LOCUS       NC_015977              19415 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Roseburia hominis A2-183, complete sequence.
ACCESSION   NC_015977 REGION: 2480616..2500030
VERSION     NC_015977.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02604129
            Assembly: GCF_000225345.1
KEYWORDS    RefSeq.
SOURCE      Roseburia hominis A2-183
  ORGANISM  Roseburia hominis A2-183
            Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
            Lachnospiraceae; Roseburia.
REFERENCE   1  (bases 1 to 19415)
  AUTHORS   Travis,A.J., Kelly,D., Flint,H.J. and Aminov,R.I.
  TITLE     Complete Genome Sequence of the Human Gut Symbiont Roseburia
            hominis
  JOURNAL   Genome Announc 3 (6), e01286-15 (2015)
   PUBMED   26543119
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19415)
  AUTHORS   Mulder,I.E., Aminov,R.I., Travis,A.J., Lan,A.,
            Gaboriau-Routhiau,V., Garden,K., Logan,E., Delday,M.,
            Coutts,A.G.P., Grant,G., Patterson,A.M., Cerf-Bensussan,N. and
            Kelly,D.
  TITLE     Bi-directional cross-talk Between a Clostridium symbiont, Roseburia
            hominis, the gut immune system and appetite regulation
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 19415)
  AUTHORS   Mulder,I.E., Aminov,R.I., Travis,A.J., Lan,A.,
            Gaboriau-Routhiau,V., Garden,K., Logan,E., Delday,M.,
            Coutts,A.G.P., Grant,G., Patterson,A.M., Cerf-Bensussan,N. and
            Kelly,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2011) Rowett Institute of Nutrition and Health,
            University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen,
            Aberdeenshire AB21 9SB, Scotland (UK)
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP003040.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000225345.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 12:47:22
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,351
            CDSs (total)                      :: 3,277
            Genes (coding)                    :: 3,213
            CDSs (with protein)               :: 3,213
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 52 of 64
            Pseudo Genes (internal stop)      :: 9 of 64
            Pseudo Genes (multiple problems)  :: 5 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..19415
                     /organism="Roseburia hominis A2-183"
                     /mol_type="genomic DNA"
                     /strain="A2-183"
                     /culture_collection="DSM:16839"
                     /culture_collection="NCIMB:NCIMB 14029"
                     /type_material="type strain of Roseburia hominis"
                     /db_xref="taxon:585394"
     gene            complement(1..1305)
                     /locus_tag="RHOM_RS11115"
                     /old_locus_tag="RHOM_11420"
                     /db_xref="GeneID:93724035"
     CDS             complement(1..1305)
                     /locus_tag="RHOM_RS11115"
                     /old_locus_tag="RHOM_11420"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080403.1"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 3 protein"
                     /protein_id="WP_014080403.1"
                     /db_xref="GeneID:93724035"
                     /translation="MNQEERRQRRQKDTKSAVIVCVIVVLILLVLVAGGVFLVGRLLP
                     KGGGQNEGTDGTELPGENVAATEEVTEQPQTEVQTDPVEEQAAQLVSQMTLEDKIAQM
                     FVITPNALTGYASGVTAAGDTTKEAYQSRPVGGIVYMADNLTDPEQTTTMLSNMQEIA
                     RERTGLPVFLCVDEEGGSVARIAGNDAFGVTDVGNMSDIGASGDVQNAYNAGSTIGSY
                     LAALGFNVDFAPVADVLTNPDNQVIGQRSFGSDAQTVAGMVTSELQGLSAAGVYGMVK
                     HFPGHGGTSGDSHDGAVSTDKTLEELMAEELVPFQSAIDGGVNFVMVGHISAPNVTGD
                     NAPATLSKVLITDVLRGQMGYNGIVITDAMNMEAITGFYNSDKAAVLAVTAGADMILM
                     PADYNTAYTGILNAVNDGTITEERINESVTRIVKAKLAMGQP"
     gene            complement(1389..3704)
                     /locus_tag="RHOM_RS11120"
                     /old_locus_tag="RHOM_11425"
                     /db_xref="GeneID:93724036"
     CDS             complement(1389..3704)
                     /locus_tag="RHOM_RS11120"
                     /old_locus_tag="RHOM_11425"
                     /EC_number="3.2.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080404.1"
                     /GO_function="GO:0008422 - beta-glucosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH1 family beta-glucosidase"
                     /protein_id="WP_014080404.1"
                     /db_xref="GeneID:93724036"
                     /translation="MFREDFVWGVASSAYQVEGTDAADGRGACVWDMFAADGRVFEHQ
                     NAGTSCDHMHHYKEDIALMKHLGIRAYRFSLNWARILPEGTGRVNEKAIAMYRDMILT
                     MKENGITPYLTLFHWEFPQALYERGGWQNPDVVQWFGEYAKVVAENFSDICEYFITIN
                     EPQCVVGLGHLSGVHAPGVKLPVAQTFLVAHHLLMAHGQAVINLRRYAVRPVKIGFAP
                     TGGVAYPYTDRPEDIEAAKKVYFGFYNPIDNWTWNVSWFSDPVFLGHYPEEGLKKFAP
                     YLPEITQEDMELIYQPLDFMGQNIYNGYYVRAGADGEPEFVDRAPGFPKTGSDWPVTP
                     EAFYYGIKFLTERYPLPLYITENGMSCHDLVSSDGRVHDPNRITFLDSYIGAMQKAYD
                     EGANVAGYFLWTFLDNFEWADGYKQRFGIVYVDFASQRRIVKDSAFWYQKIIETNGRM
                     LTMNQTTKEILFLDPVCTHNIWGGTRLRTEFGYPVEGDDIGECWGISAHPNGDGSIRN
                     GVYAGMKLSKVWEEHPEVFGNLAYDRFPLLTKIIDAKADLSIQVHPDDAYAKEHENGS
                     FGKTECWYIMDAPENATLVIGHNAKTKEELASMIHEGRWSEFIREIPVKKGDFIQIDP
                     GTVHAIKGGLLILETQQNSDITYRVYDYDRLQNGKPRELHIEKSIDVITVPAKSVEDS
                     VTSALGLPENRLNELYACGYYQIYKLDVNGTCSFAQNHPFLLMSVLEGSGIVNGQPVK
                     KGDHFILPCGFGEVEMQGEMSLVVSTVPAQA"
     gene            complement(3818..4981)
                     /locus_tag="RHOM_RS11125"
                     /old_locus_tag="RHOM_11430"
                     /db_xref="GeneID:93724037"
     CDS             complement(3818..4981)
                     /locus_tag="RHOM_RS11125"
                     /old_locus_tag="RHOM_11430"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_014080405.1"
                     /db_xref="GeneID:93724037"
                     /translation="MNMQIDLEKGIANVGDVSRMKEVMARARRGEQLVIGFIGGSITQ
                     GSLSSTPQTCYAYRVYTWWKETFPQAEFVYCNAGIGGTTSEFGAARVGTDLLAERPDF
                     VIVEFSVNDESTEHFKETYEGLVRKILGAAWNPAVLLVHNVFYHNGANAQVMHAAIGR
                     HYDLPSVSMQSSIYPEVVAGRIENRAITPDDLHPNDEGHALVASVITYFLEQVRSGKL
                     TGSNASFAPGAKLPVPLTKNAYEDSVRIRNAAAPDMAGLQQPTLDGFTPDETAQNGIT
                     DCFRYGWTAEKTGDAITFLVEGSCIAVQYRKSVKLPAPAALAVVDGDEEHAVRLDANF
                     DESWGDKLELTTLLEHGKEGRHTVTIRLAETHEDDAVPFYLVSVIAAGRRGRD"
     gene            complement(5022..6077)
                     /locus_tag="RHOM_RS11130"
                     /old_locus_tag="RHOM_11435"
                     /db_xref="GeneID:93724038"
     CDS             complement(5022..6077)
                     /locus_tag="RHOM_RS11130"
                     /old_locus_tag="RHOM_11435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_014080406.1"
                     /db_xref="GeneID:93724038"
                     /translation="MVRNIEPDDPMLQYSGRIDDDDPKAPVLIYAASWVKMIFTGTSV
                     AVTLANHHAYWTNEMGYLLDGVQGRIRLLNDGKKKTYEIAGQLPDARHELMLFKRMDA
                     CHTVTFYGFTVDGGADLLPPEPKPARRMEVFGDSVSCGEVSEAVDYVGKEDPVHDGQY
                     SNSWYSYAWMTARKLGAELHDTSQGGIALLDGTGWFGAPAYYGVESCYDKLAYNPDLG
                     EVKKWDFSRYTPQVVVVAIGQNDNHPVDYMASDPECSAAEHWRKRYREFIETLMKRYP
                     KAQIILTTTILKHHPNWDASIGTVCGQIASERVHHFLYRRNGSGTPGHIRIPEAEEMS
                     EELASYIRSLGDKIWDV"
     gene            complement(6222..7244)
                     /locus_tag="RHOM_RS11135"
                     /old_locus_tag="RHOM_11440"
                     /db_xref="GeneID:93724039"
     CDS             complement(6222..7244)
                     /locus_tag="RHOM_RS11135"
                     /old_locus_tag="RHOM_11440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006855602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 130 protein"
                     /protein_id="WP_014080407.1"
                     /db_xref="GeneID:93724039"
                     /translation="MSKYKMISPKVPNVPWQERPAELNGAPVWRYKENPIIGRNPVKG
                     VARIFNSAVMPYGDEFIGVFRGEQTNGIPYIYLGRSKDAIHWNFEENKINFVDENGES
                     FMPVYAYDPRLVKVEDTYYIIWCQDFYGAAIGMAKTTDFKTFTRIENPFLPFNRNAVL
                     FPRKIGGNFMLLSRPSDSGHTPFGDIFISESPDLTYWGKHRHVMGKGSEWWESLKIGG
                     GAAPIETSEGWLLFYHGVSGTCNGYVYSIGGAILDIDNPSIVKYRCETFLLTPEEWYE
                     ERGFVPNVCFPCATIHDSESGKIAIYYGAADSYVGLAFTELDDIIDYIKEHSVVTTTD
                     TEIGKR"
     gene            complement(7299..8474)
                     /locus_tag="RHOM_RS11140"
                     /old_locus_tag="RHOM_11445"
                     /db_xref="GeneID:93724040"
     CDS             complement(7299..8474)
                     /locus_tag="RHOM_RS11140"
                     /old_locus_tag="RHOM_11445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosidase"
                     /protein_id="WP_014080408.1"
                     /db_xref="GeneID:93724040"
                     /translation="MLHKRYYIEKEKQEKLLARKNEKSDFYNGVFDRYEYPVLTREHI
                     PLTWRYDLNPDTNPHFMERLGINAVMNSGAIELNGKYYLVARIEGNDRKSFFGVAESD
                     NGIDGFRFWDYPILLPDTCPEETNVYDMRLTKHEDGYIYGVFCSESKDTSVSDLSAAV
                     AAAGIVRTKDLKTWERLPNLITLRSPQQRNVVLHPEFVDGKYAFYTRPMDDFIETGSG
                     GGIGFGLCEDITHAVIDEEKMTSLRKYHTITEAKNGAGATPIKTEKGWIHIAHGVRNT
                     AAGLRYVIYAFATDLKDPSKVIAEPSGLLIGPRGEERVGDVSNVVFTNGAVVNEKNEV
                     FIYYASSDTRMHVATTTVEKLVDYVFHTPSDPGRSVECVAQRCGLIEKNLAFLKANE"
     gene            complement(8487..9719)
                     /locus_tag="RHOM_RS11145"
                     /old_locus_tag="RHOM_11450"
                     /db_xref="GeneID:93724041"
     CDS             complement(8487..9719)
                     /locus_tag="RHOM_RS11145"
                     /old_locus_tag="RHOM_11450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AGE family epimerase/isomerase"
                     /protein_id="WP_014080409.1"
                     /db_xref="GeneID:93724041"
                     /translation="METLESMRGEVKTELLTHIIPFWRALRDDTYGGYYGWLSYDLAL
                     DQKAEKGCILNSRITWFFSNAYTAYRKGLFTEEDCRSAGYTGEALLEEAKHGYVFLKE
                     HCIDREYGGIYWSLNYDGTPLDTTKHTYNQAFCIYALSSYYEASHDEEALALAKQLFS
                     LIEEKCTDEVGYLEAFTREFQPESNEKLSENGVLADKTMNTLLHVFEAYTELYRVSRD
                     ETVGERLRWIMDVFAEKVYNPAKRRQEVFFDAGYHTILDLHSYGHDIETAWLLDRGVK
                     VLGDEAYEAKIVPITQALAAHIYETAFDGHSLANECDRGVVNTHRVWWVQAETVVGFL
                     NACEQMPDHSEYRDAALAEWQFIKEHVIDPRRGSEWYWEVYEDGSPILDRPIVEPWKC
                     PYHNGRMCIEVLGRIKEN"
     gene            complement(9742..10596)
                     /locus_tag="RHOM_RS17790"
                     /old_locus_tag="RHOM_11455"
                     /db_xref="GeneID:93725172"
     CDS             complement(9742..10596)
                     /locus_tag="RHOM_RS17790"
                     /old_locus_tag="RHOM_11455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080410.1"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]; GO:0055085 - transmembrane transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_014080410.1"
                     /db_xref="GeneID:93725172"
                     /translation="MKKRRKQYSAGAIIWIIFKYVSLVFFSFVAVIPIISCVITAFKT
                     EEEYKTTNVMTLPQNWFNFDNFVEAFQRANMGRAFVNSVIVMVCVLIGAIIIGTQLAY
                     VLNRFQFPGNGLIRNLFLFAALLPGVAMQVTVYQIMHDLGFINHLYGYIIMMMGTDVI
                     SIYIFIQYMENIPVSLDESAIIDGASYWKIYWKIMLPLLKPAIVTACILKGVGVYNEY
                     YSANLYLTKENLKTMAISLYTFTGPLGSQYNLICAGVIISLLPALIVFIVFQKQIYSG
                     ITAGAVKG"
     gene            complement(10597..11643)
                     /locus_tag="RHOM_RS17795"
                     /old_locus_tag="RHOM_11460"
                     /db_xref="GeneID:93725173"
     CDS             complement(10597..11643)
                     /locus_tag="RHOM_RS17795"
                     /old_locus_tag="RHOM_11460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080411.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]; GO:0055085 - transmembrane transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_014080411.1"
                     /db_xref="GeneID:93725173"
                     /translation="MAATSVKKVENKTARRGFLKWAKSRKGQQTLIILAFTIIPLVLL
                     AAFTYVPFAEMVKFSFYKMKYSTPVDKRVFVGWKNYIEVFRNKDIFASLWLSLYYMVG
                     SVVQLALALFLATILSFKTRGGNLFKGLMFFPYLISGIAIGFIFKYFYTRGFVFDSIL
                     GWFGFELDSLPYWLRDQKINNWSLVATSVWRYFGNNMVLFIGAIMSVDSEMYEAAELD
                     GANKFQQFVHIILPSIKTIVTLNVILSITGALSAFEQPFVITGGSNGTATYFINMNNI
                     AHTSQKVGLASAMAVVLLLIIFACTILQKLFFKYVYRNADQDDEVMTREERKRLKQFH
                     KEQRAAKKAAKGAM"
     gene            complement(11735..13186)
                     /locus_tag="RHOM_RS11160"
                     /old_locus_tag="RHOM_11465"
                     /db_xref="GeneID:93724042"
     CDS             complement(11735..13186)
                     /locus_tag="RHOM_RS11160"
                     /old_locus_tag="RHOM_11465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080412.1"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_014080412.1"
                     /db_xref="GeneID:93724042"
                     /translation="MKLKKVLAVSLAAAMTLSMAACGGSSSDSSAASDDATTGSVAAT
                     TTESGDAAETTDGALNYASIKLGEDYTDITTTIHVFNQRTDMSEDSYPGKNWEAYIAD
                     FNEMYPNITVEVETDTNYSDDSLLRLQSGDWGDIMMIPAVDKADLSEYFLPYGTLDEM
                     EGQIKFANTWDYDGLVYGVPSTGNAQGIVYNKRVFTEAGVAETPKTPDEFIAALQAIK
                     DYDSSIIPLYTNYADGWPMEQWDGQIAGTTTGDSTYMNQKLLHTKDPFQDYGDNTHPY
                     ALYKVLYDAVADGLTEDDFTTTSWEDSKGMINRGEIATMVLGSWAYSQMVDADSHGED
                     IGYMPFPITIDGKQYASAGADYSFGINAASDADHQAAAMVFVKWMTEESGFAYNEGGI
                     PIAADDNDYPDAYAEFGDVTFVSDESALEGEEDLLNALNADSGLNINAGGKEKVQEII
                     EHASNGDMSYDDIMAEWNEKWTQAQEDNGVTAE"
     gene            13486..14436
                     /locus_tag="RHOM_RS16565"
                     /old_locus_tag="RHOM_11470"
                     /db_xref="GeneID:93725067"
     CDS             13486..14436
                     /locus_tag="RHOM_RS16565"
                     /old_locus_tag="RHOM_11470"
                     /inference="COORDINATES: protein motif:HMM:NF024242.5"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_014080413.1"
                     /db_xref="GeneID:93725067"
                     /translation="MQKGPILMEPITIKARLNQAYHFSGAAGNGIRFSDLSDDPAFVF
                     REDTSAVHNRFVPAGGRISYASPVRLTRDALPYLLFLYVESGSGTLTTAGDAVQEPES
                     CQLAPGDLMLLPDQTAYRFSTTHTPFCYHCFYLSTEYFSEYLPFLCADDRIFHTNRTE
                     ADDIVWRILPYLSRELLSDEPVSSLHLTAMLSLVLSSLAASRRAASTPSLPAHVAHMK
                     EIFDTDYAHSHSLAALESSLGVSRYRLCHDFSDCIGVPPIQYLNRVRLKAARTLLRTT
                     TLTIREVSAAVGIENTTHFINLFKKDAGITPLQFRQSSLH"
     gene            complement(14433..15464)
                     /locus_tag="RHOM_RS11170"
                     /old_locus_tag="RHOM_11475"
                     /db_xref="GeneID:93724043"
     CDS             complement(14433..15464)
                     /locus_tag="RHOM_RS11170"
                     /old_locus_tag="RHOM_11475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_014080414.1"
                     /db_xref="GeneID:93724043"
                     /translation="MAKAVKLADIAGQLGVSTVTVSKALSGQKGVSEELREKIKTLAD
                     EMGYKQPSARRREHAVKSYNIGVLIAEHWLDKYDSFYLQMYQQVATRAVAKECFTLME
                     VVSAQMETACEMPKLVQEQKADGLIIIGRLTGEYLKFLNEKAKIPLLYMDFCDEKTDT
                     DAVISDSYYGAYRMTNYLFDMGHREIAYVGTLLATGSITDRYLGYTKSLMEHGVAVRG
                     DWTIADRDIHTGKIDMDRLLQLPKEMPTAFVCNCDLTASFLIRRLHEHGYRVPEDISV
                     VGYDNYLFPGLCDVAITTYEVDMKEMARQTVHTLIKKMAGEPYRQGICIVEGHMVTKD
                     SVKARKNMG"
     gene            complement(15480..17684)
                     /locus_tag="RHOM_RS11175"
                     /old_locus_tag="RHOM_11480"
                     /db_xref="GeneID:93724044"
     CDS             complement(15480..17684)
                     /locus_tag="RHOM_RS11175"
                     /old_locus_tag="RHOM_11480"
                     /EC_number="3.2.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosidase"
                     /protein_id="WP_014080415.1"
                     /db_xref="GeneID:93724044"
                     /translation="MGAIHYYEKERVFKLDTPHTSYLIGIVDEEKFLGHIYYGAKITD
                     YDVRALMRTGEAPFVPSQNNRDRSSFLDAFPMEYPGHGVGDYRESAISVSDKNGNTAV
                     QPLYREHKIYAGKPGLPGLPATFGSEEECETLEIVLADEVLDLTVTLYYTAFYDVDVI
                     TRSVRVTNHAKEPVYLTKVFSTALDLDAEDYRMLTLHGSWARERQIEYRQIGYGKQSV
                     GSCRGESSHQEHPFVALVSANAGQEQGRVYGFHFVYSGNFLAQVEKNQFDSLRVVLGI
                     HPQDFKWELKQGETFTAPEVVLTYSDAGLGRMTRTLHDLYRKHLIRSPYKDRERPVLI
                     NNWEATYFDFDTEKLLAIAREAKKSGIEMLVMDDGWFGHRNDDNTSLGDWQVNEQKIT
                     GGLKRLVDQVNEIGLKFGIWFEPEMISPDSELYRTHPDWAIALPGRMPCRSRNQYVLD
                     LSRKEVRDYAYECVASILRSANIAYVKWDMNRQLTDLGSGVLPVEKQGELLHRYVLGV
                     YELQERLITEFPQLLLENCSGGGARFDPGMLYYSPQIWCSDDTDAIERLKIQEGTALL
                     YPLSAIGAHVSDCPNHTVGRVTPFETRGNVALAGTFGYELDVTKLPEEDRAKIPGQVA
                     LYHKYHALIRSGDYYRIASYSQNDSFDCYEVVAKDQSEALITFVQVLGRPNVHSRRIR
                     IPGLDEKKKYRVETTGEVYCGDTLLHAGLNVPAMWGDFQSALIHLSEVPDEQ"
     gene            complement(17700..19415)
                     /locus_tag="RHOM_RS11180"
                     /old_locus_tag="RHOM_11485"
                     /db_xref="GeneID:93724045"
     CDS             complement(17700..19415)
                     /locus_tag="RHOM_RS11180"
                     /old_locus_tag="RHOM_11485"
                     /EC_number="5.4.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014080416.1"
                     /GO_function="GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="WP_014080416.1"
                     /db_xref="GeneID:93724045"
                     /translation="MSYMETYKEWCTNPYFDENTKAELAAIGDDAAEIEDRFYRQLEF
                     GTGGLRGVIGAGTNRMNIYTVRQATQGLANYILSQNGQEKGVAIAHDSRIMSTEFADE
                     AALCLNANGIKAYVFDSLRPTPELSFAVRELGCISGIVITASHNPREYNGYKVYWEDG
                     AQITPPHDKNILAEVAKVTSFDQVKTMKKEDAVAAGLYKVIGKEIDDRYMEELKKQSI
                     HPEVIKEMAKDIKIVYTPLHGTGNLPVRRVLKELGFEQVYVVKEQELPDGNFPTVSYP
                     NPESPKAFELALKLAKEVDADIVLATDPDADRLGVYCKDTKTGEYVTFTGNMSGMLIA
                     EYILREKTAMGTMPENPALVETIVTTDMAKAIAAAYNVKLIEVLTGFKYIGEQIKFFE
                     QQHTYHYVFGLEESYGCLAGTYARDKDACVAVMMLCEVASWCKKHGKTLWDAMLDMYE
                     KYGYYREGLETKTLKGIDGAAQIQSMMSEYRTNPPKELGGHRVLAVRDYKEDTRKDLV
                     TGEVTKTGLPASNVLYYELSDNAWCCVRPSGTEPKIKYYFGVKGTSLADADAKLAALK
                     EDLLK"
ORIGIN      
        1 ttacggctgc cccatggcaa gctttgcctt cacgatacgc gtcacggatt cattgatccg
       61 ctcctcggtg atcgttccgt cattcaccgc attcagaatt cctgtatagg cggtattgta
      121 gtccgccggc atcaaaatca tgtctgcccc ggctgtaact gccagaaccg ccgccttgtc
      181 cgaattgtag aatccggtga tcgcttccat attcatggcg tccgtaatga caattccgtt
      241 atatcccatc tgtccgcgaa gcacatcggt aatcagcacc ttcgacagcg tagccggcgc
      301 attgtctcca gtcacattcg gagccgagat atgtccgacc atcacaaaat tcacgccgcc
      361 gtcaatcgca ctctggaacg ggacgagttc ttccgccatc agttcctcca gggtcttgtc
      421 cgtggacacc gccccgtcat gagaatctcc ggaagtgccg ccgtgtcccg ggaaatgctt
      481 gaccataccg tacactcccg ccgcggaaag tccctgcagt tcagacgtca ccattcccgc
      541 gaccgtctgc gcgtccgacc cgaacgagcg ctgtccgatc acctgattgt ccgggttggt
      601 aaggacatcc gccaccggcg cgaaatccac attgaatccg agtgccgcaa gatagctgcc
      661 gatcgtgctt cccgcattgt atgcattctg cacatccccg ctcgctccta tatcgctcat
      721 attgccgacg tccgtcaccc cgaaggcatc attgccggcg atgcgcgcga cactgccgcc
      781 ttcttcatcc acacataaaa ataccggaag tccggtgcgc tcccttgcaa tctcctgcat
      841 attggagagc atggtggtcg tctgctccgg gtcggtgagg ttgtctgcca tatacacaat
      901 tccgcccacc ggacggctct gataagcttc ctttgtggtg tcccccgcag ccgtcacacc
      961 gcttgcatat ccggtcagcg cattcggcgt aatcacaaac atctgcgcga tcttatcctc
     1021 aagcgtcatc tgggacacaa gctgcgccgc ctgctcctcc accggatcgg tctgtacttc
     1081 cgtctgcggc tgttccgtta cttcctccgt cgccgcgaca ttctctcccg gcagctcggt
     1141 tccgtcggta ccttcattct gtccgcctcc ctttggcagc aggcgtccca caagaaatac
     1201 tccgcccgcg actaacacga gcaggatcag cacgactatc acacacacaa tgaccgcact
     1261 tttcgtatct ttctgtcttc tctgacgtct ctcttcctga ttcatatgct tcctctttcc
     1321 aggtgttctc tttttctatg gtctgattat agcaaatctt ttccggaacc gaaagagcta
     1381 ttttcccctt aagcctgcgc cggcaccgtg gataccacca gactcatctc tccctgcatc
     1441 tccacctcgc cgaatccgca cggtaaaata aagtgatctc cctttttcac cggctggccg
     1501 ttgacgatac cgctaccttc cagcacagac atcagcagga acggatgatt ctgtgcaaaa
     1561 ctgcatgttc cgttgacatc cagcttgtaa atctgatagt atccgcaggc gtacagctcg
     1621 ttcagccggt tctccggcag tccgagtgca gacgttacac tgtcctcgac ggatttcgcc
     1681 ggaacggtga tcacgtcgat actcttctca atgtgaagct ctctcggctt gccgttctgc
     1741 agtctgtcat aatcgtacac acggtaggta atatcgctgt tctgctgtgt ctccaggatc
     1801 agaagcccgc ccttgatggc gtggacggtt cccggatcaa tctggataaa atctcccttt
     1861 ttcaccggaa tctcgcggat aaattcgctc cagcgtccct cgtggatcat ggaggcaagc
     1921 tcctccttcg tcttcgcatt gtgaccgatc acgagcgtgg cgttctcggg cgcatccata
     1981 atgtaccagc actccgtctt gccgaaagaa ccgttttcat gttcctttgc ataggcgtca
     2041 tccggatgta cctgaatgct caaatccgcc ttcgcatcga tgatctttgt caaaagtggg
     2101 aagcggtcgt aggcgaggtt tccaaatacc tccgggtgct cctcccacac ttttgacagt
     2161 ttcatgccgg cgtacacacc gttcctgatg ctgccgtcgc cgttcggatg tgcggagatg
     2221 ccccagcact cgccgatgtc atccccctcc accggatagc cgaactccgt tctaagccgg
     2281 gtgccgcccc agatattgtg tgtgcacacc ggatctaaaa ataagatttc ttttgttgtc
     2341 tgattcattg tcaacatcct tccattcgtc tcgattattt tctgatacca gaaagcggaa
     2401 tccttcacaa tccgcctctg gcttgcaaaa tccacataaa caatgccgaa ccgctgctta
     2461 tatccgtccg cccactcaaa attatccagg aatgtccaga ggaaatagcc ggctacattg
     2521 gcgccctcat cgtatgcctt ctgcattgcc ccgatatagg aatccaggaa agtaatgcgg
     2581 ttcgggtcat gtaccctgcc gtcactgctc accagatcat ggcaggacat gccgttctcc
     2641 gtaatgtaga gcggcagcgg atagcgctcc gtcaaaaact taatgccgta ataaaacgcc
     2701 tccggcgtca ccggccagtc cgatcccgtc ttcgggaacc ccggcgcacg gtctacaaat
     2761 tccggctcgc cgtctgcgcc ggcgcggacg tagtacccat tatatatatt ctgtcccata
     2821 aaatcaagcg gctgatagat cagctccata tcctcctgtg tgatctccgg aagatacggc
     2881 gcaaattttt tcagcccctc ctcggggtaa tgtccaagga ataccggatc ggaaaaccac
     2941 gatacattcc aggtccagtt atcgatcgga ttgtaaaatc cgaaatacac ctttttcgcc
     3001 gcctcaatgt cctccggccg gtcggtgtac ggatacgcca cgccgccggt cggagcgaaa
     3061 ccgatcttga ccggtcggac cgcatatctg cgcaggttga tgaccgcctg cccgtgcgcc
     3121 atcagaagat gatgcgccac cagaaacgtc tgcgccacgg gaagcttcac gcccggagca
     3181 tgaacaccgc tcagatgtcc aagaccgacc acgcactgcg gttcgttgat cgtaataaaa
     3241 tattcgcaga tgtcgctgaa attctcggca accaccttcg catattctcc gaaccattgc
     3301 accacgtccg ggttctgcca gccgccccgc tcataaagcg cctgcgggaa ttcccagtga
     3361 aacagcgtca ggtacggcgt gatgccgttt tccttcatcg tgagaatcat atcgcggtac
     3421 atggcgatcg ctttctcatt cacgcgcccg gttccctccg gcagaatccg cgcccagttc
     3481 agtgaaaaac ggtacgcccg gatccccaga tgcttcatca gcgcaatatc ttctttataa
     3541 tgatgcatat gatcgcagct tgtgcctgca ttctgatgtt caaacactct gccgtccgcc
     3601 gcaaacatat cccagacgca cgcgcctctg ccgtccgccg catccgttcc ctctacctga
     3661 taggcgctgc tcgcaacacc ccacacaaaa tcctctcgaa acattcttat aacctcctgc
     3721 tcctgcaatc gcagtgtctc tctttatctt ccaacatttt ttctgatttt gcaatccttt
     3781 tacacgcaca ttctgcaaaa taggctgtct cttgccgtca gtctcttcct cttctccccg
     3841 ctgcgatcac ggacaccaga taaaacggaa ccgcatcgtc ctcatgcgtc tctgcgaggc
     3901 ggatcgtgac ggtgtgccgc ccctcttttc cgtgttctaa aagcgtcgta agttccagtt
     3961 tgtctcccca gctctcatcg aagtttgcat ccagccgcac cgcatgctcc tcatcgccgt
     4021 ccacgaccgc cagtgcagcc ggcgccggaa gctttaccga tttccggtac tggacggcaa
     4081 tgcagctgcc ctccaccaaa aaggtgatgg catcccccgt cttttccgcc gtccagccat
     4141 agcggaagca gtccgtgatt ccattctgtg cggtctcatc gggcgtaaat ccatccagcg
     4201 tgggctgctg caatcctgcc atatccggcg ccgcggcatt gcggatgcgg acagaatcct
     4261 cgtaggcatt ttttgtaagc ggaaccggaa gctttgcccc cggtgcaaaa ctggcattgc
     4321 tgccggtcag ttttccgctt cgtacctgct ccagaaaata agtaatcacc gacgccacca
     4381 gcgcatgtcc ctcatcgttc gggtgcagat catccggcgt gatcgcgcgg ttttcaatcc
     4441 gtcctgccac cacctccggg taaatagagc tctgcatgct gaccgacggc agatcataat
     4501 gtctgccgat tgccgcgtgc atcacctgcg cgttggctcc attgtggtaa aacacgttgt
     4561 gtaccagaag aaccgccgga ttccacgcag caccaaggat tttccgcacc agtccttcat
     4621 aggtctcctt aaaatgctcc gtgctctcat cattgacgga aaattccaca attacaaagt
     4681 ccggtctctc cgccagaaga tccgtcccca cacgcgccgc gccgaactcc gatgtcgtgc
     4741 cgccgatccc agcattgcag tagacaaact ccgcctgcgg aaaggtctct ttccaccatg
     4801 tatacacacg gtaggcatag cacgtctgcg gtgtcgagga gaggcttccc tgcgtgatcg
     4861 agccgccgat aaaaccgatt accagctgct ctccgcgtct ggcgcgcgcc atgacctcct
     4921 tcattctgct cacatctccc acatttgcaa ttcccttttc cagatcaatc tgcatattca
     4981 tgtttctgct ccttctctct ttcttttccc tttattgtct ctcacacatc ccagatttta
     5041 tctccgagtg aacggatata ggaagccagc tcctctgaca tctcctccgc ttccggaatc
     5101 cggatgtgtc cgggcgttcc agagccgttt ctccggtata aaaagtggtg cacgcgctca
     5161 cttgcgatct gcccacacac cgtcccaatc gacgcatccc agttcggatg atgttttaag
     5221 atagttgtcg taagaatgat ctgcgccttg ggatagcgct tcatcagtgt ctcgatgaat
     5281 tcccggtagc gcttccgcca gtgctccgcc gcactgcact ccggatccga cgccatatag
     5341 tccaccggat gattgtcatt ctgcccgatg gcaaccacca ccacctgcgg cgtatagcgt
     5401 gaaaaatccc atttctttac ctctccgaga tcaggattgt atgcgagctt gtcgtaacag
     5461 gactccacac cgtagtacgc cggtgcgccg aaccatcccg tcccgtcaag cagcgcaatg
     5521 ccgccctgtg aggtatcgtg aagttctgcc ccaagctttc gcgccgtcat ccaggcatag
     5581 gaataccagc tgttggaata ctgtccgtcg tgcaccggat cctcttttcc gacatagtcg
     5641 accgcctccg acacctcgcc gcacgagaca ctgtcgccaa acacttccat ccggcgggcg
     5701 ggctttggct ccggcggcag aagatctgcg ccgccatcca cggtaaatcc gtagaatgtc
     5761 accgtatggc aggcgtccat acgcttgaac agcatgagtt catgccgcgc atccggcagc
     5821 tgccccgcaa tctcataggt tttctttttt ccgtcattca aaaggcggat gcgcccctgc
     5881 accccgtcta agagatagcc catctcattt gtccagtacg catgatggtt ggcaagcgtg
     5941 actgccaccg atgttccggt aaaaatcatt ttcacccagc ttgccgcata gataagcacc
     6001 ggcgccttcg gatcgtcgtc atcgattctt ccgctgtact gtaacatcgg atcgtccggc
     6061 tcgatattcc tgaccatttt tttttgctgt catttctttt ccccctctgc cttccggctc
     6121 cccgccggat acgcagcagg gctgcgaaag ccccgaggtg ttacgcacac aatgcgtcct
     6181 tctctttccg gctgccgcag ccccatcatt ccagttctct gttatctttt tccgatctcg
     6241 gtatcggttg tcgtcaccac actgtgttcc ttgatgtaat cgatgatgtc atccagttcc
     6301 gtgaacgcca gtcccacata gctgtctgcc gctccgtaat agattgcaat ctttccgctc
     6361 tccgaatcgt ggattgttgc acacgggaag catacgttcg gcacgaatcc gcgctcctca
     6421 taccactctt ccggagtcag aagaaacgtc tcacagcggt acttcacgat ggaaggattg
     6481 tcgatgtcta agatcgcacc gccgatcgag tacacatatc cgttgcaggt gccgctcaca
     6541 ccgtggtaga acagaagcca tccctcggat gtctcgatcg gagctgcacc gccgccgatc
     6601 tttaaggact cccaccactc ggaacccttg cccatcacat gacggtgttt tccccagtag
     6661 gtgagatccg gactctcact gataaaaata tcgccgaacg gtgtgtggcc gctgtcggac
     6721 ggtctcgaga gcagcatgaa attgccgccg atcttgcgcg ggaacagcac cgcattccgg
     6781 ttaaacggca ggaacggatt ctcgattctg gtaaatgtct taaaatccgt tgtcttcgcc
     6841 ataccgatcg ctgcgccgta gaaatcctga caccagataa tatagtaggt atcctccacc
     6901 ttcacaagtc tcggatcata agcgtagacc ggcatgaagg actcaccgtt ctcgtccaca
     6961 aagttaatct tgttttcctc aaaattccag tggatggcat ccttgcttct tcccagatag
     7021 atatacggaa ttccgttcgt ctgttctccg cggaagacgc cgatgaactc atccccgtac
     7081 ggcatcaccg cactgttgaa gattctcgcc acgcccttca ccggatttct gccgatgatc
     7141 gggttctcct tgtatctcca taccggtgct ccgtttaact ccgccgggcg ctcctgccat
     7201 ggcacattcg gtactttggg gctgatcatt ttatatttgc tcataacttc tacctctttc
     7261 tgccgccgac gcggctcatt tttctatgat gaccgtattt attcattcgc ttttaaaaat
     7321 gcaagattct tctcgatgag accgcaccgc tgtgccacac actccaccga tcttcccgga
     7381 tcggacggcg tatggaatac gtagtccacc agcttctcca ccgtcgtggt cgccacatgc
     7441 atccgtgtat ccgaggatgc gtagtaaata aacacctcgt ttttctcatt gacgaccgct
     7501 ccgttggtaa ataccacatt gctgacatcc ccgacgcgct cctcacctct cggtccgatc
     7561 agaagcccgg acggctcggc aatcaccttc gacggatctt ttaagtccgt tgcaaacgca
     7621 tagatgacat aacgcagtcc cgctgccgtg ttgcgcacac cgtgagcgat atgaatccat
     7681 cccttttccg tcttgatcgg cgtcgcaccg gctccgttct tcgcctccgt gatcgtatga
     7741 tacttgcgca gactcgtcat tttttcctca tcgatcacag cgtgtgtgat gtcctcgcag
     7801 agaccgaatc cgatgcctcc gccgcttccc gtctcgataa aatcatccat cggtctcgtg
     7861 taaaacgcat atttgccgtc gacgaattcc ggatgcagca ccacgtttct ctgctgcggg
     7921 gaacgcagcg tgatgaggtt cggcaggcgc tcccaggtct ttaaatcctt cgtgcggacg
     7981 attccggctg ccgccactgc cgctgagaga tcgctcacac tcgtatcctt tgactcggag
     8041 cagaacacgc cgtagatata accgtcctca tgcttcgtca agcgcatatc gtagacattc
     8101 gtctcctccg ggcaggtatc cggcagaaga atcgggtaat cccagaaacg gaaaccgtcg
     8161 attccgttgt cgctctccgc cacgccgaag aaagactttc tgtcatttcc ctcgatgcgc
     8221 gccaccagat aatattttcc gttcagctcg atcgctccgg agttcatcac ggcgttgatg
     8281 ccgagacgct ccataaagtg cggattggtg tcagggttta aatcataccg ccaggtcagc
     8341 ggaatatgtt ctctcgtgag aaccggatac tcgtaacggt caaatacgcc gttgtaaaaa
     8401 tccgacttct cgtttttccg tgcaagcagt ttttcctgct tttctttttc tatataatat
     8461 ctcttatgca gcataaccaa ttctcctcaa ttttccttga tgcgtcccag tacctctata
     8521 cacatgcgcc cgttgtgata cggacatttc cacggttcca cgatcggccg gtctaaaatc
     8581 gggcttccgt cctcatacac ttcccagtac cactcgcttc ccctgcgagg atcaatgaca
     8641 tgttctttga tgaactgcca ctccgccaac gccgcatccc ggtactccga atgatccggc
     8701 atctgttcac aggcatttaa aaatccgact actgtctccg cctgcaccca ccatacacgg
     8761 tgtgtattga ctacgcccct gtcacactca tttgccaggg agtgtccgtc aaacgccgtc
     8821 tcataaatat gtgccgcaag cgcctgtgtg atcggaacaa ttttcgcctc atacgcctca
     8881 tcgcccagca ccttgacgcc gcggtccaaa agccacgctg tctcaatgtc atgcccgtag
     8941 gaatgcagat ctaaaatcgt gtgatacccg gcatcgaaaa atacttcctg tctccgcttc
     9001 gccggattgt atactttctc tgcaaacaca tccatgatcc aacggaggcg ctcccccacg
     9061 gtctcatccc gcgacacacg gtacagctcc gtgtacgcct caaaaacatg aagcagggtg
     9121 ttcatcgtct tatctgcaag cacgccgttc tccgacagct tctcgttgga ttccggctgg
     9181 aactctctgg taaaagcctc caggtatccg acctcatccg tacacttctc ttcgatcagg
     9241 gaaaagagct gcttcgccag tgcaagcgct tcctcgtcgt gcgacgcctc atagtaggag
     9301 gacaatgcat agatgcaaaa cgcctggttg taggtgtgct ttgtcgtatc aagcggtgtc
     9361 ccgtcatagt ttaatgacca gtagatgccg ccgtactccc ggtcgatgca gtgctctttc
     9421 aaaaagacgt agccgtgttt tgcttcctcc aagagcgcct ctccggtata gcctgcgctt
     9481 ctacagtctt cctccgtaaa aagtcccttt cgatatgccg tgtaggcatt ggagaaaaac
     9541 catgtgatgc ggctgtttaa aatgcatcct ttttccgctt tctgatccag tgcaagatca
     9601 taagacagcc agccgtaata gccgccgtaa gtgtcgtcac gcagtgcacg ccagaaggga
     9661 atgatatgtg tgagaagttc cgttttaact tctcctcgca tgctttctaa tgtttccatc
     9721 gctgttcctc ttttcctgta atcagccctt gactgcgcct gccgtaatgc cgctgtagat
     9781 ctgcttctgg aatacgataa acacgatgag tgccggcagc agggaaatga taacacctgc
     9841 acagatcagg ttgtactggc ttccaagcgg tccggtaaag gtatagaggg agatcgccat
     9901 cgtctttaag ttttccttgg tcagatacag gtttgccgaa tagtattcgt tgtacacgcc
     9961 cacgcccttt aagatgcagg cggtcacaat tgccggcttt agcagcggaa gcatgatctt
    10021 ccagtagatc ttccagtagg acgctccgtc gatgattgcc gactcatcca gcgacaccgg
    10081 aatattttcc atgtactgga taaagatgta gatggagatg acatccgttc ccatcatcat
    10141 gatgatgtag ccgtacagat gattgataaa gccaagatca tgcatgatct ggtagaccgt
    10201 tacctgcatg gcaacacccg gaagcagtgc cgcgaataaa aacaggttgc ggatcagccc
    10261 gttgcccggg aactggaaac ggtttaacac atacgcaagc tgtgtaccga tgatgatggc
    10321 tccgatcagg acacagacca taacgatcac ggaattcacg aatgcccttc ccatgttcgc
    10381 acgctggaac gcttccacaa agttgtcaaa attgaaccag ttctgcggca gtgtcataac
    10441 attcgtcgtc ttatactctt cctccgtctt gaatgcagtg atgacgcagg aaataatggg
    10501 aatcacggcg acaaaggaaa aaaacacaag cgatacatat ttaaaaatga tccagataat
    10561 ggctcctgcc gaatactgtt ttctgcgctt tttcatttac atcgccccct ttgctgcttt
    10621 tttcgccgct ctctgttctt tgtgaaactg tttcaaccgc tttctctctt ccctggtcat
    10681 gacttcatcg tcctgatccg cattgcggta tacatattta aagaacagtt tctgtaagat
    10741 cgtacatgcg aaaatgataa gaagtaacac aaccgccatc gccgacgcga gtccgacctt
    10801 ctggctggta tgtgcaatat tgttcatgtt gataaaatac gttgccgttc cgttggaacc
    10861 tccggtaatt acgaacggct gctcgaatgc gctcagtgct cctgtgatgg ataaaatcac
    10921 attcagcgtc acaatcgtct tgatgctcgg cagtatgata tgtacaaact gctgaaattt
    10981 atttgcaccg tccagctccg ccgcctcgta catctcggaa tctacagaca taatcgctcc
    11041 gataaaaagc accatgttgt tgccgaaata tctccagaca gaagttgcaa ccagtgacca
    11101 gttgttgatc ttctgatcgc gcagccagta cggaagacta tccagttcaa atccaaacca
    11161 tccgaggatg gaatcgaata caaatcctct tgtgtaaaaa tatttaaaga taaatccgat
    11221 cgcaataccg ctgatcagat acgggaaaaa catcagtccc ttaaagagat tgcctcccct
    11281 tgtcttaaag ctcaaaatcg ttgcaaggaa cagcgcaagc gcaagctgta ccaccgaacc
    11341 taccatgtag tagaggctta accacaggga tgcaaaaata tccttgttgc ggaatacctc
    11401 gatataattc ttccaaccca caaatacccg tttatctacc ggcgtggaat atttcatttt
    11461 gtaaaaactg aacttcacca tttcagcaaa tggcacatag gtaaatgctg ccaacagcac
    11521 aagcggaatt atggtaaatg ccagtataat cagtgtctgc tgccccttcc tgctttttgc
    11581 ccacttcagg aatccacgcc tggctgtttt attttctact ttctttactg atgtcgccgc
    11641 catatccaac ctccatcttt ttcaccctgt ttttaaaata acgggaccgg aaacagatct
    11701 ctcattccgg tcccgtctgt gcatgatgtc ttatttattc tgccgtcacg ccattgtctt
    11761 cctgtgcctg tgtccacttc tcattccact cagccatgat gtcatcgtag gacatatcac
    11821 cgttagaagc atgctcaatg atctcctgaa ccttctcttt tccgcctgca ttgatgttca
    11881 atccggaatc agcgttcaat gcattgagta aatcttcctc gccctctaat gcggactcgt
    11941 cggatacaaa tgtcacatca ccgaactctg cgtatgcatc cggataatcg ttatcgtctg
    12001 cagcgatcgg gataccgccc tcgttgtatg caaaaccgga ctcttctgtc atccatttta
    12061 cgaataccat tgctgctgcc tgatgatctg catccgatgc cgcattgata ccgaagctgt
    12121 agtcagcgcc tgcggaagca tactgcttgc cgtcgatcgt gatcgggaat ggcatgtagc
    12181 cgatatcctc gccatgagaa tcagcgtcta ccatctggga atatgcccag gagccaagta
    12241 ccatggtcgc gatctcgcct ctgttgatca tgcccttgga atcttcccag gacgttgtgg
    12301 tgaagtcatc ctctgtcagt ccgtctgcca ctgcatcgta gagtaccttg tacagtgcat
    12361 acggatgtgt gttatcgccg taatcctgga acggatcctt tgtgtgaaga agcttctggt
    12421 tcatataggt agaatcaccg gttgtcgtac ctgcgatctg tccgtcccac tgctccatcg
    12481 gccatccgtc tgcatagttc gtgtagagcg gaatgatgga agaatcgtaa tccttgattg
    12541 cctgcagtgc cgcgatgaac tcatccggtg tcttcggtgt ctctgcaacg ccggcctctg
    12601 tgaagactct cttgttgtat acaataccct gtgcattgcc ggtagaagga acaccgtata
    12661 ccagtccgtc gtaatcccag gtatttgcga acttgatctg tccttccatc tcatcgagtg
    12721 taccgtacgg caggaaatac tcacttaagt ctgccttgtc aactgccggg atcatcatga
    12781 tgtcgcccca gtcaccgctc tgtaaacgaa gcagggaatc gtcggaataa ttggtatccg
    12841 tctcaacctc tacggtgata ttcgggtaca tctcattgaa atcagcaatg taagcttccc
    12901 agttctttcc cggatagctg tcctcggaca tatcggttct ctggttgaat acatggatgg
    12961 ttgtcgtgat atcggtgtaa tcctcgccca atttgatgct tgcataattc agagcaccat
    13021 ctgtggtctc tgctgcatcc ccactctcag ttgtggttgc tgccacactt cctgttgtcg
    13081 catcatcaga tgctgcgctg ctgtcagatg aactgccgcc gcatgctgcc atgctcaaag
    13141 tcattgctgc tgccaggctg actgccagaa cttttttcaa cttcataata aaaatcctcc
    13201 ttttttatag ctcattttgt agcttaattt aattatatat tttttctatt tttagtcatc
    13261 acatattatt gcataatata ttattttctt gcgttttcct gcattttcca catgttatac
    13321 aaattttata tcctgttttt agtcattttt catattttag cctcttcttt ttctctcttt
    13381 ttcctcttaa tttaatttta attacttaat ttttgctatt ttttaaccta ataatcaaga
    13441 aacctattgt attgcaaaat agttccgcta taatatagga tagttatgca gaaaggaccg
    13501 attcttatgg aacccatcac gatcaaggca cgcctgaatc aggcttatca cttctccggg
    13561 gcagccggaa acggcattcg tttttccgat ctttcagacg acccggcttt cgttttccgc
    13621 gaggacacat cggctgtaca caaccgtttt gtccctgcag gagggcgcat cagctacgcg
    13681 tcccccgtcc gtctgacgcg ggatgcgctg ccgtacctcc tctttctcta tgtcgaatcc
    13741 ggaagcggca ctttaacgac tgccggcgac gctgtgcagg agccggaatc ctgccagctt
    13801 gcaccggggg atctcatgct tcttccggat cagaccgcat accggttttc cacgacgcat
    13861 acccctttct gctaccactg tttttatctg tccacagagt atttttcgga atatcttccg
    13921 tttttgtgtg cggacgaccg catttttcat acgaaccgga ccgaggcgga tgacatcgta
    13981 tggcgtattc tgccctacct ctcccgcgag ctgctctccg atgaaccagt ttcctcgctt
    14041 catctgaccg ccatgctctc gcttgtcctg tcctccctcg ccgcttcccg ccgtgctgca
    14101 tcgacgcctt cccttcccgc gcatgtggca cacatgaaag agattttcga caccgattac
    14161 gcacattccc actctctcgc cgcgctcgag agttctctcg gagtcagccg ctaccggctc
    14221 tgccatgatt tttcagactg catcggtgtt ccgccaatcc agtatctgaa ccgggtccgg
    14281 ctgaaagccg cacgcacgct gctgcgcacg acaaccctca ccatccgtga ggtcagcgcc
    14341 gccgtaggga ttgaaaacac gacacatttt atcaatctgt tcaaaaaaga tgccggaatc
    14401 acacctctgc aattccggca gtcttccctg cactaaccca tattttttct ggcttttacg
    14461 ctgtcctttg tgaccatatg tccctcgacg atacagattc cctggcggta cggttcgcct
    14521 gccattttct tgatcagcgt gtgaaccgtc tgtctcgcca tctccttcat atccacctca
    14581 taagtggtga tcgccacatc acagagtccc gggaaaagat aattgtcata tcccacaacc
    14641 gatatatcct ccggcacacg gtatccgtgc tcatgcagcc tgcggatcag aaaactcgcc
    14701 gtcagatcac agttacacac aaaagccgtc ggcatctcct ttggcagctg caacagccgg
    14761 tccatatcaa tcttgcccgt atggatgtcg cggtctgcga tcgtccagtc ccccctcacc
    14821 gcaacgccgt gctccatcag ggatttcgta taccccagat agcggtccgt gatggatccc
    14881 gttgcaagca gggttcccac ataggcaatc tccctgtgtc ccatgtcgaa cagataattc
    14941 gtcatgcggt aagcaccgta atagctgtcc gaaatcaccg catccgtatc tgtcttctcg
    15001 tcacagaaat ccatatacag aagcggaatt tttgcttttt cattcaaaaa cttcagatat
    15061 tctcccgtca ggcgtccgat gataatcaga ccgtccgcct tctgctcctg cacaagcttc
    15121 ggcatctcgc aggcagtctc catctgtgcg ctgaccactt ccatcagcgt aaaacattcc
    15181 ttcgccaccg cgcgcgtcgc cacctgctga tacatctgca gatagaagga atcatactta
    15241 tccagccagt gctcggcaat cagcacaccg atattatagc tttttaccgc gtgttcgcgc
    15301 cgcctggcgg acggctgttt gtatcccatc tcatcggcaa gcgtttttat cttctcccgc
    15361 agttcctcgc tgacgccttt ctgtccggac agcgccttcg atacggtaac cgtactcacg
    15421 ccaagctgtc ccgcaatatc tgccagcttt accgcttttg ccattttttc atcctccaac
    15481 tactgttcat caggcacctc ggataagtgt atcagtgccg actggaaatc tccccacatc
    15541 gccggaacat tcagtcccgc atgcaggagg gtatctccgc agtacacttc ccccgttgtc
    15601 tcaacacgat attttttctt ctcatcaagt cccggtatcc ggatccgtct gctgtgcaca
    15661 ttcggtctgc caagcacctg aacaaaggtg atcagcgcct ccgactgatc ctttgccacc
    15721 acctcataac agtcaaacga atcattctgc gaataggaag cgatccggta atagtcgccg
    15781 cttcgtatca gcgcatgata tttgtggtac agcgccacct gccccggaat tttcgcccgg
    15841 tcttcctccg gaagctttgt cacatccagc tcgtagccga acgtacccgc cagcgccaca
    15901 tttcctctgg tctcaaacgg agtcacgcgt cccaccgtgt ggttcgggca gtcggacaca
    15961 tgcgcgccga tcgcagagag cggatacagc agcgccgttc cctcctgaat ctttaagcgc
    16021 tctatggcat ccgtgtcgtc ggagcaccag atctgcggac tgtaatacaa cattcccggg
    16081 tcaaatctcg ccccaccgcc ggagcagttc tcgagaagca gctgcggaaa ttcggtgatc
    16141 agacgctcct gtaattcata gacgcccagt acatagcgat gcagcaattc tccctgcttt
    16201 tccaccggaa gcacaccgct tcccagatcg gtcagctgcc ggttcatatc ccacttgaca
    16261 taagcgatgt tcgcgctgcg caaaatggat gccacacact catacgcata atcccgcact
    16321 tcttttctgg agagatcgag cacatactga tttctcgacc ggcacggcat tctccccgga
    16381 agggcaatcg cccagtccgg atgcgtccgg tacagctccg aatccggcga gatcatctcc
    16441 ggctcaaacc agatgccgaa ctttaatccg atctcattca cctgatcgac cagccgtttt
    16501 aatccacccg taatcttctg ctcgtttacc tgccagtcgc cgagacttgt gttgtcatcg
    16561 ttgcggtggc cgaaccatcc gtcgtccatg accagcatct cgattccgga tttcttcgcc
    16621 tctctcgcaa tcgcaagcag cttctccgtg tcaaagtcaa agtaggttgc ctcccagttg
    16681 ttgatgagca ccgggcgctc cctgtcctta tacgggctgc ggatcagatg cttccggtag
    16741 agatcatgca gcgttctcgt catcctgcca agcccggcat ccgaataggt cagcacaacc
    16801 tccggtgccg taaatgtctc cccctgcttt aattcccact taaaatcctg cggatgaatt
    16861 cccagcacca cgcgcaggga atcaaactgg ttcttctcca cctgcgccag gaaattgccg
    16921 gaatacacaa aatggaatcc gtacacgcgc ccctgctcct gtccggcgtt tgcggacacc
    16981 agcgccacga acgggtgctc ctgatgggaa gattcaccgc ggcaggagcc aacagactgt
    17041 tttccgtagc cgatctggcg gtattcgatc tgtcgctctc tcgcccagga accatgcagc
    17101 gtcagcatcc ggtaatcctc cgcgtcaaga tccaacgccg tagaaaatac cttcgtaaga
    17161 tacaccggtt ctttggcatg gttcgtcacg cgcacgctcc gcgtaatgac atccacgtca
    17221 taaaatgccg tgtagtacaa tgtgaccgta agatccagca cttcatccgc cagcacaatc
    17281 tcaagcgtct cacactcttc ttcgctgccg aacgtggccg gaagtcccgg aagtcccggt
    17341 ttgcccgcat agatcttatg ctccctgtaa agcggctgca ccgccgtatt gccgtttttg
    17401 tccgatacgg aaatcgcact ctccctgtaa tcgccgacgc cgtgccccgg atactccatc
    17461 ggaaacgcat ccagaaaaga gctccggtcg cggttgttct gtgaaggaac aaacggtgcc
    17521 tccccggtgc gcatcagcgc acggacgtca tagtccgtga tctttgcgcc gtaatagata
    17581 tgtcccaaaa acttttcttc atccacgata ccgatcagat aactggtatg tggtgtatcc
    17641 agtttaaaaa cccgttcttt ttcgtaataa tgaattgctc ccataccatc tcccgcttct
    17701 tatttcaaca gatcttcctt caatgccgca agctttgcat ccgcgtctgc aagggaagtc
    17761 ccctttacgc caaagtagta tttgatcttc ggctccgttc cggacgggcg cacacagcac
    17821 cacgcattat cggaaagttc ataataaagt acgttggatg ccggcagtcc ggtctttgtc
    17881 acctcgccag tcacaagatc ctttctggtg tcctccttgt aatcgcgcac cgccagtacc
    17941 cgatgaccgc ccagctcctt cggtgggttc gtgcggtact cactcatcat cgactgaatc
    18001 tgtgccgcac cgtcgattcc ctttaaggtc ttcgtctcca atccctctct gtaatagccg
    18061 tacttctcat acatatccag cattgcatcc cacagggtct tgccgtgctt cttgcaccag
    18121 gaagccacct cgcaaagcat catgaccgcc acgcacgcat ccttgtctct cgcgtaggtt
    18181 cctgccagac agccgtagct ctcctccagt ccgaatacat agtgataggt atgctgctgc
    18241 tcgaagaact tgatctgctc tccgatatac ttaaatccgg tcagcacctc gatcagcttc
    18301 acgttgtagg ctgccgcgat cgcttttgcc atatctgtcg tcacgatcgt ctccacgagc
    18361 gccgggttct ccggcatggt tcccatcgcc gtcttctctc ttaagatgta ctctgcgatc
    18421 agcataccgg acatatttcc ggtaaatgtc acatactcgc cggtctttgt gtccttgcag
    18481 tacacgccga gacggtctgc atccgggtct gtcgcgagca cgatgtccgc atcgacttct
    18541 tttgccagct ttaacgcaag ttcaaatgcc ttcggggact ccgggttcgg gtaggatacc
    18601 gtcgggaaat taccgtccgg cagctcctgc tcttttacca cgtacacctg ctcgaatcca
    18661 agctccttta acacgcggcg caccggaagg ttaccggttc cgtggagcgg tgtgtataca
    18721 atcttaatgt ccttcgccat ctccttgatg acttccggat ggatcgactg cttcttcagc
    18781 tcctccatgt aacgatcgtc gatctctttt ccgatgacct tgtaaagtcc tgcggcaacg
    18841 gcatcttctt tcttcatcgt cttcacctgg tcgaaagatg tcaccttcgc cacttccgcc
    18901 aggatattct tgtcgtgcgg cggtgtgatc tgtgctccgt cctcccagta taccttgtag
    18961 ccgttgtatt ctctcgggtt atggctcgcc gtaatcacaa ttccggaaat acagccgagt
    19021 tcacgcacgg caaaggaaag ctccggcgtc ggacgcaggc tgtcgaacac atacgccttg
    19081 atgccgtttg cgttcaggca gagcgccgcc tcatccgcaa attcggtgga catgattctg
    19141 gaatcgtggg cgatcgcaac acccttctcc tgtccgttct gggagagaat gtagttcgcc
    19201 agtccctgtg tcgcctgacg cacggtataa atgttcatgc ggttcgttcc cgctccgatc
    19261 acgccgcgca gtccgccggt tccaaactct aactgacggt aaaaacgatc ctcaatctcc
    19321 gccgcatcgt cccctattgc agcaagttct gcctttgtat tctcatcaaa atacgggttt
    19381 gtgcaccact ctttgtaagt ctccatgtaa ctcat
//
