaatgcacc
     7681 gtgagccttt acgtcacgag tctgctcatc tgctatgccc ccataacata ccagcgaacc
     7741 aatgttatca cgatccccct tacctattga aatacctgtt ttccagttat catgttctac
     7801 ggagccgatc accagaccgt tccggctttc attattgaat atggctgtca cttcataact
     7861 caccaatgta tcgaaaccaa gcgggtgaga ctgatatctg atccatttgt cattgtcgaa
     7921 cggaacaaaa agagcacggt tatcacctgc ctgcaagaat ccggatatag aatcgacatt
     7981 aacaggagcc attctgccgg aacggatttc ctctttcgct tcgaccgtaa aatcggtcag
     8041 tatatattcc ttacccggat aaagatagaa atactgagtc agcttcggaa gctccttatc
     8101 cgtatactcc accttatata tatgtccttt cccgaaagaa tcggaaactt tgcccgtact
     8161 gattttatgg cgggcatagt cacttgtctt gatctccttc ccttcccatt gataggaagc
     8221 atacattccg ttacaaatat tttttgactt ataagtgagt gctattcccc cttgctgatc
     8281 atcgtaagtt atattccata catcggtaga gaaaatcttg tctccactgg cacagttgga
     8341 aatgaaaaga aacagaagaa gcatcaggga tactcccgac atttttttta gtagtagctt
     8401 ttggtttttc atatggtaca atgttcttat gtaaaaaaat aaagcatacc cgaataagaa
     8461 acctttttct cttattgagg tatgccacaa aggtaaggat tggcatctcc tttactatat
     8521 acaaacgatt caaaaaatga taaaaatacg gcaaataagc tccaatgcgg gctaaaagag
     8581 gtattttatc tattttgtgc cctctcctgc ctcgacattc tttatctcct gcgtgataat
     8641 gatctgcttg ccggattgat attgtttctc aaaatctttg ggtgtcatgc cgaattgttt
     8701 caggaataac ttgctgaaat aagacggcga attgatgccg accatatagc agatatctcc
     8761 gatccggtat ttaccttcct ggataaactc ggctgccttt ttcaacttga tcaaccggat
     8821 aaaatcgagc ggagacaagt tgaacagtgt cttgattttc cttaacaaac tagaacgact
     8881 catgcagagt atatccgcca tccgttctac accgaaatta tcatcggtta tgttatcttc
     8941 aatgaccttg atcactttat tcataaattc ctcgtccgcc ttgttcatct gcatattgtt
     9001 gacagagaag aaggggcgtt tcgcaaaggc ttctctttcc ctgcgcctgt tgtcaagcaa
     9061 ggacaggact tgttctttca gataattgaa agagaaaggt ttctcaacgt atgcttccgc
     9121 accatatttc agaccgttga ttttgctgtc gatgtcattc ttggctgtca ggaagataat
     9181 aggaatatga gaaagctcca tatccgattt tacttccttg cagagttggt atccgtccat
     9241 tacaggcatc atgatatcac tgatgatcaa gtcgatatgg ctgcttctca atatttccag
     9301 tgcttctacc ccgttcatcg ctgtctctac ggtgaagttt tcctgcaagc gttcgagaat
     9361 aaaggtcagc atactttcgt tgtcttctac caacagaagg gtatatccat acatatcggc
     9421 cgtgacgggc gtatgttcgt ccagctcgac aatgtctttc tgtatggctt tgttgttctc
     9481 ctgtttaatg ccctccatat tcaaaggaat ggtcagtaca aacatattgt tttcctgacg
     9541 ggtatccaga tagatcgtgc ctttgtgcag ggatgccaac gaacgtgcca gagacaagcc
     9601 gatgcctact ccattacggg gcttctcctt tctgtccacc tgatagaacg gttcgaatat
     9661 atattggctg acttcggccg gaatcttgtt tccatcactg gtgacacgaa tcgtaaagct
     9721 gtcttctccc ttttccagtt ctaccagtac attctggcta gcatacttca gcgcattatt
     9781 gagcaggttg ctcagtatct tggtgattgc ttctttatct acagctgccc acacctgctc
     9841 atctgtcgat tttaactgca attctttccg gttcaggctg aacgtcactt caaagcgtgc
     9901 cacgattccg gcaagaagtt cggtaatgtc cacgctctca aatttcatgg tcagcttgtt
     9961 ggcaccgatc ttctggaagt ccagcagttg tccggtaagt tccagcaggc gtttggtgtt
    10021 ctggaccatc acactgatat acttcttcat cttgggctcc tgtatctcca tttcctcaat
    10081 ggcttcgaga ggaccgttga tcagtgtcaa aggggtacgc acttcgtgcg ctatctctgt
    10141 gaagaagtcc actttggatt cgtacagttc cttctccttt tcgatctcga acagcttttg
    10201 ccgttcttcc agttgtttct ccttgcggcg tttgtaccat aagatggtgc caaccacgat
    10261 caggataata catacggtat atacaatgta agcaatgata gactgccacc acggaggaag
    10321 aatgataata gacagagagc gtgtggacga ctcggacttg ctgccgtgag tagcctgcac
    10381 acggaaggtg tattttcccg gcggaagttt ggcatacgag atgttctggt tgctggctgc
    10441 ccgtacccaa tccctgtcaa gcggttccat acgataatag tattggttgg actcggccgt
    10501 agagtagctg agcaatgcca catcaaagct tatattggcc tggtcgtaag gcaggacgat
    10561 ttcatccgta tgtacaatac attgtttcag gggtgattca ggagtatgca ccgtcacctc
    10621 cttattatat atactgaact tggaaatgta aacaggcgga agcggctttt cctcctcctg
    10681 aacagtagga tcgaacgcga tcaatccgtc cacccctccg aagtagaacc ttccatcctg
    10741 agctttcaat gccgattgat aattgaactg attacccagc aatccgtcct tattggtaaa
    10801 gacacgtaca tctccactct cgggattgaa cttgaccaat cctttattgg tgccaaacca
    10861 cagatttccg gcatcatctt ccaatatgtt gtaagctacg tcatccggta gtccgtcttc
    10921 aatactgaaa gtggtaaagt tgtcctgcgc ttcattatat ctgcatatac caccacggtc
    10981 ggtagagaac catatattcc ctttactgtc ctgcatgatg gagctgacgg agttggagct
    11041 tagagagttg tcaactcctt ccttataaga ataattctta taagaattat tcttaggatc
    11101 acatttccaa acaccatttc ccatagtagc aagccaaatt gtaccatctc tagcctccat
    11161 tatatcgaaa acccagttat atcctacttc ttccacacgg tgaaatttcc tttccttagg
    11221 ttgtgataca tataatcccc acccaggtcc tatccaagta cgacctttac tatcttttaa
    11281 aaaactatat acacttcctt cttcaatacc caaatcctta tcactgacgt atttaagatg
    11341 ttcaccaggt atactaatat cattcattcc ttgtttaaat aatccaacat atatatgatt
    11401 ttcataatgt tttactgata gtgtaatgag acgacctgga acattatcat atatctgatg
    11461 tactttacct gttcgaggat ccaatacatt aacaccatta tcttcagtac ctatccaaat
    11521 acacccatta ttatcttctg ccaatccacg gatacgtttg gtatttaaag aatatgaatc
    11581 gcttcccggt acatatttag caaaagtcaa gatacgatta ggcagatagt tgacacctcc
    11641 aaacattgtt ccaatccaaa ttcctccttc ataatcttta taaatagaat aaatactatt
    11701 atccgataaa ctaaatgaac gcatcaggtc ttctttcaaa tgaataacat tattttcttt
    11761 ctcattaata atgaaaattc catgaagaga acctacccaa atttcatctc caaaacacat
    11821 tacatctcgc aaaaatgttt ttttctcacc aaggaacgaa acttcactca actcatctgt
    11881 tcgagtatta tatttcagca aatctccttc atgtattccc aaaatagcat tttctttctg
    11941 aaaacaaata cttataattg ttttgtcaat taacgaacgt cccattcggt ctgtcaaata
    12001 ttgttcaaaa ttatcatccc gataattgta cttgaataaa cctattcctg atgtacctac
    12061 ccatacttcg ccctgctcat tgatacaaat acattccgga ttattatttt ttaaattgtc
    12121 tttatctatc aatgaataat gatgtacctt tccgtcttta taacgaaaaa gtccctgatc
    12181 aggaatcaac acccaaatat tatctagtga atcagacaga atttccgcta cccagttatc
    12241 aagagttatc ccttctgatg aagctatttt gaaacgttta aatacatcga ccgccggatt
    12301 atatatatta acataaagct ctaaagcagt caaaggagaa taagagaggt tggaacgtaa
    12361 acagttggga atgagcagat ttgcacaaag ttgccaaatc ggcat
//
