LOCUS       NC_012034              17669 bp    DNA     linear   CON 13-DEC-2024
DEFINITION  Caldicellulosiruptor bescii DSM 6725, complete sequence.
ACCESSION   NC_012034 REGION: 939000..956668
VERSION     NC_012034.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02598462
            Assembly: GCF_000022325.1
KEYWORDS    RefSeq.
SOURCE      Caldicellulosiruptor bescii DSM 6725
  ORGANISM  Caldicellulosiruptor bescii DSM 6725
            Bacteria; Bacillati; Bacillota; Bacillota incertae sedis;
            Caldicellulosiruptorales; Caldicellulosiruptoraceae;
            Caldicellulosiruptor.
REFERENCE   1  (bases 1 to 17669)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H.,
            Bruce,D., Goodwin,L., Pitluck,S., Sims,D., Meincke,L., Brettin,T.,
            Detter,J.C., Han,C., Larimer,F., Land,M., Hauser,L., Kyrpides,N.,
            Ovchinnikova,G., Kataeva,I. and Adams,M.W.W.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Complete sequence of chromosome of Caldicellulosiruptor becscii DSM
            6725
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 17669)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Tice,H.,
            Bruce,D., Goodwin,L., Pitluck,S., Sims,D., Meincke,L., Brettin,T.,
            Detter,J.C., Han,C., Larimer,F., Land,M., Hauser,L., Kyrpides,N.,
            Ovchinnikova,G., Kataeva,I. and Adams,M.W.W.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2009) US DOE Joint Genome Institute, 2800
            Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP001393.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4084710
            Source DNA available from Michael Adams (adams@bmb.uga.edu)
            Bacteria available from DSMZ: DSM 6725
            Contacts: Michael Adams (adams@bmb.uga.edu)
                 David Bruce (microbe@cuba.jgi-psf.org)
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-LANL
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. it is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Meta information:
             Organism display name: Caldicelulosiruptor becscii Z-1320, DSM
            6725
             Culture Collection IDs: DSM 6725
             GOLD ID: Gi03121 http://genomesonline.org/GOLD_CARDS/Gi03121.html
             Sequencing Platforms: Sanger, 454
             Phenotypes: Thermoacidophile, Cellulose degrader
             Diseases: None
             Habitat: Fresh water, Hot spring
             Oxygen Requirement: Anaerobe
             Temperature Range: Thermophile
             Biotic Relationship: Free living
             Isolation: Hot spring on the Kamchatka peninsula in Russia.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000022325.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 12:57:17
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,844
            CDSs (total)                      :: 2,783
            Genes (coding)                    :: 2,660
            CDSs (with protein)               :: 2,660
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 71 of 123
            Pseudo Genes (incomplete)         :: 66 of 123
            Pseudo Genes (internal stop)      :: 36 of 123
            Pseudo Genes (multiple problems)  :: 46 of 123
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..17669
                     /organism="Caldicellulosiruptor bescii DSM 6725"
                     /mol_type="genomic DNA"
                     /strain="DSM 6725"
                     /type_material="type strain of Caldicellulosiruptor
                     bescii"
                     /db_xref="taxon:521460"
                     /note="type strain of Caldicelulosiruptor becscii DSM
                     6725"
     gene            1..1671
                     /locus_tag="ATHE_RS04240"
                     /old_locus_tag="Athe_0847"
                     /db_xref="GeneID:31772202"
     CDS             1..1671
                     /locus_tag="ATHE_RS04240"
                     /old_locus_tag="Athe_0847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013290099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_015907390.1"
                     /db_xref="GeneID:31772202"
                     /translation="MSKKLKVFAWFICFVFIFSTLITFPSLKSDFVKAASSNQPVKTL
                     TFFYGDSNADPHPDLFSTPIGKEITKLTGVKLKIEYLAGQDEATKIGLMLASGDLPDL
                     IHGHQEHGKLIEAGVLVPLDNYIQKYGKYCKQIYTDKDLKRLRQKDGKIYFLSPYRNE
                     ITPDLKPDGFWLPIDLLEKAKWPKVRYWEDYQQLIRDYVKKNPTIEGKPTIGFTFITE
                     SWRFFTLENPPSYLMGYQNDGDVIVDPKTYEAKVYSTMGGSKRYYKDLNKMWKEGLID
                     KEVFVQNYDTYLSKIAQGRVVGFYDQWWQFGYDAEASLKNAKKYNRMHISFPVVYKGV
                     QRARYLMIQPIGARDGISITKKCKDPVTAFKFLDKLCSLEAQKLMYWGIKGVDYSVDK
                     NGKMYLTDKQKKQREDPVYRKKQGLGYWWVFPHAYLKLQDGNYREPGFDPEYVYKNFS
                     PAEKKVLDAYKAKYFMQPPFTDPPLETPYGFAWEINIPADKPQVTIAQQKMSEVRRKY
                     LPQLVMAKTDADFDRIWKEFVQAFEKTNYKVYEQFKTEMIRWRVKNWN"
     gene            1782..2867
                     /locus_tag="ATHE_RS04245"
                     /old_locus_tag="Athe_0848"
                     /db_xref="GeneID:31772203"
     CDS             1782..2867
                     /locus_tag="ATHE_RS04245"
                     /old_locus_tag="Athe_0848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013290100.1"
                     /GO_function="GO:0004853 - uroporphyrinogen decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uroporphyrinogen decarboxylase family protein"
                     /protein_id="WP_015907391.1"
                     /db_xref="GeneID:31772203"
                     /translation="MDLSKFDVKKFWEENDFCRLNFDKKTRIPIHFWLDDHFLFELVG
                     PFSTVDYYSKKSYRLQIHKKANDVLEKELGRRFYSEEEIEPPEPTRFEIVMGSKVVIS
                     EGGTPWLEPAIESLDEMKSYIEKIEKIDVKKVVTPELLKAKEDYEKATGKKLKWGHMT
                     RGPATIATSLLGTTSLCILLMDEPELMDEFFEILKEKLVEYIKNLRDYCEVEYNGIAI
                     NDDNCFLFSPKLYERYCAPILESLFKNFAPRKEDTRYQHSDSNMQHLLPILNDLGVNS
                     VNFGPEIHPATIRKFMPNALIYGQMPPFILRNGSAEEIIEYVKRDMQVLKDDGNFIET
                     PAGSVASGTPLENIKIYMWAVQEYGKI"
     gene            3007..4683
                     /locus_tag="ATHE_RS04250"
                     /old_locus_tag="Athe_0849"
                     /db_xref="GeneID:31772204"
     CDS             3007..4683
                     /locus_tag="ATHE_RS04250"
                     /old_locus_tag="Athe_0849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013403700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_015907392.1"
                     /db_xref="GeneID:31772204"
                     /translation="MKFLRKISIVVALVFIISAVLGGIVPVSSQKVEGASKKVVTFTM
                     FSADATVQYHPDIFSTAIGQEITKRTGVRLKIEHFVGMDQATKISLMLASGDLPDLVY
                     GSGEHKQFIQNKALVPLDNYIQKYGQWTKKAYSQADLRKLRQADGHIYFLSYTRGEVS
                     PSASGEGLYVMIDMLQKNNWPRLKYWEDLMPMLRNYVKKYPKYKGMPVIGMSAITEGA
                     RFYVIQDPATGLNGLIADTVQVDPKTYKASYDPAGIGMYKAYKALNALWNEGLFDKEA
                     FVQTYDQWAAKVAQGRVVTSWGRSWHFNTAFNTLRKNGEDDRILVPFGIVFKGVKKSR
                     YVMLQSIGTRDGISITKKCKDPVRAFQFLDQMLNPDIQKLMFWGIKGRDYLVDNKGKM
                     YRTQAMIDKARDPVYQKQEGLGYWNIWPRWQLKLPDGNYVKPELDPDIAYMQWAPAQK
                     KVLEAYKAKTFVEPPFADEPECPPWGYAWEINVPPEKQKEIQVPLNIANDLARKYIPM
                     LIMAPKGKYDEVWNKYKAEVRSKINTKPIEEFYTQEMRQRMADWYGIKVK"
     gene            4806..5744
                     /locus_tag="ATHE_RS04255"
                     /old_locus_tag="Athe_0850"
                     /db_xref="GeneID:31772205"
     CDS             4806..5744
                     /locus_tag="ATHE_RS04255"
                     /old_locus_tag="Athe_0850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013430736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="WP_015907393.1"
                     /db_xref="GeneID:31772205"
                     /translation="MDAVYYNGSKKTFWQKVKEQKELVFMIFPFVLYVILFHYIPLWW
                     WVIAFKEYRPFQGVWGSEWVGLQQFKDLFSDSGFWLAMRNTIVISFLKLVTSFAAAIL
                     LALMLNEVKNMLFKRTIQTISYLPHFVSWVVAASIVISVLSPESGILNQILMSLKIIK
                     QPIVWMGEGHYFWWILALSNVWKETGWNAIVYLAAMTSIDPELYDAASVDGCGRLQKI
                     RYVTLPGIAPTISMLLILNVGWLLNAGFEQVLLLRNPLVQDYSQILDTYVLDYGITMY
                     RYSYATAAGMFKSVVSILLVLFANKVAAKLNASTVV"
     gene            5778..6677
                     /locus_tag="ATHE_RS04260"
                     /old_locus_tag="Athe_0851"
                     /db_xref="GeneID:31772206"
     CDS             5778..6677
                     /locus_tag="ATHE_RS04260"
                     /old_locus_tag="Athe_0851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013433072.1"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]; GO:0055085 - transmembrane transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_013430735.1"
                     /db_xref="GeneID:31772206"
                     /translation="MFKKKTAEDIIVDLVVYISLIFVGIVTLYPFLNVLAVSFNDALD
                     TVRGGIYIWPRKWTLKNYEIIVSNPQIYNAALVSVARTVLGTVLGIICTMFVAYPLSR
                     KDFVLRRPFSAIMVLTMYFGAGLIPTYLLYRSLGLLNTFWVYIVPALLGMFNVVVVRS
                     YIESLPSSLIESAKIDGASEFRILWQIIFPLTLPAVATIALFIGVGHWNSWFDVYIFN
                     SQRPDLSTLQYELQKILASVSMQVGRNPDYQMGAMAETQQVTPNSVRASMTIVATAPI
                     IMVYPFLQRYFVKGLTLGSVKGE"
     gene            6795..8627
                     /locus_tag="ATHE_RS04265"
                     /old_locus_tag="Athe_0852"
                     /db_xref="GeneID:31772207"
     CDS             6795..8627
                     /locus_tag="ATHE_RS04265"
                     /old_locus_tag="Athe_0852"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015907394.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0000155 - phosphorelay sensor kinase activity [Evidence
                     IEA]; GO:0004673 - protein histidine kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="WP_015907394.1"
                     /db_xref="GeneID:31772207"
                     /translation="MWWNKVLKKFFKFSKERILDRLDNLSVRKKLLLVYILCVLIPTL
                     VSHFIFTIFIIKNLQQQKITQIKSAFNILNTNIKKVIDEAILYSNTLYTDDLLNDMLD
                     INYHGMDDFYSNYVQYLRNRIYQGRNVYSNIARVTIYTNNPTILNSDGYRKLNIQEVK
                     EWYDKVINNLQGIVIIPTSDDGVNGEEGYVSLIRNLNQYEQRSTSTGNNSKYTKIAKI
                     DIYLSSFFNSINFEVFGGEIYLIDSSNRIIAAHTYNNLIFTKPFVKFETSKFVPKGSY
                     VFVNNLDINLLNGWKLVGVFSRSYMMGEIYRAIEFILLISLLSLIFATFLIRLITSSI
                     SNRLELLERHMRKVKKQRFEILTCREGNDEIGNLIREFNNMTIRLKELIEKEMLSEIQ
                     KKTLEVEKKQAEINALQSQINPHFLFNTLDSIRMRSVLKNELETAEIIKYLTRTLRRL
                     IYWGNDITTVQEEINFVEDFLKIQQYRFGEKLTYEIFVEEDAKNCLIPKMTIQPLVEN
                     ACIHGIEEKEDSGKVIVKVKKEGINLIIEVADNGIGMNEKKLEELYANLNNPLYDKSI
                     GLKNVYRRLMLYYNDNAEFYIESSINKGTKVVIKLPLELPAFVS"
     gene            8650..10179
                     /locus_tag="ATHE_RS04270"
                     /old_locus_tag="Athe_0853"
                     /db_xref="GeneID:31772208"
     CDS             8650..10179
                     /locus_tag="ATHE_RS04270"
                     /old_locus_tag="Athe_0853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013433070.1"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="WP_015907395.1"
                     /db_xref="GeneID:31772208"
                     /translation="MIKILLVEDEIFMRKGIIKLIDWERLGFEIAYEAGNGQEALDIL
                     KSEKVDVIITDIKMPVMDGIELIKRVSEKFENKPAIIIISGYNEFEFAKAAIKYGVND
                     YLLKPIDENELIQTLERIKTRISSEKEDYKKKELFEYVRRNSAFIKALEIQNDDYLVS
                     SSEDGVKKYLGISKQEAFQYEDDLTIYEKLMETEKSVNTKYLDKGIEIKCYWDSYFNL
                     LFVVNTIQGYKKNSLVKQVFDEIRSLLNLQAIIVQEYVSSQKIHTLYKQLLRKFNFAQ
                     FYEKSGVIEASEIGEFEHYLEDKKLSKELIRLIEEKRFEDINVKVSRFFDECQTNKVS
                     PEVIKGYILFAVLEIIDYFEVYQLFETDSIKFIFRTNIQKSKFLSKVMEILEQIINCI
                     DENSKFNGSSFMKKIELFIKENYNRDITIKSIAQQFYINPIYLGRMFKKHFNMPFNKY
                     LHLVRIENAKRLLLKTDKKIYEIAKEVGYSDPDYFALKFEEYVGKSPSKFRNSVSVNE
                     E"
     gene            10239..12320
                     /locus_tag="ATHE_RS04275"
                     /old_locus_tag="Athe_0854"
                     /db_xref="GeneID:31772209"
     CDS             10239..12320
                     /locus_tag="ATHE_RS04275"
                     /old_locus_tag="Athe_0854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014042590.1"
                     /GO_function="GO:0046559 - alpha-glucuronidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0045493 - xylan catabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucuronidase family glycosyl hydrolase"
                     /protein_id="WP_015907396.1"
                     /db_xref="GeneID:31772209"
                     /translation="MILSRSSNPNYSMCWLSYKPIGKKEYVHEVEKFLGQIVLLEKNI
                     YFENAANELKKALCVLFETELRLNNALSLYVDSGIILGKVTNENLRGFITDVEKEAVG
                     EEGFIIKLVDKSKKKYIIVASKGEKGIIYGIFHLINKFRLKTGLKELNCIENPKASLR
                     IINHWDNMDGSIERGYAGKSIFFTNGRIKRNYKRIWDYARLLASIGINGVVINNVNVR
                     DKAIWLITPKYLNDLSKIAEIFRLYGIKLYLSINFASPIYIGGLDTADPLDKNVQKWW
                     KDTVKTIYSYIPDFGGFLVKADSEFNPGPYVYGRTHADGANMLAEALLPYGGVVIWRA
                     FVYNCLQDWRDTKTDRAKAAYDNFKPLDGMFSKNVILQIKYGPMDFQVREPVSPLFGA
                     MEKTNQMIEFQITQEYTGQQIHLCYLGTLWKEILEFDTYCKGKGSYVKRIVDGSLFGM
                     KYAGFAGVSNIGDSINWTGHDLAQANLWTFGKLAWDPDKKIEDIAREWAILTFGDDKK
                     VVDNILWMLLNSHGIYEKYTTPLGLGWMVNPGHHYGPNPEGYEYSKWGTYHRSDTKAI
                     GVDRTSRGTGYTLQYHKPWQEIFDDINKCPEELLLFFHRVPYDFRLKNGKTLLQFMYD
                     SHFEGADMVDKLIEKWEELRGKIDEEIFNRVYERLKMQKEHAMEWRDVINTYFYRKTG
                     IPDEKGRLIYP"
     gene            12356..13975
                     /locus_tag="ATHE_RS04280"
                     /old_locus_tag="Athe_0855"
                     /db_xref="GeneID:31772210"
     CDS             12356..13975
                     /locus_tag="ATHE_RS04280"
                     /old_locus_tag="Athe_0855"
                     /EC_number="1.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013290107.1"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannitol dehydrogenase family protein"
                     /protein_id="WP_015907397.1"
                     /db_xref="GeneID:31772210"
                     /translation="MFELKIKDISKQDLWQKANIILPKFDIEKIKNATYTNPVWVHFG
                     AGNIFRGYIAAIVQDLIERGELDRGVIAAELFDYEIIDRIYKPYDNLCLVVTSDAKGN
                     LEKRVIASITEGLKCDKSFEADWQRLCRIFKSSTLELVTFTITEKGYNLFDLKGDYLP
                     AVKEDIENGPQSPKSSMGKVAALAYVRYKSGKKPIAYVSLDNCSKNGEKLQSSIVQIA
                     IEWAKRGFVEEDFVEYLNDNSLVSFPWSMIDKIVPRPSERIKELLEKDGLKNMDIICT
                     SKNTYIAPFVNTEKAQYLVIEDSFPNGRPPLERAGVFMTDRKTVEDSERMKVQTCLNP
                     LHTALAIFGCLLGYKTIYEEVKDEHLKRLIEKIGYDEGLKVVVNPKIINPREYIKEVI
                     EERFPNPYIPDTPQRIATDTSQKMPIRFGETIKAYAESPDLDVKSLKYIPLVIAGWLR
                     YLMCIDDEGRAFEPSPDPLILELKKHLEGIELGKKYEDLEEKLRPILTNEVIFRVDLF
                     EVGLSQRVVEYFKEMIQGIGAVRKTLQKYVN"
     gene            14006..15097
                     /gene="uxuA"
                     /locus_tag="ATHE_RS04285"
                     /old_locus_tag="Athe_0856"
                     /db_xref="GeneID:31772211"
     CDS             14006..15097
                     /gene="uxuA"
                     /locus_tag="ATHE_RS04285"
                     /old_locus_tag="Athe_0856"
                     /EC_number="4.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013403693.1"
                     /GO_function="GO:0008927 - mannonate dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006064 - glucuronate catabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannonate dehydratase"
                     /protein_id="WP_015907398.1"
                     /db_xref="GeneID:31772211"
                     /translation="MGFKMTFRWFGPKDDNIPLEYIRQIPGIYGVVTALFDIPVGEVW
                     PEDRIFELKKMVEGAGLKFEVIESVNVHEDIKLGLPSRDRYIENYKQTIRNLAKAGVK
                     VICYNFMPVFDWLRTDLAKKLPDGSEVMEYNHEILKNMTPDELVKSMERGSQGFSLPG
                     WESYRLKQLQSLFEMYKDVDENKLLQNLIYFLENIIPVCEQCDVKMAIHPDDPPWSLF
                     GLPRVVTNKENIEKFLKAVDSPYNGLTLCTGSLGANRENNIPELIRYFGKMGRIHFMH
                     VRNIKFTGERSFYETSHLSTDGSFDMFEIMKAIYDIGFDGYMRPDHGRMIWGEKGRPG
                     YGLYDRALGIAYLNGLWEAIDKMSRNEKK"
     gene            15237..17669
                     /locus_tag="ATHE_RS04290"
                     /old_locus_tag="Athe_0857"
                     /db_xref="GeneID:31772212"
     CDS             15237..17669
                     /locus_tag="ATHE_RS04290"
                     /old_locus_tag="Athe_0857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013430729.1"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 2 TIM barrel-domain
                     containing protein"
                     /protein_id="WP_041727352.1"
                     /db_xref="GeneID:31772212"
                     /translation="MQKINLDRSWEYLELGFANVLNLTSSEYEWKKVDLPHDAVIEKE
                     RSEANPSGAGEGYTAGCSLYYKKELILDEEWQGKNLILEFEGIMGIAEVFVNGRLVAK
                     HFNGYTSFLIDITKHVKFDDKNIIIVRVENTHKPSSRWYAGCGIYRHVWLHIGGKVYI
                     KPWHLHVQTRAIENETAKLEVRAVVVNSVNEKVQGVIKFDVFSKDEKLILSSEEKFLI
                     GKNEEKVIAKTLELKPFKYWDIEDPYLYKIQATIICDESIEDSASTLFGIRTISVDPK
                     EGFKLNGKPLKLKGGCIHHDNGPLGSASYDRAEERKVELLKASGFNAVRLAHNPFAPA
                     FLDACDRLGMLVIEEFFDVWHAGKVSFDYHLFFDKYWEEDLESTIMRDYNHPSIIMWS
                     IGNEITWGVGVDVDDDSSYSIYTWCERLAKKVKSLDSSRLITAALCAIPDDYKRLFAI
                     IEEGNYVIRMLKQEVDVIEDKWGEFSEKFSRFLDVVGYNYKVDRYGFDRYKYPDRVIC
                     GTETYPYTLFKNWKQTIENSNVIGDFVWTAIDYLGEAGLGRVSIEADDLKSFCGSYPW
                     FLANCGDIDICGEKRPQSYYRDVVWGNRKDPYIVILPPQVYGKKLYFKPWAWEPVERN
                     YTFPGYEGMKVAIHVYADADEVELFVNGRSLGRKEVGINTQFKMVYDTIYEPGVIEAV
                     AYKDGKEIGRDKIETTGEPVALKLVPDREVISSSYGDLCYIKIMAVDRKGREVVFADN
                     RIVVEVEGVGELVALGSSNPLSTEPFVSRERKLYKGRALAIVKSIGKKGEFKLKAWAE
                     GLDGAQVFVKCI"
ORIGIN      
        1 atgtcaaaaa aattaaaagt atttgcttgg tttatttgtt ttgtgttcat tttttcaact
       61 cttattacat tcccaagttt aaaatctgat tttgtgaaag cggcttcaag caatcaaccc
      121 gtaaagacat tgacattttt ctatggagat tcaaatgcag atcctcatcc agacctgttt
      181 agcactccta ttggtaaaga aattacaaaa cttacaggtg taaaactcaa aatcgaatac
      241 ttagcaggac aggatgaagc aacaaaaatt ggtcttatgt tagcatctgg tgatttacca
      301 gatttgattc atggtcatca ggagcatgga aagttaatag aagctggtgt attggtacca
      361 cttgataact atattcaaaa atacgggaaa tattgtaaac agatttacac tgataaagac
      421 ctcaaaagac tcagacagaa agatggaaaa atttatttct tgtctcctta cagaaacgaa
      481 ataactccag acttaaaacc agatggcttc tggctaccaa ttgatcttct tgaaaaagca
      541 aaatggccga aggtaaggta ttgggaggac tatcagcagc tcattagaga ttatgtaaag
      601 aaaaatccta ctattgaggg gaaaccaacc attggattta catttattac agaaagttgg
      661 agattcttca ctttagaaaa tccgccttca tatcttatgg gatatcaaaa tgatggtgat
      721 gtaattgttg acccgaagac atatgaagca aaagtttatt ctacaatggg agggtcaaag
      781 agatactata aagatttgaa taagatgtgg aaagagggac ttattgacaa agaagtgttc
      841 gttcaaaact acgacacata tctttctaag attgctcagg gtagagttgt aggattctat
      901 gatcagtggt ggcaatttgg atatgatgca gaggcttcac tgaagaatgc aaagaaatac
      961 aatagaatgc atatttcatt cccagttgtt tacaaaggtg ttcaaagagc aagatatctt
     1021 atgattcagc cgattggcgc aagagatggt attagcataa ctaagaagtg taaagatcct
     1081 gttacagcat ttaagttctt ggacaaactg tgctctttag aagctcaaaa acttatgtat
     1141 tggggaataa aaggtgttga ttacagtgta gacaaaaacg gaaaaatgta cctaacagat
     1201 aaacagaaaa aacagagaga agaccctgtt tacaggaaga aacaaggtct tggatactgg
     1261 tgggtatttc cacatgcata tttgaagctg caggatggaa attacagaga gcccggattt
     1321 gacccagagt atgtatacaa gaacttctca ccagctgaaa agaaagttct cgatgcatat
     1381 aaagctaaat acttcatgca acctccattt acagatcctc cacttgaaac accttatgga
     1441 tttgcatggg aaatcaatat tcctgctgat aagcctcaag ttacaattgc tcaacagaag
     1501 atgagcgaag tgagaagaaa atatctacca caacttgtaa tggcaaagac agatgcagat
     1561 tttgatagaa tatggaaaga atttgttcag gcatttgaaa aaacaaatta caaagtttat
     1621 gagcagttca agacagaaat gattcgctgg agagtaaaga attggaacta aatatggaat
     1681 aaatttgtgg tatattctat agggaagtcc tcttatttta gaggtcttcc ctataaattt
     1741 ttgtaaccta aaaataattt caacaaagga ggagggttct tgtggactta tctaaatttg
     1801 atgtaaaaaa attctgggaa gagaatgatt tttgtaggct taattttgac aaaaaaacaa
     1861 ggattcctat ccacttttgg cttgatgacc attttctgtt tgagctggtg ggtccttttt
     1921 caacagttga ttattattct aaaaaatcat acagacttca aattcataaa aaagctaatg
     1981 acgtattgga aaaggaactt ggaagaagat tttattctga ggaagaaatt gagccaccag
     2041 aaccaacaag gtttgagatt gtcatgggaa gtaaagtagt gatatcagaa ggtgggacac
     2101 cttggcttga accggcaatt gaaagtttag atgagatgaa gagttatata gaaaaaatag
     2161 agaagattga tgtaaaaaaa gtagttacac ctgaactttt gaaggcaaaa gaagattatg
     2221 aaaaagcgac agggaagaaa ctaaaatggg ggcatatgac aagaggacct gctacaattg
     2281 caacaagttt attggggaca acaagtcttt gtatattgct catggatgag ccagagctta
     2341 tggatgagtt ttttgagata ttaaaggaaa agctcgtgga atatataaaa aatttaagag
     2401 attactgtga agttgaatat aacggaattg caattaatga tgataactgt tttttatttt
     2461 cgcccaagtt atatgaaaga tactgtgcac ctattttaga gagtttgttt aaaaattttg
     2521 caccaagaaa agaagatact cgctatcaac attcggatag caatatgcag cacctacttc
     2581 ctattttaaa tgaccttgga gtaaatagcg ttaattttgg gcctgaaatt caccctgcaa
     2641 cgataagaaa gtttatgcca aatgcattga tttatggaca gatgccacca tttatattga
     2701 gaaatgggag tgcagaagaa attatcgagt acgtaaaaag agatatgcaa gttttaaaag
     2761 atgatggaaa ctttatcgag acaccagcag gttctgttgc atcaggtact cctcttgaaa
     2821 acataaaaat atacatgtgg gcagttcaag aatatggaaa aatatagact tttgacatat
     2881 caattttatg ggggaaatat gttagatttt aagggttgtt tttatctaaa tactatgtaa
     2941 aatgaacagt agagaatgat aattgttcat ccttgataaa aattcaaaga gaggaggcgt
     3001 ttcaatttga aatttttaag aaaaatttcg attgtggtag cgcttgtttt cattatttcc
     3061 gcggtgctgg gtgggattgt acctgtatct tcccagaagg ttgaaggtgc atcaaaaaag
     3121 gttgtaactt ttacaatgtt tagtgcagat gcgacagtac agtatcaccc agatattttc
     3181 agtactgcta ttgggcaaga gattacaaaa aggacaggcg taagattgaa aatcgaacac
     3241 tttgtaggaa tggaccaggc aacaaagata tcacttatgc ttgcatctgg tgatttacca
     3301 gacttggttt atggcagtgg tgagcacaaa caatttattc agaacaaagc tttagttccg
     3361 cttgataact acattcaaaa atatggtcag tggacaaaga aggcgtactc tcaggcagat
     3421 ttgaggaaac ttcgccaagc tgatggacat atttatttct tgagctacac aagaggtgaa
     3481 gtgtcaccaa gtgcaagtgg tgaaggttta tatgtaatga ttgacatgtt acaaaagaat
     3541 aactggccaa gattaaagta ctgggaagat ttgatgccaa tgttaagaaa ttatgttaag
     3601 aaatatccaa agtacaaagg tatgcctgta ataggcatgt cagcaattac agaaggcgca
     3661 agattctatg taattcaaga tcctgcaaca ggtttgaatg gtcttatagc agatactgta
     3721 caagttgatc cgaaaacata taaagcaagc tatgaccctg caggaatagg aatgtacaaa
     3781 gcttacaagg cactaaatgc tctgtggaat gaaggtttgt ttgataaaga agcatttgtt
     3841 cagacatatg accaatgggc tgcgaaagtt gctcaaggta gagttgtgac aagctgggga
     3901 aggtcatggc actttaacac agcattcaat acactacgaa agaatggcga agatgataga
     3961 atccttgttc catttggcat tgtatttaaa ggggttaaaa aatcaagata tgtgatgctt
     4021 cagtcaattg gaacaagaga tggcataagc attacaaaga agtgtaaaga tcctgtaaga
     4081 gcattccagt tcttagacca aatgctcaat ccagatattc agaaacttat gttctggggt
     4141 attaaaggaa gagattatct tgttgacaat aaaggtaaga tgtacagaac acaagctatg
     4201 attgacaaag caagagaccc tgtttaccag aaacaagaag ggcttggcta ctggaacatc
     4261 tggccaagat ggcagctcaa gcttccagat ggaaattatg taaaacctga acttgatcca
     4321 gatattgcat atatgcaatg ggcaccagca caaaagaaag tgcttgaagc atacaaagca
     4381 aaaacatttg ttgaaccacc atttgctgat gaacctgaat gtccaccttg gggatatgca
     4441 tgggagatca acgttccacc tgaaaagcaa aaagaaatcc aggttccact caacattgct
     4501 aacgaccttg caaggaagta tataccaatg cttataatgg ctccaaaggg caagtatgat
     4561 gaggtatgga acaaatacaa agcagaggtt agatcaaaga ttaacacaaa accaattgaa
     4621 gagttctata cacaggaaat gagacagaga atggcagatt ggtacgggat taaagttaag
     4681 taatgtttct gaaacctcaa agggaagagg taaaaccctc ttcccttata taactaaatt
     4741 gttaagacta cattataatg ggtactaatc ttgtaggagc aaagttttaa aaggaggtaa
     4801 ttacattgga tgcagtatac tacaatggtt caaagaaaac gttctggcaa aaagtaaaag
     4861 agcagaaaga acttgttttt atgatatttc catttgtctt gtatgtaatt ttgtttcact
     4921 acataccact ttggtggtgg gtcattgcat ttaaagaata caggccattc caaggtgttt
     4981 ggggttcaga gtgggtaggt ttgcagcaat ttaaagattt attcagcgac tctggttttt
     5041 ggcttgctat gagaaataca attgttataa gctttttgaa gcttgttacg tcctttgcag
     5101 cagctatctt acttgcattg atgcttaacg aagtgaagaa tatgttattt aaaagaacta
     5161 ttcagacaat ttcatatctt ccacactttg tttcttgggt tgtggcggcg agtatagtta
     5221 taagtgtgct ttcacctgag tcaggtatac tcaatcaaat tttgatgtca ctcaagatta
     5281 ttaaacagcc aattgtctgg atgggtgaag gacattattt ctggtggata ttggctctct
     5341 cgaatgtttg gaaggaaaca ggatggaatg ctatagtgta tttggcagca atgacaagta
     5401 tagaccctga actttacgat gctgcaagcg tggatggttg tggaagactg cagaagataa
     5461 gatatgtaac actgccaggg attgctccaa caattagtat gcttcttatt ctcaacgttg
     5521 gttggctttt gaatgctggt tttgaacagg ttcttttgct cagaaacccc cttgttcagg
     5581 attactctca aattcttgac acctatgttc ttgattatgg tattacaatg tacagatatt
     5641 catatgctac agctgctggt atgtttaaga gcgttgtaag tattttgctt gtgttgtttg
     5701 caaataaggt tgctgcaaaa ttgaatgcat caactgttgt ataaaaaagc ttaaacgtta
     5761 aggagggaaa attcaaaatg tttaagaaaa aaacagccga ggatattata gttgacttgg
     5821 ttgtttatat aagtttgatt tttgtcggta ttgtgacttt atatccattt ttaaatgtat
     5881 tagctgtttc attcaacgat gcacttgaca cagttcgagg aggaatttat atctggccaa
     5941 gaaaatggac attaaaaaac tatgaaatta ttgttagcaa tccgcagatt tacaatgcag
     6001 ctttagtatc tgttgcaaga acagttcttg gtacagtgct tggtattatt tgtacaatgt
     6061 ttgttgctta tcctttgtca agaaaagatt ttgtattaag acgtccgttt tctgcaataa
     6121 tggttttgac tatgtatttt ggagcaggtt taattccaac ctacttattg tataggtcgc
     6181 tcggactttt aaacacattt tgggtttata ttgttcctgc acttttggga atgtttaatg
     6241 ttgttgtggt cagaagctat atagaatctt tgccatcaag tttgatagaa tctgctaaaa
     6301 ttgatggagc aagcgaattt agaattttgt ggcagataat ctttccactt accctgccag
     6361 cagttgcgac aatagcactc tttattggag ttgggcattg gaattcatgg tttgacgtat
     6421 atatctttaa ttcgcaaaga cctgacctga gtactcttca gtatgagctt caaaaaattc
     6481 tggcatctgt aagcatgcag gttggaagaa atcctgacta tcaaatggga gcaatggctg
     6541 aaactcagca ggttactcca aactcggtaa gagcaagtat gacaattgtt gccacagctc
     6601 caattattat ggtttatcca ttcttgcaga gatattttgt aaagggtctt actcttggta
     6661 gcgttaaagg agagtaatca aagcttttta aagtgggtga ttttcgccca ctttgatttg
     6721 ttttttataa gtaaataaaa tacagttatt atccttgtgt attatgatat aattaagctt
     6781 aggagatata aaacttgtgg tggaataaag tgttaaaaaa gttttttaaa ttttcaaaag
     6841 aaagaatact tgacagatta gataatcttt ctgtccgaaa gaaattgtta cttgtataca
     6901 ttctatgtgt tttaatcccc acattagtaa gccattttat atttaccatt ttcattataa
     6961 aaaatcttca acaacaaaaa attacccaga taaaaagtgc ttttaacatc ttaaatacta
     7021 acataaaaaa ggtaatagat gaagctatat tgtattcaaa tacattgtat acagatgatt
     7081 tacttaacga tatgcttgac attaattacc atggtatgga tgatttttat tctaattatg
     7141 ttcagtatct gagaaatagg atatatcagg gtagaaatgt gtattcaaac attgctcgcg
     7201 taacaatata tacaaacaat cctacaattt taaatagtga cgggtataga aagttaaata
     7261 ttcaagaggt taaagaatgg tatgataaag taattaataa tctgcaagga atagttataa
     7321 tacctaccag cgacgatgga gttaatggag aagaaggata tgtgtcattg ataagaaatc
     7381 tcaatcaata tgagcaaaga agtacttcga cgggaaacaa tagtaaatat acgaaaatag
     7441 caaaaattga tatttatctt tcaagctttt ttaattccat aaattttgag gtatttggtg
     7501 gagaaattta cttaatagac agcagtaaca gaataattgc agctcataca tacaataatt
     7561 taatttttac caagcctttt gtaaaatttg agacgagtaa atttgtgccg aaaggttcgt
     7621 atgtgtttgt aaataatctg gatataaatc ttttaaatgg atggaaactt gttggagtat
     7681 tttcgcgatc gtatatgatg ggagagatat acagagctat tgagttcata ttacttattt
     7741 cccttttgag cttgatattt gcaacctttt taataagact cataacttct tctatatcaa
     7801 atagactgga acttttagaa agacatatga gaaaagttaa gaagcagcgc ttcgagattc
     7861 tgacatgcag agaagggaac gatgagattg gaaatcttat aagagaattt aacaatatga
     7921 caataagact taaagaacta atagagaagg aaatgctttc tgaaattcaa aagaagacac
     7981 ttgaagttga aaaaaaacag gcagagataa atgcgcttca gagtcagata aatccacatt
     8041 ttcttttcaa tacactggac tcaataagaa tgcgttctgt tttgaagaac gaactggaaa
     8101 cagctgagat aattaagtat ctaacaagga ctttaaggag gcttatttac tggggaaatg
     8161 atataaccac agttcaggaa gaaatcaatt ttgtagaaga ttttctaaaa atacagcaat
     8221 acagatttgg tgaaaaattg acatatgaaa tttttgtaga agaggatgct aaaaattgtt
     8281 tgattcctaa gatgacaatc cagccacttg ttgaaaatgc gtgtatacat ggtatagaag
     8341 aaaaagaaga cagtggtaaa gtaatagtta aagtaaaaaa agagggtata aatttaataa
     8401 tagaagttgc tgacaacggg atagggatga acgagaaaaa gcttgaggag ctttatgcta
     8461 accttaacaa tccactctat gataaaagca ttgggcttaa aaatgtttac agaaggttaa
     8521 tgctgtacta caacgacaat gctgagtttt atattgaaag ttctatcaat aaagggacaa
     8581 aggttgttat taaacttcct ttagaattgc cagcatttgt ttcatagaat atagtgaggg
     8641 tgtgtaacca tgataaagat tcttttggtt gaagatgaga tattcatgag aaagggtata
     8701 attaaactta ttgattggga aagacttgga tttgaaattg catatgaagc gggaaatggt
     8761 caggaagccc ttgatattct caaaagtgag aaagtagatg tgataataac ggatataaaa
     8821 atgccagtaa tggatggaat tgagctgata aaaagagtct cagagaagtt tgaaaacaaa
     8881 ccggcaataa taattataag tgggtacaat gagtttgaat ttgcaaaggc agctataaag
     8941 tatggtgtaa atgattatct attaaaacct atagatgaga atgagcttat tcaaacctta
     9001 gagaggataa aaacgaggat atcaagcgaa aaggaagact ataaaaagaa agaattattt
     9061 gaatatgtga gaaggaactc agcttttata aaagctcttg agatacaaaa tgatgattat
     9121 cttgtaagta gtagtgaaga tggagtgaaa aaatatcttg gaatttcaaa acaggaagct
     9181 tttcaatatg aagatgattt gaccatttat gaaaaattaa tggaaacaga aaaaagtgta
     9241 aataccaagt atttggacaa aggtatagag attaaatgtt attgggatag ttactttaac
     9301 ttactttttg tagtaaacac cattcaaggg tataagaaaa atagtttagt taaacaggtt
     9361 tttgacgaga taagaagtct attaaatttg caggcaataa ttgtgcagga gtatgtatct
     9421 agccagaaga tacatacatt gtataaacag cttttgagaa aattcaactt tgcccaattt
     9481 tacgaaaaga gtggtgtcat tgaggcatca gagatagggg aatttgaaca ttaccttgag
     9541 gataaaaaac tttcaaaaga gttgattaga ctaatcgaag aaaaacgatt tgaagatata
     9601 aatgttaaag tttcaagatt ttttgatgag tgtcagacta ataaagtgtc gcctgaggtg
     9661 attaagggtt atattctttt tgctgtgctt gaaataatag attattttga agtttaccag
     9721 ttatttgaga ctgatagtat aaagtttata tttagaacca atatacaaaa aagtaaattc
     9781 ttgagtaaag ttatggaaat tttggagcag attataaact gcattgacga aaattctaaa
     9841 tttaatggtt cgagttttat gaagaaaata gagttgttta taaaggaaaa ttacaacaga
     9901 gatataacaa ttaaaagtat tgctcaacaa ttttatatca atcctatata tttgggaagg
     9961 atgtttaaaa aacactttaa catgccattt aacaaatatt tgcatttagt gcgcattgag
    10021 aatgcaaaaa gattacttct taaaactgat aaaaagattt atgaaatagc taaggaagta
    10081 ggttatagtg atcctgacta ttttgcatta aaatttgagg aatatgtagg caaaagtcct
    10141 tcaaaattta gaaattctgt ttctgtcaac gaggagtaat gtggttttta ttatttagaa
    10201 atcgttttct aaatagctgc ggaaaggtgt gattaattat gattttatca aggagcagta
    10261 acccaaacta ttctatgtgt tggctttctt ataaacctat aggtaagaaa gaatatgtac
    10321 atgaagttga aaaattttta gggcaaatag ttttattgga gaaaaatatt tatttcgaaa
    10381 atgcggcgaa tgaacttaaa aaggctttat gtgtattgtt tgaaactgaa ctaagattga
    10441 acaatgcttt aagtctttat gttgacagtg gaattatttt aggtaaagtg acaaatgaaa
    10501 atcttagagg ttttataacc gatgttgaaa aagaagcagt aggtgaggaa gggtttataa
    10561 taaaacttgt agataaaagt aagaaaaaat acattattgt tgcttcaaag ggtgaaaaag
    10621 gaataatata tgggatattt catttgataa acaaatttag acttaaaaca ggattaaaag
    10681 aactcaattg tatagaaaat ccaaaggcct cgttacgaat tattaaccat tgggataata
    10741 tggatggaag tattgaaaga ggatatgcgg gtaaatcaat attttttaca aatggtagaa
    10801 taaaacgcaa ttataaacgt atatgggatt atgcaaggct tcttgcctca attggaataa
    10861 acggtgttgt aataaataat gtgaatgtaa gagataaggc tatatggtta attacgccaa
    10921 aatatctaaa tgacctctcg aaaatagcag aaatttttag actctatggg ataaaacttt
    10981 accttagcat aaactttgca agcccaattt atataggagg tcttgacact gcagacccac
    11041 ttgacaaaaa cgttcaaaag tggtggaagg acactgtaaa aactatttac agctacatac
    11101 cagactttgg tggatttttg gtaaaagccg attctgagtt caatccaggg ccgtatgtat
    11161 acggtagaac acatgcagat ggagcaaaca tgcttgcaga ggcacttttg ccttatggag
    11221 gagttgttat atggcgtgcg tttgtttaca actgcttgca ggattggaga gatacaaaga
    11281 cagacagggc aaaggctgca tatgacaatt ttaaaccact tgatgggatg ttctctaaaa
    11341 atgtcatttt acagataaag tatggtccga tggattttca ggtaagagaa cctgtttcac
    11401 ctctttttgg cgctatggaa aagacaaacc agatgataga gtttcaaata acccaagaat
    11461 atacggggca acaaattcat ctgtgctatt tggggacgct atggaaagag attttagagt
    11521 ttgacacata ttgtaaagga aaaggttcgt acgtaaagag aatagtggat ggaagtcttt
    11581 ttggaatgaa atatgcagga tttgcaggtg tttcgaatat tggggatagc atcaactgga
    11641 caggtcatga ccttgcacag gcgaatctgt ggacgtttgg aaaacttgca tgggacccag
    11701 ataaaaagat tgaagatata gcaagagagt gggccatttt aacatttgga gatgacaaaa
    11761 aagtggttga caacatttta tggatgcttc ttaattctca cgggatctac gaaaaatata
    11821 caactccgct tgggcttggc tggatggtaa atccaggtca tcactatggt ccaaacccgg
    11881 aagggtatga gtattcaaag tggggaacgt atcatcggtc agatacaaaa gcaattggag
    11941 ttgacagaac ttcaagaggg acaggttata ctttgcaata tcacaagccc tggcaggaaa
    12001 tattcgatga tataaataaa tgtcctgaag aacttcttct atttttccac agagtgccgt
    12061 atgattttag actgaaaaat ggaaaaacgc tcctgcagtt tatgtatgac tctcactttg
    12121 aaggggctga tatggtagat aaacttatag aaaagtggga ggaactgaga ggaaagattg
    12181 atgaggagat cttcaacaga gtatatgaaa gattgaagat gcaaaaagaa catgcaatgg
    12241 aatggagaga tgttatcaac acatattttt atagaaagac aggaatacct gatgaaaagg
    12301 gaagactaat atatccgtaa tatatatttt ttgaaagcga ggttgaaaag ttgaaatgtt
    12361 tgaactgaag ataaaagata tatcaaagca agatttatgg caaaaagcca atattatttt
    12421 gcctaagttt gacattgaaa aaataaaaaa tgctacttac acaaatcctg tttgggtaca
    12481 ttttggagca ggtaacatct ttagagggta tattgcagca atagttcagg atttaataga
    12541 aagaggggaa cttgacagag gagtaattgc agcagagctt tttgactatg agataattga
    12601 cagaatatac aagccttatg acaatctctg cttggttgtg acatctgatg caaaaggcaa
    12661 tttagaaaaa agagtgattg caagcattac agaggggcta aagtgtgata aaagctttga
    12721 agcagactgg caaagacttt gtagaatttt taaaagttcc actcttgagc tggtgacatt
    12781 tacaataaca gaaaaaggat acaacctctt tgacctcaaa ggtgactatc tgcctgcggt
    12841 aaaagaggat atagaaaatg gaccgcaaag tccaaaaagt tcgatgggca aagttgcagc
    12901 attggcatat gttcgataca aaagcggcaa aaagccaatt gcatatgtga gccttgacaa
    12961 ctgttctaaa aatggtgaaa aattgcaaag ttcaatagtt caaatagcta tagagtgggc
    13021 gaaaagaggt tttgttgaag aggattttgt tgaatacttg aacgataatt ctttagtaag
    13081 tttcccatgg agcatgatag acaagattgt cccaaggcca tcggagagaa taaaggaact
    13141 tttagagaaa gatggactga agaatatgga tatcatttgc acatcaaaga atacgtacat
    13201 tgcaccgttt gtcaatacag aaaaggctca gtatcttgtg atagaagata gttttccaaa
    13261 tgggagaccg ccactggaaa gagcaggagt atttatgaca gatagaaaga ctgtggaaga
    13321 ctctgagcgg atgaaggttc agacatgttt gaatcctctt cacacggctt tggctatatt
    13381 tggctgtttg cttgggtata agacaattta tgaagaggta aaagatgagc atttaaaaag
    13441 gcttatcgaa aagataggat atgatgaggg attgaaggtt gttgttaacc cgaagataat
    13501 aaatccgagg gagtatataa aggaagtgat agaagaaaga tttccaaacc cgtatatacc
    13561 tgacacaccg cagaggattg caacagacac atcacaaaag atgccaatta gatttggaga
    13621 gactataaaa gcatacgcag aaagcccgga tttagatgta aaaagcctta aatacattcc
    13681 tcttgtaata gcagggtggc tgagatattt gatgtgcatt gatgatgaag ggagagcttt
    13741 tgagccaagc ccagatccac ttatacttga gcttaaaaaa catcttgagg gcatagaact
    13801 tggcaaaaag tatgaagatt tggaagaaaa gctaagacca attctaacca atgaggttat
    13861 tttcagggtt gacttatttg aagtgggact atctcagagg gtagtagaat attttaaaga
    13921 gatgatacaa ggcattggag ctgtgagaaa gaccttgcaa aagtatgtaa attaaaagat
    13981 tttcaaaaag aaaggggcta gaaaaatggg ttttaagatg acatttaggt ggtttggacc
    14041 aaaggatgac aatattcctc ttgagtatat acgtcagatt ccaggcatat atggtgttgt
    14101 gacagcgctt tttgatattc cagttggaga ggtatggcca gaagatagga tttttgagct
    14161 aaaaaaaatg gtagaaggtg cagggcttaa gtttgaggta atagaaagcg taaatgtcca
    14221 tgaggacata aaacttggtc ttccaagtcg agataggtat atagaaaact ataaacagac
    14281 cataaggaac ttagcaaaag cgggagtaaa ggtaatatgc tataacttta tgcctgtatt
    14341 tgactggctg aggacagacc ttgcaaaaaa gctccctgat ggttctgagg ttatggaata
    14401 taaccatgag atacttaaaa atatgacacc agatgaactt gtaaaaagca tggaaagggg
    14461 ctcacaagga ttttctcttc ctggttggga gagctacagg ttaaaacagc tccagagcct
    14521 gtttgagatg tacaaagatg ttgatgagaa taagcttttg caaaatctta tctacttttt
    14581 ggagaatata attcctgtgt gtgagcagtg cgatgttaaa atggcaatac acccagatga
    14641 tccaccgtgg tcactttttg gtcttccaag ggttgtaaca aacaaggaaa atatagaaaa
    14701 gtttttaaaa gcggttgata gtccgtacaa tgggttgact ttgtgcacag ggtcgcttgg
    14761 agcaaacagg gaaaacaaca ttccggagct tataaggtat tttggcaaaa tgggaagaat
    14821 acattttatg catgtgagaa atataaaatt tacaggtgag aggtcttttt acgaaacatc
    14881 ccacctgtcg acagatggtt catttgacat gtttgagatt atgaaggcta tatacgacat
    14941 aggttttgac gggtatatgc gacctgacca tggaaggatg atttggggcg aaaaagggag
    15001 acctggttat ggactttatg atagagcact tggcattgcg tatttgaacg ggctgtggga
    15061 ggcaattgac aagatgtcaa gaaatgagaa aaagtagtaa gtagaaaaga gaaaggtttc
    15121 tccccaaaac cgcctgctgg ggctgggaga ctttgatgtg gcggactata aataccccag
    15181 ccatcttgag ccgctgcttt tctgaagcgg ctcaagatgt tcttgagttt caaaaaatgc
    15241 agaagataaa tttggacagg tcatgggaat atcttgagct tggttttgca aatgtattaa
    15301 acttaacaag ttcagaatat gagtggaaaa aggtggatct gccacatgat gctgtaattg
    15361 aaaaagaaag aagtgaggct aatccctcag gtgccggtga agggtatact gcgggatgca
    15421 gtttgtatta caaaaaagaa ttgattttag atgaagagtg gcaaggcaaa aacttaatac
    15481 ttgagtttga aggaatcatg ggtatagctg aggtttttgt aaatggtagg ttagttgcta
    15541 aacacttcaa tggatacaca agttttctaa ttgatataac aaagcatgtc aagtttgatg
    15601 ataagaacat tattattgtg cgtgtagaaa atactcataa gccaagctca agatggtacg
    15661 caggttgtgg catatacaga cacgtgtggc tacacattgg tggcaaggtg tatataaaac
    15721 catggcattt gcatgttcaa accagagcaa ttgaaaatga aactgcaaag ttagaagtaa
    15781 gagctgttgt tgtcaacagt gttaatgaaa aagttcaagg agtaataaaa tttgatgtat
    15841 tttcaaaaga tgagaaacta attctcagca gtgaagagaa gtttttgatt ggtaaaaatg
    15901 aagaaaaggt aattgccaaa accttagaac taaaaccatt taaatattgg gatatagaag
    15961 acccatatct ttataaaatt caagcaacta ttatttgtga tgagagtatt gaagatagtg
    16021 cttctacatt gtttggtatt cggacaattt cagttgatcc caaggaagga tttaaattaa
    16081 atggtaagcc attaaaatta aaaggtggct gtattcatca tgacaatgga ccacttggaa
    16141 gtgcgagtta cgatagggca gaagagagaa aagtagaact tttaaaagct tctggattca
    16201 atgcggtaag acttgcacat aatccttttg ctccagcttt tttggatgca tgtgatagat
    16261 tagggatgct tgtgatagaa gaattttttg atgtatggca tgctggcaag gttagctttg
    16321 actaccatct attttttgac aagtactggg aagaagattt ggagtccacc ataatgaggg
    16381 actataatca tccttcgata ataatgtggt caataggaaa cgagattaca tggggagttg
    16441 gagttgatgt tgatgacgat agtagctact caatatacac ctggtgtgaa cgattagcaa
    16501 aaaaggtaaa aagtttggat tcatcaaggc taataacagc ggcactgtgc gcaattccgg
    16561 atgattataa aaggcttttt gctataattg aagaaggtaa ctatgtaatt agaatgctaa
    16621 aacaagaagt agatgttatt gaagataaat ggggcgagtt ttcagagaag ttttcaagat
    16681 ttctggatgt agttggttat aactataaag tagatagata tggattcgat aggtataaat
    16741 atcctgaccg agtaatctgt ggcacagaaa cttatccata tactcttttt aaaaactgga
    16801 aacaaacaat agaaaattca aatgttatag gtgattttgt gtggacggct attgattatt
    16861 tgggcgaagc aggtcttggt agggtaagta ttgaagcaga tgaccttaaa tctttctgcg
    16921 ggtcttatcc atggttttta gcaaattgtg gggatattga tatttgtggg gaaaaacgtc
    16981 ctcaatcgta ttatagagat gttgtttggg gaaatagaaa agacccttat attgtaatac
    17041 ttccaccgca agtttatggc aaaaaactat attttaaacc ctgggcatgg gaaccggtcg
    17101 aaagaaacta cacttttcct ggatatgaag ggatgaaggt ggctatacat gtctatgcag
    17161 atgcagatga ggttgagctg tttgtaaatg gcagaagttt gggaagaaaa gaagtaggga
    17221 ttaatactca gtttaaaatg gtttatgaca caatttatga accaggagtg atagaagctg
    17281 tagcatacaa agatggtaaa gagattggca gagacaaaat agaaacaaca ggtgagcccg
    17341 tagccttaaa actggtgcct gatagagaag ttatatcctc ttcttatggt gatttgtgct
    17401 atataaaaat aatggcagta gatagaaagg gaagagaggt tgtttttgca gataacagaa
    17461 tagttgtaga agttgaaggt gttggcgaac ttgttgcttt aggaagtagc aatcctttgt
    17521 caacagaacc atttgttagc cgagagagaa agctctataa ggggcgagca ttggcaatag
    17581 taaagagcat tggcaaaaaa ggagaattta aattgaaagc ttgggcagaa ggattggatg
    17641 gtgcacaagt ttttgtaaaa tgcatttaa
//
