LOCUS       NC_004663              10865 bp    DNA     linear   CON 05-SEP-2024
DEFINITION  Bacteroides thetaiotaomicron VPI-5482, complete sequence.
ACCESSION   NC_004663 REGION: 4017692..4028556
VERSION     NC_004663.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02604314
            Assembly: GCF_000011065.1
KEYWORDS    RefSeq.
SOURCE      Bacteroides thetaiotaomicron VPI-5482
  ORGANISM  Bacteroides thetaiotaomicron VPI-5482
            Bacteria; Pseudomonadati; Bacteroidota; Bacteroidia; Bacteroidales;
            Bacteroidaceae; Bacteroides.
REFERENCE   1  (bases 1 to 10865)
  AUTHORS   Mahowald,M.A., Rey,F.E., Seedorf,H., Turnbaugh,P.J., Fulton,R.S.,
            Wollam,A., Shah,N., Wang,C., Magrini,V., Wilson,R.K.,
            Cantarel,B.L., Coutinho,P.M., Henrissat,B., Crock,L.W., Russell,A.,
            Verberkmoes,N.C., Hettich,R.L. and Gordon,J.I.
  TITLE     Characterizing a model human gut microbiota composed of members of
            its two dominant bacterial phyla
  JOURNAL   Proc Natl Acad Sci U S A 106 (14), 5859-5864 (2009)
   PUBMED   19321416
REFERENCE   2  (bases 1 to 10865)
  AUTHORS   Xu,J., Bjursell,M.K., Himrod,J., Deng,S., Carmichael,L.K.,
            Chiang,H.C., Hooper,L.V. and Gordon,J.I.
  TITLE     A genomic view of the human-Bacteroides thetaiotaomicron symbiosis
  JOURNAL   Science 299 (5615), 2074-2076 (2003)
   PUBMED   12663928
REFERENCE   3  (bases 1 to 10865)
  AUTHORS   Mahowald,M.A. and Gordon,J.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2009) Center for Genome Science, Washington
            University in St. Louis, 4444 Forest Park Ave., St. Louis, MO
            63108, USA
  REMARK    Protein update by submitter
REFERENCE   4  (bases 1 to 10865)
  AUTHORS   Xu,J., Bjursell,M.K., Himrod,J., Deng,S., Carmichael,L.K.,
            Chiang,H.C., Hooper,L.V. and Gordon,J.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-OCT-2002) Department of Molecular Biology and
            Pharmacology, Washington University in St. Louis, 660 S. Euclid,
            St. Louis, MO 63110, USA
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            AE015928.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000011065.1-RS_2024_09_05
            Annotation Date                   :: 09/05/2024 02:14:13
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,888
            CDSs (total)                      :: 4,801
            Genes (coding)                    :: 4,687
            CDSs (with protein)               :: 4,687
            Genes (RNA)                       :: 87
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 55 of 114
            Pseudo Genes (incomplete)         :: 60 of 114
            Pseudo Genes (internal stop)      :: 20 of 114
            Pseudo Genes (multiple problems)  :: 17 of 114
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..10865
                     /organism="Bacteroides thetaiotaomicron VPI-5482"
                     /mol_type="genomic DNA"
                     /strain="VPI-5482"
                     /type_material="type strain of Bacteroides
                     thetaiotaomicron"
                     /db_xref="taxon:226186"
     gene            complement(<1..324)
                     /locus_tag="BT_RS15970"
                     /old_locus_tag="BT3154"
                     /old_locus_tag="BT_3154"
                     /pseudo
     CDS             complement(<1..324)
                     /locus_tag="BT_RS15970"
                     /old_locus_tag="BT3154"
                     /old_locus_tag="BT_3154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007848344.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="two-component regulator propeller
                     domain-containing protein"
     gene            492..2918
                     /locus_tag="BT_RS15975"
                     /old_locus_tag="BT3155"
                     /old_locus_tag="BT_3155"
     CDS             492..2918
                     /locus_tag="BT_RS15975"
                     /old_locus_tag="BT3155"
                     /old_locus_tag="BT_3155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011108674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl hydrolase family 95 catalytic
                     domain-containing protein"
                     /protein_id="WP_011108674.1"
                     /translation="MRNVTLGLIIGAALLVSGSLSLKATENKMKLWYDKPADEWMKSL
                     PLGNGRLGVMIYGGIETETLALNESTMWSGEYDEHQQRPFGREKLNQVRKLFFENNLS
                     EGNHVAGNMMAGSPHSVGTHLPIGDLKINFSYPQGEISDYRHELDLHTAINTVSYKVG
                     NTEYIRQCIASNPDDVVAMHIKASRPKAITMELELKLLRQANVVASGNQLIYTGNAEF
                     EKHGKGGVHFEGRIAVQIKGGTIKAEGKKLYIEKATEVTLLSDVRTNFKNNTFSGYNY
                     KIKCEKTIELASKKDFKTLKKKHIEDYSPLFSRVGLSFEHHAKFDHLPNDERWARVKK
                     GESDPGLDALFFQYARYLLIASSRPNSPLPVALQGFFNDNLACHMGWTNDYHLDINTE
                     QNYWIANVGNLAECHLPLFDYIKDLSIHGAKTAKDLYGCKGWTAHTTANPWGYTAVSG
                     SILWGLFPTASSWLASHLWTQYDYTQDKDFLKNTAYPLLKSNAEFLLDYMVIDPRNNY
                     LVTGPSISPENSFRHQGQEFCASMMPTCDRVLAYEIFSACLQSTEILNVDASFADSLR
                     TAISKLPPFRISTNGGVQEWFEDYEEAHPNHRHTTHLLSLYPYSQITLNKTPELAKAA
                     RKTIERRLAAKDWEDTEWSRANMICFYARLKDSENAYNSVKQLLGKLSRENMFTVSPA
                     GIAGAGEDIFAFDGNTAGAAGIAEMLLQSHDNCIELLPCLPKEWKNGNFKGLCARGGI
                     EIDASWKNSQIVNAVLKATAPIEFTLRLSNAKLYCWKLNKKTFIPKIKDDGLIYISMN
                     KGDNLTIIIP"
     gene            3136..6297
                     /locus_tag="BT_RS15980"
                     /old_locus_tag="BT3156"
                     /old_locus_tag="BT_3156"
     CDS             3136..6297
                     /locus_tag="BT_RS15980"
                     /old_locus_tag="BT3156"
                     /old_locus_tag="BT_3156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016269154.1"
                     /GO_component="GO:0009279 - cell outer membrane [Evidence
                     IEA]; GO:0016020 - membrane [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SusC/RagA family TonB-linked outer membrane
                     protein"
                     /protein_id="WP_162303094.1"
                     /translation="MKERLFSFFKMNRLIPVIFCLFFATSIYAQNREVKGIVTGDDNE
                     PMAGATIKIKNSQGGAIADIDGKFTMRVKTGDILEISFLGMKKQEIKVDSNDFYSIKL
                     FPEANEFDEVTVVAFAKQKKESVISAISTVNPQELKVPSSNLTTALAGRMSGLIAFQT
                     TGEPGKDNAQFFVRGATTFGYKKDPLILIDNIELSTDDLARLNVDDIAQFSIMKDATA
                     TALYGARGANGVILVTTKQGVAGKPKVSVRVEQSVSTPRKKVELTDPITFMRLNNEAV
                     NSRRDPNNPAASANYTVYSQEKIENTIAGTNPYCYPAVNWYDELFNNYALSTRVNTNL
                     SGGGSAVRYYVAASYTKDGGVIKNDKLNNYNSNINWQRYSVRSNINMDLSKTTEFSIR
                     VNGNFDDYTGPLDSGEGLYKKVMKTSPVMYPKSYPATGEYVNATHVLFGNADKGAYIN
                     PYADMVRGYKESNNLLVAAQAELKQKFDFVTKGLDARILVSTTRSSYSDLTRAINPYY
                     YQADYDKETNSYTLTNIVEGEEYLSYNQGSRNINTTNYVEAAISYNRTFGVHATSGML
                     VYTRREEKRSSEDTLQKSLPRRNQGLAGRFTYAYDSRYFAEFNFGYNGSERFAAHERY
                     GFFPSFGLGYIISNESFWEPLLNTMDKLKFKMTYGLVGNDAIGSSDDRFYYLSEVNPN
                     DGGRGQYFGTNYGNQMNGVSISRYPNTNITWEKSKKGNFGIELGMFNSALEVQADFFY
                     ERRTQIYQNRAYIPSTMGLSAGVSANIGEASSRGVDLSVNYSYIANKDFWIKGMGNFT
                     LAKGRYEVYEEPDYASYGQGYRSRIGQPINFNYGYIAERLFIDENDVANSPSQTSFNG
                     GAMPGDIKYKDLNNDGKITSEDQIFLGYPNQPEITYGFGFSTGYKGFDLSMFFQGNAR
                     VSFFIDPRNTSPFVNYDAGGKTGVQQCLDVIAKDHWSEDNRNIYAFWPRLSPTLVENN
                     MQTSTWWMHDGSFIRLKTVELGYTFSQKALKKIGVQSLRLYLTGSNLLTFSKFKLWDA
                     EMGNNGLGYPIQRVYNLGININF"
     gene            6309..8324
                     /locus_tag="BT_RS15985"
                     /old_locus_tag="BT3157"
                     /old_locus_tag="BT_3157"
     CDS             6309..8324
                     /locus_tag="BT_RS15985"
                     /old_locus_tag="BT3157"
                     /old_locus_tag="BT_3157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016269155.1"
                     /GO_component="GO:0009279 - cell outer membrane [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RagB/SusD family nutrient uptake outer membrane
                     protein"
                     /protein_id="WP_011108676.1"
                     /translation="MKKITKYIPTIILTLLCSCSDYLDIVPDNVTTLDIVFNNRNTAE
                     RYLANCYHFVPDHGSVKRIPGMGAGHECWFYTTNDSHFDNEVSFYIARGLQNIDAPYA
                     NYWDGEGGSNLPMFRAIRECNIFLDYVRDQHKVNDLTDSERKRWIAEVNVLKAYYHFF
                     LFEHYGPIPIVDKALPVSTDPEGVKVTRMPVDQIVDYMVKLIDDSYKDLPPVITMEAT
                     EMGRLTQPAALALKAKILLWAASPLFNGNKDYANFRNEEGKPFINQEFSREKWVRTAE
                     ACKEAIESAETNGCQLYDCSMDMSYSQDLPEEIFYSMNIRQTVTERFNSELIWSVGKQ
                     GTNELQNLSMACIVPSLQQGSGNGQVTGSILQSRAAGVYAPTLETAEQFYSKNGVPID
                     EDKEWLTSGKYDNRYTTRQVTSADKYNMRTGWTTAVLHFNREPRFYGSLGFDGSTWYG
                     NGRTDVNDLNYVDGKYGRNSGNKWGFNYSITGYFAKKVVYYQNAITQSSQVVYEYPFP
                     IIRLGDLYLMYAESLNEATEGDNNVPEEVYTYLRKVRERSGLKKGVLGQTEDIGDVRV
                     AWEKYSNDPTKPKTKDGMRSIIKQERKIELALEGHQYNDLRRWKDASKELSKSIKGWN
                     VQGEIEEDFYKVTTLFVPRAFTTKDYLWPIKKQDLQVDDKLIQTYGW"
     gene            8344..9552
                     /locus_tag="BT_RS15990"
                     /old_locus_tag="BT3158"
                     /old_locus_tag="BT_3158"
     CDS             8344..9552
                     /locus_tag="BT_RS15990"
                     /old_locus_tag="BT3158"
                     /old_locus_tag="BT_3158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016269156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5000 domain-containing lipoprotein"
                     /protein_id="WP_011108677.1"
                     /translation="MKKRILYYIWIACAAVLLHSCEDVETHKPYGDGSGHAPGTVQVT
                     SYEQIPGGVTLKFIAPTDEDLLYIKIKYTLDNGKEMEARASLYTDETTIEGFGNTNPK
                     KLVISAVNKMEKEGEAIITEIVPGKPAYLTAIEEIEVNPTFGGIYIHTTNGGRNYLIF
                     DVSTKDSKGNWNIEHTEYTSVKNIGFTLRGFSAEPHDFKVRVRDLYDNQSEEYLTTLT
                     PLYEEKLDLTKFKTFYLANDIKMDNAGHTLESLFNGDHGLNSWNYAHGYDFNPSEFPV
                     WFTFDMGQTAQLSRFTSWQRSMGGSYYYRAGAIKEWEVWGRSDLPSSDGSWDGWTKLA
                     DCESIKPSGWPTGSNSEEDITYASKGEEFEFLADIPPVRYIRFKILSTHDGAGLVVMQ
                     QLWFYGTPIQ"
     gene            9573..10865
                     /locus_tag="BT_RS15995"
                     /old_locus_tag="BT3159"
                     /old_locus_tag="BT_3159"
     CDS             9573..10865
                     /locus_tag="BT_RS15995"
                     /old_locus_tag="BT3159"
                     /old_locus_tag="BT_3159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011108678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4998 domain-containing protein"
                     /protein_id="WP_011108678.1"
                     /translation="MKKINILILCSILCFFYSCNGMLDGIQPYLDEGEKIYVGKLDSL
                     KAFTGKNRIKIEGKMMYGVNQVKCVISYKDPITLEEKFKEFPIERTEPRETFEFMLEN
                     LTEGQYDFSIVTYDPKNNTSIPTEVSAYAYGELYQQALTNRILHSISPEQKEIVNESG
                     QSERIWAAKLNWNISRGDGLVGCNLEYERQDGTLGSKYISVDETTTELDNFKANGILR
                     YNSIYKPTTTSLDEFVTEYKEVTLPSQSYIGITKDLTSLYIKNAGYPFRGYDVNNKWG
                     KPYDWKWNEVMETKNANGGAGFTEYNDGTIQFETTQWSQGYYDNGKIWQTFTLPEGKY
                     EMRIEVKNAANIGSGSTNIHFAVAQGESLPDNEELEKSDIILSYLKFESEHTNKTSAL
                     PIFELTEEKTITVGWVVSFSDICRNIEFKSVRLWSVAE"
ORIGIN      
        1 aacacccctg tctgttccaa cccataaatt cctttcttta tcctcaaaaa gagcaccaat
       61 attatgatta cctgtaccct cctccaaatc atcgcaatcg aattggagaa tagaagttcc
      121 atcatagcgg ttgagcccat tttttgtccc aaaccacata aatccatagc tatcctgcaa
      181 gattgctttt acattactct ctgataaacc attttctcca ttaacacggg tgaaataaaa
      241 atcagaatat tcttgagcaa aaatacaaat agataagaat agcaatccat ttatgaaagc
      301 taatcgtagt aggtgtttct tcataaatta tatagtggtt atatttggct gtgcgcgcaa
      361 atatacacta aaaaacagta tataaaaagg agttgacgca tttgtttcag taatagccgc
      421 atttgttcat ttttactttt cccttctcct atacctttgc aatatcattt tgaaataaac
      481 tattttataa catgagaaac gtaacattag gcctgataat aggggccgca cttctagtta
      541 gtggtagtct gtcactgaag gcaaccgaga ataaaatgaa attatggtat gataaacctg
      601 cagatgaatg gatgaagtct cttcctttgg ggaacggtcg tcttggtgta atgatctatg
      661 gtggcataga aacagaaaca ctcgctctaa acgaatcaac aatgtggtca ggggaatatg
      721 atgaacatca gcaacgtcca ttcggaagag aaaaactcaa tcaagtaaga aagctatttt
      781 ttgaaaataa cttgtcagaa ggtaatcatg tcgcaggaaa tatgatggca ggtagcccac
      841 attcagtagg aacacatctt cccataggtg acttgaaaat aaatttttca tatcctcaag
      901 gagaaatatc agattatcgc catgaactgg atttacatac tgctataaat acagttagct
      961 ataaagtagg taatactgaa tatatacgcc aatgtatcgc ttctaatcca gatgacgtag
     1021 ttgctatgca tataaaagct agtcgtccaa aagcaataac gatggaactt gaattgaaat
     1081 tactcagaca ggcaaatgta gtagcatccg gtaaccaact tatttatacc ggtaatgcag
     1141 aatttgaaaa acatggtaaa ggaggagtac attttgaagg acgtattgct gtacaaataa
     1201 aaggaggaac aataaaggct gaagggaaaa aactttatat tgagaaagct actgaagtca
     1261 ctttattatc tgatgtacgt accaatttta aaaacaatac gttctctggt tacaactaca
     1321 aaataaaatg tgagaaaaca attgaattag catcaaagaa agattttaag actctgaaga
     1381 aaaaacatat agaagactat tctccacttt tctcccgggt aggactttcg tttgagcatc
     1441 acgcaaagtt tgatcaccta ccaaacgatg aacgttgggc acgggtaaag aaaggagaat
     1501 ctgatcctgg attagatgca ttatttttcc aatatgcccg ctatctgttg atcgcttctt
     1561 cacgtcctaa ttctcctcta cctgtagctt tacaaggttt ttttaacgat aatctcgctt
     1621 gccatatggg atggactaac gattatcatt tggatatcaa tactgaacaa aattattgga
     1681 ttgctaatgt aggtaattta gcagaatgtc atctccctct ttttgactat attaaagatc
     1741 tatcaattca tggtgcaaaa acagcaaaag atttatatgg ttgtaaagga tggactgcac
     1801 atactacagc caatccatgg ggatatacag ctgtatcagg tagtattctt tggggattat
     1861 tcccgactgc atcttcttgg cttgcctctc atttatggac acaatatgat tacacacaag
     1921 ataaagattt tttaaagaat accgcatatc cattattaaa aagtaatgct gaatttctat
     1981 tagattatat ggtaatagac ccacgaaata actatttggt aacaggtcct agtatctcgc
     2041 cggaaaacag ttttcgccat caaggacaag aattttgcgc atctatgatg ccgacttgcg
     2101 accgtgtact ggcttatgag atattctcgg catgcctgca atctacggaa atattaaatg
     2161 tcgatgcctc atttgccgac agcctccgta ccgctatcag caaactccct cctttccgta
     2221 tcagcacaaa cggaggagta caggaatggt ttgaagatta cgaagaagca catcccaatc
     2281 accgtcacac cacacactta ttatccctct atccttattc tcagattacc ttaaataaaa
     2341 cacccgaatt agcaaaagct gcccgaaaaa ctattgaaag acgtttagca gccaaagatt
     2401 gggaagatac agaatggagt cgtgctaaca tgatttgctt ttatgcccga ttaaaagact
     2461 ctgaaaatgc ttataatagt gtaaaacaat tacttggaaa actatcacgt gaaaacatgt
     2521 ttacagtttc tcccgctggt attgccggag caggtgaaga catcttcgct tttgacggga
     2581 atacagccgg agcagcaggt attgcagaaa tgttattaca aagtcacgat aattgcattg
     2641 aattattacc gtgcttacct aaagaatgga aaaacggaaa ttttaaagga ctttgtgctc
     2701 ggggaggtat tgaaatagat gcgagttgga aaaatagcca aatagtaaat gcagtactaa
     2761 aagctaccgc tccaatagaa tttactcttc gtctatcaaa tgcaaaacta tactgttgga
     2821 agttgaacaa aaaaacattc attcctaaaa taaaggatga tggactaatt tatatatcca
     2881 tgaataaagg agataatctt accataatca tcccttaata acaattttgc agtaaatgcg
     2941 ttattttttg ctgcgtttat acactattaa aataacacat ttacctaatt ttgactcgtt
     3001 gaatttagaa aattatcaca ttaaatctaa taatatatga aacgaattcg agatttcccc
     3061 accactgaca agacaacgat ctagttgcct gaaatgtatt aacctaatat taattttaaa
     3121 ttatccatga aaaatatgaa agaaagactt ttttcattct ttaaaatgaa tcgactgatt
     3181 ccagtcatat tctgtctttt ctttgcgaca agtatatatg cgcaaaatag agaagtgaag
     3241 ggtatagtga caggtgacga taatgaacct atggcaggag ctaccatcaa aataaaaaac
     3301 agtcaaggtg gtgcaattgc agatattgac ggaaaattca ctatgcgagt aaaaaccgga
     3361 gatatattag aaatttcgtt tcttggcatg aaaaagcaag aaataaaagt agatagtaac
     3421 gacttttact ctattaaatt atttcctgaa gctaatgagt ttgacgaagt aacggtagtt
     3481 gcttttgcca agcaaaagaa agagagcgta attagtgcca tctctacagt aaatccacag
     3541 gaactgaaag taccgagtag caatctgaca accgctcttg ccggaagaat gtccggacta
     3601 attgctttcc aaacaacagg tgaacccggt aaggacaatg ctcagttctt tgtgcgtggt
     3661 gccacaacat ttggttataa aaaagatcct cttattttga ttgacaacat tgaattgagt
     3721 acagatgatc ttgcccgctt gaatgtggat gacattgctc aattttctat tatgaaagac
     3781 gctacagcca ctgctttgta cggcgcgcgt ggagcaaatg gagtaatcct tgtgaccact
     3841 aaacaaggag tcgccggaaa gccgaaagta tccgtccgtg tagaacaatc agtatccact
     3901 cctcgaaaga aggtggaatt aacagatcct atcaccttta tgcgattaaa taatgaagct
     3961 gtaaactctc ggcgtgatcc taacaatcct gccgccagcg ctaattacac agtttatagt
     4021 caagaaaaaa tagaaaatac aattgctggt accaacccat attgttatcc ggcagtaaat
     4081 tggtatgatg aactattcaa taactacgct ctttctacaa gagtaaatac taatctaagt
     4141 ggaggaggca gtgcagtacg ttattatgta gcagcttcat ataccaaaga cggaggagtg
     4201 atcaaaaatg ataaactcaa caactacaac agtaacatta actggcaacg ttattctgtt
     4261 cggtctaata tcaatatgga tcttagcaag actacagaat tctctattcg cgtcaatgga
     4321 aattttgatg actataccgg tccgttggac agtggtgaag gactttataa gaaggtaatg
     4381 aagacaagcc ctgttatgta tcctaaaagt tatcctgcaa caggcgaata tgtcaatgct
     4441 acgcatgtgc tatttggtaa tgccgataaa ggagcctaca ttaatccata tgcagatatg
     4501 gttagaggat acaaagaatc caataattta ttggtagctg cacaagcaga attaaaacaa
     4561 aagttcgact tcgtaaccaa aggattggat gcccgaatct tagttagtac cactcgctct
     4621 tcttattccg accttactcg agctatcaat ccttattatt atcaggccga ctatgacaaa
     4681 gaaaccaata gttatacatt gactaacatt gtagaagggg aagagtattt gtcatacaat
     4741 caaggaagca gaaatatcaa cactaccaac tatgtagaag ctgccatcag ctataaccga
     4801 acattcggtg tgcatgccac tagcggaatg ttagtatata ctcgccgaga agaaaaaaga
     4861 tcaagtgaag acactctaca gaaatcacta ccacgcagaa accaagggct agcaggtcgc
     4921 tttacctatg cttacgattc cagatatttt gcagaattca actttggata taacggttct
     4981 gaacggtttg ctgctcacga acgatacggt ttcttccctt ccttcggttt agggtatatc
     5041 atttcgaacg aaagcttttg ggagccatta ttaaacacaa tggataaact gaaattcaaa
     5101 atgacctatg gtctggtagg taatgatgcc attggaagtt cagatgatcg tttctattat
     5161 ttatcggaag taaatccaaa tgatggtgga cgtggccaat attttggaac aaattacggc
     5221 aaccaaatga atggtgtatc tatttctcgt tatcccaaca ctaatattac atgggagaaa
     5281 tcaaagaaag ggaactttgg tattgaatta ggtatgttca acagtgcatt agaagttcaa
     5341 gctgacttct tctatgaacg tcgtactcaa atttaccaaa accgcgccta cattccttct
     5401 acaatgggac tttctgccgg agtaagtgct aatataggtg aagcatcttc ccgaggagtt
     5461 gatttatcag tcaactattc ttatattgcc aataaagatt tctggataaa aggaatgggt
     5521 aatttcacgc ttgccaaagg aaggtatgaa gtctatgaag aaccagatta tgctagttac
     5581 ggacaagggt atcgttctag aatagggcaa ccaatcaact ttaattacgg atatatcgcc
     5641 gaacgcctat ttattgatga aaatgatgtt gccaactctc cctcacaaac aagtttcaat
     5701 ggtggagcca tgccgggaga tattaaatat aaagatttaa ataatgatgg aaaaattact
     5761 agtgaagacc aaatttttct cggttatcct aatcaacctg aaattactta cggatttggt
     5821 ttctctaccg gctacaaagg attcgacctc tctatgtttt ttcaaggaaa tgcaagagta
     5881 tcttttttca tcgaccctag aaacacatct ccttttgtaa actacgatgc aggtggaaag
     5941 acgggtgttc aacaatgttt ggatgttata gccaaagatc attggtctga agacaatcgt
     6001 aatatatacg cattttggcc acgtttatct cctacacttg ttgaaaataa tatgcaaaca
     6061 agtacctggt ggatgcatga cggatcattt attcgtctga aaactgtaga attaggttat
     6121 acattctcgc aaaaagctct gaaaaaaata ggtgtacaat ctttgcgcct atacttaaca
     6181 ggaagtaacc tactaacctt cagcaaattt aaactatggg atgcagaaat gggtaataat
     6241 ggcctaggat atcctattca gcgagtatat aacctcggca ttaacattaa cttctaaaaa
     6301 gcaatgatat gaaaaaaatt acgaaatata ttccgactat cattttgacg ttgctttgtt
     6361 cttgttcaga ttatttggat atagttcccg ataatgtgac aacattggac attgtattca
     6421 acaacagaaa tacagccgaa cgctatttgg ccaactgcta ccattttgtt ccagaccatg
     6481 gatctgtcaa acgaattccc ggcatgggag ccggacacga atgttggttc tatactacta
     6541 atgactctca ctttgacaat gaagtcagct tttatatagc ccgtggatta cagaatattg
     6601 atgctcctta tgccaattat tgggacggag aaggaggcag taatcttccc atgttccgtg
     6661 ccattagaga gtgtaatatc tttcttgatt atgtaagaga tcagcataaa gtgaacgact
     6721 tgacagattc tgaacgaaaa agatggatcg ccgaagtaaa cgtactaaaa gcctattacc
     6781 attttttcct atttgaacac tatggcccta ttcctattgt agacaaagct cttcctgtat
     6841 cgactgatcc agaaggagta aaagttactc gcatgccggt agatcaaata gttgattaca
     6901 tggtaaagct catagacgac tcgtacaaag acttgccacc agtcatcact atggaagcta
     6961 cagaaatggg acgtttgaca caacctgcag cattagccct taaagccaaa atactgctgt
     7021 gggcagctag tcctctcttc aatggaaaca aagattatgc aaatttcaga aatgaagaag
     7081 gaaaaccatt catcaaccaa gaattcagcc gtgaaaaatg ggtgagaaca gctgaagcat
     7141 gtaaagaggc catagaatct gcagaaacca acggatgtca actttatgac tgcagcatgg
     7201 acatgtctta tagccaggac ctaccagaag aaatatttta cagcatgaat atccgtcaaa
     7261 cagtaacaga acgttttaac tccgaattga tatggagcgt aggcaaacag ggtaccaatg
     7321 aactgcaaaa cctatcgatg gcttgtatcg ttccttcttt gcaacaagga agtggaaacg
     7381 gtcaagtaac aggcagtatt ttgcaaagca gggcagcagg tgtatatgct cctacactgg
     7441 aaactgcaga acaattttac agtaaaaatg gagtgcccat tgacgaagac aaagaatggt
     7501 taacaagcgg aaaatatgat aatcgttaca caacccgaca agtgactagt gctgataaat
     7561 ataacatgcg aacaggctgg accactgccg tacttcactt caacagagaa ccccgcttct
     7621 acgggtctct cggtttcgat ggttccactt ggtatggtaa cggacgtaca gatgtcaatg
     7681 acttgaatta tgtagatggt aaatatggaa gaaactctgg aaacaaatgg ggatttaact
     7741 actccattac aggttatttc gctaaaaaag tagtatatta tcaaaatgct ataactcaat
     7801 cttcacaagt agtctacgaa tacccattcc ctattatcag attaggcgac ttgtatctaa
     7861 tgtatgcaga atcacttaat gaagctacag aaggtgataa taatgtaccg gaagaagttt
     7921 atacatacct acggaaggta cgcgaacgtt ctggattgaa aaaaggtgta cttggacaga
     7981 ccgaagatat aggagatgtc agagtagcat gggaaaagta cagcaatgat cctaccaaac
     8041 ctaaaactaa agatgggatg agaagtatca tcaaacagga acgtaaaatt gaacttgcgt
     8101 tggaaggaca tcaatacaat gatctcagac gatggaaaga cgcttcaaaa gaactgagta
     8161 aatccattaa aggatggaac gtacaaggag aaatagagga agacttttat aaagtcacaa
     8221 ctctctttgt tcctcgcgca tttacaacta aagactattt gtggcctata aaaaaacaag
     8281 acttacaagt agacgacaaa ttaattcaaa cgtatggatg gtaattataa acatcgaaaa
     8341 acaatgaaaa aaagaatctt atattatata tggatagcat gtgcggcagt attgctacac
     8401 agttgcgaag atgtagaaac tcataaacct tatggggatg gcagtggaca tgctcctggt
     8461 acagtacaag tgacttccta tgaacaaatt cctggtggag tgacattgaa attcattgct
     8521 ccaacagacg aagatctatt gtatatcaaa ataaaatata cacttgacaa tggaaaagaa
     8581 atggaagcac gtgcttctct ctatactgat gaaacgacaa tagaaggttt cggaaatacg
     8641 aatccgaaaa aactagtaat ctcagccgtt aacaaaatgg agaaagaagg agaagctatc
     8701 atcaccgaaa tagtacctgg aaaaccggca taccttactg ccattgaaga aatagaggta
     8761 aatcctacat tcggaggtat ttatatacat actacaaatg gaggcagaaa ctatctcatc
     8821 tttgatgtat ctacaaaaga ttcaaaaggt aattggaata tagaacatac agaatatact
     8881 tctgtaaaaa acatcggctt tacactccga gggttctctg ccgaaccaca tgattttaaa
     8941 gttcgtgtcc gcgatctata tgataaccag tcagaagaat acttaacaac cttgacacca
     9001 ctatatgaag aaaaattgga tttgaccaaa ttcaaaactt tctatctagc caatgatata
     9061 aagatggaca acgcaggtca tactttggag tctttattca atggagatca tggattaaac
     9121 agttggaatt atgctcacgg ttatgacttt aatccttccg agtttcctgt atggtttaca
     9181 ttcgatatgg gtcaaaccgc tcaattaagc cgcttcacct catggcaacg ctccatggga
     9241 ggtagttatt actatcgtgc aggtgctatc aaagaatggg aagtatgggg acgttctgat
     9301 ttaccatctt cggacggaag ttgggacgga tggaccaaac tggcagattg tgaaagcata
     9361 aaaccttccg gatggcccac cggttcaaat tcagaagaag atataacata tgctagtaaa
     9421 ggagaagaat ttgaatttct agcagatatt cctccagtaa gatacattcg atttaaaata
     9481 ctttctactc atgacggtgc cggattggta gttatgcagc aactttggtt ctacggaacc
     9541 ccgatacaat aaccttttaa caaagcaaaa gtatgaaaaa aataaatata ttgattctct
     9601 gtagtatcct gtgctttttc tattcatgta atggcatgct ggatggcatt cagccttatc
     9661 tagacgaggg agaaaaaatc tatgtaggaa aacttgattc actcaaagct tttactggaa
     9721 aaaacagaat caaaatagaa ggaaaaatga tgtacggtgt aaatcaggta aaatgtgtta
     9781 tcagttacaa agatcctatt acattggaag aaaagtttaa agagtttcca atagaacgta
     9841 cggaaccacg agaaaccttc gaatttatgt tagagaattt aacagaagga caatatgact
     9901 tctcgatagt cacctatgat cccaaaaaca acacatctat cccgacagag gtatctgctt
     9961 atgcatatgg cgaactatac caacaagcat taaccaaccg gattttacat agtatctctc
    10021 ctgaacaaaa agaaattgta aatgaaagtg gacaatcaga aagaatatgg gcagccaaac
    10081 tgaattggaa tatatcaaga ggagatggtt tagtaggctg taaccttgaa tatgaacgtc
    10141 aggacggaac tttaggctcg aaatatattt cagttgacga gactacaaca gaactcgaca
    10201 attttaaagc taatggaata ctccggtaca atagtatata taaaccgaca acaacttcct
    10261 tggacgaatt tgttacagaa tataaagaag ttacattgcc ttcccaaagt tacattggca
    10321 ttacaaaaga cctaaccagt ctttatatta agaatgccgg atatccattt agaggatatg
    10381 atgtaaacaa taaatgggga aaaccttacg attggaaatg gaatgaagtt atggaaacta
    10441 aaaatgccaa tggaggtgcc ggcttcacag aatataacga tggaacaatt cagttcgaaa
    10501 caacacaatg gagtcaggga tattatgaca acggaaagat ctggcaaaca tttactttac
    10561 cagaaggaaa gtatgaaatg cgtatcgaag taaaaaacgc cgcaaatata ggttctggca
    10621 gtaccaatat ccattttgct gtagctcaag gcgaatcact acccgacaat gaagaattgg
    10681 aaaagtcaga cattatcctc tcttacctca aatttgagtc agaacatact aataaaacat
    10741 ctgccttacc tatatttgaa ctaacagaag aaaaaactat taccgtaggc tgggtagtat
    10801 ctttctcaga tatctgtaga aatatagaat ttaagtcagt aagattgtgg agtgtagctg
    10861 aataa
//
